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Colourants used in food and pharmaceuticals – A comparison of natural and synthetic colours 食品和药品用着色剂。天然和合成着色剂的比较
CURRENT MEDICAL AND DRUG RESEARCH Pub Date : 2019-07-20 DOI: 10.53517/cmdr.2581-5008.312019193
Preethy Bhasimon
{"title":"Colourants used in food and pharmaceuticals – A comparison of natural and synthetic colours","authors":"Preethy Bhasimon","doi":"10.53517/cmdr.2581-5008.312019193","DOIUrl":"https://doi.org/10.53517/cmdr.2581-5008.312019193","url":null,"abstract":"Colourants are mainly used to impart a distinctive appearance to the food and various pharmaceutical dosage forms. Colourants can be considered as the cosmetics for food and dosage forms as the aesthetic appearance are enhanced by various colours. The colourants are strictly studied, regulated and monitored before it is used at the intended level. The colourants used may be either naturally occurring colours or synthetically prepared. A colourant is a substance which when applied to a food, drug or cosmetics is capable of imparting colour. FDA is responsible for regulating all colourants are safe to eat, contain only approved colours and are accurately labelled and certified. Colours are those which are synthetically prepared and are capable of imparting an intense uniform colour, less expensive and blend more easily to create a huge variety of hues. Good health makes a lot of sense, but it doesn’t make a lot of dollars. Manufactured food is pumped full of toxic chemicals meant to dress it up and entice consumers to buy. The synthetic colours are responsible for specific teratogenic and carcinogenic effects.","PeriodicalId":335276,"journal":{"name":"CURRENT MEDICAL AND DRUG RESEARCH","volume":"34 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-07-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"116486352","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Hazards of cosmetics and the role of Ayurveda in skincare 化妆品的危害和阿育吠陀在护肤中的作用
CURRENT MEDICAL AND DRUG RESEARCH Pub Date : 2018-11-20 DOI: 10.53517/cmdr.2581-5008.222018190
J. K. Painuli, Mayank Bhatkoti
{"title":"Hazards of cosmetics and the role of Ayurveda in skincare","authors":"J. K. Painuli, Mayank Bhatkoti","doi":"10.53517/cmdr.2581-5008.222018190","DOIUrl":"https://doi.org/10.53517/cmdr.2581-5008.222018190","url":null,"abstract":"Skin is the largest organ of the human body and requires proper care. In the present era, there is a demand for a good appearance either a slim body or beautiful skin. Increasing call of cosmetics all over the world from teen to adult has increased awareness related to safety issue. Group of fragrances, preservatives, antioxidants, ultraviolet absorbers, emollients, emulsifiers etc are the most common ingredient in cosmetic. A number of skin problems, skin irritation, skin carcinoma, etc. are reported due to the use of cosmetic made up of harmful chemicals. In the traditional era, people were used various Lepa, Alepa, Pralepa, etc. for saundarya prasadam karma. Nature has offered the way to keep up that parity. Herbs are one such means. The Federal Food, Drug and Cosmetic Act (FD)","PeriodicalId":335276,"journal":{"name":"CURRENT MEDICAL AND DRUG RESEARCH","volume":"78 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2018-11-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"126315494","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Antimicrobial activity of a new entomopathogenic bacteria Acinetobacter 一种新的昆虫病原细菌不动杆菌的抑菌活性
CURRENT MEDICAL AND DRUG RESEARCH Pub Date : 2018-11-20 DOI: 10.53517/cmdr.2581-5008.222018189
I. Deepa, C. Mohandas
{"title":"Antimicrobial activity of a new entomopathogenic bacteria Acinetobacter","authors":"I. Deepa, C. Mohandas","doi":"10.53517/cmdr.2581-5008.222018189","DOIUrl":"https://doi.org/10.53517/cmdr.2581-5008.222018189","url":null,"abstract":"The entomopathogenic nematodes (EPNs) are a nematode-bacterium complex. The symbiotic nematode-bacterial mutualism is highly specific. Novel EPN belonging to the family rhabditidae were reported for the first time from the Central Tuber Crops Research Institute. These new EPNs belonging to the Rhabditis sp. and their symbionts offer great scope for their exploitation of bio separation and identification of novel bioactive molecules. The present work is mainly focused on the antimicrobial activity of a new entomopathogenic bacteria Acinetobacter. The bacteria were isolated from infective third stage dauer juveniles of the nematode isolate collected from Vellayani, Thiruvananthapuram. The incubation time of the bacteria