Jurnal Ilmiah Kedokteran Wijaya Kusuma最新文献

Effectiveness of Facial Acupressure and Acupuncture on Musculus Facei 面部指压和针灸对面部肌肉的效果

Jurnal Ilmiah Kedokteran Wijaya Kusuma Pub Date : 2024-03-29 DOI: 10.30742/jikw.v13i1.3401

Ayly Soekanto, Putu Oky Ari Tania, Emillia Devi Dwi Rianti, Hardiyono Hardiyono

{"title":"Effectiveness of Facial Acupressure and Acupuncture on Musculus Facei","authors":"Ayly Soekanto, Putu Oky Ari Tania, Emillia Devi Dwi Rianti, Hardiyono Hardiyono","doi":"10.30742/jikw.v13i1.3401","DOIUrl":"https://doi.org/10.30742/jikw.v13i1.3401","url":null,"abstract":"Background: Fatigue on the face can affect the brightness of the face, if the facial muscles function well, the health of the face will be immediately visible. There are many facial care methods currently offered, which can be done with facial acupuncture and acupuncture. This study aims to determine the effectiveness of facial acupressure and acupuncture on the facial muscles, which has never been done before. Methods: Analytical experimental research was divided into two groups, the first group was given facial acupuncture treatment and the second group was given facial acupuncture treatment. The data obtained in the form of facial muscle relaxation is indicated by the disappearance of wrinkles on the face with a score of (1, 2, 3). The dependent variables are facial acupuncture and facial acupuncture. Inclusion criteria were women aged 40 – 50 years, agreed to take part in this study, and had no facial abnormalities. The exclusion criteria are women aged less than 40 years or over 50 years, and there are defects in the facial area. This research will be carried out in May – June 2023 at the Wijaya Surabaya doctor's practice and polyclinic. Results: The results of the study found that 20 minutes of facial acupuncture was useful for relaxing the facial muscles by up to 60%, on the sixth day the face looked brighter and cleaner, while acupuncture therapy on the facial muscles experienced relaxation of up to 60% on the sixth day with 30 minutes. The effectiveness of facial acupressure therapy is 10 minutes faster than acupuncture. Conclusion: Facial acupressure therapy and acupuncture therapy have proven to be effective in relaxing the facial muscles.","PeriodicalId":33090,"journal":{"name":"Jurnal Ilmiah Kedokteran Wijaya Kusuma","volume":"9 5","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-03-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140368834","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Occupational Risk Factors Associated with Hip Osteoarthritis in Agricultural Communities in Jember 农业社区与髋关节骨关节炎相关的职业危险因素

Jurnal Ilmiah Kedokteran Wijaya Kusuma Pub Date : 2023-09-30 DOI: 10.30742/jikw.v12i2.2811

Ristianto Yoga Pratama, Laksmi Indreswari, Ika Rahmawati Sutejo

{"title":"The Occupational Risk Factors Associated with Hip Osteoarthritis in Agricultural Communities in Jember","authors":"Ristianto Yoga Pratama, Laksmi Indreswari, Ika Rahmawati Sutejo","doi":"10.30742/jikw.v12i2.2811","DOIUrl":"https://doi.org/10.30742/jikw.v12i2.2811","url":null,"abstract":"Occupational risk factors have a significant effect on osteoarthritis (OA). It has been studied before. However, no one has looked into occupational risk for the prevalence of hip OA in agricultural communities of Jember. This study aims to determine the relationship between risk factors (gender, age, body mass index, work history, work posture, length of work, and length of work) and hip OA incidence. This analytical observational study uses a cross-sectional design at Doctor Soebandi Jember's Regional Hospital and Jember Clinic Hospital, East Java-Indonesia. This study included all hip OA patients who visited the orthopedic clinic from January 2020 to December 2021. Thirty-six patients and 18 samples had hip OA (50%). Of eighteen subjects with hip OA, 14 were female (77.8%), 12 were aged ≥55 years old (66.7%), 12 were pre-obese with BMI >25 (66.7%), 14 had a history of lifting heavy weights (77.8%), 16 related to bending working posture (88.9%), 13 had a long working year >10 years (72.7%), 11 had a long working duration >44 hours (61.1%), 9 worked as a housewife and farmers (50%). %). A significant relationship of hip OA was observed with gender (p-value 0.003), age (p-value 0.019), work posture (p-value 0.002), length of work (p-value 0.003), and duration of work (p-value 0.018) based on contingency coefficient statistical analysis. We can conclude that the significant risk factors related to hip osteoarthritis in agricultural areas are gender, age, work posture, work length, and work duration.","PeriodicalId":33090,"journal":{"name":"Jurnal Ilmiah Kedokteran Wijaya Kusuma","volume":"216 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136280149","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Relationship of Fever Onset with NS1 Examination Results, IgM, and IgG in Dengue Hemorrhagic Fever Patients 登革出血热患者发热与NS1检查结果、IgM、IgG的关系

