International Clinical Neuroscience Journal最新文献_第9页

Neurological Manifestation of COVID-19: A Literature Review COVID-19的神经学表现:文献综述

International Clinical Neuroscience Journal Pub Date : 2020-09-28 DOI: 10.34172/ICNJ.2020.20

Arash Azhideh, Iman Menbari-Oskouie, Maryam Yousefi-Asl

{"title":"Neurological Manifestation of COVID-19: A Literature Review","authors":"Arash Azhideh, Iman Menbari-Oskouie, Maryam Yousefi-Asl","doi":"10.34172/ICNJ.2020.20","DOIUrl":"https://doi.org/10.34172/ICNJ.2020.20","url":null,"abstract":"In December 2019, the coronavirus ((COVID-19) outbreak related to severe acute respiratory syndrome (SARS-CoV2) originated in China and expanded exponentially as a public health pandemic to over 200 countries. Over 8 million validated cases and approximately 800 000 deaths. The main type is cardiac and respiratory but neurological symptoms are further mentioned as case series and case records in the research. The most frequent manifestations have been reported to include dizziness and headache followed by delirium and encephalopathy. Gillian barre syndrome, acute transversal myelitis, cerebrovascular accident, and encephalitis are among the complications noted. The most prominent occurrence at the periphery was hyposmia. This is also known that neurological demonstrations will also lead to regular features such as cough and fever, which evolve in these cases later on normal manifestations. For the timely diagnosis and separation of cases, therefore, a great suspicion guide is needed to arrest spread in neurology departments. This research provides a narrative study of COVID-19’s neurological symptoms and complexities. Our goal is to inform the neurologists and clinicians who work amidst potential COVID-19 patients regarding potential neurological symptoms, and likely neurological problems arising from the aforementioned new virus.","PeriodicalId":33222,"journal":{"name":"International Clinical Neuroscience Journal","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-09-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42621312","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 9

Leaving Against Medical Advice Among Patients With Brain Tumours in the Middle East: Khoula Hospital Experience 中东脑肿瘤患者违背医嘱离开：Khoula医院的经验

International Clinical Neuroscience Journal Pub Date : 2020-09-28 DOI: 10.34172/ICNJ.2020.22

T. Al-Saadi, A. Alsharqi, Jawahir ALSharqi, Khadija ALBulushi, Asma A. Alrasbi, Maather Al-Farsi, Shamsa Al-Ghafri, S. Al-Abri, H. Al-Saadi

{"title":"Leaving Against Medical Advice Among Patients With Brain Tumours in the Middle East: Khoula Hospital Experience","authors":"T. Al-Saadi, A. Alsharqi, Jawahir ALSharqi, Khadija ALBulushi, Asma A. Alrasbi, Maather Al-Farsi, Shamsa Al-Ghafri, S. Al-Abri, H. Al-Saadi","doi":"10.34172/ICNJ.2020.22","DOIUrl":"https://doi.org/10.34172/ICNJ.2020.22","url":null,"abstract":"Background: Leaving against medical advice (LAMA) can be defined broadly as a patient’s insistence upon leaving the hospital against the treating team has expressed advice, which is both a challenge and concern for physicians, as these patients lost to follow-up, and their outcomes remain unknown. There is no previous study conducted to find the prevalence and causes of LAMA in brain tumors patients in the Middle East to the best of our knowledge.Methods: Patients studied in this research are those who were diagnosed with any type of brain tumors and were admitted to the Neurosurgical Department in Khoula Hospital (KH) but signed LAMA in the two years between January 2017 to December 2018 by going through the electronic medical records. Data obtained from the health information system includes socioeconomic characteristics, health status-related data, diagnosis-related data, and the reasons for LAMA.Results: A total number of 302 patients with brain tumors included in this study. Twenty-eight patients (9.2%) signed LAMA with a majority of those who signed LAMA were in the young adult’s group (3-39 years) and represented 18 (64%). Eight patients (28.57%) among the LAMA group and 43 patients (15.69%) in the non-LAMA group have tumors in the frontal lobe, which has found to be the most familiar location (29%). There was a significant relationship between the reason for LAMA and gender (P = 0.020).Conclusion: Younger patients, male, Omani, newly diagnosed tumors, and tumors in the frontal lobe were all risk factors for LAMA. Education and awareness about LAMA recommended in order to avoid readmission and loss of follow up.","PeriodicalId":33222,"journal":{"name":"International Clinical Neuroscience Journal","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-09-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43453315","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 7

