mjl@ kly@ lTb最新文献

{"title":"Effects of hypertension with and without smoking on salivary electrolytes concentration","authors":"Maha Alramadany, Layla S. Yas","doi":"10.32007/jfacmedbagdad.6512046","DOIUrl":"https://doi.org/10.32007/jfacmedbagdad.6512046","url":null,"abstract":"Background: Hypertension from smoking is a chronic medical condition that impacts human health. It has been proved that it could be a significant risk factor for different disorders like brain damage, the lung disease and has been related to the growth of oral diseases. However, there are few and conflicting research on its effect on salivary electrolytes concentrations.\u0000Aim of the study: To assess the effect of hypertension with and without smoking on electrolyte concentrations in saliva and to identify its effect on normal oral balance.\u0000Methods: A total number of 90 subjects included, which is comprised of (49) (54.4 %) males subjects and (41) (45.6 %) females subjects in the gender. They were divided into three groups, G1, G2 and G3 groups. Group 1 comprised 30 subjects of hypertension with smoking, Group 2 comprised 30 subjects of hypertension without smoking and Group 3 comprised 30 subjects of healthy non-smoking controls.  \u0000Results: Findings displayed a highly significant difference in concentration of calcium in saliva and there was no significant difference in potassium and sodium for the three groups. There was a significant difference of calcium in saliva concentration for all study group with respect to P-Value (0.000).\u0000Conclusion: The salivary calcium concentration in the saliva can be affected by hypertension with smoking and the increase in salivary calcium levels might be a risk factor for development of periodontal diseases.","PeriodicalId":33125,"journal":{"name":"mjl@ kly@ lTb","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-04-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48721204","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"تأثير عقار داباغليفلوزين على مستوى هيموجلوبين في الدم","authors":"Ahmed A. Obeed, Tahseen A. AL-Kinani, Huda Ibrahim AL- Qadhi","doi":"10.32007/jfacmedbagdad.6441973","DOIUrl":"https://doi.org/10.32007/jfacmedbagdad.6441973","url":null,"abstract":"الخلفية: قصور القلب هو متلازمة إكلينيكية معقدة تنتج عن أي مرض قلبي وظيفي أو هيكلي يقلل من قدرة البطين على تعبئة الدم أو ضخه. فقر الدم شائع لدى مرضى قصور القلب ويرتبط بالتدهور من خلال تنشيط المسارات الهرمونية العصبية. عقار داباكليفلوزين  هو مثبط انتقائي وقابل للانعكاس للناقل المشترك للصوديوم الجلوكوز 2 (SGLT2). يزيد داباجليفلوزين من مستوى الهيموجلوبين من خلال آليات مختلفة مثل زيادة تركيز البلازما عن طريق إدرار البول أو زيادة تخليق الإريثروبويتين.\u0000الهدف: تقييم تأثير الداباجليفلوزين الإضافي في العلاج التقليدي على الهيموجلوبين في مرضى قصور القلب المصابين بمرض الكلى المزمن (CKD) مع أو بدون داء السكري DM.\u0000المرضى والطرق: كانت هذه دراسة سريرية مستقبلية أجريت في أجنحة طبية في مركز  الناصرية  للقلب خلال الفترة من 1 نوفمبر / 2021 إلى نهاية يوليو / 2022. تم إجراء البحث على 120 مشاركًا يعانون من قصور في القلب وضعف كلوي. تم تقسيم المرضى إلى مجموعتين. ضمت المجموعة الأولى 60 مريضاً تم إعطاؤهم داباجليفلوزين بالإضافة إلى الأدوية التقليدية ، وتألفت المجموعة الأخرى من 60 مريضاً تلقوا العلاج التقليدي فقط. تمت مطابقة كلا المجموعتين فيما يتعلق بالخصائص الاجتماعية والديموغرافية. تم تسجيل تركيز الهيموجلوبين في اليوم الأول كزيارة أساسية ثم تمت متابعتها بعد أربعة أشهر.\u0000النتائج: قبل العلاج لم تكن هناك فروق ذات دلالة إحصائية في العوامل الاجتماعية والديموغرافية والسريرية بين المجموعتين. في مجموعة داباجليفلوزين ، كان مستوى الهيموجلوبين أعلى بكثير من مستوى ما قبل العلاج (12.53 جم / لتر مقابل 11.85 جم / لتر ، P = 0.016) ، كان لدى المرضى في المجموعة الضابطة مستوى متوسط ​​أقل بكثير من الهيموجلوبين بعد العلاج مقارنة بمستوى خط الأساس ( 11.88 جم / لتر مقابل 12.56 جم / لتر ، P = 0.001).\u0000الاستنتاج: أظهرت الدراسة أن داباجليفلوزين يزيد تركيز الهيموجلوبين ويصحح  فقر الدم لدى مرضى قصور القلب المصابين بمرض الكلى المزمن مقارنة بمجموعة التحكم.","PeriodicalId":33125,"journal":{"name":"mjl@ kly@ lTb","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42657570","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A short-term comparison between the effect of two different concentrations of methotrexate on ovarian tissues and function of female albino rats","authors":"Alak Hussein","doi":"10.32007/jfacmedbagdad.6441967","DOIUrl":"https://doi.org/10.32007/jfacmedbagdad.6441967","url":null,"abstract":"Back ground: methotrexate is an antifolate that is widely used in cancers and inflammatory or auto- immune diseases, it is also known to be contraindicated in pregnancy, breast feeding and not recommended in patients planning to be parents since it has a