Journal of Modern Research in English Language Studies最新文献

筛选
英文 中文
Antibacterial and Urease Inhibitory activity of New Piperazinyl N-4 Functionalized Ciprofloxacin-oxadiazoles 新型哌嗪基N-4功能化环丙沙星-恶二唑的抗菌和脲酶抑制活性
Journal of Modern Research in English Language Studies Pub Date : 2019-07-01 DOI: 10.21608/JMR.2019.12650.1001
M. Abdel-Aal, S. Abdel-Aziz, M. Shaykoon, M. Mohamed, G. E. Abuo-Rahma
{"title":"Antibacterial and Urease Inhibitory activity of New Piperazinyl N-4 Functionalized Ciprofloxacin-oxadiazoles","authors":"M. Abdel-Aal, S. Abdel-Aziz, M. Shaykoon, M. Mohamed, G. E. Abuo-Rahma","doi":"10.21608/JMR.2019.12650.1001","DOIUrl":"https://doi.org/10.21608/JMR.2019.12650.1001","url":null,"abstract":"This research includes design of new ciprofloxacin bearing oxadiazole at the N-4 piperazinyl for the purpose of having urease inhibitory activity as well as antibacterial activity. Hence, a group of new N-4 piperazinyl oxdiazole derivatives of ciprofloxacin was prepared and characterized using different spectroscopic and analytical techniques including 1H-NMR, 13C-NMR, MS and elemental analysis. Compounds 5b and 5c experienced moderate activity against the urease producing Klebsiella pneumoniae strains better than the standard drug used chloramphenicol and less than the parent drug ciprofloxacin. On the other hand, most of the tested compounds showed a urease inhibitory activity more than the parent drug, ciprofloxacin and comparable to standard, thiourea. The docked compounds exhibited better binding to urease enzyme of H. pylori than standard, AHA with binding scores for correlate to the anti-urease assay results. Compound 5b was the most potent anti-Klebsiella pneumoniae urease inhibitor with activity higher the standard (IC50 = 67.8 and 78.89 µM, respectively).","PeriodicalId":33372,"journal":{"name":"Journal of Modern Research in English Language Studies","volume":"98 2 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73799546","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 8
Exact Solutions For some nonlinear Partial Differential Equations by A Variation of (𝑮′𝑮⁄)-Expansion Method: 一类非线性偏微分方程的(𝑮'𝑮⁄)变分的精确解——展开法
Journal of Modern Research in English Language Studies Pub Date : 2019-07-01 DOI: 10.21608/JMR.2019.11763.1000
A. Shehata, F. Abdel Basser, Safaa S. M. Abu-amra
{"title":"Exact Solutions For some nonlinear Partial Differential Equations by A Variation of (𝑮′𝑮⁄)-Expansion Method:","authors":"A. Shehata, F. Abdel Basser, Safaa S. M. Abu-amra","doi":"10.21608/JMR.2019.11763.1000","DOIUrl":"https://doi.org/10.21608/JMR.2019.11763.1000","url":null,"abstract":"","PeriodicalId":33372,"journal":{"name":"Journal of Modern Research in English Language Studies","volume":"74 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80638040","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 3
0
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
相关产品
×
本文献相关产品
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术官方微信