Karger Kompass Autoimmun最新文献_第2页

Konsequenz aus der geschlechtsspezifischen Prävalenz von Autoimmunerkrankungen 其结果是汽车免疫疾病普遍程度的性别效应

Karger Kompass Autoimmun Pub Date : 2020-05-01 DOI: 10.1159/000506968

Carmen-Marina Mihai

{"title":"Konsequenz aus der geschlechtsspezifischen Prävalenz von Autoimmunerkrankungen","authors":"Carmen-Marina Mihai","doi":"10.1159/000506968","DOIUrl":"https://doi.org/10.1159/000506968","url":null,"abstract":"Women have a higher incidence and prevalence of autoimmune diseases than men, and 85% or more patients of multiple autoimmune diseases are female. Women undergo sweeping endocrinological changes at least twice during their lifetime, puberty and menopause, with many women undergoing an additional transition: pregnancy, which may or may not be accompanied by breastfeeding. These endocrinological transitions exert significant effects on the immune system due to interactions between the hormonal milieu, innate, and adaptive immune systems as well as pro- and anti-inflammatory cytokines, and thereby modulate the susceptibility of women to autoimmune diseases. Conversely, pre-existing autoimmune diseases themselves impact endocrine transitions. Concentration-dependent effects of estrogen on the immune system; the role of progesterone, androgens, leptin, oxytocin, and prolactin; and the interplay between Th1 and Th2 immune responses together maintain a delicate balance between host defense, immunological tolerance and autoimmunity. In this review, multiple autoimmune diseases have been analyzed in the context of each of the three endocrinological transitions in women. We provide evidence from human epidemiological data and animal studies that endocrine transitions exert profound impact on the development of autoimmune diseases in women through complex mechanisms. Greater understanding of endocrine transitions and their role in autoimmune diseases could aid in prediction, prevention, and cures of these debilitating diseases in women.","PeriodicalId":333153,"journal":{"name":"Karger Kompass Autoimmun","volume":"202 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2020-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"127701923","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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Steckbrief Forschung 通缉令研究

Karger Kompass Autoimmun Pub Date : 2020-05-01 DOI: 10.1159/000507385

引用次数: 0

Veranstaltungskalender 酒店

Karger Kompass Autoimmun Pub Date : 2020-05-01 DOI: 10.1159/000507948

引用次数: 0

Allogene mesenchymale Stammzelltransplantation bei schwerer Manifestation von systemischen Lupus erythematodes 超形形色色胶质瘤细胞移植

Karger Kompass Autoimmun Pub Date : 2020-05-01 DOI: 10.1159/000507304

S. Adler

{"title":"Allogene mesenchymale Stammzelltransplantation bei schwerer Manifestation von systemischen Lupus erythematodes","authors":"S. Adler","doi":"10.1159/000507304","DOIUrl":"https://doi.org/10.1159/000507304","url":null,"abstract":"Systemic lupus erythematosus (SLE) is an autoimmune disease with a broad range of clinical manifestations and a heterogeneous disease course. There is no cure for SLE, but current standard pharmacotherapies can improve disease prognosis in most patients. However, some patients are refractory to conventional treatments and require alternative treatment options. The present study is aimed at identifying predictors of clinical response to allogeneic bone marrow-derived or umbilical cord-derived mesenchymal stem cell (BM-/UC-MSC) transplant in SLE. All adult patients identified in the Nanjing database with an SLE Disease Activity Index (SLEDAI) score ≥ 8 at baseline that had undergone MSC transplant and who had at least 1 year of follow-up after one or two successive intravenous injections of allogeneic BM-/UC-MSCs (1 million/kg) were analyzed. SLE symptoms and SLEDAI were assessed at baseline and during follow-up to determine low disease activity (LDA) and clinical remission (CR) at 1, 3, 6, and 12 months. Sixty-nine patients were included in the study, with a median (range) SLEDAI of 13 (8-34) at baseline. Among the 69 patients, 40 (58%) achieved LDA and 16 (23%) achieved CR with a SLEDAI of 9 (4-20), 8 (0-16), 6 (0-18), and 5 (0-18) after 1, 3, 6, and 12 months, respectively. Older age (p = 0.006) and no arthralgia/arthritis at baseline (p = 0.03) were associated with a higher rate of LDA. Achieving CR was associated with older age (p = 0.033), no arthralgia/arthritis at baseline (p = 0.001), and no prior use of cyclophosphamide (p = 0.003) or hydroxychloroquine (p = 0.016). Future studies using unique immunosuppressive regimens and allogeneic MSC sources will further elucidate determinants of clinical response to MSC transplant in SLE.","PeriodicalId":333153,"journal":{"name":"Karger Kompass Autoimmun","volume":"4 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2020-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"133941975","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Juckreiz als typische Missempfindung der Haut - nicht nur bei den klassischen allergischen Erkrankungen 痒是典型的皮肤不适——不仅仅是经典的过敏病症

