{"title":"Comparing The Antibacteria Activity Of Ethanolic Extract Of Vernonia amygdalina and Occimum gratissimum with someAntibiotics of choice","authors":"Jude Ojei B.S, I. T.A, O. Ola-Iyabo","doi":"10.5580/241f","DOIUrl":"https://doi.org/10.5580/241f","url":null,"abstract":"Aqueous and ethanolic extracts of Vernonia amygdalina and Ocimum gratissimum were assessed for their antibacterial activities at varying concentrations against medically significant pathogenic bacterial strains capable of causing gastroenteritis. The ethanolic extracts showed a better antibacterial potency with diameter of zones of inhibition ranged 1.0±0.33 to 9.33±0.63 (mm).Selected antibiotics of choice were tested against the test isolates and compared with the results of the extracts. The antibiotics had better activity compared to the extracts at the same concentration but relatively comparable at 100% increment of the concentrations of the extracts.","PeriodicalId":331725,"journal":{"name":"The Internet Journal of Tropical Medicine","volume":"11 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2009-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"116939344","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Self Diagnosis as a Possible Means of Diagnosing Urinary Schistosomiasis among School Children in an Endemic Community in Nigeria.","authors":"Pc Inyang-Etoh, A. Eyo, V. Usanga","doi":"10.5580/9ae","DOIUrl":"https://doi.org/10.5580/9ae","url":null,"abstract":"Self diagnosis as a possible means of diagnosing urinary schistosomiasis in an endemic community was studied among school children aged 1 -15 years in Adim community, Biase Local Government Area of Cross River State, Nigeria. Questionnaire and parasitological data were collected from 900 children randomly selected from all the schools in Adim community. Parasitological analysis revealed infection in 357 (39.7%). Children within the ages of 14 years and above had the highest prevalence rate 36 (66.7%). Male subjects had a higher prevalence rate of infection 195 (39.9%) than the females 162 (39.4) but there was no statistically significant difference in the distribution of infection by gender (P> 0.05). The percentage of children with knowledge of having the infection was 300 (33.3%) while those who truly had the infection were 357 (39.7%). The questionnaire data revealed that children of Adim community can easily detect the symptoms of urinary schistosomiasis but do not have knowledge of the aetiologic agents, mode of infection nor what to do if infected. We conclude that urinary schistosomiasis is still endemic in Adim Community and self diagnosis can be used as a possible means of diagnosing urinary schistosomiasis for the purpose of administering mass treatment and also monitoring outcome of the treatment in the community.","PeriodicalId":331725,"journal":{"name":"The Internet Journal of Tropical Medicine","volume":"9 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2009-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"128957302","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
D. Tagoe, S. E. Baidoo, I. Dadzie, V. G. Kangah, H. Nyarko
{"title":"A Comparison Of The Antimicrobial (Antifungal) Properties Of Garlic, Ginger And Lime On Aspergillus Flavus, Aspergillus Niger And Cladosporium Herbarum Using Organic And Water Base Extraction Methods","authors":"D. Tagoe, S. E. Baidoo, I. Dadzie, V. G. Kangah, H. Nyarko","doi":"10.5580/1099","DOIUrl":"https://doi.org/10.5580/1099","url":null,"abstract":"The study aim at comparing the antimicrobial (antifungal) properties of garlic, ginger and lime on Aspergillus flavus, Aspergillus niger and Cladosporium herbarum using organic and water base extraction. Pure cultures of the test fungal were isolated from rotten vegetables, air spora, and a swab of the skin surface whilst filtered plant extracts were obtained by means of organic (absolute ethanol) and aqueous (distilled water) extraction techniques. The pour plate technique was applied in the antifungal sensitivity testing using Potato Dextrose Agar (PDA) and results obtained by measuring diameter of fungal growth over a 7day incubation period. Growth results showed high but varied levels of antimicrobial effectiveness. Ginger showed the highest antimicrobial effect against all the test fungi (P 0.05) using ethanol extraction. In the water (aqueous) base extraction medium, lime exhibited the highest antimicrobial (antifungal) effect (P 0.05) but highly fungicidal on C. herbarum (P<0.01). Thus water base extraction technique was the most effective in inducing antifungal properties of lime whiles ethanol base extraction technique was the best for ginger. Garlic on the other hand exhibited a good antimicrobial (antifungal) property in both ethanol and water extraction media. The study thus confirms the antifungal properties of these medicinal plants and suggests the type of extraction to yield the best results.","PeriodicalId":331725,"journal":{"name":"The Internet Journal of Tropical Medicine","volume":"20 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2009-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"117201730","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Cardioprotective Potential Of Vernonia Amygdalina And Ocimum Gratissimum Against Streptozotocin (Stz) – Induced Diabetes In Wistar Rats.","authors":"O. R. Asuquo, A. Igiri, J. E. Akpan, M. Akpaso","doi":"10.5580/907","DOIUrl":"https://doi.org/10.5580/907","url":null,"abstract":"Diabetes mellitus is characterized by disordered metabolism and abnormally high blood sugar resulting from insufficient levels of insulin. It is a disease of the developed world that is