mjl@ kly@ lTb最新文献

{"title":"Immunogenicity of the biosimilar CT-P13 infliximab or the original infliximab in Iraqi patients with Ankylosing spondylitis does not correlate with their demographic characteristics","authors":"Mohammed M. Kamil, M. Jabarah, Nizar A.l. Jasim","doi":"10.32007/jfacmedbagdad.6441969","DOIUrl":"https://doi.org/10.32007/jfacmedbagdad.6441969","url":null,"abstract":"Background: Ankylosing spondylitis is a rare disease affecting people with hereditary factors. Its treatment includes life style modification and use of drugs such as the biologic agent infliximab or its biosimilar, CT-P13 infliximab. Despite their therapeutic usefulness, these agents are associated with a number of serious adverse effects such as immunogenicity.\u0000Objectives: The aim of current study was to investigate if immunogenicity of the biosimilar CT-P13 infliximab or the original infliximab, in Iraqi patients with Ankylosing spondylitis, is affected by any of the patients’ demographic characteristics.\u0000Methods: A retrospective open-label study was conducted from December 2021 to March 2022 at the Rheumatology Unit, Baghdad Teaching Hospital/Medical City, Baghdad. Forty-four patients were taking Infliximab, and another 50 patients were taking CT-P13, both at a dose of 5mg/kg for 3 months prior to recruitment in current study. Disease activity was assessed by ASDAS-CRP score while antibodies and C-reactive protein were tested by Enzyme-Linked Immunosorbent Assay technique. Statistical analyses were performed using SPSS statistical package for Social Sciences version 20.0. The level of significance was considered at P<0.05.\u0000Results: There was non-significant correlation between anti-infliximab antibodies and demographic data of patients (P>0.05). Similar data were reported regarding the biosimilar CT-P13 infliximab except for smoking and disease activity which exhibited significant correlation with development of anti-CT-P13 antibodies (P<0.05).\u0000Conclusion: Immunogenicity of the biosimilar CT-P13 infliximab, but not that of the original Infliximab, may be influenced by demographic characteristics or disease activity in patients with ankylosing spondylitis.","PeriodicalId":33125,"journal":{"name":"mjl@ kly@ lTb","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44066455","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hematologic abnormalities and pregnancy outcomes in pregnant women with COVID-19","authors":"Huda Mozer AbdAlraheem, R. D. Aljanabi","doi":"10.32007/jfacmedbagdad.6441976","DOIUrl":"https://doi.org/10.32007/jfacmedbagdad.6441976","url":null,"abstract":"Background: Since declaring coronavirus disease 19 as a pandemic by the World Health Organization, a great concern was directed toward pregnant women and their fetuses. Despite the substantial impact of COVID-19 disease on pregnancy, there is a scarcity of national researches discussing this important issue.          \u0000Objectives: To study the relationship between peripheral blood abnormalities and COVID-19 in pregnant women.\u0000Patients and methods: A case control study was conducted in the labour wards of Baghdad Teaching Hospital in the Medical complex / Baghdad /Iraq during the period from 1st of February till 31st of July, 2021. Fifty pregnant women diagnosed with COVID-19 disease were compared to 50 healthy pregnant women as controls. The pregnant women enrolled in the study were tested by COVID-19-Reverse transcription RT-PCR test upon admission to hospital. The confirmation of COVID-19 diagnosis was done according to the Iraqi guidelines approved by the Iraqi Ministry of Health.\u0000Results: Dyspnea was a significant clinical presentation of pregnant women with COVID-19 disease. Those women had abnormal white blood cell count, lymphocytopenia, high neutrophil to lymphocyte ratio, high platelets to lymphocyte ratio and mild to moderate anemia which were significant when compared to controls. The maternal and neonatal morbidity and mortality rates were higher among pregnant women with COVID-19 disease. Abnormalities in peripheral blood system parameters like lymphocyte count, neutrophils count, platelets count and hemoglobin level were predictors of maternal morbidity and mortality.