was standardized and cell free culture filtrate was prepared. The cell free culture filtrate was then separated into an organic and aqueous fraction. Antibacterial and antifungal activity of the organic fraction were tested. The organic fraction of 72 hr have highest antibacterial activity against B.subtilis with a zone diameter of 20 mm and lowest antibacterial activity with a zone diameter of 13 mm against P. aeruginosa and antifungal activity (29 mm zone diameter) in case of A. flavus and lower in case of F. oxysporum (18 mm zone diameter). Antimycotic and antibacterial activity was not observed in 24 hr organic fraction. From the study, it can be concluded that the organic fraction has significant antibacterial and antifungal activity. The present study also reveals that this entomopathogenic bacteria will be useful for the production of bioactive metabolites effective against bacterial and fungal diseases of plants and animals.","PeriodicalId":335276,"journal":{"name":"CURRENT MEDICAL AND DRUG RESEARCH","volume":"132 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2018-11-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"121584393","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A clinical trial for the efficacy of Ashwagandha powder in obsessive-compulsive disorder 印度人参散治疗强迫症的临床研究
CURRENT MEDICAL AND DRUG RESEARCH Pub Date : 2018-11-20 DOI: 10.53517/cmdr.2581-5008.222018188
N. Saini
{"title":"A clinical trial for the efficacy of Ashwagandha powder in obsessive-compulsive disorder","authors":"N. Saini","doi":"10.53517/cmdr.2581-5008.222018188","DOIUrl":"https://doi.org/10.53517/cmdr.2581-5008.222018188","url":null,"abstract":"Obsessive-compulsive disorder (OCD) is a ceaseless mental issue that is causally connected to the dysregulation of the serotonergic framework. OCD is believed to be a standout amongst the most obstinate and impairing nervousness related mental issues in the network, described by steady and pain causing considerations (obsessions), which are egodystonic and apparently intentional conduct (impulses). The present examination has assessed the viability of Ashwagandha choorna (powder). The powder at a dose of 4.5 g, twice a day, after sustenance, nearby nectar was given to them orally for multi-month. In the wake of completing treatment, follow-up was done. Three examinations of before treatment, after treatment and after improvement were done. Criteria of examination relied upon the scoring of Yale-Brown Obsessive Compulsive Scale (Y-BOCS) and Yale-Brown Obsessive Compulsive Symptom Checklist was used to perceive signs. Paired 't' test was used for real appraisal. The results showed that Ashwagandha powder gave 24.66% of help (p","PeriodicalId":335276,"journal":{"name":"CURRENT MEDICAL AND DRUG RESEARCH","volume":"56 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2018-11-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"124507175","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Mucoadhesive assessment – An encyclopedic review 黏合剂评估。百科全书式回顾
CURRENT MEDICAL AND DRUG RESEARCH Pub Date : 2018-11-20 DOI: 10.53517/cmdr.2581-5008.222018187
R. Semwal, R. Semwal, D. Semwal
{"title":"Mucoadhesive assessment – An encyclopedic review","authors":"R. Semwal, R. Semwal, D. Semwal","doi":"10.53517/cmdr.2581-5008.222018187","DOIUrl":"https://doi.org/10.53517/cmdr.2581-5008.222018187","url":null,"abstract":"Primary objectives behind the use of mucoadhesive drug delivery devices are to prolong their residential time at the particular site to make them target specific, and to enhance the drug absorption process. In this way, the measurement of mucoadhesivity is a crucial step to design the mucoadhesive drug delivery systems. The strategy of the use of mucoadhesive polymeric materials to improve the efficacy of therapeutic treatments has been introduced as long ago and the approach is still of a great interest in the field of pharmaceutical sciences. Nowadays, various methods used to measure the mucoadhesivity are included in the present review. These systems are usually in vitro or ex vivo in nature, and due to their relative ease of implementation and cost-effectiveness, these are limited in scope and still a serious need to improve their trait. The selection of such systems for the in vivo studies is a big challenge. Hence, the new discovery in the field of mucoadhesive drug delivery could be a great achievement to the scientific society.","PeriodicalId":335276,"journal":{"name":"CURRENT MEDICAL AND DRUG RESEARCH","volume":"27 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2018-11-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"126571637","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 4
