Korean Journal of Transplantation最新文献

{"title":"Factors associated with rituximab-mediated B cell depletion in ABO-incompatible adult living donor liver transplantation.","authors":"Suk Kyun Hong,&nbsp;Kwang-Woong Lee,&nbsp;Jae-Yoon Kim,&nbsp;Jaewon Lee,&nbsp;Jiyoung Kim,&nbsp;Hyun Hwa Choi,&nbsp;Su Young Hong,&nbsp;Jeong-Moo Lee,&nbsp;YoungRok Choi,&nbsp;Nam-Joon Yi,&nbsp;Kyung-Suk Suh","doi":"10.4285/kjt.23.0031","DOIUrl":"10.4285/kjt.23.0031","url":null,"abstract":"<p><strong>Background: </strong>Pretransplant therapies such as rituximab and plasmapheresis have led to an increase in ABO-incompatible (ABOi) living donor liver transplantation (LDLT), thus helping to overcome organ shortages. This study evaluated the changes in anti-A/B titers and CD19 levels over time in patients undergoing ABOi LT and aimed to understand the effect of single-nucleotide polymorphisms (SNPs) in Fc gamma receptor (FcγR) on rituximab therapy.</p><p><strong>Methods: </strong>Two SNPs of <i>FCGR2A</i> (131H/R) and <i>FCGR3A</i> (158F/V) were identified. The clinical data on 44 patients who underwent ABOi LDLT between May 2019 and October 2021 at Seoul National University Hospital were reviewed retrospectively.</p><p><strong>Results: </strong>Following desensitization with rituximab and subsequent LDLT, the anti-A/B titer recovered within 1 week, but decreased thereafter. The CD19 level increased at 3 months after LT. The genotyping data for <i>FCGR3A</i> (158F/V) indicated that two patients had the V/V genotype, and 42 had the F/V genotype. In the genotyping data for <i>FCGR2A</i> (131H/R), 21 patients had the H/H genotype, three had the R/R genotype, and 20 had the H/R genotype. However, there were no significant differences in anti-A/B and CD19 levels, bacteremia rates, T cell-mediated rejection, antibody-mediated rejection, or the survival rate among the <i>FCGR2A</i> types.</p><p><strong>Conclusions: </strong>There were significant changes in the anti-A/B titers and CD19 levels over time in each patient after ABOi LDLT. The difference in outcomes following LT according to the FcγR SNP type for rituximab was unclear. Further studies with larger sample sizes are needed to confirm the effect of FcγR SNPs on rituximab therapy.</p>","PeriodicalId":33357,"journal":{"name":"Korean Journal of Transplantation","volume":" ","pages":"170-178"},"PeriodicalIF":0.0,"publicationDate":"2023-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/8c/35/kjt-37-3-170.PMC10583967.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10257691","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Optical quality of the cornea after Descemet membrane endothelial keratoplasty surgery: early results from Türkiye.","authors":"Emine Esra Karaca,&nbsp;Feyza Dicle Işık,&nbsp;Özlem Evren Kemer","doi":"10.4285/kjt.23.0032","DOIUrl":"10.4285/kjt.23.0032","url":null,"abstract":"<p><strong>Background: </strong>Descemet membrane endothelial keratoplasty (DMEK) is increasingly favored in the treatment of endothelial dysfunction due to its benefits, which include swift visual rehabilitation and recovery, a relatively low rejection rate, and superior refractive stability. In this study, we examined alterations in corneal clarity among patients who underwent DMEK and correlated these densitometry findings with other optical parameters of corneal topography.</p><p><strong>Methods: </strong>The study incorporated 35 eyes from 35 patients who had previously undergone DMEK surgery for pseudophakic bullous keratopathy at Ankara Bilkent City Hospital. The results from these patients were compared with those from a healthy control group. The preoperative and postoperative optical parameters of the patients were assessed using Pentacam Scheimpflug topography (Oculus).</p><p><strong>Results: </strong>We observed significant decreases in corneal densitometry in the 0-2 mm and 2-6 mm zones of the anterior, posterior, central, and total layers at the sixth month postoperatively compared to the preoperative period (P<0.05). The corneal densitometry values at postoperative month 6 were elevated in all layers and zones relative to the healthy group (P<0.05). The root mean square of higher-order aberrations in postoperative period was elevated significantly (P<0.001).</p><p><strong>Conclusions: </strong>Six months after operation, the optical quality of the cornea following DMEK surgery did not achieve the level of a healthy cornea.