\u0000Conclusions: The clinical presentations and hematological abnormalities are useful in the diagnosis of COVID-19 disease in pregnant women and may be used as predictors of maternal and neonatal morbidity and mortality.","PeriodicalId":33125,"journal":{"name":"mjl@ kly@ lTb","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49316722","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Immunohistochemical Study of Stathmin-1 as A Prognostic factor In Non-small cell lung carcinoma","authors":"Muhammed Whaeeb Salman Al-Obaidy, Nadhema Bahaa Hussein Wetwet, H. Kerbel, A. Baay","doi":"10.32007/jfacmedbagdad.6441948","DOIUrl":"https://doi.org/10.32007/jfacmedbagdad.6441948","url":null,"abstract":"Abstract    \u0000  \u0000Background \u0000Stathmin1 (also known as metablastin) is a major microtubule-depolymerizing protein that involved in cell cycle progression and cell motility. \u0000 Stathmin1 has been found to be up-regulated in some cancers and correlated with cell differentiation and proliferation.   \u0000Stathmin1 is a major cytosolic phosphoprotein that regulates microtubule dynamics and is associated with malignant phenotypes in various cancers, including non-small cell lung cancer. \u0000  \u0000Objective \u0000 To evaluate the role of Immunohistochemical expression of stathmin1 in non-small lung carcinoma and its correlation to different prognostic factors or parameters. \u0000  \u0000Materials and methods \u0000This retrospective study carried on formalin fixed paraffin embedded surgical specimens of lung tumors  Applying the Immunohistochemical techniques by using the primary antibodies to stathmin1, statistical analysis done and assessment of correlation with different clinical and pathological parameters measured. \u0000  \u0000 Results \u0000Fifty cases of Non-small lung carcinomas that 42% adenocarcinoma,44% squamous cell carcinoma 10% adenosequamous and 4% non-small lung carcinoma 84 % were Stathmin-1 positive. \u0000 No significant correlation between Stathmin-1 expression with age and gender of patients but Stathmin-1 expression were correlated with parameters including type and grade of tumor. \u0000High expression was noted in poorly differentiated tumors. \u0000  \u0000Conclusions \u0000Measurement of stathmin1 level may be a beneficial prognostic biomarker for non-small lung tumors especially those of poorly differentiated tumors \u0000Stathmin1 expression in non-small cell lung carcinoma significantly correlated with poor tumor differentiation and could be considered as independent prognostic factor.","PeriodicalId":33125,"journal":{"name":"mjl@ kly@ lTb","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48506527","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of sociodemographic characteristics and drug-related side effects on quality of life of patients with hepatocellular carcinoma receiving sorafenib treatment in Iraqi hospitals","authors":"Tuqa H. Qasim, Mazin J. Ibraheem, M. Jabarah","doi":"10.32007/jfacmedbagdad.6442009","DOIUrl":"https://doi.org/10.32007/jfacmedbagdad.6442009","url":null,"abstract":"Background: Sorafenib is an oral multikinase inhibitor which has been given approval by the United States Food and Drug Administration for the treatment of patients diagnosed with hepatocellular carcinoma and advanced renal cell carcinoma . However, measuring quality of life and patient-reported symptoms may provide further information for evaluating and comparing treatment efficacy and toxicity profiles during cancer treatment. Despite the critical importance of patients' quality of life while receiving anticancer treatment, neither Iraqi patients undergoing anti-cancer medications in general nor those receiving Sorafenib in particular had any published data evaluating this important parameter.\u0000Objectives: The study aimed to assess the quality of life of Sorafenib-treated Iraqi patients diagnosed with hepatocellular carcinoma.\u0000Methods: A prospective, cross-sectional study was performed at the oncology clinic of (Oncology Teaching Hospital, Al-Amal Hospital and Al -Imamein Al- Kadhimein Medical City in Baghdad, Iraq) during the period from November 2021 to July 2022. Patients were enrolled in current study by using a convenient sampling method. Assessment of quality of life was performed using a questionnaire from the “European Organization for Research and Treatment of Cancer”. Statistical analyses were performed using statistical package for Social Sciences. Student’s t-test and ANOVA test were used to compare categorical data. P value of <0.05 was considered statistically significant.