Korean Journal of Transplantation最新文献_第2页

Sotrovimab in solid organ transplant recipients with COVID-19: a systematic review and meta-analysis. Sotrovimab在新冠肺炎实体器官移植受者中的应用：系统综述和荟萃分析。

Korean Journal of Transplantation Pub Date : 2023-12-31 Epub Date: 2023-11-03 DOI: 10.4285/kjt.23.0038

Behnam Amani, Rouhollah Shabestan, Kourosh Rajabkhah, Bahman Amani

{"title":"Sotrovimab in solid organ transplant recipients with COVID-19: a systematic review and meta-analysis.","authors":"Behnam Amani, Rouhollah Shabestan, Kourosh Rajabkhah, Bahman Amani","doi":"10.4285/kjt.23.0038","DOIUrl":"10.4285/kjt.23.0038","url":null,"abstract":"Background: Despite widespread implementation of vaccination against coronavirus disease 2019 (COVID-19), solid organ transplant recipients (SOTRs) can remain particularly vulnerable to this disease. The present study was conducted to investigate the efficacy and safety of sotrovimab in the treatment of SOTRs with COVID-19.Methods: A search was performed of PubMed, Cochrane Library, Web of Science, medRxiv, and Google Scholar to gather relevant evidence through July 25, 2023. The quality of the included studies was assessed using the risk of bias tool. Comprehensive Meta-Analysis software (ver. 3.0, Biostat) was employed for data analysis.Results: Ten studies, involving a total of 1,569 patients, were included. The meta-analysis revealed significant differences between the patients administered sotrovimab and those treated with the standard of care. These differences were observed in mortality rate (odds ratio [OR], 0.15; 95% confidence interval [CI], 0.03-0.67), hospitalization rate (OR, 0.35; 95% CI, 0.21-0.57), intensive care unit (ICU) admission rate (OR, 0.16; 95% CI, 0.04-0.62), the need for supplemental oxygen therapy (OR, 0.22; 95% CI, 0.09-0.51), and the need for mechanical ventilation (OR, 0.09; 95% CI, 0.01-0.70). However, no significant difference was observed between sotrovimab and other treatments regarding the rates of hospitalization or ICU admission (P>0.05). Regarding safety, sotrovimab was associated with a lower rate of adverse events compared to the absence of sotrovimab (OR, 0.15; 95% CI, 0.02-0.86).Conclusions: These results suggest that sotrovimab may improve efficacy outcomes among SOTRs with COVID-19. Nevertheless, additional high-quality trials are necessary to confirm these findings.","PeriodicalId":33357,"journal":{"name":"Korean Journal of Transplantation","volume":" ","pages":"277-285"},"PeriodicalIF":0.0,"publicationDate":"2023-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10772269/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71427464","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Modified patch-conduit venoplasty for portal vein hypoplasia in pediatric liver transplantation. 改良补片导管静脉成形术治疗小儿肝移植门静脉发育不全。

Korean Journal of Transplantation Pub Date : 2023-12-31 Epub Date: 2023-11-01 DOI: 10.4285/kjt.23.0037

Jung-Man Namgoong, Shin Hwang, Gil-Chun Park, Hyunhee Kwon, Sujin Gang, Jueun Park, Kyung Mo Kim, Seak Hee Oh