harmful effect on fetus and gonads. \u0000    Ovarian function can be evaluated by certain parameters like the levels of female hormones or anti- Mullerian hormone which is considered as a good indicator for this purpose or histopathological examination of ovarian follicles especially the primordial follicles. \u0000  Objective: the aim of this study is to determine the effect of two different concentrations of methotrexate on ovarian tissue integrity and function. \u0000  Materials and method: adult female albino rats (n=30) were randomly divided in to 3 groups; group A (n=10) in which animals were treated with i. p injection of normal saline once weekly for four weeks, group B (n=10) in which animals were treated with i. p. injection of 1mg/ kg bw of methotrexate once weekly for four weeks, and lastly group C in which animals were treated with i. p. injection of 2.5 mg/ kg bw of methotrexate once weekly for four weeks. Then serum level of anti- Mullerian hormone were measured and histopathological examination of the ovaries were done to evaluate ovarian injury caused by methotrexate treatment. \u0000    Results: this study has demonstrated that methotrexate in the both 1mg and 2.5 mg / kg of BW doses did not significantly reduce the levels of anti- Mullerian hormone and the number of primordial follicles and atretic follicles were also not significantly affected by the treatment of methotrexate in both doses. While histopathological examination revealed mild ovarian damage in case of treatment with 1mg/ kg bw of methotrexate and moderate damage in case of treatment with 2.5 mg/ kg bw of methotrexate. \u0000     Conclusions: there is no important difference between the effects of 1 and 2.5 mg/ kg of BW of methotrexate on ovarian function but there is a slight difference in the effects of the two different doses on the integrity of ovarian tissue.","PeriodicalId":33125,"journal":{"name":"mjl@ kly@ lTb","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46742628","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of liraglutide on weight control and blood pressure in type 2 diabetes mellitus Iraqi patients","authors":"Ahmed J. Abdulrahman, M. Jabarah, Samer A. Najjar","doi":"10.32007/jfacmedbagdad.6441971","DOIUrl":"https://doi.org/10.32007/jfacmedbagdad.6441971","url":null,"abstract":"Background: Diabetes mellitus is the most common endocrine illness, affecting an increasing number of people all over the world. It is caused by a lack, or inadequate synthesis of insulin by the pancreas leading to an increase in blood glucose concentrations. Type 2 diabetes mellitus is the most strongly linked disease to obesity of all disorders. The number of obesity-related diabetes is predicted to reach 300 million by 2025. The term 'diabesity' was coined as a result of this strong link, therefore, weight loss is seen as a key therapeutic goal in the prevention and management of type 2 diabetes mellitus. Liraglutide is a glucagon-like peptide-1 (GLP-1) receptor agonist that stimulates insulin secretion in a glucose-dependent manner. Also, it has weight-losing benefits which is assumed to be due to appetite suppression and delayed gastric emptying.   \u0000Objectives: To evaluate the effectiveness of Liraglutide on weight management, body mass index, renal function and blood pressure in type 2 diabetic mellitus obese patients in Iraq.\u0000Methods: An open-label therapeutic trial was conducted from November 2021 to June 2022 at Baquba Teaching Hospital/ Diyala. (23 males and 27 females) with Type 2 Diabetes mellitus for 2 - 4 years were included in the study. They were obese, hypertensive and dyslipidemic. They received metformin and liraglutide for 12 weeks as 0.6 mg/day during the first week, which was gradually increased to 1.2 mg and up to 1.8 mg/day according to patient tolerance and requirement for control at the beginning the study. The patients had their height as well as body weight measured, calculated, blood pressure measured and renal functions tested. The statistical analysis was performed using SAS (Statistical Analysis System - version 9.1). Two-way ANOVA and Least significant differences (LSD) post hoc test were performed as well as paired t-test. P< 0.05 was considered statistically significant.\u0000Results: Treatment with liraglutide for 12 weeks has resulted in a significant decrease in body weight, BMI, and blood pressure (P<0.05). The changes in the results of renal function test of liraglutide-treated patients were not significant.