Journal of Pharmacogenomics and Pharmacoproteomics最新文献

Assessment of In Vitro Antioxidant and Anti-Inflammatory Potentials of Methanol Extract of Chrysophyllum albidum Cotyledon 菊花子叶甲醇提取物的体外抗氧化和抗炎活性评价

Journal of Pharmacogenomics and Pharmacoproteomics Pub Date : 2020-12-01 DOI: 10.36108/PAJOLS/0202/40(0340)

Christianah Dare, Nelson O. Elvis

{"title":"Assessment of In Vitro Antioxidant and Anti-Inflammatory Potentials of Methanol Extract of Chrysophyllum albidum Cotyledon","authors":"Christianah Dare, Nelson O. Elvis","doi":"10.36108/PAJOLS/0202/40(0340)","DOIUrl":"https://doi.org/10.36108/PAJOLS/0202/40(0340)","url":null,"abstract":"This study was aimed at analysing the phytochemicals in Chrysophyllum albidum cotyledon extract and their in vitro antioxidant and anti-inflammatory effects. The star apple fruit was bought at Igbona market Osogbo, Osun State, Nigeria. The seed from the fruit was removed and defatted. The residue was exhaustively extracted with methanol. The Chrysophyllum albidum cotyledon methanol extract (CCME) was phytochemically screened, flavonoids and phenol contents, antioxidant and anti-inflammatory assays were carried out on the extract using standard procedures. Phytochemicals analysis revealed the presence of steroids, tannins, flavonoid, saponin, triterpenes and xanthoproteins. The phenolic concentration, total flavonoids concentration and total sugar concentration were found to be 26.72 ± 0.048 μgTAE/mg, 23.12 ± 1.92μg of Rutin equivalent (RTE)/mg (10.49 ± 1.12μg of Quercetin equivalent (QE)/mg) and 778.38 ± 12.82 μg of glucose/ml respectively. The extract demonstrated significant inhibitory effect compared with the standards as potent antioxidant with percentage inhibition of DPPH as 38.10 % – 39.51 %, lipid peroxidation as 45.85 % – 65.85 %, ferric reducing power showed linear correlation to the standard, and the anti-inflammatory potential with 22.06 % – 26.37 % protection of the human red blood membrane and the percentage inhibition of denaturation of albumin 3.42 % – 7.32 %. The study showed that C. albidum cotyledon methanol extract is a potent antioxidant and anti-inflammatory agent to combat oxidative stress and pathological diseases caused by reactive species.","PeriodicalId":333396,"journal":{"name":"Journal of Pharmacogenomics and Pharmacoproteomics","volume":"100 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2020-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"115473199","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Utilization of Hormonal Interaction during Stress to Get Better Performance 应激时荷尔蒙相互作用的利用以获得更好的表现

Journal of Pharmacogenomics and Pharmacoproteomics Pub Date : 2018-02-02 DOI: 10.4172/2153-0645.1000177

Alaa A Elnour

引用次数: 1

Meanders of an Atypical Research Work on Helicobacter pylori in the Democratic Republic of Congo: Influence of HIV and other Factors and Study of some Interesting Cases 刚果民主共和国幽门螺杆菌非典型研究工作的曲折:HIV等因素的影响及一些有趣案例的研究

Journal of Pharmacogenomics and Pharmacoproteomics Pub Date : 2018-01-12 DOI: 10.4172/2153-0645.1000176