{"title":"Modified patch-conduit venoplasty for portal vein hypoplasia in pediatric liver transplantation.","authors":"Jung-Man Namgoong, Shin Hwang, Gil-Chun Park, Hyunhee Kwon, Sujin Gang, Jueun Park, Kyung Mo Kim, Seak Hee Oh","doi":"10.4285/kjt.23.0037","DOIUrl":"10.4285/kjt.23.0037","url":null,"abstract":"Background: Portal vein (PV) interposition can induce various PV-related complications, making more reliable techniques necessary. The present study describes the development of a modified patch venoplasty technique, combining the native PV wall and a vein homograft conduit, called modified patch-conduit venoplasty (MPCV).Methods: The surgical technique for MPCV was optimized by simulation and applied to seven pediatric patients undergoing liver transplantation (LT) for biliary atresia combined with PV hypoplasia.Results: The simulation study revealed that inserting the whole-length native PV wall as a longitudinal rectangular patch was more effective in preventing PV conduit stenosis than the conventional technique using triangular partial insertion. These findings were used to develop the MPCV technique, in which the native PV wall was converted into a long rectangular patch, acting as a backbone for PV reconstruction. A longitudinal incision on the vein conduit converted the cylindrical vein into a large vein patch. The wall of the native PV was fully preserved as the posterior wall of the PV conduit, thus preventing longitudinal redundancy and unwanted rotation of the reconstructed PV. This technique was applied to seven patients with biliary atresia undergoing living-donor and deceased-donor split LT. None of these patients has experienced PV complications for up to 12 months after transplantation.Conclusions: This newly devised MCPV technique can replace conventional PV interposition. MCPV may be a surgical option for reliable PV reconstruction using fresh or cryopreserved vein homografts during pediatric LT.","PeriodicalId":33357,"journal":{"name":"Korean Journal of Transplantation","volume":" ","pages":"260-268"},"PeriodicalIF":0.0,"publicationDate":"2023-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10772270/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71427463","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cell cycle arrest biomarkers for the early detection of acute allograft dysfunction and acute rejection in living donor kidney transplantation: a cross-sectional study from Egypt. 用于早期检测活体肾移植急性移植物功能障碍和急性排斥反应的细胞周期停滞生物标志物：一项来自埃及的横断面研究。

Korean Journal of Transplantation Pub Date : 2023-12-31 Epub Date: 2023-12-20 DOI: 10.4285/kjt.23.0048

Mahmoud M Elnokeety, Wessam Mustafa Hussein, Samar Ahmed Abdelrazek, Mohamed Momtaz

{"title":"Cell cycle arrest biomarkers for the early detection of acute allograft dysfunction and acute rejection in living donor kidney transplantation: a cross-sectional study from Egypt.","authors":"Mahmoud M Elnokeety, Wessam Mustafa Hussein, Samar Ahmed Abdelrazek, Mohamed Momtaz","doi":"10.4285/kjt.23.0048","DOIUrl":"10.4285/kjt.23.0048","url":null,"abstract":"Background: Urinary tissue inhibitor of metalloproteinase-2 (TIMP-2) and insulin-like growth factor-binding protein 7 (IGFBP7) are G1 cell arrest biomarkers that have demonstrated accuracy and validity in predicting and diagnosing acute kidney injury (AKI). This study aimed to evaluate the validity of [TIMP-2]×[IGFBP7] in diagnosing acute allograft dysfunction and its utility in distinguishing acute rejection (AR) from nonrejection causes in kidney transplantation.Methods: This study included 48 adult living donor kidney transplant recipients (KTRs; 18 with AR, 15 with nonrejection causes of AKI, and 15 with stable grafts). Urinary TIMP-2 and IGFBP7 were measured, and [TIMP-2]×[IGFBP7] was calculated in all subjects.Results: IGFBP7, TIMP-2, and [TIMP-2]×[IGFBP7] were statistically significantly higher in KTRs with acute allograft dysfunction than in those with stable grafts. [TIMP-2]×[IGFBP7] was statistically significantly higher in KTRs with AR than in those with nonrejection AKI. [TIMP-2]×[IGFBP7] at a cutoff level of 0.278 (ng/mL)2/1,000 had an area under the curve (AUC) of 0.99 with a sensitivity of 100% and a specificity of 93.3% in diagnosing acute allograft dysfunction, while at a cutoff level of 0.803 (ng/mL)2/1,000 had an AUC of 0.939 with a sensitivity of 94.4% and a specificity of 83.3% in diagnosing AR.Conclusions: Besides its role in the early detection of acute allograft dysfunction, [TIMP-2]×[IGFBP7] may help to differentiate between AR and nonrejection causes in KTRs. However, whether and how urinary [TIMP-2]×[IGFBP7] can be used in clinical diagnosis still requires further research.","PeriodicalId":33357,"journal":{"name":"Korean Journal of Transplantation","volume":" ","pages":"250-259"},"PeriodicalIF":0.0,"publicationDate":"2023-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10772274/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138810706","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Factors associated with operational tolerance after liver transplantation: a single center retrospective study. 肝移植术后操作耐受的相关因素：一项单中心回顾性研究。