</p>","PeriodicalId":33357,"journal":{"name":"Korean Journal of Transplantation","volume":" ","pages":"203-209"},"PeriodicalIF":0.0,"publicationDate":"2023-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/86/a1/kjt-37-3-203.PMC10583968.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10257688","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Recent trends in perioperative blood transfusion during elective kidney transplantation.","authors":"Juhye Roh,&nbsp;Sangkeun Park,&nbsp;Hee Jung Kang","doi":"10.4285/kjt.23.0041","DOIUrl":"10.4285/kjt.23.0041","url":null,"abstract":"<p><strong>Background: </strong>Accurately predicting the demand for blood transfusions is crucial for blood banks. Given the potential for emergency situations, it is imperative that blood banks maintain a sufficient inventory of blood products. In this study, we examined the use of perioperative transfusions in patients undergoing elective kidney transplants.</p><p><strong>Methods: </strong>Data on all complement-dependent cytotoxicity-crossmatched assays between 2013 and 2022 were collected. We excluded repeated assays and patients who did not undergo kidney transplantation. Transfusion records and transfusion adverse reactions were reviewed retrospectively.</p><p><strong>Results: </strong>In total, 30 patients underwent elective kidney transplantation from 2013 to 2022. The mean age of the patients was 48.1±9.7 years. The male-to-female ratio was 1.5:1. Four patients received transfusions intraoperatively, whereas eight patients were transfused postoperatively. The postoperative hemoglobin level of the transfusion group (n=9, 8.9±1.3) was significantly lower than that of the nontransfusion group (n=21, 10.4±1.2). The most commonly transfused blood product intraoperatively was leuko-reduced filtered red blood cells, followed by fresh frozen plasma. When the study period was divided into two halves based on the time of operation, the first half showed a higher number of significant transfusions.</p><p><strong>Conclusions: </strong>In most elective kidney transplant cases, surgery was conducted without the need for blood transfusion. The timing of transfusion, when necessary, shifted from during the operation to after the operation. The implementation of patient blood management, coupled with advancements in surgical techniques, appears to have impacted the pattern of perioperative transfusion.</p>","PeriodicalId":33357,"journal":{"name":"Korean Journal of Transplantation","volume":"37 3","pages":"197-202"},"PeriodicalIF":0.0,"publicationDate":"2023-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/00/f4/kjt-37-3-197.PMC10583966.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41131386","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Robot-assisted kidney transplantation in a morbidly obese patient with incisional hernia reconstruction and abdominoplasty: a case report.","authors":"Jin-Myung Kim,&nbsp;Hye Eun Kwon,&nbsp;Youngmin Ko,&nbsp;Joo Hee Jung,&nbsp;Hyunwook Kwon,&nbsp;Young Hoon Kim,&nbsp;Eun Key Kim,&nbsp;Sung Shin","doi":"10.4285/kjt.23.0021","DOIUrl":"10.4285/kjt.23.0021","url":null,"abstract":"<p><p>Performing kidney transplantations in patients with morbid obesity presents unique challenges using the conventional retroperitoneal approach. Robot-assisted kidney transplantation (RAKT) offers several advantages, such as better access to hard-to-reach areas. A 56-year-old morbidly obese woman presented with end-stage renal disease due to diabetic nephropathy. The patient had a history of obesity for over 20 years, with a peak body mass index (BMI) of 46.9 kg/m². Before transplantation, she successfully reduced her BMI to 28.9 kg/m², but was left with excessive skin folds. The surgery began with the removal of the sac from the incisional hernia and umbilical hernia, which was then used as the site for the GelPOINT port. The da Vinci X robot system was utilized to perform RAKT. After completing RAKT, the plastic surgery team initiated abdominal reconstruction involving panniculectomy, followed by hernial reconstruction and abdominoplasty. The patient's postoperative course was uneventful, and she was discharged on postoperative day 7. Her creatinine level was 0.69 mg/dL, and she did not experience any episodes of rejection during the 16 months following RAKT. This case report describes the successful combination of RAKT with incisional hernia reconstruction and abdominoplasty in a patient with morbid obesity.