Jurnal Ilmiah Kedokteran Wijaya Kusuma Pub Date : 2023-09-30 DOI: 10.30742/jikw.v12i2.2645

Engla Merizka, Assha Luthfianie Alifah, Sri Wahyuni Handayani, Aninda Dinar Widiantari, Farida Murtiani

{"title":"The Relationship of Fever Onset with NS1 Examination Results, IgM, and IgG in Dengue Hemorrhagic Fever Patients","authors":"Engla Merizka, Assha Luthfianie Alifah, Sri Wahyuni Handayani, Aninda Dinar Widiantari, Farida Murtiani","doi":"10.30742/jikw.v12i2.2645","DOIUrl":"https://doi.org/10.30742/jikw.v12i2.2645","url":null,"abstract":"Fever onset represents the average number of days from the beginning of fever symptoms to the time when IgM and IgG examinations are conducted. Determining the right timing for these examinations can significantly impact their accuracy. In November 2021, there was a notable surge in cases of Dengue Hemorrhagic Fever at the Karawang Health Center, Sukabumi. This study aimed to investigate the relationship between the duration of fever and the results of dengue antigen and antibody tests. The research employed a descriptive analysis with a cross-sectional approach, and a sample of 50 individuals was gathered through consecutive sampling. The data was then analyzed using the Chi-Square test. The study revealed a positive correlation between the duration of fever and the outcomes of the NS1 and IgG Dengue examinations (p<0.05), highlighting the significance of timing when conducting these tests. NS1 was predominantly detected within the first three days of fever, while IgG showed reactivity after more than five days of fever. These findings underscore the importance of timing when conducting these tests and interpreting their results.","PeriodicalId":33090,"journal":{"name":"Jurnal Ilmiah Kedokteran Wijaya Kusuma","volume":"55 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136280463","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Difficult Airway Intubation Due to Mouth Opening Limitation Caused by Mandibular Abscess: A Case Report 下颌骨脓肿所致开口受限致气管插管困难1例

Jurnal Ilmiah Kedokteran Wijaya Kusuma Pub Date : 2023-09-30 DOI: 10.30742/jikw.v12i2.2674