Drug Interactions in Iranian Veterans With Chronic Spinal Cord Injury - A Descriptive Study 伊朗退伍军人慢性脊髓损伤的药物相互作用-一项描述性研究

International Clinical Neuroscience Journal Pub Date : 2020-09-28 DOI: 10.34172/ICNJ.2020.25

Ashkan Divanbeigi, A. Seddighi, Sepideh Amiri, S. Jamshidi, Hesam Rahimi Baghdashti, Afsoon Seddighi

{"title":"Drug Interactions in Iranian Veterans With Chronic Spinal Cord Injury - A Descriptive Study","authors":"Ashkan Divanbeigi, A. Seddighi, Sepideh Amiri, S. Jamshidi, Hesam Rahimi Baghdashti, Afsoon Seddighi","doi":"10.34172/ICNJ.2020.25","DOIUrl":"https://doi.org/10.34172/ICNJ.2020.25","url":null,"abstract":"Background: Veterans with chronic spinal cord injury usually have various comorbidities. They are, therefore, visited by different doctors and use different medications. It is necessary to monitor the health of these veterans. One of the important issues in this regard is the attention to drug interactions. The purpose of this study was to investigate the drugs used and their interactions.Methods: This descriptive study of the cross-sectional studies was carried out retrospectively in 2015 under the Shefa Neuroscience Research Center’s supervision, examining the medical records of veterans with spinal cord injury participating in the health screening program at Khatam Alanbiya hospital in Tehran. Demographic data, comorbidities, used drugs, and the level of involvement collected. According to the FDA, drug interactions among the drugs used for each patient has evaluated and classified into three severe, moderate, and weak groups. SPSS v. 21 analyzed data.Results: The study population consisted of 404 men, ranging in age from 41 to 74, with a mean of 51.6 ± 6.4 years. One hundred forty-two of them (35.1%) had a complete injury, and 262 veterans (64.8%) had an incomplete injury. Only 17 veterans (4.2%) had no drug interactions. The number of drug interactions varied from 1 to 38, with an average of 5.9 ± 12.8 interactions per patient. The total number of interactions was 2856, of which 32.5% were weak, 55.3% moderate, and 12.2% severe, with a 95% confidence interval. Among the severe drug interactions in the study, the highest number belonged to the antidepressant drugs.Conclusion: This study highlights the necessity of developing a strategy for investigating and preventing drug interactions in veterans with chronic spinal cord injury. It has recommended that physicians pay more attention to other medications used by the patient and prescribe as little as possible of the drug and the drug with the least number of interactions.","PeriodicalId":33222,"journal":{"name":"International Clinical Neuroscience Journal","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-09-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41514705","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Novel Coronavirus Characteristic Cerebrovasculopathic Effects 新型冠状病毒的特征性脑血管病变作用

International Clinical Neuroscience Journal Pub Date : 2020-09-28 DOI: 10.34172/ICNJ.2020.19

Sara Zandpazandi, M. Shahmohammadi

引用次数: 1

Investigating the Association Between Serum Vitamin D Deficiency and Idiopathic Benign Paroxysmal Positional Vertigo 血清维生素D缺乏与特发性良性发作性位置性眩晕的相关性研究

International Clinical Neuroscience Journal Pub Date : 2020-06-21 DOI: 10.34172/icnj.2020.12

Jignesh Dhirubhai Dhameliya, U. Chandra, S. Vishwakarma, Dattaprasad Ganganpalli, A. Verma