J. Ndelo-di-Phanzu, Mputu Malolo, P. Matondo, Y. Nuapia, Tsomba Hondo Bin Salum, S. M. Nsukini

{"title":"Meanders of an Atypical Research Work on Helicobacter pylori in the Democratic Republic of Congo: Influence of HIV and other Factors and Study of some Interesting Cases","authors":"J. Ndelo-di-Phanzu, Mputu Malolo, P. Matondo, Y. Nuapia, Tsomba Hondo Bin Salum, S. M. Nsukini","doi":"10.4172/2153-0645.1000176","DOIUrl":"https://doi.org/10.4172/2153-0645.1000176","url":null,"abstract":"During the 3rd Euro case reports in Valencia, Spain, a strange medical case taking place in the DRC has been presented. Indeed, while the Congolese population is, until now, convinced of the existence of massive criminal poisonings, throughout the national area, originating from the East region of the country, we incredibly observed and demonstrated that actually, the phenomenon is a silent, surprising and unexpected Helicobacter pylori epidemic with numerous extra-digestive pathologies. The present subject will deal with picturesque meanders by which our research work passed, lengthening it to more than twenty years before getting appropriate results. The presentation will start by a brief summary of the DRC Helicobacter pylori phenomenon described in Valencia and hypothesis raised for better knowledge of Helicobacter pylori infection, at the international level. In a second time, it will focus on the influence and consequences of some followed factors in our study: HIV infection, political situation in DRC, lack of equipment and financial means, population ignorance, traditional practitioners’ cupidity, deficiency of south-North collaboration, and so on. Afterwards, two interesting incredible extra-digestive DRC Helicobacter pylori cases observed in our study will be discussed. Finally a brief conclusion will present some useful propositions drawn from the experience of this DRC Helicobacter pylori research work.","PeriodicalId":333396,"journal":{"name":"Journal of Pharmacogenomics and Pharmacoproteomics","volume":"40 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2018-01-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"132167177","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Arrhythmogenic right ventricular cardiomyopathy with multiple thrombi - Case report 伴多发血栓的心律失常性右室心肌病1例报告

Journal of Pharmacogenomics and Pharmacoproteomics Pub Date : 2017-12-11 DOI: 10.45172/2153-0645-C1-018

Livija Sušić, V. Baraban, J. Vincelj, L. Maričić, M. Sikora, Jasmina Ćatić, R. Blažeković

引用次数: 0

Anti-Rheumatic Activity of Celecoxib and Methotrexate in Collagen Induced Arthritis: A Proteomic Approach 塞来昔布和甲氨蝶呤在胶原诱导关节炎中的抗风湿活性:蛋白质组学方法

Journal of Pharmacogenomics and Pharmacoproteomics Pub Date : 2017-10-12 DOI: 10.4172/2153-0645.1000175

R. Baru, Prasanth Bitla

引用次数: 0

KDR gene as a Predictive Biomarker of Response to Regorafenib in Patients with Metastatic Colorectal Cancer (mCRC) KDR基因作为转移性结直肠癌(mCRC)患者对瑞非尼反应的预测性生物标志物

Journal of Pharmacogenomics and Pharmacoproteomics Pub Date : 2017-09-25 DOI: 10.4172/2153-0645.1000173

S. Bj, Lalkota Bhanu Prakash, M. Nasiruddin, N. Radheshyam

{"title":"KDR gene as a Predictive Biomarker of Response to Regorafenib in Patients with Metastatic Colorectal Cancer (mCRC)","authors":"S. Bj, Lalkota Bhanu Prakash, M. Nasiruddin, N. Radheshyam","doi":"10.4172/2153-0645.1000173","DOIUrl":"https://doi.org/10.4172/2153-0645.1000173","url":null,"abstract":"Background: Regorafenib is an oral diphenyl urea multikinase inhibitor which is anti- angiogenic, and has shown promising anti-tumor activity in Metastatic Colorectal Cancer (mCRC). Reports have shown that response to regorafenib is more favourable in patients with KDR gene mutation. This study correlates KDR gene mutation as an ideal predictive biomarker to regorafenib (Tyrosine Kinase Inhibitor) response in metastatic colorectal cancer (MCRC). \u0000 \u0000Methods: This is a single centre prospective analysis of total 9 patients at HCG cancer speciality centre, Bengaluru, India. The median age of 9 patients was 54 years (21-71 years). 5 patients were male and 4 patients were female, 6 patients are African and 3 were Indian. KRAS gene was found to be mutated in 6 patients and wild type in 3 patients. Out of 9 patients, 6 have received FOLFOX-4 chemotherapy+Biological for 6 cycles and 3 patients received FOLFIRI chemothearpy+Biological for 3 cycles as 1st line treatment. These patients received tab Regorafenib as 3rd line treatment. For all patients 48 Gene panel was done, which includes extended RAS and KDR gene mutation analysis. \u0000 \u0000Results: Analysis at the end of 3 months of treatment, 2 patients had PR, 1 patient had SD, 5 patients had PD and 1 patient defaulted. There was no correlation of response with KRAS mutational status. KDR (VEGFR-2) was wild type in all the patients. With regards to safety, the drug was well tolerated by all patients and no one withdrawn because of adverse effects. Conclusions: Absence of KDR gene mutation may not respond to regorafenib treatment in MCRC. To predict KDR gene mutation as a biomarker, large number of studies with mutated KDR gene is required.","PeriodicalId":333396,"journal":{"name":"Journal of Pharmacogenomics and Pharmacoproteomics","volume":"35 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2017-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"114998525","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Nanoparticles Mediated Drug Delivery 纳米颗粒介导给药

