Jurnal Ilmiah Kedokteran Wijaya Kusuma最新文献

{"title":"POTENSI JUS BUAH NAGA MERAH (HYLOCEREUS POLYRHIZUS) TERHADAP PERBAIKAN JARINGAN ORGAN OTAK TIKUS (RATTUS NORVEGICUS) DIABETES","authors":"I. Putra, Dorta Simamora","doi":"10.30742/JIKW.V8I2.622","DOIUrl":"https://doi.org/10.30742/JIKW.V8I2.622","url":null,"abstract":"Diabetes mellitus is a metabolic disease characterized by hyperglycemia due to disturbances in insulin secretion, insulin action, or both. The purpose of this study was to analyze the effect of the red dragon fruit juice (Hylocereus polyrhizus) to repair brain organ histopathologic female wistar rats (Rattus norvegicus Wistar strain) with diabetes. This research is a true experiment research with randomized control - group pretest - posttest design and were conducted at the in Vivo Laboratory of Wijaya Kusuma University Surabaya. Twenty five female wistar rats were randomly divided into 5 groups, normal rats group KA (without alloxan induction), diabetic rats group KB (alloxan induction and without given any red dragon fruit juices), treatment group KC (alloxan induction + 2 gr/2,5ml of red dragon fruit juices), treatment group KD (alloxan induction + 4 gr/2,5ml of red dragon fruit juices) and treatment group KE (alloxan induction + 8 gr/2,5ml of red dragon fruit juices). The study was conducted during the period of 16 days with standard feeding adaptations for 7 days. On day 16, all the rats were terminated. Glucose meter is used to measure the levels of blood glucose in rats. Histopathologic observation of rat brain tissue using a microscope Olympus CX21 with Haematoksilin eosin (HE) staining. The results showed the best dose of red dragon fruit juices to decrease blood glucose levels compare between KB and KE with significance p-value = 0.000 (α < 0.05), the blood glucose levels decreased in diabetic rats significantly between KB and KE also decreased in rat brain tissue necrosis with p-value = 0.000 (α <0.05).","PeriodicalId":33090,"journal":{"name":"Jurnal Ilmiah Kedokteran Wijaya Kusuma","volume":"215 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-10-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73014503","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"POTENSI MADU SEBAGAI TERAPI TOPIKAL OTITIS EKSTERNA","authors":"Yunis Sucipta Ibnu","doi":"10.30742/JIKW.V8I2.619","DOIUrl":"https://doi.org/10.30742/JIKW.V8I2.619","url":null,"abstract":"Otitis externa (OE) is an external microbial Meatus acousticus (MAE) infection due to damage to the normal MAE serumen skin coat that protects and maintains MAE moisture and temperature. Living in the warm and humid tropics, a decrease in skin pH due to activity in the water including swimming, and excess cerumen cleaning are predisposing factors for OE. The use of antibiotics locally concentrated in OE can not only attack pathogenic microbes but also have an impact on normal flora so that it has the potential to cause resistant microbes. Honey has anti-bacterial properties without the risk of resistance and has even been shown to modulate immunity and inflammation. Various invivo and invitro studies prove that honey has broad spectrum anti-bacterial activity. Honey is proven invitro to modulate immunity by affecting the release of various inflammatory cytokines. This shows that honey has the potential for OE therapy. This article aims to discuss the potential of honey as a topical OE therapy in the hope that it can be an alternative choice of therapy in the management of OE in humans that is safe, effective, and efficient.","PeriodicalId":33090,"journal":{"name":"Jurnal Ilmiah Kedokteran Wijaya Kusuma","volume":"21 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-10-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79589649","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"HUBUNGAN TINGKAT PENCAHAYAAN, KELEMBABAN UDARA, DAN VENTILASI UDARA DENGAN FAKTOR RISIKO KEJADIAN TB PARU BTA POSITIF DI DESA JATIKALANG KECAMATAN KRIAN KABUPATEN SIDOARJO","authors":"Sukma Sahadewa, Eufemia Eufemia, Edwin Edwin, Niluh Niluh, Shita Shita","doi":"10.30742/JIKW.V8I2.617","DOIUrl":"https://doi.org/10.30742/JIKW.V8I2.617","url":null,"abstract":"Tuberculosis is an infectious disease caused by Mycobaterium tuberculosis which can be influenced by several factors. The physical condition of an unhealthy home environment plays an important role in the transmission and proliferation