</p>","PeriodicalId":33357,"journal":{"name":"Korean Journal of Transplantation","volume":"37 3","pages":"210-215"},"PeriodicalIF":0.0,"publicationDate":"2023-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/14/2c/kjt-37-3-210.PMC10583988.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41178588","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The role of acidification of the medium on the erythrocyte agglutinating and adsorbing properties of blood group-specific monoclonal antibodies.","authors":"Yuriy Pavlovich Delevsky,&nbsp;Olexandr Anatoliyovich Zinchenko","doi":"10.4285/kjt.23.0033","DOIUrl":"10.4285/kjt.23.0033","url":null,"abstract":"<p><strong>Background: </strong>Studies on the specificity of ABH antigen-antibody interactions at different pH values are rare. Therefore, the aim of this study was to estimate the effect of acidification of the reacting medium on the agglutinating ability of anti-A monoclonal antibodies (mABs) and their inhibition by glycoconjugates of red blood cell membranes.</p><p><strong>Methods: </strong>Anti-A mABs were obtained from the Fourth International Workshop on Monoclonal Antibodies Against Human Red Blood Cell and Related Antigens (on July 19-20, 2002, in Paris, France). The glycoconjugates were isolated from erythrocytes' membranes. The inhibition of the lipid and protein isotypes of the blood group A antigen was assessed.</p><p><strong>Results: </strong>The acidic medium decreased the agglutinating ability of acid immunoglobulin M (IgM) anti-A mABs, in contrast to alkaline immunoglobulin G (IgG) mABs. Meanwhile, at pH 6.5, IgM antibodies exhibited a high adsorption capacity, while IgG antibodies demonstrated a strong adsorption capacity at an alkaline pH. mABs 2-19, 2-28, 2-22, and 2-8 were inhibited by the acidic lipid and protein glycotopes of erythrocyte membranes. However, mAB 2-8 was inhibited by both acidic and alkaline glycotope variants.</p><p><strong>Conclusions: </strong>The agglutinating and adsorbing abilities of mABs, which are revealed at opposing pH values, should be taken into account during studies of antigen-antibody interactions.</p>","PeriodicalId":33357,"journal":{"name":"Korean Journal of Transplantation","volume":"37 3","pages":"189-196"},"PeriodicalIF":0.0,"publicationDate":"2023-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/90/21/kjt-37-3-189.PMC10583970.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41168483","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Culture-independent diagnostic approaches for invasive aspergillosis in solid organ transplant recipients.","authors":"In Young Yoo,&nbsp;Yeon-Joon Park","doi":"10.4285/kjt.23.0043","DOIUrl":"10.4285/kjt.23.0043","url":null,"abstract":"<p><p>Prompt and accurate diagnosis of invasive aspergillosis (IA) is crucial for immunocompromised patients, including those who have received a solid organ transplant (SOT). Despite their low sensitivity, microscopic detection and conventional culture are considered the 'gold standard' methods. In conjunction with conventional culture, culture-independent assays such as serum galactomannan testing and <i>Aspergillus</i> polymerase chain reaction (PCR) have been incorporated into the diagnostic process for IA. The recently revised consensus definitions from the European Organization for Research and Treatment of Cancer and the Mycosis Study Group have adjusted the threshold for positive galactomannan testing based on the sample type, and have excluded 1,3-β-D-glucan testing as a mycological criterion. Following extensive standardization efforts, positive <i>Aspergillus</i> PCR tests using serum, plasma, or bronchoalveolar lavage fluid have been added. However, there are limited studies evaluating the clinical utility of these culture-independent assays for the early diagnosis of IA in SOT recipients. Therefore, further research is required to determine whether these assays could aid in the early diagnosis of IA in SOT recipients, particularly in relation to the organ transplanted. In this review, we examine the culture-independent diagnostic methods for IA in SOT recipients, as well as the clinical utility of these assays.