\u0000Results: The present study included 52 patients in total. Of the latter, 90.4% experienced fatigue, making it the most frequent adverse event, followed by anorexia, anemia, nausea, diarrhea and vomiting (71.2%, 67.3%, 65.4%, 59.6%, 26.9%, respectively). In spite of that, some participants had a good quality of life while others did not.\u0000Conclusion: Patients with hepatocellular carcinoma on sorafenib treatment have variable quality of the life. The latter is significantly affected by patients’ sociodemographic characteristics and treatment-related adverse events.","PeriodicalId":33125,"journal":{"name":"mjl@ kly@ lTb","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42550414","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Kidney functions and electrolyte disturbance among Iraqi patients with bladder cancer","authors":"Noor Ibraheem ahmed ibraheem, Rawaa H. Ali, Mohammed B. Ismail","doi":"10.32007/jfacmedbagdad.6441985","DOIUrl":"https://doi.org/10.32007/jfacmedbagdad.6441985","url":null,"abstract":"Background: Bladder cancer is among the most prevalent cancers worldwide, with 549,393 new cases reported in 2018. Approximately 3% of all new cancer diagnoses and 2.1% of all cancer deaths are due to urinary bladder cancer.\u0000Objectives: This study aims to explore the efficiency of renal system functions as indicated by renal function tests and electrolyte levels among bladder cancer patients.\u0000Methods: All patients in this case-control study were recruited from Ghazi Al-Hariri Hospital for surgical specialties in Baghdad during the period from December 2021 to June 2022. A total of 100 individuals were enrolled in this study and divided into two groups. The first group included 50 patients with an age range of (16-79) years. All patients were first diagnosed and investigated with a bladder mass by transurethral resection of bladder tumor (TURBT) and sent to the histopathological examination for biopsy of bladder lesion. The second group included 50 healthy individuals.\u0000Results: The results of the present study showed that all renal function tests and serum electrolyte levels were in the upper limit or within the normal range, although some of these levels were significantly different between patients and controls.\u0000Conclusion: All renal function tests were within the upper limits of the normal range as most of the bladder tumors were low-grade small-sized masses.","PeriodicalId":33125,"journal":{"name":"mjl@ kly@ lTb","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49219281","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Influence of Metformin Dose and Treatment Adherence on Glycemic Control, Adiposity, and Cardiovascular Risk Markers in Iraqi Patients with T2DM","authors":"Z. Abdulrahman, Mohammed Qasim Alatrakji, A. A. Al-Maliky, K. Hussein, S. Hussain","doi":"10.32007/jfacmedbagdad.6441939","DOIUrl":"https://doi.org/10.32007/jfacmedbagdad.6441939","url":null,"abstract":"Background: Numerous factors, including metformin doses and treatment adherence, may contribute to significant variations in glycemic control and adiposity markers of type 2 diabetes (T2DM) patients.\u0000Objectives : This study aims to determine the influence of metformin dose and treatment adherence on glycemic control and adiposity markers in Iraqi patients with T2DM.\u0000Methods: Between October 2021 and March 2022, a case-series study at the Diabetes and Endocrinology Center – Baghdad included 153 T2DM patients with a disease duration of more than one year. Clinical and physical examinations were conducted before enrolment. We measured anthropometric variables to calculate the body mass index (BMI), waist-to-hip ratio (WHR), visceral adiposity index (VAI), and other surrogate indicators. We measured glycated hemoglobin (HbA1c), leptin, C-reactive protein (CRP), total cholesterol, HDL-c, and triglycerides in the serum.\u0000Results: Increasing metformin doses did not improve the studied parameters. Adherence to treatment significantly influences fasting glycemia, HbA1c level, and the markers of adiposity. Meanwhile, increasing metformin doses is not associated with changes in insulin resistance and cardiovascular disease risk markers.