Journal of Pharmacogenomics and Pharmacoproteomics Pub Date : 2017-08-14 DOI: 10.4172/2153-0645.1000172

N. Khan

引用次数: 5

Modes of Action of Some Recently and Previously Discovered and Used Antimicrobial Agents/Drugs and Molecules: An Overview 一些最近和以前发现和使用的抗菌药物/药物和分子的作用方式:综述

Journal of Pharmacogenomics and Pharmacoproteomics Pub Date : 2017-08-03 DOI: 10.4172/2153-0645.1000171

WR Ali, Mf Aslam, Jawaria Irfan

{"title":"Modes of Action of Some Recently and Previously Discovered and Used Antimicrobial Agents/Drugs and Molecules: An Overview","authors":"WR Ali, Mf Aslam, Jawaria Irfan","doi":"10.4172/2153-0645.1000171","DOIUrl":"https://doi.org/10.4172/2153-0645.1000171","url":null,"abstract":"The need of controlling infectious microbes has increased in the past years due to the increased resistance of the microorganisms towards the antimicrobial agents as a result of the changes in their cellular membrane proteins, ionic channels, and cell surface receptors. Scientists are working their best to offer such an agent that could prove practical to harmful microbes that pose threats to the lives of people. This review focuses on the information about the modes of actions of some antimicrobial agents that are recently discovered, approved or used by scientific laboratories and pharmaceutical companies to make the future studies somewhat easier for the young scientists to make their way through their research works leading to newer drug discoveries with new and improved mechanisms against microbial integrity. Many new drugs have recently been reported to have performed their best against multidrug resistant Staphylococcus aureus and Pseudomonas, apart from bacterial control several new antifungal and antiviral agents have also been reported that are known to have performed best at clinical levels.","PeriodicalId":333396,"journal":{"name":"Journal of Pharmacogenomics and Pharmacoproteomics","volume":"123 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2017-08-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"131569210","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Beyond SNPs and CNV: Pharmacogenomics of Polymorphic Tandem Repeats 超越snp和CNV:多态串联重复序列的药物基因组学

Journal of Pharmacogenomics and Pharmacoproteomics Pub Date : 2017-06-27 DOI: 10.4172/2153-0645.1000170

Evgeny Krynetskiy

{"title":"Beyond SNPs and CNV: Pharmacogenomics of Polymorphic Tandem Repeats","authors":"Evgeny Krynetskiy","doi":"10.4172/2153-0645.1000170","DOIUrl":"https://doi.org/10.4172/2153-0645.1000170","url":null,"abstract":"Polymorphic Short Tandem Repeats (STR) emerged as a separate class of genetic mutation, which together with Single Nucleotide Polymorphisms (SNPs) and Copy Number Variations (CNVs) can explain variability in response to pharmacotherapy. STR draws interest in pharmacogenomics research because of their prevalence in the human genome, and their putative functional role as regulators of gene expression. Depending on the search algorithm, there are approximately 700,000–1,000,000 STR loci with 2-6 bp long motifs in the human reference genome. STR is non-randomly distributed across Untranslated Regions (UTRs), protein-coding sequences, and introns, and is overrepresented in the promoter regions of the human genes. The functional role of STR has been demonstrated by effects on gene expression, splicing, protein sequence, and association with pathogenic effects. An intrinsic property of STR is the high rate of mutation by expansion or contraction in the number of repeat units. Variation in the length of STR plays an important role in modulating gene expression, and STR is likely to be general regulatory elements which attenuate expression of multiple genes. Elucidating the effects of STR on gene expression may in part explain variability in drug response, something that cannot be achieved by focusing analysis exclusively on SNPs or CNV. This review summarizes the role of polymorphic STR in clinical manifestations including response to pharmacotherapy.","PeriodicalId":333396,"journal":{"name":"Journal of Pharmacogenomics and Pharmacoproteomics","volume":"17 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2017-06-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"114893049","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Pharmacogenomics: A Step towards Advancing Clinical Trials 药物基因组学:迈向临床试验的一步

Journal of Pharmacogenomics and Pharmacoproteomics Pub Date : 2017-05-04 DOI: 10.4172/2153-0645.100E157

P. Prashanth, Ya.

引用次数: 1