{"title":"Investigating the Association Between Serum Vitamin D Deficiency and Idiopathic Benign Paroxysmal Positional Vertigo","authors":"Jignesh Dhirubhai Dhameliya, U. Chandra, S. Vishwakarma, Dattaprasad Ganganpalli, A. Verma","doi":"10.34172/icnj.2020.12","DOIUrl":"https://doi.org/10.34172/icnj.2020.12","url":null,"abstract":"Background: It is suggested that there is a positive association between vitamin D deficiency and benign paroxysmal positional vertigo (BPPV). We suggest, as a hypothesis, there is a positive association between vitamin D deficiency and BPPV. The current study aimed to investigate the association between vitamin D levels and BPPV.Methods: The present observational case-control study was planned and conducted on 100 participants (50 cases and 50 controls) in the Department of Neurology, Choithram Hospital & Research Center (CHRC), Indore, MP, India, from January 2018 to December 2018. All consecutive patients with diagnosis of idiopathic BPPV who were above the age of 18 years with a negative neurological status were included. Analyses were performed using SPSS software version 10. Results: BPPV was more common among those aged 50 to 70 years (64%). Out of 100 participants, 72 (72%) had vitamin D deficiency, in which 40 (80%) were cases and 32 (64%) were controls. 32 (64%) patients had posterior canal involved, out of them 20 (40%) were females and 12 (24%) were males, and in both groups posterior canal was more involved. Canal involvement according to gender was not statistically significant (P value=0.45). Mean vitamin D level for cases and controls was 34.9 and 46.5 nmol/L, respectively, and this difference was statically very significant with a p-value of 0.01 (P value < 0.05).Conclusion: According to the findings, there is a statistically significant association between vitamin D3 deficiency and Idiopathic BPPV. It can be noted that vitamin D3 deficiency may be a risk factor for the BPPV.","PeriodicalId":33222,"journal":{"name":"International Clinical Neuroscience Journal","volume":"7 1","pages":"122-126"},"PeriodicalIF":0.0,"publicationDate":"2020-06-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41992985","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Effectiveness of Extremely Low Frequency Electromagnetic Field and Pulsed Low Level Laser Therapy in Acute Stroke Treatment 极低频电磁场与脉冲低能级激光治疗急性脑卒中疗效观察

International Clinical Neuroscience Journal Pub Date : 2020-06-21 DOI: 10.34172/icnj.2020.13

F. Ashrafi, A. Rezaei, Arash Azhideh, F. Tabeie, L. Gachkar, M. Ahmadi, Maryam Yousefi-Asl, A. Zali, R. Khoshnoud

{"title":"Effectiveness of Extremely Low Frequency Electromagnetic Field and Pulsed Low Level Laser Therapy in Acute Stroke Treatment","authors":"F. Ashrafi, A. Rezaei, Arash Azhideh, F. Tabeie, L. Gachkar, M. Ahmadi, Maryam Yousefi-Asl, A. Zali, R. Khoshnoud","doi":"10.34172/icnj.2020.13","DOIUrl":"https://doi.org/10.34172/icnj.2020.13","url":null,"abstract":"Introduction: Stroke is one of the most devastating neurologic conditions in the world. Despite all the efforts that have been made for effective treatment, the prevalence of this medical condition is still high. One of the new methods in the treatment of patients is the use of low power laser and pulsed magnetic fields. The previous studies investigated the effectiveness of these methods individually. However, the present study aimed to investigate their effectiveness in combination.Methods: We divided the patients into control (n = 26) and experimental (n=26) groups. The primary variables included the Mini-Mental State Examination (MMSE) and the National Institute of Health Stroke Scale (NIHSS). The experimental group received Extremely Low-Frequency Electromagnetic Field (EMF-ELF) treatment with 1 mT power and laser in rejection with a wavelength of 840 nm for 5 days and 45 minutes per day. Results: The variable measured during this study, in addition to comparing the results of the intervention between the control and experimental groups, showed a significant difference in all indicators before and after the intervention. The mean and standard deviations of the Modified Rankin Scale (mRS), functional status (Barthel’s index), and cognitive status (MMSE) (p<0.001) were signed between two groups.Conclusion: Laser and magnetic field combination can be effective in the treatment of stroke. Further studies are recommended to ensure a better comparison.Keywords: Stroke; Low Level Light Therapy; Electromagnetic Field; Nonablative Laser Treatments","PeriodicalId":33222,"journal":{"name":"International Clinical Neuroscience Journal","volume":"7 1","pages":"127-131"},"PeriodicalIF":0.0,"publicationDate":"2020-06-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43792136","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

Noninvasive Deep Brain Stimulation 无创脑深部刺激

International Clinical Neuroscience Journal Pub Date : 2020-06-21 DOI: 10.34172/icnj.2020.10

P. Azimi, A. Zali

引用次数: 6

The Anxiety Disorder Among the Healthcare Providers During The COVID-19 Infection Pandemic: A Systematic Review 新冠肺炎感染大流行期间医疗服务提供者的焦虑症：系统综述

International Clinical Neuroscience Journal Pub Date : 2020-06-21 DOI: 10.34172/icnj.2020.11