Korean Journal of Transplantation Pub Date : 2023-12-31 DOI: 10.4285/kjt.23.0066

Sunghae Park, Gyu-Seong Choi

{"title":"Factors associated with operational tolerance after liver transplantation: a single center retrospective study.","authors":"Sunghae Park, Gyu-Seong Choi","doi":"10.4285/kjt.23.0066","DOIUrl":"10.4285/kjt.23.0066","url":null,"abstract":"Background: Liver transplantation has adverse effects from life-long immunosuppression that limit the improvement of long-term outcomes. Achieving clinical operational tolerance is a major goal in organ transplantation.Methods: This study analyzed liver transplantation patients at a single institution from 1998 to 2020, excluding those who died within 1-year posttransplant. Operational tolerance was defined as normal liver function even after immunosuppressive drugs were discontinued. Propensity score matching was implemented at a 1:2 ratio for the tolerant group (TG) and the nontolerant group (NTG).Results: Out of 2,300 recipients, 99 achieved operational tolerance without rejection. No significant differences in sex or body mass index (BMI) were found between the TG and NTG. There was a significantly higher percentage of children in the TG (24.0%) than in the NTG (10.1%). The NTG had more living donor liver transplants. Among 2,054 adult recipients, no significant differences in age, sex, or BMI were found between the TG and the NTG. However, the rate of living donor liver transplantation was 40.3% (29/75) in the TG and 84.8% in the NTG (P<0.001). The propensity score-matched analysis showed higher chronic renal failure rates and a higher graft recipient weight ratio in the TG, along with shorter warm ischemic times during surgery. After immunosuppressant withdrawal, a significant increase in the ratio of CD4+CD25+ T cells to total CD4+ T cells was observed in the TG.Conclusions: These findings suggest that larger, healthier grafts are more conducive to inducing tolerance, and regulatory T cells are crucial in achieving tolerance.","PeriodicalId":33357,"journal":{"name":"Korean Journal of Transplantation","volume":"37 4","pages":"286-292"},"PeriodicalIF":0.0,"publicationDate":"2023-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10772272/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139049436","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Delayed diagnosis of bronchobiliary fistula complicating a pediatric living donor liver transplantation: a case report. 儿童活体肝移植并发支气管胆道瘘的延迟诊断：一例报告。

Korean Journal of Transplantation Pub Date : 2023-12-31 Epub Date: 2023-10-27 DOI: 10.4285/kjt.23.0044

Vipul Gautam, Vikram Kumar, Shaleen Agarwal, Subhash Gupta

{"title":"Delayed diagnosis of bronchobiliary fistula complicating a pediatric living donor liver transplantation: a case report.","authors":"Vipul Gautam, Vikram Kumar, Shaleen Agarwal, Subhash Gupta","doi":"10.4285/kjt.23.0044","DOIUrl":"10.4285/kjt.23.0044","url":null,"abstract":"Bronchobiliary fistula (BBF) is a very rare condition in children. Only a few pediatric BBF cases have been reported, in the context of a ruptured hydatid cyst or liver abscess. BBF after living donor liver transplantation (LDLT) has not been reported in the pediatric literature. We report a 7-year-old female child with Wilson disease, who developed BBF post-LDLT. She had a clinically uneventful course in the immediate post-transplant period. She was readmitted on postoperative day (POD) 75 with a productive cough and respiratory difficulty, which was diagnosed as bilioptysis secondary to BBF. Endoscopic retrograde cholangiopancreaticography was attempted but failed. Exploratory laparotomy showed a fistula from the strictured biliary anastomotic site to the right thoracic cavity; it was excised, and a Roux-en-Y hepaticojejunostomy was performed. She tolerated the procedure well and remained clinically well on follow-up through POD 185. BBF is extremely rare in children. This is the first case report of BBF in a child following LDLT. BBF requires a high index of suspicion for a timely intervention to prevent subsequent complications.","PeriodicalId":33357,"journal":{"name":"Korean Journal of Transplantation","volume":" ","pages":"293-298"},"PeriodicalIF":0.0,"publicationDate":"2023-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10772266/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"54231342","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