Karger Kompass Autoimmun Pub Date : 2020-05-01 DOI: 10.1159/000506964

M. Sticherling

引用次数: 0

Zusammenhänge verstehen, individuelle Unterschiede beachten und Weiterbildung hinterfragen 对复杂情况的理解，关注个体差异，质疑深奥教育

Karger Kompass Autoimmun Pub Date : 2020-05-01 DOI: 10.1159/000507720

引用次数: 0

Bronchiolitis als mögliche unerwünschte Wirkung von Immuncheckpoint-Inhibitoren 空免疫疫苗抑制剂可能会带来不良影响

Karger Kompass Autoimmun Pub Date : 2020-05-01 DOI: 10.1159/000507303

N. Kahn

{"title":"Bronchiolitis als mögliche unerwünschte Wirkung von Immuncheckpoint-Inhibitoren","authors":"N. Kahn","doi":"10.1159/000507303","DOIUrl":"https://doi.org/10.1159/000507303","url":null,"abstract":"Immune checkpoint inhibitors (ICIs) have been shown to improve overall and progression-free survival in various cancers but have been associated with various immune-related adverse events (IRAEs), including interstitial lung disease, especially organizing pneumonia. We report 2 cases of isolated severe airway disease attributable to ICIs, a rarely reported pattern of lung toxicity. The first patient received nivolumab with or without ipilimumab in a randomized double-blind trial for locoregional metastatic melanoma. The second patient was treated with nivolumab for lung adenocarcinoma. An IRAE was suspected in both cases due to a temporal relationship between ICI initiation and symptom onset. ICIs were stopped, and high-dose prednisone, inhaled corticosteroids, and bronchodilators were administered, allowing a rapid clinical and functional improvement in Patient 1. In Patient 2, despite prolonged high-dose prednisone, only a stabilization of forced expiratory volume in 1 s could be achieved, and the disease course was complicated by respiratory infections resulting in further loss of lung function. The patient died 1 year later due to progression of metastatic disease. These 2 cases suggest that pulmonary IRAEs secondary to ICIs may present as isolated bronchitis or bronchiolitis, with variable outcomes following ICI withdrawal and systemic corticosteroids.","PeriodicalId":333153,"journal":{"name":"Karger Kompass Autoimmun","volume":"33 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2020-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"124014474","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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Wissenschaftlicher Beirat / Impressum 科学委员会/发行

Karger Kompass Autoimmun Pub Date : 2020-02-01 DOI: 10.1159/000505943

引用次数: 0

PharmaNews

Karger Kompass Autoimmun Pub Date : 2020-02-01 DOI: 10.1159/000505944

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Vaskultitiden - an der Haut häufig erstes, aber nicht einziges Zeichen 血管蒂酮一般是最先出现的症状但没有一种徵兆

Karger Kompass Autoimmun Pub Date : 2020-02-01 DOI: 10.1159/000505386

M. Sticherling

{"title":"Vaskultitiden - an der Haut häufig erstes, aber nicht einziges Zeichen","authors":"M. Sticherling","doi":"10.1159/000505386","DOIUrl":"https://doi.org/10.1159/000505386","url":null,"abstract":"Objective: It is unknown whether epidemiological or clinical characteristics of Henoch-Schönlein purpura (HSP) have changed over time. This study aimed at evaluating the epidemiological and clinical changes of HSP during 3 decades. Methods: We retrospectively analyzed the data of 515 children with HSP (0-15 years of age) between 1987 and 2015. We compared the two HSP patient groups: those admitted from 1987 to 1996 (group A, 238 cases) and those admitted from 2006 to 2015 (group B, 98 cases), apart a decade. Results: In total 515 patients, the mean age was 6.5 ± 3.0 years and the male-to-female ratio was 1.2:1 (278:237). The age distribution showed a peak at age 5 with a bell-shaped distribution pattern. The annual number of cases varied in each year with a trend of reduced cases in the recent decade. There were less cases during the summer season. Purpura, gastrointestinal involvement, joint involvement, and renal involvement were found in 100%, 56%, 38%, and 18% of the patients, respectively. In comparison between the two groups, there were similar findings in mean age, age distribution, and seasonal distribution. However, the hospitalization stay was longer, and the proportion of recurrent cases (14 cases vs. 0 case) and proteinuria (15% vs. 3%) were higher in the group A than in the group B. Conclusions: Long-term epidemiologic features of HSP were similar to those in other countries. Clinical manifestations of HSP showed a trend towards a less severe clinical phenotype over time in Deajeon, Korea. Key Points. It is unknown whether epidemiological and clinical traits of Henoch-Schönlein purpura (HSP) have changed over time. We reported that clinical manifestations of HSP have changed to milder phenotype through a long-term observation of three decades at a single hospital in Daejeon, South Korea. Clinical phenotype of infection-related diseases, including HSP, may be changed over time, and the etiology and the reason of clinical changes over time remain to be solved.","PeriodicalId":333153,"journal":{"name":"Karger Kompass Autoimmun","volume":"357 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2020-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"120968414","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0