Sepideh Paybast, Fatemeh Baghalha, A. Emami, Mohsen Koosha

{"title":"The Anxiety Disorder Among the Healthcare Providers During The COVID-19 Infection Pandemic: A Systematic Review","authors":"Sepideh Paybast, Fatemeh Baghalha, A. Emami, Mohsen Koosha","doi":"10.34172/icnj.2020.11","DOIUrl":"https://doi.org/10.34172/icnj.2020.11","url":null,"abstract":"Background: The outbreak of the novel coronavirus disease (COVID-19) imposes a considerable psychological burden on the medical staff working in central hospitals for COVID-19. In this systematic review, we will discuss the prevalence and the risk factors of anxiety disorder among the frontline medical staff dealing with COVID-19 patients.Methods: PubMed, Scopus, Embase, Web of Science data bases were systematically searched from December 01, 2019 to April 30, 2020 for related published articles. In all electronic databases, the following search strategy was implemented and these key words (in the title/abstract) were used: “COVID-19” OR “novel Coronavirus” AND “anxiety” OR “psychology” OR “psychiatry” OR “psychological distress” AND “nurses” or “clinicians”. We included only the cross sectional studies.Results: Through the search strategy, we could identify eight related cross sectional articles about anxiety among the healthcare workers in central hospitals for COVID-19 infection. However, the authors scanned the reference lists of the included studies and identified multiple references. According to our findings, the frontline medical staff are at risk developing anxiety disorder which is mainly mild. Additionally, the female nurses are more susceptible to experience anxiety during the COVID-19 pandemic.Conclusion: Regarding to the outbreak of COVID-19 worldwide and the workload of the frontline medical staff dealing with COVID-19 patients, a particular attention should be given on the mental health of the healthcare provides.","PeriodicalId":33222,"journal":{"name":"International Clinical Neuroscience Journal","volume":"7 1","pages":"115-121"},"PeriodicalIF":0.0,"publicationDate":"2020-06-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48934635","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 10

Guillain-Barre syndrome as a neurological complication of COVID-19 infection: a case series and review of the literature 格林-巴利综合征作为新冠肺炎感染的神经并发症：病例系列和文献回顾

International Clinical Neuroscience Journal Pub Date : 2020-06-21 DOI: 10.34172/icnj.2020.18

H. Mozhdehipanah, Sepideh Paybast, R. Gorji

引用次数: 19

Expression of the Apoptotic Proteins in Glioblastoma U87-MG Cell Line Treated by Botulinum Toxin 肉毒杆菌毒素作用下胶质母细胞瘤U87-MG细胞凋亡蛋白的表达

International Clinical Neuroscience Journal Pub Date : 2020-06-21 DOI: 10.34172/icnj.2020.14

M. Farhadi, S. Moniri, M. Jameie, Nasrin Hosseini, M. Jameie, S. B. Jameie

{"title":"Expression of the Apoptotic Proteins in Glioblastoma U87-MG Cell Line Treated by Botulinum Toxin","authors":"M. Farhadi, S. Moniri, M. Jameie, Nasrin Hosseini, M. Jameie, S. B. Jameie","doi":"10.34172/icnj.2020.14","DOIUrl":"https://doi.org/10.34172/icnj.2020.14","url":null,"abstract":"Background: Glioblastoma multiforme (GBM) is the most type of brain malignancy in adults. Radical excision surgery, chemotherapy, and radiotherapy in some cases are still unsuccessful, and most patients with GBM die within three to six months following diagnosis. Botulinum toxin type A (BtxA) has cellular toxin effects and suppresses the cell division of certain types of cancer cell lines in vivo and in vitro study. The present study designed to evaluate the apoptotic effect of BtxA on the GBM cell line.Material & methods: U87-MG GBM cell line cultured according to the routing protocols, divided into two groups including, trial (BtxA treated) and control groups. Cells of the trial group exposed to different doses of BtxA. The cell viability, cycle arrest, and pro-apoptotic proteins evaluated respectively by MTT assay, SubG1, and Western blotting.Results: MTT assay showed that the viability of the BtxA treated cells at doses of 1.45 Unit and other doses after 24 to 48 hours, significantly decreased (p<0.001) compared to the control groups. Apoptosis percentage of the SubG1 test also indicated that 1.45 Unit dose significantly increased in the cells exposed to BtxA compared to the control group in 24 hours. The expression of P53 and Caspase 3 proteins indicated a significant increase.Conclusion: BtxA induces apoptosis in U87- MG cell line via p53 and caspase three pathways and could have clinical applications. In vivo studies need to confirm the clinical application of the present findings.","PeriodicalId":33222,"journal":{"name":"International Clinical Neuroscience Journal","volume":"7 1","pages":"132-137"},"PeriodicalIF":0.0,"publicationDate":"2020-06-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48551067","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0