gradually creeping into developing countries, especially in Africa where Westernized diets are imbibed. Vernonia amygdalina and Ocimum gratissimum have been used singly for the management of diabetes in Nigeria, especially in the South Eastern part. The acceptance of the use of polyherbal therapy necessitated the research of the combination of these two herbs in the management of diabetes. Forty Wistar rats of an average weight of 140g were used for this study and were randomly divided into five (5) groups of eight (8) rats each. Groups A and B served as the normal and diabetic controls respectively and were given placebo treatment. Groups C, D and E were the experimental groups administered with 200mg/kg body weight of the extracts by gastric intubations for 28 days. Groups C and D received extracts of Vernonia amygdalina and Ocimum gratissimum respectively. Group E received a combination of both extracts. Fasting blood glucose (FBG) level was checked on a weekly basis. Results showed a significant lowering of FBG level of animals in the treated groups, while the diabetic control group recorded a significant increase in FBG. The normal control group had FBG level within the normal range. Histological examination revealed a normal cytoarchitecture in the group A animals. The diabetic control group B animals showed degeneration of myocytes, loss of nuclei, loss of cross striation of the cardiac muscles and an increase in myofibre diameter. These conditions were greatly reversed in the treated groups that received the extracts. It can therefore be concluded that Vernonia amygdalina and Ocimum gratissimum may be effective and safe in the proper management of cardiomyopathy, one of the numerous complications of diabetes mellitus.","PeriodicalId":331725,"journal":{"name":"The Internet Journal of Tropical Medicine","volume":"288 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2009-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"132490432","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Pattern and outcome of gynaecological emergencies at a Nigerian secondary Health Care Centre","authors":"D. Buowari","doi":"10.5580/152d","DOIUrl":"https://doi.org/10.5580/152d","url":null,"abstract":"BACKGROUND: Gynaecological emergencies form a large proportion of workload for the doctor.METHOD: This is a prospective study of all emergencies presenting with gynaecological problems from February to November 2006 was included in this study.RESULT: 153 patients presented with gynaecological emergencies in this study. 143(93.5%) had spontaneous abortion and 10(6.5%) women had ectopic pregnancy.CONCLUSION: Emergency gynaecological practice is more stressful in Nigeria than in developed countries because of poor infrastructure and difficulty in sourcing the materials required to treat patients.","PeriodicalId":331725,"journal":{"name":"The Internet Journal of Tropical Medicine","volume":"13 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2009-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"131629096","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Socio-Economic And Socio-Cultural Predisposing Risk Factors To Hiv/Aids: Case Study Of Some Locations In Eastern Nigeria","authors":"U. Dibua","doi":"10.5580/17b3","DOIUrl":"https://doi.org/10.5580/17b3","url":null,"abstract":"The prevalence of HIV/AIDS and associated sociocultural and socioeconomic risk behaviours were studied among Commercial Sex Workers, Single parents, Long-Distance-Truck Drivers, Street Children and Students along the North-South highway in Eastern Nigeria. Screening for HIV antibodies was by EIA and ELISA. Structured questionnaires and focus group discussions were used for investigative data collection tested by t-test and Chi-square. HIV prevalence occurred as follows: Commercial Sex Workers 23%; Students 21%; Single Parents 20%, Long-Distance-TruckDrivers 19%, Street Children 16%. Major mode of HIV transmission was heterosexual transmission; severe economic repression (poverty), illiteracy, economic-driven-migrationalactivities and unemployment were chief socioeconomic risk factors, while polygamy/concubinage, marriage for the dead, surrogate marriage of women to woman were main sociocultural lapses which create vulnerability of women to clandestine sex working/prostitution and subsequent exposure to STDs including HIV/AIDS. The study further observed that major high-ways constitute flashpoints through which the HIV gets foothold in the communities.","PeriodicalId":331725,"journal":{"name":"The Internet Journal of Tropical Medicine","volume":"46 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2009-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"132450709","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"The Impact Of A Cash Driven Health Care System On Blood Utilization : An Analysis Of Blood Utilization During Elective Surgeries At The University Of Nigeria Teaching Hospital Ituku-Ozalla- A Pilot Survey","authors":"A. A.O, Ajuzieogu V.O, E. R.L","doi":"10.5580/20f7","DOIUrl":"https://doi.org/10.5580/20f7","url":null,"abstract":"One of the tasks of the anaesthetists includes making a decision on the need for blood transfusion during surgical procedure. This task though daunting in the face of epileptic blood supply, will save lives, but may result in over ordering and wasting of blood. AIMS/OBJECTIVES 1 To assess the efficacy of blood ordering practice.2 To assess the feasibility of a prospective random work to develop practice guidelines. MATERIALS AND METHODS: A prospective study involving patients booked for elective surgical procedures who were asked to provide blood for the surgery. The study spanned