\u0000Conclusion: In obese type 2 diabetic patients, liraglutide has the potential of reducing body weight, body mass index and blood pressure. It seemed safe in terms of its systemic effects\u0000 \u0000 \u0000 \u0000 \u0000 ","PeriodicalId":33125,"journal":{"name":"mjl@ kly@ lTb","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44042559","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of serum Podocalyxin in Iraqi women with Polycystic Ovary Syndrome","authors":"Noor Mohammed Fadhil, R. A. Hamdi","doi":"10.32007/jfacmedbagdad.6441983","DOIUrl":"https://doi.org/10.32007/jfacmedbagdad.6441983","url":null,"abstract":"Background: Polycystic ovarian syndrome is the most common endocrine disease in females of childbearing time of life. Women with polycystic ovarian syndrome  have a higher chance of developing complications such as dyslipidemia, hypertension, and obesity. Obesity is a state of extreme fat buildup which leads to the development of multiple complications involving non-alcoholic fatty liver disease, cardiovascular disease and type2 diabetes mellitus. Podocalyxin is an element of the endothelial cells plasma membranes that is widely spread, it is limited to the luminal membrane area and is irregularly located on the surface of endothelial cells lining blood vessels.\u0000Objectives: To estimate serum Podocalyxin in polycystic ovarian syndrome women and compare its level with healthy controls. Also, to find the correlation between serum Podocalyxin and anthropometrics parameters which are (body mass index, waist circumference, waist to hip ratio).\u0000 Methods: This case control study included 124 women who were grouped into 2 groups: group 1 included 63 females diagnosed with PCOS (patients) and group 2 included 61 healthy women (controls). Serum podocalyxin was measured by Enzyme-linked immunosorbent assay technique and anthropometrics measures (“body mass index (BMI), waist circumference (WC) and waist to hip ratio WHR”) were done.\u0000Results: The results of this study showed significantly high mean BMI(P=0.001), WC(P=0.002) and WHR(P=0.001) in patients as compared to healthy controls. The results also showed a significant increase in mean value of serum PODXL (P=0.001) in PCOS females when compared with healthy controls. In patients group, significant positive correlations were found between serum PODXL and BMI (r=0.395, p=0.001), waist circumference (WC) (r.=0.433, p.=0.001) and waist to hip ratio (WHR) (r.=0.427, p.=0.001 ).\u0000Conclusion: PCOS women have greater body mass represented by BMI, WC and WHR which reflect the risk of multiple complications like hypertension, dyslipidemia and cardiovascular disease. Moreover, PCOS women have higher serum PODXL which is considered as a marker for the vasculature thus might be a potential marker for prediction of early atherosclerosis.","PeriodicalId":33125,"journal":{"name":"mjl@ kly@ lTb","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44902826","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Detection of Chronic Obstructive Pulmonary Disease among Smokers Aged ≥40 years Attending Primary Health Care Centers in Baghdad-AL-Karkh and AL-Resafa","authors":"Isra A. Abd Ala, Nada Abdul Wahhab Mousa, F. Al-Lami","doi":"10.32007/jfacmedbagdad.6441936","DOIUrl":"https://doi.org/10.32007/jfacmedbagdad.6441936","url":null,"abstract":"Background: Chronic obstructive pulmonary disease causes permanent morbidity, premature mortality and great burden to the healthcare system. Smoking is it's most common risk factor and Spirometry is for diagnosing COPD and monitoring its progression.\u0000Objectives: Early detection of chronic obstructive pulmonary disease in symptomatic smokers’ ≥ 40years by spirometry.\u0000Methods: A cross sectional study on all symptomatic smokers aged ≥ 40 years attending ten PHCCs in Baghdad Alkarkh and Alrisafa. Those whose FEV1/FVC was <70% on spirometry; after giving bronchodilator, were considered COPD +ve.\u0000Results:  Overall, airway obstruction was seen in 206(46.8%). It is significantly associated with increase age (50-y), more in male and increase with increase duration and amount of smoking\u0000Conclusions: COPD was prevalent among men and women. Early diagnosis of COPD is good for both patient and community. Routine spirometry is an easy way for screening and identifying asymptomatic patients. Before adoption of spirometry Cost-effectiveness is needed.","PeriodicalId":33125,"journal":{"name":"mjl@ kly@ lTb","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47049768","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Measuring of Specific Bone Alkaline phosphatase ( BAP ) Bone Remodeling biomarker for Post-COVID Iraqi Patient","authors":"Islam Alazawi","doi":"10.32007/jfacmedbagdad.6441978","DOIUrl":"https://doi.org/10.32007/jfacmedbagdad.6441978","url":null,"abstract":"Background: There are several diseases in the body following recovery from COVID-19 infection because this virus operates on human genes in various types of peripheral tissue in the human body. It penetrates host cells via Angiotensin-converting enzyme-2 receptors and may have effects on bone remodeling, leading to osteopenia or osteoporosis, which are characterized by low bone mineral density, resulting in diminished bone strength. Bone Alkaline Phpsphatase is an enzyme released into the bloodstream as a soluble homodimer after being cleaved by a phospholipase and can be utilized as a biomarker of bone development.