Spectral studies and pharmacological relevance of berberine isolated from Berberis aristata roots 小檗根中小檗碱的光谱研究及其药理意义
CURRENT MEDICAL AND DRUG RESEARCH Pub Date : 2018-06-03 DOI: 10.53517/cmdr.2581-5008.212018181
R. Semwal, D. Semwal, Sonali Aswal, Ankit Kumar
{"title":"Spectral studies and pharmacological relevance of berberine isolated from Berberis aristata roots","authors":"R. Semwal, D. Semwal, Sonali Aswal, Ankit Kumar","doi":"10.53517/cmdr.2581-5008.212018181","DOIUrl":"https://doi.org/10.53517/cmdr.2581-5008.212018181","url":null,"abstract":"Berberis aristata DC., commonly known as Indian barberry or Daruharidra, belongs to the Berberidaceae family. The plant root is well-known Ayurvedic medicine for diabetes, eye problems, skin disorders, and urinary tract diseases. The plant contains a variety of alkaloids including berberine, oxyberberine, berbamine, aromoline, karachine, palmatine, oxycanthine and taxilamine. The plant is reported to have hypoglycemic, antimicrobial, antipyretic, anti-inflammatory, hepatoprotective, antioxidant, anticancer and antiplatelet activities in different experimental models. In the present study, berberine was isolated in the form of its chloride salt from the roots of B. aristata. The molecule was characterised by a detailed spectral analysis including two-dimensional NMR studies. The molecule was also reviewed for its pharmacological relevance together with the possible mode of action.","PeriodicalId":335276,"journal":{"name":"CURRENT MEDICAL AND DRUG RESEARCH","volume":"21 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2018-06-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"115939988","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 3
Cannabis a "new" old medicine? - The challenges of its medical use in the XXI century 大麻是“新”旧药?- 21世纪其医疗用途的挑战
CURRENT MEDICAL AND DRUG RESEARCH Pub Date : 2018-03-25 DOI: 10.53517/cmdr.2581-5008.212018182
Silvia Etcheverry
{"title":"Cannabis a \"new\" old medicine? - The challenges of its medical use in the XXI century","authors":"Silvia Etcheverry","doi":"10.53517/cmdr.2581-5008.212018182","DOIUrl":"https://doi.org/10.53517/cmdr.2581-5008.212018182","url":null,"abstract":"Cannabis sativa L. is an ancient plant, that has been used during centuries as rope, cloth, paper, oil and birdfeed and also a well-known psychoactive drug included in the lists of UN 1961 Convention and the following documents related. Likewise, it has remarkable pharmacological properties recognized by tradition that now object of scientific research. This plant produces a unique series of secondary metabolites called cannabinoids which exhibit a typical C21 terpenophenolic skeleton, responsible for its pharmacological profile. These cannabinoids interact with the endogenous endocannabinoid system, involved in the regulation of a variety of physiological and cognitive processes including fertility, pregnancy, during pre- and postnatal development, appetite, painsensation, mood and memory. Some of these pharmacological activities are so novel and interesting that justify the scientific research in these areas which is performing now. This process is expensive and takes a lot of time, and in the meantime, millions of people use cannabis herb, for medical treatments based in traditional use. Taking into consideration this fact, there are some countries have approved the medical use of cannabis, creating specific regulations. Also, the Expert Committee on Drug Dependencies, of the World Health Organization (WHO) held in June 2018 a report about the medical use of cannabis. This report recommends that a critical review of the scientific literature on the cannabis plant and its resin, extracts or tinctures should be performed and that Cannabidiol (CBD) should not be included in the lists of prohibited substances","PeriodicalId":335276,"journal":{"name":"CURRENT MEDICAL AND DRUG RESEARCH","volume":"103 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2018-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134588811","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A clinical trial to establish the relationship between behavioural patterns and health status 建立行为模式与健康状况之间关系的临床试验
CURRENT MEDICAL AND DRUG RESEARCH Pub Date : 2018-03-25 DOI: 10.53517/10.53517/cmdr.2581-5008.212018183
Bodhini Lakshika Edirisinghe, K.C. Perera