of Mycobacterium tuberculosis. The aim of the study was to analyzed the relationship between lighting levels, air humidity, and air ventilation with risk factors for positive Acid resistant bacteria pulmonary TB incidence in Jatikalang Village, Krian District, Sidoarjo Regency. The population of the cases in this study were all patients who were declared positive result of Acid resistant bacteria pulmonary tuberculosis who came to the Krian Health Center for the period January 2017 - December 2017 with a sample size of 34 respondents. The data analysis was used is the odds ratio test. The results of the analysis showed that there was a significant relationship between home ventilation and the incidence of tuberculosis with p-value = 0.006 (<0.05) and OR = 7.800 (> 1) are obtained. The result showed that poor home ventilation has a risk of 7,800 times greater to experience the incidence of pulmonary TB.","PeriodicalId":33090,"journal":{"name":"Jurnal Ilmiah Kedokteran Wijaya Kusuma","volume":"37 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-10-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83246835","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"TIGA KASUS IMPLAN KOKLEA PADA DISPLASIA MONDINI","authors":"Muhammad Arif Sudianto Utama, Artono Artono","doi":"10.30742/JIKW.V8I2.573","DOIUrl":"https://doi.org/10.30742/JIKW.V8I2.573","url":null,"abstract":"Mondini dysplasia is a kind of cochlear malformation caused by a failure growth of cochlea in the seventh week of pregnancy, results in cochlear turn which only reaches 1,5 turn until less than 2,5 turn. There is sensorineural hearing loss in Mondini dysplasia caused by anatomical malformation. The diagnosis of Mondini dysplasia is made by accurate anamnesis, audiology assessments and imaging results. This case study explains the importance of the holistic process of diagnosis and treatment of Mondini's dysplasia. Purpose: To explain that Mondini dysplasia should be diagnosed immediately and given the cochlear implant. Cases: There had been reported three cases of cochlear malformation of Mondini dysplasi type. They were first diagnosed with sensorineural hearing loss and speech delay in the age of 2-4 years. After had been done sequence of audiology assessments and imaging CT-scan and MRI simultaneously there were obtained that those three patients had Mondini dysplasia. Case Management: The use of hearing aid in those three patients had no effectiveness that brought them to the decision of cochlear implantation. Cochlear implant became such a great challenge even through for experienced physicians considering the scarcity of the case and the risk for complications like pelymph gusher and incorrect insertion of electrode. Cochlear implant surgeries had been done to those three patients with carefu consideration and the selection for appropriate type of electrode. On the first case there had been applied right ear cochlear implant, on the second case was bilateral, and on the third case was in the left ear. Complications of the surgeries were bleeding and perilymph gusher but they had been solved properly. Electrode insertion in all three cases had been placed correctly. Conclusion: Found three cases of Mondini dysplasia with symptoms of bilateral hearing loss, speech development, bilateral Mondini dysplasia, techniques and complications of cochlear implants. These three cases differ in the shape, width and size of the cochlear anatomy if they are studied more specifically. Two cases of unilateral cochlear implant placement and one bilateral case.","PeriodicalId":33090,"journal":{"name":"Jurnal Ilmiah Kedokteran Wijaya Kusuma","volume":"25 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-10-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75490530","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"TRAUMA KEPALA PADA ANAK: KLASIFIKASI HINGGA PEMANTAUAN JANGKA PANJANG","authors":"Erny Erny, Okky Prasetyo, Denny Prasetyo","doi":"10.30742/JIKW.V8I2.620","DOIUrl":"https://doi.org/10.30742/JIKW.V8I2.620","url":null,"abstract":"Head trauma in children are frequent caused by falling, games, traffic accidents and more. Not all of head trauma continues to be brain injury. According with this, all of doctor must be able to established the diagnosis and classified head trauma to determine the optimal management and prognosis especially related with problems of brain