CURRENT MEDICAL AND DRUG RESEARCH最新文献

COVID-19 and risk of cardiomyocyte injury: The prevailing scenario COVID-19和心肌细胞损伤的风险:普遍情况

CURRENT MEDICAL AND DRUG RESEARCH Pub Date : 2021-05-25 DOI: 10.53517/cmdr.2581-5008.512021211

M. Al-Niemi, Nawar R. Hussain, H. Al-kuraishy, Ali I. Al-Gareeb

引用次数: 2

Current and future role of immobilized enzymes in medical field 固定化酶在医学领域的应用现状及前景

CURRENT MEDICAL AND DRUG RESEARCH Pub Date : 2021-05-25 DOI: 10.53517/cmdr.2581-5008.512021213

M. R. Khan

引用次数: 2

The potential role of Bromhexine in the management of COVID-19: Decipher and a real game-changer 溴甲胺在COVID-19管理中的潜在作用:破译和真正的游戏规则改变者

CURRENT MEDICAL AND DRUG RESEARCH Pub Date : 2021-05-25 DOI: 10.53517/cmdr.2581-5008.512021212

H. Al-kuraishy, M. Al-Niemi, Nawar R. Hussain, Ali I. Al-Gareeb, C. Lugnier

引用次数: 2

Elucidation of the origin of autoimmune diseases via computational multiscale mechanobiology and extracellular matrix remodeling: theories and phenomenon of immunodominance 通过计算多尺度机械生物学和细胞外基质重塑阐明自身免疫性疾病的起源:免疫优势的理论和现象

CURRENT MEDICAL AND DRUG RESEARCH Pub Date : 2021-05-25 DOI: 10.53517/cmdr.2581-5008.512021215

R. Kumar

引用次数: 1

Spatial mapping and enshrined capacity: Assessment of COVID-19 servicing Indian hospitals 空间制图和庄严的能力:评估为印度医院提供服务的COVID-19

CURRENT MEDICAL AND DRUG RESEARCH Pub Date : 2021-05-25 DOI: 10.53517/cmdr.2581-5008.512021214

N. Ravichandran, S. Shivangi, B. Rakesh

{"title":"Spatial mapping and enshrined capacity: Assessment of COVID-19 servicing Indian hospitals","authors":"N. Ravichandran, S. Shivangi, B. Rakesh","doi":"10.53517/cmdr.2581-5008.512021214","DOIUrl":"https://doi.org/10.53517/cmdr.2581-5008.512021214","url":null,"abstract":"In Public health crises like COVID-19, healthcare services alone won‟t essentially cause the well-liked changes within the health status and outcome. Human resources with needed competency for managing healthcare crisis could be a challenge, and can‟t be over accentuated. A systemic approach adopted to analyze knowledge, management, and delivery of COVID-19 services in the Indian context while the concentration curve alongside regression statistical techniques was used to examine the nature of competency and skill variations among the health-functionaries. Training processes on COVID-19 aren‟t streamlined and systematic. The method of organizing a training programme depends upon the need-based mostly. This mirrored within the variability of health-functionaries reported with adverse events, infected with the coronavirus. Several COVID-19 strategies focused on healthcare-functionaries and its associated front-liners to save lots of lives and alter the lifestyles of the population. The stigmatized COVID-19 disease brutally distanced the frontline health-workers and socially distanced the sufferers' delay in reporting, with heightened morbidity and mortality. Training is just on information rather than on competencies for action. The quality training and the level of community-based health intervention flaunted not to expect health functionaries to perform expectedly. Training-competency and skills-related inequality and inequity in health exist. There‟s a necessity to sources information equitably to empower the healthcare providers to deliver service effectively.","PeriodicalId":335276,"journal":{"name":"CURRENT MEDICAL AND DRUG RESEARCH","volume":"7 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-05-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"126854546","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cotrimoxazole and teicoplanin in the management of Covid-19: Pleiotropic effects, shadows and lights 复方新诺明和替柯planin在Covid-19治疗中的作用:多效性、阴影和光明

CURRENT MEDICAL AND DRUG RESEARCH Pub Date : 2020-09-25 DOI: 10.53517/cmdr.2581-5008.422020210

H. Al-kuraishy, Ali I. Al-Gareeb, Ali K. Al-buhadily

{"title":"Cotrimoxazole and teicoplanin in the management of Covid-19: Pleiotropic effects, shadows and lights","authors":"H. Al-kuraishy, Ali I. Al-Gareeb, Ali K. Al-buhadily","doi":"10.53517/cmdr.2581-5008.422020210","DOIUrl":"https://doi.org/10.53517/cmdr.2581-5008.422020210","url":null,"abstract":"At present, coronavirus disease 2019 (Covid-19), caused by SARS-CoV-2 infection, has turned into a global pandemic. Comparable to the H7N9 virus, SARS-CoV-2 causes soaring mortality in elderly patients who have pre-existing chronic diseases. SARS-CoV-2 infects human epithelial cells by binding to human angiotensin-converting enzyme2 (ACE2). Multi-organ failure has been observed in some patients with severe COVID-19. TheACE2 expression profile suggests that SARS-CoV-2 infection may initiate or even directly cause organ failure. In addition to direct infection, evidence shows that an elevated inflammatory immune response is also involved in the pathogenesis of SARS-CoV-2 infection. The immunomodulatory and anti-inflammatory activity of the cotrimoxazole (CTX) and teicoplanin are seen in several studies that show the lower concentrations of plasma pro-inflammatory markers like CRP, IL6 in continuous CTX prophylaxis, suggesting its role as anti-inflammatory and immunomodulation. The present review concludes that both teicoplanin and CTX are effective in the management of Covid-19 through anti-SARS-CoV-2 and anti-inflammatory effects as well as controlling of secondary bacterial infections.","PeriodicalId":335276,"journal":{"name":"CURRENT MEDICAL AND DRUG RESEARCH","volume":"88 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2020-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"126697636","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