{"title":"A clinical trial to establish the relationship between behavioural patterns and health status","authors":"Bodhini Lakshika Edirisinghe, K.C. Perera","doi":"10.53517/10.53517/cmdr.2581-5008.212018183","DOIUrl":"https://doi.org/10.53517/10.53517/cmdr.2581-5008.212018183","url":null,"abstract":"In the present time, bad lifestyle is a major cause of metabolic and heart-related disorders including stroke, obesity and diabetes. The present work aimed to establish the relationship between behavioural patterns and health status in human. A randomized clinical trial was conducted in Borella in which 50 patients were selected for the present study. All the patients were registered in the OPD of the Ayurvedic hospital, Borella. A questionnaire was used to collect information about the habits and health-related issues. The results suggested that there was no significant relationship of bad habits including cigarettes smoking, alcohol consumption and the day time sleeping with the body mass index (BMI). The study concluded that the intake of sweets and oily foods was positively related to increased BMI.","PeriodicalId":335276,"journal":{"name":"CURRENT MEDICAL AND DRUG RESEARCH","volume":"100 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2018-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"132485877","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Management of Vicarcika (eczema) with Rukshana, Snehana and Virechana procedures Rukshana、Snehana和Virechana程序治疗湿疹
CURRENT MEDICAL AND DRUG RESEARCH Pub Date : 2018-03-25 DOI: 10.53517/cmdr.2581-5008.212018184
Prerok Regmi, Sudheendra V. Honwad, Madan Bhandari, Misant Dhakal
{"title":"Management of Vicarcika (eczema) with Rukshana, Snehana and Virechana procedures","authors":"Prerok Regmi, Sudheendra V. Honwad, Madan Bhandari, Misant Dhakal","doi":"10.53517/cmdr.2581-5008.212018184","DOIUrl":"https://doi.org/10.53517/cmdr.2581-5008.212018184","url":null,"abstract":"Vicarcika is a chronic illness characterized by skin eruptions and itching with oozing. If it is neglected then normal condition of the body may be affected. This condition is called as Kushta in Ayurveda. Most of such cases have appearance of Kandu (excessive itching), Pidaka (papules, vesicles and pustules), Shyava (erythema with discolouration), Bahusrava (profuse discharge and oozing), Raji (thickening and lichenification of the skin), Ruja (pain) and Ruksha (dry lesion). The present study highlights a case of 69years old male patient with major complains of discharge, itching on skin and severe pain on both lower limbs. He was managed successfully with treatment steps of Rukshana, Snehana and Virechana procedures. After 10 days of treatment, the acute inflammation was reduced with no discharge, old dead scaly layer get dried out and scaled off whereas the edema was markedly reduced. Moreover, pain and itching sensation were reduced in patient while the condition of erythema was completely disappeared.","PeriodicalId":335276,"journal":{"name":"CURRENT MEDICAL AND DRUG RESEARCH","volume":"28 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2018-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"133922561","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Biomarkers in cancer diagnosis – Status and challenges 生物标志物在癌症诊断中的地位和挑战
CURRENT MEDICAL AND DRUG RESEARCH Pub Date : 2017-07-20 DOI: 10.53517/cmdr.2581-5008.112017171
A. Chauhan
{"title":"Biomarkers in cancer diagnosis – Status and challenges","authors":"A. Chauhan","doi":"10.53517/cmdr.2581-5008.112017171","DOIUrl":"https://doi.org/10.53517/cmdr.2581-5008.112017171","url":null,"abstract":"Cancer is the second largest disease throughout the world with an increasing mortality over the past few years. This is mainly because of highly heterogeneous in nature and a few effective therapeutic strategies for the treatment. This also represents challenges amongst healthcare professionals and governments. Although a significant advance has been made in cancer treatment, the morbidity and mortality are still enormous. The possibility of detecting cancer at early stages, before it spreads to distant tissues, has been a matter of great interest amongst physicians and scientists because early diagnosis is a key factor for the successful treatment of cancer. To achieve this, we still need of a potential biomarker with significant diagnostic accuracy for cancer.","PeriodicalId":335276,"journal":{"name":"CURRENT MEDICAL AND DRUG RESEARCH","volume":"11 12 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2017-07-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"128641137","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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