a period of three months and variables included pre/ post operative haemoglobin level estimation, duration of surgery, blood loss, number of units of blood provided and number of units of blood transfused. Cross-match/transfusion ratio, degree of over/under transfusion, and transfusion index, transfusion probability were calculated. ResultsCross match to transfusion ratio is higher than 2.5: 1 during procedures such as thyroidectomy, cholecystectomy, and myomectomy, elective caesarean section but lower during open prostatectomies, laminectomy and aneurysm surgery . Logistic problems affected post operative haemoglobin estimation but from the few that had their post operative haemoglobin level checked, the patients were under-transfused.Conclusion There is definitely over-ordering of blood which needs to be minimized by changing the blood ordering pattern through the development of a maximum surgical blood ordering schedule. Provision of refrigerators for storing blood in the theatre (theatre mini blood bank) would limit the need for palpable blood in the theatre before it is needed and help in preventing ageing of blood.","PeriodicalId":331725,"journal":{"name":"The Internet Journal of Tropical Medicine","volume":"40 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2009-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134409524","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Ogoina Dimie, Obiako O. Reginald, Nkoro Kuffrey, A. M. Mohammed, Iheonye Henry, B. K. Isa
{"title":"Acute Meningococcemia Complicating Epidemic Meningitis In Zaria, Nigeria","authors":"Ogoina Dimie, Obiako O. Reginald, Nkoro Kuffrey, A. M. Mohammed, Iheonye Henry, B. K. Isa","doi":"10.5580/200b","DOIUrl":"https://doi.org/10.5580/200b","url":null,"abstract":"Neisseria meningitidis is a bacterium known to cause 5-10 years cyclical epidemic meningitis in the meningitic belt of Africa. In these case reports, we highlight the multi-systemic manifestations and management challenges of acute meningococcemia, a rare life threatening complication of epidemic meningitis.","PeriodicalId":331725,"journal":{"name":"The Internet Journal of Tropical Medicine","volume":"97 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2009-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"122539029","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Seroprevalence of Hepatitis B Surface Antigen and Liver Function Tests among Adolescents in Abakaliki, South Eastern Nigeria","authors":"E. Ugwuja, N. Ugwu","doi":"10.5580/1726","DOIUrl":"https://doi.org/10.5580/1726","url":null,"abstract":"Of the 785 apparently healthy adolescents, 386 (49.2%) males and 399 (50.8%) females (mean age, 15.6 ± 2.3 years) screened for hepatitis B surface antigen (HBsAg) using a third generation enzyme linked immunosorbent assay method, 32 (4.1%) were seropositive. Although, males and females did not differ significantly in HBsAg seropositivity (17 vs. 15; 95%CI: -0.025-0.065) more infections were found in patients from lower- than middle-/or and upper- socioeconomic classes (p < 0.05). The major routes of HBV transmission in this population were unsafe injection (28.1%; 95%CI; 0.03-0.15), tribal marks/circumcision/scarification (12.5%; 95%CI; 0.00-0.08) and blood/blood products transfusions (6.3%; 95%CI; -0.04-0.28) while 53.1% (95%CI; 0.02-0.04) of HBV infections have no identifiable mode of transmission. While HBsAg seropositive patients showed significantly higher levels of liver enzymes and lower conjugated bilirubin than their seronegative counterparts, total protein, albumin and total bilirubin were comparable among the groups. Asymptomatic HBV infection among adolescents without proper identifiable risk factors or mode of acquisition calls for general surveillance, mass immunisation, and public health education to curtail the spread of the virus and its sequalae.","PeriodicalId":331725,"journal":{"name":"The Internet Journal of Tropical Medicine","volume":"21 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2009-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"133979159","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Hepatoprotective and antioxidant effect of Sphaeranthus indicus against acetaminophen–induced hepatotoxicity in rats.","authors":"B. Tiwari, R. Khosa","doi":"10.5580/ba9","DOIUrl":"https://doi.org/10.5580/ba9","url":null,"abstract":"The flower heads of Sphaeranthus indicus Linn (Asteraceae) a traditional Indian medicinal plant is commonly used to nourish and improve the liver conditions. This study was designed to evaluate the hepatoprotective and antioxidant effect of aqueous (AQS) and methanolic (MES) extract of flower heads of Sphaeranthus indicus on Acetaminophen (APAP)-induced heptotoxicity in rat’s in-vivo. Activities of liver marker enzymes ,glutamate-oxaloacetate transaminase (SGOT) glutamate pyruvate transaminase (SGPT), acid phosphatase (ACP) and alkaline phosphatase (ALP) bilirubin and total protein at an oral dose of MES (300mg/kg) showed a significant hepatoprotective effect in comparison with the same dose of aqueous extract. This fact was also confirmed by studying the liver histopathology of treated animals. As Regards the antioxidant activity, MES exhibited a significant effect showing increasing levels of superoxide dismutase (SOD), Catalase (CAT), and glutathione peroxides (GPX) by reducing malondialdehyde (MDA) levels.","PeriodicalId":331725,"journal":{"name":"The Internet Journal of Tropical Medicine","volume":"28 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2009-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"121295926","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}