One-way donor-to-recipient human leukocyte antigen mismatch and graft-versus-host disease in liver transplantation: an observational study of a single-center experience in Korea. 肝移植中的单向供体-受体人白细胞抗原错配和移植物抗宿主病:韩国单中心经验的观察性研究

Korean Journal of Transplantation Pub Date : 2023-12-31 Epub Date: 2023-11-23 DOI: 10.4285/kjt.23.0053

Seung Hyuk Yim, Deok-Gie Kim, Jae Geun Lee, Dong Jin Joo, Myoung Soo Kim

{"title":"One-way donor-to-recipient human leukocyte antigen mismatch and graft-versus-host disease in liver transplantation: an observational study of a single-center experience in Korea.","authors":"Seung Hyuk Yim, Deok-Gie Kim, Jae Geun Lee, Dong Jin Joo, Myoung Soo Kim","doi":"10.4285/kjt.23.0053","DOIUrl":"10.4285/kjt.23.0053","url":null,"abstract":"Background: Graft-versus-host disease (GVHD) is a rare, but potentially fatal complication of liver transplantation. One-way human leukocyte antigens (HLA) mismatch has emerged as a risk factor for GVHD. However, the risk of mortality associated with HLA-one-way mismatch (OWMM) remains uncertain. We investigated the incidence and characteristics of GVHD.Methods: In total, 899 patients who underwent liver transplantation at a single center were retrospectively reviewed. The incidence of GVHD and 1- and 5-year survival rates were compared according to whether HLA-OWMM developed.Results: In the HLA-OWMM group, GVHD developed in two patients (14.3%). Notably, GVHD was only observed in living donor liver transplant (LDLT) recipients in the HLA-OWMM group. The HLA-OWMM group exhibited a lower 1-year patient survival rate than the control (i.e., non-HLA-OWMM) group (78.6% vs. 90.7%, P=0.120). However, the 5-year survival rate in the HLA-OWMM group was similar to that in the control group (78.6% vs. 78.2%, P=0.821). When the HLA-OWMM group was further stratified by the number of mismatched loci, the 5-year survival rate was 83.3% in patients with HLA-OWMM at one to two loci and 75.0% in those with HLA-OWMM at three loci.Conclusions: Despite the higher incidence of GVHD in LDLT recipients with HLA-OWMM, the 5-year patient survival rates were comparable to those in recipients without HLA-OWMM. The decision to perform LDLT in patients with HLA-OWMM depends on the patient's status and the organ supply of a specific region.","PeriodicalId":33357,"journal":{"name":"Korean Journal of Transplantation","volume":" ","pages":"269-276"},"PeriodicalIF":0.0,"publicationDate":"2023-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10772268/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138296166","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Regulatory macrophages in solid organ xenotransplantation. 实体器官异种移植中的调节性巨噬细胞

Korean Journal of Transplantation Pub Date : 2023-12-31 Epub Date: 2023-12-20 DOI: 10.4285/kjt.23.0055