development after head trauma. Long-term follow up should be done especially in severe and moderate head trauma to early detection any problems about development progress in this child","PeriodicalId":33090,"journal":{"name":"Jurnal Ilmiah Kedokteran Wijaya Kusuma","volume":"67 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-10-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73718570","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"INSIDEN DAN ETIOLOGI KELUMPUHAN SARAF III, IV DAN VI YANG DISERTAI DIPLOPIA BINOKULER DI RSUD DR. WAHIDIN SUDIROHUSODO","authors":"Rini Kusumawar Dhany, Y. Tanjung, Farren Jennel","doi":"10.30742/JIKW.V8I2.480","DOIUrl":"https://doi.org/10.30742/JIKW.V8I2.480","url":null,"abstract":"The purpose of this study is to determine the incidence and etiology of III, IV and VI nerve paralysis with binocular diplopia in RSUD dr. Wahidin Sudiro Husodo General Hospital Mojokerto. Method of this study was descriptive study using secondary medical record data. Incidence rates are adjusted for age and sex distribution of the population. The mean age of onset was 45.6 years, seven male subjects (58.3%) and five female subjects (41.7%). We identified 12 cases of acquired III, IV and VI nerve palsy over a 4-year period. The most common cause of binocular diplopia was sixth nerve palsy (33.3%), 3 patients experienced partial third nerve palsy (25%), one patient with third nerve palsy with pupil sparing (8.3%). Most common etiology was microvascular (58,3%), neoplasms (16.7%), aneurysms (8.3%) trauma (8.3%), and post meningioma neurosurgery (8.3%). Six patients (50%) with microvascular third nerve palsy had diabetes mellitus, while 1 patient (8.3%) had grade 2 hypertension. The most common cause of binocular diplopia was VI nerve palsy. Risk factors such as hypertension and diabetes mellitus which have a significant effect on diplopia. Patients with N. III, IV and VI palsy need to be done early MRI examination so that complications and progression can be prevented.","PeriodicalId":33090,"journal":{"name":"Jurnal Ilmiah Kedokteran Wijaya Kusuma","volume":"41 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-10-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86931401","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"PENYENGATAN MENINGEAL SISTERNA BASALIS MENINGITIS TB PADA COMPUTED TOMOGRAPHY SCANNING: SEBUAH ULASAN BERGAMBAR","authors":"A. Tjan, M. Asih, Elysanti Dwi Martadiani","doi":"10.30742/JIKW.V8I2.623","DOIUrl":"https://doi.org/10.30742/JIKW.V8I2.623","url":null,"abstract":"Tuberculosis (TB) is one of the major worldwide threat and global burden in Indonesia. CNS tuberculosis is the most severe form of TB infection. CT evaluation on diagnosing tuberculosis meningitis (TBM) with triad of hydrocephalus, basal meningeal enhancement and infarction was reported to be sensitive. PCR cerebrospinal fluid (CSF) is known to be specific, however negative results have been reported due to presence of PCR’s inhibitors, poor lysis of mycobacteria, and the uneven distribution in specimens. CT Scan plays the vital role in diagnosing TBM patient with the presence of TBM CT triad, especially basal cistern enhancement (BME) which is the specific enhancement pattern in MTB patient. There are 9 must know BME pattern, such as contrast filling the cistern, double and triple line, linear enhancement at MCA cistern, Y sign, posterior infundibular recess enhancement, ill defined border, join the dots sign, nodular enhancement, and asymmetry off all pattern. Familiarizing BME criteria is essential to provide confident diagnosis and reduce morbidity and mortality","PeriodicalId":33090,"journal":{"name":"Jurnal Ilmiah Kedokteran Wijaya Kusuma","volume":"48 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-10-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72516152","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"PENGARUH PEMBERIAN JUS BUAH BELIMBING WULUH (AVERRHOA BILIMBI L.) TERHADAP KADAR KOLESTEROL LDL DARAH TIKUS PUTIH (RATTUS NORVEGICUS) JANTAN GALUR WISTAR DENGAN DIET TINGGI LEMAK","authors":"Kartika Dwi Rahminiwati, Igm Antara Hambarsika, Fitri Handajani","doi":"10.30742/JIKW.V8I2.572","DOIUrl":"https://doi.org/10.30742/JIKW.V8I2.572","url":null,"abstract":"A high-fat diet can increase lipoprotein levels, total cholesterol, (Low Density Lipoprotein) LDL, and triglycerides. Starfruit has saponin and