\u0000Objective: This research was designed to investigate the alteration of bone homeostasis balance in Iraqi post-COVID-19 infection patients.\u0000Cases and Methods: This is a case control study. The study has received approval from the ethical committee at the Faculty of Medicine, Baghdad University, established on November 20, 2021–March 2, 2022. A hundred and thirty individuals were enrolled in this study. The subjects were divided into two groups; the first group (80) post-COVID-19 infection patients and the second group (50) non-COVID-19 individuals. Also, measuring markers like serum Angiotensin-converting enzyme-2 and Bone Alkaline Phosphatase by using the ELISA technique. The bone mineral density was measured by a DEXA scan.\u0000Results:This study found that there is an effect of coronavirus infection on the bone strength measured by the mean ± SD Bone Alkaline Phosphatase level, which was found to be highly significant in the serum of post-COVID-19 patients when compared with non-COVID-19 individuals (P-value = 0.001), but the mean ± SD of Angiotensin-converting enzyme-2 level was statistically non-significant between the two groups (P-value = 0.13). who had recovered from a coronavirus infection for 3 months or more. Also, the bone mineral density of Post COVID-19 patients that was measured by DEXA scan had a highly significant T-score% when compared between the two groups.\u0000Conclusions:This research found that COVID-19 has an impact on the bone remodeling process, leading to osteopenia or osteoporosis, which may be identified by checking the blood levels of the bone biomarker BAP and the bone mineral density (by DEXA scan) at least three months following coronavirus recovery. This investigation also discovered that some of the individuals had osteopenia rather than osteoporosis.","PeriodicalId":33125,"journal":{"name":"mjl@ kly@ lTb","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43667802","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of Lenalidomide Ointment on TNF-α Tissue Levels in Mice with Imiquimod-Induced Psoriasis.","authors":"Sajjad Mustafa Thamer, Mohammed Q. Yahya","doi":"10.32007/jfacmedbagdad.6441959","DOIUrl":"https://doi.org/10.32007/jfacmedbagdad.6441959","url":null,"abstract":"Background: Lenalidomide is an immunomodulatory drug having notable anti-inflammatory, and anti-antineoplastic properties. Lenalidomide suppresses the production of pro-inflammatory cytokines that have been linked to a variety of hematologic malignancies. Lenalidomide enhances the immune system of the host by regulating T cell proliferation, which results in changes in inflammation that are related to the etiology of psoriasis.\u0000Objectives: The objectives of this study were to determine the efficacy of lenalidomide as an ointment in treating mouse models of psoriasis as well as how it may affect TNF-α levels in skin tissue in different experimental groups.\u0000Methods: The study was carried out between November 2021 and June 2022. 70 healthy male albino mice were randomly divided into 7 groups of 10 animals each. In groups (1, 2, 3, 4, 5 and 6), imiquimod produced psoriasis. Only imiquimod cream was administered to Group 1, after psoriasis induced, Clobetasol ointment was applied to Group 2, placebo ointment was applied to Group 3, and lenalidomide ointment (1%, 2%, and 3%) were applied to Groups (4, 5, and 6), respectively. Healthy mice were utilized as a comparative control in Group 7. SPSS was utilized for the statistical analysis of the data (version 26).\u0000Results: Following lenalidomide treatment, the psoriatic region improved. Lenalidomide's effectiveness to treat imiquimod-induced mouse psoriasis was explained by the difference in tissue levels of TNF-α between the examined groups.