Galenic Hospital Laboratory during COVID-19 emergency - A practical experience in an advanced country 盖伦医院实验室在COVID-19紧急情况下-先进国家的实践经验

CURRENT MEDICAL AND DRUG RESEARCH Pub Date : 2020-09-25 DOI: 10.53517/cmdr.2581-5008.422020209

C. Fiazza, A. Ferraiuolo, M. Luisetto, R. Sahu

{"title":"Galenic Hospital Laboratory during COVID-19 emergency - A practical experience in an advanced country","authors":"C. Fiazza, A. Ferraiuolo, M. Luisetto, R. Sahu","doi":"10.53517/cmdr.2581-5008.422020209","DOIUrl":"https://doi.org/10.53517/cmdr.2581-5008.422020209","url":null,"abstract":"In the actual Covid-19 emergency, as pandemic disease, in many countries at the same time, there was the rapid need to use preventive and therapeutic measures to control the diffusion of infection. In PC Area (Italy North) during the period between March and May 2020, there were observed about 1000 deaths related to Covid-19 (in March 2020 +271% death vs 2019). Between all the measures submitted by a public international institution like WHO, OMS, CDC and many others, the deeply use of disinfectants product became a crucial fact in safety procedure and protocols. The high amount of these disinfectants and antiseptic was needed especially in hospital settings or assimilates structure (named as the Covid-19 hospital) but also for territorial healthcare need. So, it was needed to buy these products from industries but also to start an internal production in Galenic Laboratories. This was because of pharmaceutical industries were not provided, in some cases, the requested amount of these safe life products. In this work, we reported a practical experience in a public hospital, PC area related galenic extra-ordinary production of disinfectants and antiseptics. The result of this local experience can be easily translated to other advanced and developing countries in the world.","PeriodicalId":335276,"journal":{"name":"CURRENT MEDICAL AND DRUG RESEARCH","volume":"73 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2020-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"115910956","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Phytochemical, antimicrobial and antioxidant studies of the leaf extract of Hamelia patens 金缕梅叶提取物的植物化学、抗菌和抗氧化研究

CURRENT MEDICAL AND DRUG RESEARCH Pub Date : 2020-09-25 DOI: 10.53517/cmdr.2581-5008.422020206

S. Megala, G. Kumar, R. Shalini, V. P. Manjamadha

引用次数: 0

Antimicrobial activity of the water-soluble ash extract from the invasive weed Parthenium hysterophorus L. 入侵杂草子宫草水溶性灰分提取物的抑菌活性研究。

CURRENT MEDICAL AND DRUG RESEARCH Pub Date : 2020-09-25 DOI: 10.53517/cmdr.2581-5008.422020208

S. Joshi, D. Semwal, Amit Kumar, A. Chauhan

{"title":"Antimicrobial activity of the water-soluble ash extract from the invasive weed Parthenium hysterophorus L.","authors":"S. Joshi, D. Semwal, Amit Kumar, A. Chauhan","doi":"10.53517/cmdr.2581-5008.422020208","DOIUrl":"https://doi.org/10.53517/cmdr.2581-5008.422020208","url":null,"abstract":"Parthenium hysterophorus L., also known as congress grass or carrot grass, is a widely distributed invasive weed which is a big challenge for sustainable agriculture. For the past several years, a number of attempts have been made to evaluate its medicinal properties. The present study aimed to evaluate the antimicrobial activity of the water-soluble ash extract of P. hysterophorus against different bacterial and fungal pathogens. The disc diffusion method was used to measure zone of inhibition (ZOI) whereas broth microdilution method was used to evaluate minimum inhibitory concentration (MIC) of the extract. The extract was found most effective against Staphylococcus aureus with a ZOI value of 33.5 mm at 33 mg/mL concentration when compared with ofloxacin (ZOI = 39.5 mm at 5 μg/disc). The extract was also found active against Salmonella enterica, Staphylococcus epidermidis and Escherichia coli with ZOI values of 25.5, 32.5 and 25.5 mm, respectively. The present study revealed that the ash extract of P. hysterophorus has potential to inhibit various bacterial species. However, the tested fungal pathogens like Candida albicans were found unaffected after treating with the ash extract.","PeriodicalId":335276,"journal":{"name":"CURRENT MEDICAL AND DRUG RESEARCH","volume":"36 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2020-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"122871036","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Baicalein inhibits KB oral cancer cells by inducing apoptosis via modulation of ROS 黄芩素通过调控ROS诱导KB口腔癌细胞凋亡抑制KB口腔癌细胞

CURRENT MEDICAL AND DRUG RESEARCH Pub Date : 2020-08-20 DOI: 10.53517/cmdr.2581-5008.412020204

S. Vijay, R. Vidhyavathi, E. Raj, Vijaya Lobo, R. A. Kumar

引用次数: 0