flavonoid compounds which are expected to reducing LDL cholesterol levels. The aim of the study was to determine the effect of starfruit juice on lowering the blood cholesterol LDL of Wistar rats fed with high-fat diet. Experimental study with post-test only control group design. As many as 24 male white rats from the Wistar strain were divided into 3 groups: negative control groups (K-) that were given standard feed for 28 days; positive control group (K+) who were given a high-fat diet for 28 days; the treatment group (KP) was given a high-fat diet for 28 days and on the 15th day 28th they were given a starfruit juice with a dose of 4ml / 200grBB / day. Day 29 measured LDL cholesterol. The statistic test showed a significant increase in LDL cholesterol levels (p=0.001) in the positive control group (x=12.125±2.642 mg/dL) compared to the negative control group (x=7.625±1.506 mg/dL). There was no significant different the mean cholesterol level of the treatment group (x=11±1.927) compared to the mean LDL cholesterol level of the positive control group (x=12.125±2.642). A high-fat diet significantly increases the mean LDL cholesterol level. Starfruit juice did not significantly reduce LDL cholesterol level.","PeriodicalId":33090,"journal":{"name":"Jurnal Ilmiah Kedokteran Wijaya Kusuma","volume":"53 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-10-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73541006","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"KEHAMILAN KEMBAR DISERTAI MOLA HIDATIDOSA","authors":"Harya Narottama, Erry Gumilar, B. Askandar","doi":"10.30742/JIKW.V8I2.621","DOIUrl":"https://doi.org/10.30742/JIKW.V8I2.621","url":null,"abstract":"Twin pregnancy with Hydatidiform Mole is a rare case, only about 1 in 22.000 to 100.000 pregnancies. Molar pregnancy with triplet pregnancy is even rarer, which is only 6 cases reported and mostly occurred in women who received therapy for infertility. Management in cases of twin pregnancy with hydatidiform mole is dilemmatic both for the patient and physician. We present a case of 29 years old woman with her first pregnancy of twin fetuses complicated with hydatidiform mole. Diagnostic approaches were made mainly by ultrasound examination, continued with laboratory and radiology examinations which some did not performed due to worsened vaginal bleeding. This case ended with premature labor with the result of delivery of two babies and placenta with vesicles which is a characteristic of hydatidiform mole.","PeriodicalId":33090,"journal":{"name":"Jurnal Ilmiah Kedokteran Wijaya Kusuma","volume":"5 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-10-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87288172","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"ANALISIS EKSPRESI PROTEIN TLR-9, CD90 DAN VEGF PADA MESENCHYMAL STEM CELL DI JARINGAN TUMOR OSTEOSARKOMA","authors":"Pratika Yuhyi Hernanda","doi":"10.30742/JIKW.V8I2.625","DOIUrl":"https://doi.org/10.30742/JIKW.V8I2.625","url":null,"abstract":"For further investigation on the effect of Mesenchymal Stem Cell (MSC) on tumor / cancer growth, it is necessary to start with tumor MSC profile from tumor / cancer tissue. In this study, we use MSC from osteosarcoma tissue as a representative. The MSC profile analysis method used were the comparing the phenotype and characteristics of MSC fromosteosarcoma tissue with MSC from normal adiposa tissue. The characteristics of MSC were represented by protein expression of several candidate genes namely TLR-9, CD-90 and VEGF. From the results of immunofluorescence staining on adiposa MSC compared withosteosarcoma MSC, it has obviously seen that although the phenotypes were similar, there was no significant difference in CD-90 expression in osteosarcoma MSC and adiposa MSC. Although VEGF expression appears to be slightly prominent in osteosarcoma MSCs, the difference between the two was also not significant. Whereas TLR9 expression is very prominent in osteosarcoma MSC and significantly different from adiposa MSC. Thus TLR9 may be of concern in subsequent studies to investigate the mechanism of MSC triggers tumor growth.","PeriodicalId":33090,"journal":{"name":"Jurnal Ilmiah Kedokteran Wijaya Kusuma","volume":"12 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-10-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82001199","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}