</p>","PeriodicalId":33357,"journal":{"name":"Korean Journal of Transplantation","volume":"37 3","pages":"155-164"},"PeriodicalIF":0.0,"publicationDate":"2023-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/c6/95/kjt-37-3-155.PMC10583980.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41171793","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Minimally invasive recipient procedure in kidney transplantation.","authors":"Yoshifumi Miura,&nbsp;Yuki Nakafusa,&nbsp;Naoko Yokota-Ikeda,&nbsp;Mitsue Ota,&nbsp;Naoki Otomo","doi":"10.4285/kjt.23.0022","DOIUrl":"10.4285/kjt.23.0022","url":null,"abstract":"<p><strong>Background: </strong>There are several procedural variations for kidney transplant donors, including open, laparoscopic, hand-assisted, and robotic methods, with either an intra- abdominal or retroperitoneal approach. Conversely, fewer options are available for the recipient procedure. We introduce a method that involves a small incision, with the goal of being less invasive for recipients.</p><p><strong>Methods: </strong>Our current method was introduced in April 2022. As of July 2023, we have completed 27 cases. We analyzed several factors in these 27 cases, including the size of the incision, rewarming time, anastomosis time, graft function, analgesic use, and complications.</p><p><strong>Results: </strong>The average incision size was 73 mm. The time taken for anastomosis was 24. 1 minutes, while the rewarming time averaged 43.1 minutes. There were no instances of primary nonfunction. One case necessitated postoperative dialysis three times due to heart failure. Following stent removal, one patient developed grade 1 hydronephrosis. There was one instance of bleeding from the drain insertion site. Another case involved a clamp injury to the external iliac artery, which necessitated stent insertion on the fourth postoperative day. Compared to procedures performed using conventional methods, the use of analgesics was less in these cases.</p><p><strong>Conclusions: </strong>Our minimally invasive technique, which involves a small incision, is a feasible alternative that could potentially be less invasive than traditional methods.</p>","PeriodicalId":33357,"journal":{"name":"Korean Journal of Transplantation","volume":"37 3","pages":"165-169"},"PeriodicalIF":0.0,"publicationDate":"2023-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/3e/a5/kjt-37-3-165.PMC10583972.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41158145","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Recommendations for SARS-CoV-2 testing and organ procurement from deceased donors in the Republic of Korea.","authors":"Si-Ho Kim,&nbsp;Yu Mi Wi,&nbsp;Chisook Moon,&nbsp;Ji-Man Kang,&nbsp;Minhwa Kim,&nbsp;Jungok Kim,&nbsp;Jong Man Kim,&nbsp;Hyeri Seok,&nbsp;Hye Jin Shi,&nbsp;Su Jin Lee,&nbsp;Ji Yeon Lee,&nbsp;Su Jin Jeong,&nbsp;Pyoeng Gyun Choe,&nbsp;Kyungmin Huh,&nbsp;Sang-Oh Lee,&nbsp;Sang Il Kim","doi":"10.4285/kjt.23.0034","DOIUrl":"10.4285/kjt.23.0034","url":null,"abstract":"<p><p>We present a summary of the evidence on testing for severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) and organ procurement from deceased donors and provide recommendations based on current clinical data and the guidelines from major transplant organizations. Because of the limited historical experience with coronavirus disease 2019 (COVID-19), certain recommendations in this document are based on theoretical rationales rather than clinical data. The recommendations in this manuscript may be subject to revision as subsequent clinical studies provide definitive evidence regarding COVID-19 in organ procurement.</p>","PeriodicalId":33357,"journal":{"name":"Korean Journal of Transplantation","volume":" ","pages":"145-154"},"PeriodicalIF":0.0,"publicationDate":"2023-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/f1/aa/kjt-37-3-145.PMC10583974.