\u0000Conclusions: Findings suggest that different concentrations of lenalidomide ointment can improve mouse models of imiquimod-induced psoriasis. Histopathology and immunohistochemistry assays show that lenalidomide ointment was more effective and had no side effects that were associated with the use of the standard drugs.","PeriodicalId":33125,"journal":{"name":"mjl@ kly@ lTb","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42241096","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pudendal nerve versus Lower Limb nerves electrophysiological abnormalities in diabetics with erectile dysfunction in Baghdad","authors":"M. Al-Hadeethi","doi":"10.32007/jfacmedbagdad.6441992","DOIUrl":"https://doi.org/10.32007/jfacmedbagdad.6441992","url":null,"abstract":"ِAbstract: \u0000 \u0000Autonomic neuropathy, vasculogenic causes, endocrine deficit, drug-induced, psychosocial problems, or a combination of these causes might lead to Erectile dysfunction (ED). \u0000 \u0000Aim: \u0000 \u0000This study aimed to compare between pudendal neuropathy against limb neuropathy in patients with diabetics and complaining from Erectile dysfunction by considering the Electrophysiological studies. \u0000 \u0000Methodology: \u0000 \u000084 diabetic subjects were enrolled in this analytic cross-sectional study with an average age of 38.4 years presented with impotence. All of them were assessed by Electrophysiological studies using Bulbocavernosus induced Reflex to assess competence of pudendal nerve and other nerve studies to assess lower limbs nerve competences. \u0000 \u0000Results: \u0000 \u0000The results of assessing the pudendal nerve versus limb nerves revealed earlier involvement of the peripheral lower limb nerves in comparison with pudendal nerve. \u0000 \u0000Conclusion: \u0000 \u0000Electrophysiological assessment is a practical test which can be useful in identifying neurologic deficit of diabetic patients with erectile dysfunction.","PeriodicalId":33125,"journal":{"name":"mjl@ kly@ lTb","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49539975","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between Aggregatibacter actinomy-cetemcomitans bacterial load and NLRP3 inflam-masome activation in periodontitis patients with Diabetes","authors":"Mohammed J. Al-Obaidi","doi":"10.32007/jfacmedbagdad.6441972","DOIUrl":"https://doi.org/10.32007/jfacmedbagdad.6441972","url":null,"abstract":"Abstract: Background: Aggregatibacter actinomycetemcomitans is one of the most common periodontal pathogen that has a direct effect on periodontium. Diabetes and periodontitis considered as chronic diseases with a bidirectional relationship between them. Evidence has shown that the Node Like Receptor Pyrine-3  inflammasome, is crucial for both illnesses. Aim of study: This investigation was conducted to observe the association between bacterial load of A. actinomyctecomtans and serum level of NLRP3 inflammasome in periodontitis patient with and without type 2 DM and control group. Materials and Methods: This case-control study included 85 participants, whose ages ranged from (23-55) years. Split into three groups; the control group, which had a clinically and systemically healthy periodontium, and the two groups with periodontitis, one of which also had type 2 DM. Samples of the four most profound periodontal pockets were sampled for subgingival plaque, and from the gingival sulcus in the control group. The real-time (PCR) was utilized in this experiment. to quantify A. actinomyctecomtans DNA was isolated from samples of dental plaque. All subjects' serum was collected, and the concentration of NLRP3 was measured using an ELISA technique. Results: The results showed that the bacterial count was higher in two groups of patient than the control group, but there were no-significant differences. On the other hand, there was a significant correlation between the bacterial count and periodontal parameters in periodontitis with type 2 DM group, while in periodontitis group there was positive correlation with clinical attachment loss and bleeding on probing. A significant positive correlation also noticed between NLRP3 inflammasome and periodontal parameters in periodontitis patient with type2 DM. Regarding the group of periodontitis patients without systemic disease there was no significance correlation between inflammasome and clinical parameters. Finally, there is a non-significant correlation of A. actinomyctecomtans with inflammasome. Conclusions: A. actinomyctecomtans detection rate was strongly higher in patient groups compared to healthy subjects but statically non-significant. Moreover, the lack of correlation between A. actinomyctecomtans and the NLRP3 inflammasome indicates that NLRP3 activation is associated   with inflammatory processes that are induced by a number of external factors, other than bacteria.","PeriodicalId":33125,"journal":{"name":"mjl@ kly@ lTb","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43523452","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}