\u0000Conclusion: Beyond metformin dose up-titration, treatment adherence affects glycemic control, visceral adiposity, and CVD risk surrogates. Metformin dose up-titration was not linked to insulin resistance and body fat contents.","PeriodicalId":33125,"journal":{"name":"mjl@ kly@ lTb","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45657940","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Referee report. For: Network Pharmacology Analysis Reveals Bioactive Compounds and Potential Targets of Sea cucumber for Cervical Cancer Therapy [version 1; peer review: 1 approved]","authors":"Mohd Rehan","doi":"10.5256/f1000research.151488.r216762","DOIUrl":"https://doi.org/10.5256/f1000research.151488.r216762","url":null,"abstract":"","PeriodicalId":33125,"journal":{"name":"mjl@ kly@ lTb","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147917545","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Referee report. For: Navigating the Environmental, Social, and Governance (ESG) landscape: constructing a robust and reliable scoring engine - insights into Data Source Selection, Indicator Determination, Weighting and Aggregation Techniques, and Validation Processes for Comprehensive ESG Scoring Systems [version 1; peer review: 3 approved]","authors":"Matkovskyy, Roman","doi":"10.21956/openreseurope.17573.r34021","DOIUrl":"https://doi.org/10.21956/openreseurope.17573.r34021","url":null,"abstract":"","PeriodicalId":33125,"journal":{"name":"mjl@ kly@ lTb","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147895294","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Referee report. For: Effectiveness of BNT162b2 and ChAdOx1 against SARS-CoV-2 household transmission: a prospective cohort study in England [version 2; peer review: 1 approved, 1 approved with reservations]","authors":"Kubale, John","doi":"10.21956/wellcomeopenres.22475.r69546","DOIUrl":"https://doi.org/10.21956/wellcomeopenres.22475.r69546","url":null,"abstract":"","PeriodicalId":33125,"journal":{"name":"mjl@ kly@ lTb","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147922041","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Measurement of the serum level of Elabela for the early detection of acute kidney injury in hospitalized Iraqi COVID-19 patients","authors":"Maha hassan Gadhi, Eman S. Saleh","doi":"10.32007/jfacmedbagdad.6431928","DOIUrl":"https://doi.org/10.32007/jfacmedbagdad.6431928","url":null,"abstract":"Background: Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) is caused coronavirus disease2019 (COVID-19) affecting people worldwide. The angiotensin converting enzyme2 (ACE2) represents areceptor of SARS-CoV-2 on the infected host cell. Apelin or its receptor agonists suppress the production ofangiotensin-converting enzyme (ACE) and angiotensin II (Ang-II) and is characterized by a protective effectagainst SARS-CoV-2.Objective: The study aims to assess the serum level of Elabela biomarker as an early detector for AcuteKidney Injury (AKI) in patients with COVID-19.Cases and Methods: This is a case-control study which included 45 hospitalized adult patients in multiplecenters (public hospitals) receiving COVID-19 cases in Baghdad. These cases had a positive real-time orreverse transcription polymerase chain reaction (RT-PCR) of nasal/oropharyngeal swabs. Excluded from thestudy were those with a negative PCR and comorbidities and 43 apparently healthy adult subjects as controls.The age range of the cases and controls was (20 to 60) yearsResult: There are no a statistically significant differences between the two groups in terms of age and genderdistribution. Statistically significant differences were found in terms of eGFR, S. Creatinine, D. dimer,NEU×103/µL, LYM×103/µL and ELA biomarker. Significant negative correlations were found betweenElabela with D. dimer and NEU×103/µL, and between eGFR with S. creatinine, D. Dimer, and NUT×103/µL.Conclusion: The Elabela biomarker can be used for the early detection of acute kidney injury in COVID-19patients.","PeriodicalId":33125,"journal":{"name":"mjl@ kly@ lTb","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-10-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41590309","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}