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10415531","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Characteristics of living liver donors in a national referral hospital in Indonesia: a 13-year experience with living donor liver transplantation.","authors":"Arnetta Naomi Louise Lalisang,&nbsp;Afid Brilliana Putra,&nbsp;Nathaniel Jason Zacharia,&nbsp;Vania Myralda Giamour Marbun,&nbsp;Lam Sihardo,&nbsp;Ridho Ardhi Syaiful,&nbsp;Febiansyah Ibrahim,&nbsp;Wifanto Saditya Jeo,&nbsp;Yarman Mazni,&nbsp;Agi Satria Putranto,&nbsp;Toar Jean Maurice Lalisang","doi":"10.4285/kjt.23.0030","DOIUrl":"10.4285/kjt.23.0030","url":null,"abstract":"<p><strong>Background: </strong>Hepatocellular carcinoma and biliary atresia lead to end-stage liver disease, which requires liver transplantation and is linked to increased mortality. Dr. Cipto Mangunkusumo Hospital is the national referral center in Indonesia and is the only center that routinely performs living donor liver transplantation (LDLT). This study presents the characteristics of living liver donors (LLDs) in Indonesia.</p><p><strong>Methods: </strong>Using the LDLT registry, we conducted a retrospective analysis of all approved donors from 2010 to 2022. The variables included clinical characteristics of the donors, graft types, and intraoperative and postoperative characteristics.</p><p><strong>Results: </strong>The LDLT rate has increased from 5.8 to 8.8 procedures/year in the last 8 years. The average age of the 76 LLDs was 31.8 years. They were predominantly female (59%) and lived within a family relationship (90%). Pediatric LDLT was more frequent than adult LDLT (88% vs. 12%, respectively). Most grafts (86%) were obtained by left lateral sectionectomy, with a median ratio of remnant liver volume to total liver volume of 79.5% (range, 47.7%-85.8%) and a mean graft-to-recipient weight ratio of 2.65%±1.21%. The median intensive care unit length of stay (LOS) was 2 days (range, 1-5 days) and the total hospital LOS was 7 days (range, 4-28 days). The complication rate was 23%. No donor mortality was reported.</p><p><strong>Conclusions: </strong>LDLT in Indonesia has increased over the years. The shortage of donors for adult-to-adult liver transplantation is due to cultural differences and challenges in finding eligible donors. This study aims to explain the eligibility criteria of LLDs and contribute to creating a national policy.</p>","PeriodicalId":33357,"journal":{"name":"Korean Journal of Transplantation","volume":" ","pages":"179-188"},"PeriodicalIF":0.0,"publicationDate":"2023-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/19/90/kjt-37-3-179.PMC10583976.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10516192","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The first use of hypothermic machine perfusion in Korea to recover a procured kidney graft and prevent prolonged cold ischemic time: a case report.","authors":"Young-Heun Shin,&nbsp;Taerim Ko,&nbsp;John Hee Park,&nbsp;Won-Bae Chang","doi":"10.4285/kjt.23.0017","DOIUrl":"https://doi.org/10.4285/kjt.23.0017","url":null,"abstract":"<p><p>To overcome the shortage of donor grafts in kidney transplantation (KT), the use of marginal grafts has evolved. However, prolonged cold ischemic time (CIT) is especially critical when using marginal grafts. Recently, hypothermic machine perfusion (HMP) has been used to overcome the negative effects of prolonged CIT, and we report the first use of HMP in Korea. The donor was a 58-year-old man with severe hypoxia (PaO₂ <60 mmHg, FiO₂ 100%) for 9 hours prior to procurement. The patient's kidneys were the only organs accepted for transplantation, and both kidneys were assigned to Jeju National University Hospital. After procurement, the right kidney was preserved using HMP immediately, and the left kidney was directly transplanted into a patient with a CIT of 2 hours 31 minutes. The second operation was performed following the first, using the right kidney graft that had been preserved by HMP for 10 hours and 30 minutes. Although postoperative graft function gradually recovered in both patients, the serum creatinine level decreased faster in the HMP patient. Neither patient showed signs of delayed graft function, and both were discharged without significant complications. The short-term outcomes in this transplantation of mate kidney grafts demonstrated that graft function can be safely preserved using HMP, and that HMP is beneficial in overcoming the negative effects of prolonged CIT.</p>","PeriodicalId":33357,"journal":{"name":"Korean Journal of Transplantation","volume":"37 2","pages":"129-134"},"PeriodicalIF":0.0,"publicationDate":"2023-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/58/43/kjt-37-2-129.PMC10332281.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10172619","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}