Drug Interactions in Iranian Veterans With Chronic Spinal Cord Injury - A Descriptive Study

International Clinical Neuroscience Journal Pub Date : 2020-09-28 DOI:10.34172/ICNJ.2020.25

Ashkan Divanbeigi, A. Seddighi, Sepideh Amiri, S. Jamshidi, Hesam Rahimi Baghdashti, Afsoon Seddighi

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引用次数: 1

Abstract

Background: Veterans with chronic spinal cord injury usually have various comorbidities. They are, therefore, visited by different doctors and use different medications. It is necessary to monitor the health of these veterans. One of the important issues in this regard is the attention to drug interactions. The purpose of this study was to investigate the drugs used and their interactions.Methods: This descriptive study of the cross-sectional studies was carried out retrospectively in 2015 under the Shefa Neuroscience Research Center’s supervision, examining the medical records of veterans with spinal cord injury participating in the health screening program at Khatam Alanbiya hospital in Tehran. Demographic data, comorbidities, used drugs, and the level of involvement collected. According to the FDA, drug interactions among the drugs used for each patient has evaluated and classified into three severe, moderate, and weak groups. SPSS v. 21 analyzed data.Results: The study population consisted of 404 men, ranging in age from 41 to 74, with a mean of 51.6 ± 6.4 years. One hundred forty-two of them (35.1%) had a complete injury, and 262 veterans (64.8%) had an incomplete injury. Only 17 veterans (4.2%) had no drug interactions. The number of drug interactions varied from 1 to 38, with an average of 5.9 ± 12.8 interactions per patient. The total number of interactions was 2856, of which 32.5% were weak, 55.3% moderate, and 12.2% severe, with a 95% confidence interval. Among the severe drug interactions in the study, the highest number belonged to the antidepressant drugs.Conclusion: This study highlights the necessity of developing a strategy for investigating and preventing drug interactions in veterans with chronic spinal cord injury. It has recommended that physicians pay more attention to other medications used by the patient and prescribe as little as possible of the drug and the drug with the least number of interactions.

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伊朗退伍军人慢性脊髓损伤的药物相互作用-一项描述性研究

背景:退伍军人慢性脊髓损伤通常有多种合并症。因此，他们被不同的医生拜访，使用不同的药物。有必要监测这些退伍军人的健康状况。这方面的一个重要问题是对药物相互作用的关注。本研究的目的是调查所使用的药物及其相互作用。方法:在Shefa神经科学研究中心的指导下，回顾性分析2015年在德黑兰Khatam Alanbiya医院参加健康筛查项目的脊髓损伤退伍军人的医疗记录，进行横断面研究的描述性研究。收集人口统计数据、合并症、使用药物和参与程度。根据FDA的规定，每个患者使用的药物之间的相互作用已经被评估并分为三个严重、中度和弱组。SPSS v. 21分析数据。结果:研究人群包括404名男性，年龄41 ~ 74岁，平均年龄51.6±6.4岁。其中完全性损伤142人(35.1%)，完全性损伤262人(64.8%)。只有17名退伍军人(4.2%)没有药物相互作用。药物相互作用次数为1 ~ 38次，平均每位患者发生5.9±12.8次相互作用。总交互次数为2856次，其中32.5%为弱交互，55.3%为中度交互，12.2%为重度交互，可信区间为95%。在研究中严重的药物相互作用中，抗抑郁药物的数量最多。结论:本研究强调了制定研究和预防慢性脊髓损伤退伍军人药物相互作用策略的必要性。它建议医生更多地关注患者使用的其他药物，并尽可能少地开这种药物和相互作用最少的药物。

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来源期刊

International Clinical Neuroscience Journal

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0.00%

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审稿时长

4 weeks