Thi Xoan Hoang, Jae Young Kim

{"title":"Regulatory macrophages in solid organ xenotransplantation.","authors":"Thi Xoan Hoang, Jae Young Kim","doi":"10.4285/kjt.23.0055","DOIUrl":"10.4285/kjt.23.0055","url":null,"abstract":"Due to a critical organ shortage, pig organs are being explored for use in transplantation. Differences between species, particularly in cell surface glycans, can trigger elevated immune responses in xenotransplantation. To mitigate the risk of hyperacute rejection, genetically modified pigs have been developed that lack certain glycans and express human complement inhibitors. Nevertheless, organs from these pigs may still provoke stronger inflammatory and innate immune reactions than allotransplants. Dysregulation of coagulation and persistent inflammation remain obstacles in the transplantation of pig organs into primates. Regulatory macrophages (Mregs), known for their anti-inflammatory properties, could offer a potential solution. Mregs secrete interleukin 10 and transforming growth factor beta, thereby suppressing immune responses and promoting the development of regulatory T cells. These Mregs are typically induced via the stimulation of monocytes or macrophages with macrophage colony-stimulating factor and interferon gamma, and they conspicuously express the stable marker dehydrogenase/reductase 9. Consequently, understanding the precise mechanisms governing Mreg generation, stability, and immunomodulation could pave the way for the therapeutic use of Mregs generated in vitro. This approach has the potential to reduce the required dosages and durations of anti-inflammatory and immunosuppressive medications in preclinical and clinical settings.","PeriodicalId":33357,"journal":{"name":"Korean Journal of Transplantation","volume":" ","pages":"229-240"},"PeriodicalIF":0.0,"publicationDate":"2023-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10772277/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138810712","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Accidental ABO-incompatible pediatric liver transplantation with blood group antigen immune and operational tolerance: a case report with 21 years of follow-up. 血型抗原免疫和操作耐受的意外ABO不相容小儿肝移植：随访21年的病例报告。

Korean Journal of Transplantation Pub Date : 2023-12-31 DOI: 10.4285/kjt.23.0070

Hyo-Sin Kim, Soo Jin Na Choi, Ho Kyun Lee, Sola Lee

引用次数: 0

Sirolimus-induced leukocytoclastic vasculitis. 西罗莫司诱导的白细胞破裂性血管炎。

Korean Journal of Transplantation Pub Date : 2023-12-31 Epub Date: 2023-11-23 DOI: 10.4285/kjt.23.0050

Vishal Ramteke, Sainath Pattewar, Nitin Barde, Nishant Deshpande

引用次数: 0

Graft lymphoma in a kidney transplant recipient: a case report. 肾移植受者的移植物淋巴瘤：一例报告。

Korean Journal of Transplantation Pub Date : 2023-09-30 Epub Date: 2023-09-12 DOI: 10.4285/kjt.23.0035

Ji Hyun Yeom, Won Kim, Kyung Pyo Kang, Hyeongwan Kim, Hee Chul Yu, Hong Pil Hwang, Byeoung Hoon Chung, Kyu Yun Jang, Sik Lee

{"title":"Graft lymphoma in a kidney transplant recipient: a case report.","authors":"Ji Hyun Yeom, Won Kim, Kyung Pyo Kang, Hyeongwan Kim, Hee Chul Yu, Hong Pil Hwang, Byeoung Hoon Chung, Kyu Yun Jang, Sik Lee","doi":"10.4285/kjt.23.0035","DOIUrl":"10.4285/kjt.23.0035","url":null,"abstract":"Posttransplant lymphoproliferative disorders (PTLDs) are severe complications with heterogeneous clinical pictures involving abnormal lymphoproliferation in solid organ transplants and are known to be closely associated with Epstein-Barr virus (EBV) infection. Herein, we present a case of graft lymphoma in a febrile kidney transplant recipient. A 37-year-old woman was admitted with an abrupt 39 °C fever, mild graft discomfort, and gross hematuria. She had received deceased donor kidney transplantation 8 years earlier, but developed graft failure due to a recurrence of immunoglobulin A nephropathy. Laboratory tests revealed anemia and elevated levels of inflammatory markers. Enhanced abdominopelvic computed tomography showed graft swelling with perirenal fat stranding. Thus, we administered antibiotics for a urinary tract infection and increased the doses of steroids due to suspicion of graft intolerance syndrome. However, the patient's symptoms gradually worsened. Eventually, we performed graft nephrectomy and histologically confirmed EBV-positive diffuse large B cell lymphoma. We report a case in which a PTLD was considered in the differential diagnosis of a kidney transplant recipient with symptoms similar to those of a urinary tract infection or graft intolerance syndrome.","PeriodicalId":33357,"journal":{"name":"Korean Journal of Transplantation","volume":" ","pages":"216-219"},"PeriodicalIF":0.0,"publicationDate":"2023-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/17/d2/kjt-37-3-216.PMC10583984.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10204200","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0