Wiliam Yuhono, Michael Jaya

{"title":"Difficult Airway Intubation Due to Mouth Opening Limitation Caused by Mandibular Abscess: A Case Report","authors":"Wiliam Yuhono, Michael Jaya","doi":"10.30742/jikw.v12i2.2674","DOIUrl":"https://doi.org/10.30742/jikw.v12i2.2674","url":null,"abstract":"Appropriate management of difficult airway is imperative, particularly in cases with anticipated difficult airway. It customarily requires deliberate perioperative assessment. In this article we present a case of limited mouth opening along with restricted mobility of the temporomandibular joint secondary to mandibular abscess which requires surgical intervention. Preoperatively, difficult airway intubation was expected (based on LEMON mnemonic on preoperative evaluation). Therefore, Macintosh video laryngoscope and fiberoptic bronchoscope was prepared to aid in intubation. Due to the patient’s anxiety towards the procedure, the intubation was done while the patient is asleep. Preoxygenation was uneventfully. Following induction with general anesthesia, several attempts to conduct nasotracheal intubation using Macintosh video laryngoscope were made but all were abortive. This failed attempt is primarily due to the limited mouth opening and jaw mobility. Hence, fiberoptic bronchoscope-assisted nasotracheal intubation was conducted and was able to achieve airway patency. In conclusion, preoperative management holds great importance in selecting airway management strategy. To add, fiberoptic bronchoscope-assisted intubation is a safe option for intubation","PeriodicalId":33090,"journal":{"name":"Jurnal Ilmiah Kedokteran Wijaya Kusuma","volume":"9 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136280467","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Connection of Body Mass Index (BMI) Against Angle Shape Arch Pedis Longitudinal on Students of The Faculty of Medicine, Universitas Wijaya Kusuma Surabaya 泗水维嘉亚Kusuma大学医学院学生身体质量指数(BMI)与足弓纵向角度形状的关系

Jurnal Ilmiah Kedokteran Wijaya Kusuma Pub Date : 2023-09-30 DOI: 10.30742/jikw.v12i2.2683

Ayly Soekanto, Teofilus Dani Prasetyoadi, Hardiyono Hardiyono

{"title":"Connection of Body Mass Index (BMI) Against Angle Shape Arch Pedis Longitudinal on Students of The Faculty of Medicine, Universitas Wijaya Kusuma Surabaya","authors":"Ayly Soekanto, Teofilus Dani Prasetyoadi, Hardiyono Hardiyono","doi":"10.30742/jikw.v12i2.2683","DOIUrl":"https://doi.org/10.30742/jikw.v12i2.2683","url":null,"abstract":"Physical growth during adolescence will occur at more than 20% of total height growth, and 50% of bone mass has also been achieved during this period. Body Mass Index (BMI) to control normal body weight is achieved by adjusting body height. BMI can be used to interpret the possibility that the person is at risk of developing risk of weight-related diseases. The human feet are the most important part of supporting our body and can be correlated with body weight. The aim of this research is to determine the relationship between Body Mass Index (BMI) and the shape of the longitudinal arcus pedis angle in medical students in Surabaya. An analytic observational method with a cross-sectional research design was used with a sample size of 53 students. The results of this study conclude that there is a significant relationship between Body Mass Index and the shape of the longitudinal curve of the pedis in students (p-value: 0.009). An increased BMI will cause the pedis angle to widen which will result in the feet becoming flatter, thus affecting the body's balance when standing for a long time. Strong legs are associated with a normal Body Mass Index.","PeriodicalId":33090,"journal":{"name":"Jurnal Ilmiah Kedokteran Wijaya Kusuma","volume":"44 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136341975","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Antiobesity Potential of Butterfly Pea Flower (Clitoria Ternatea): A Literature Review 蝴蝶豌豆花的抗肥胖潜力:文献综述

Jurnal Ilmiah Kedokteran Wijaya Kusuma Pub Date : 2023-09-30 DOI: 10.30742/jikw.v12i2.2670

Nur Aini Djunet, Muflihah Rizkawati

{"title":"Antiobesity Potential of Butterfly Pea Flower (Clitoria Ternatea): A Literature Review","authors":"Nur Aini Djunet, Muflihah Rizkawati","doi":"10.30742/jikw.v12i2.2670","DOIUrl":"https://doi.org/10.30742/jikw.v12i2.2670","url":null,"abstract":"Obesity is a health problem with an increasing prevalence every year in many countries including Indonesia. Obese patients are at risk for complications related to some non-communicable diseases. The difficulty of losing weight in obese patients is due to low awareness of a good lifestyle, appropriate dietary patterns, and discipline in taking drugs to prevent complications. However, the need for drug consumption takes a long time. The risk of side effects arising from long-term drug use needs to be considered. Using herbal plants as an additional dietary intervention could be a better choice. This review described the benefits of the butterfly pea (Clitoria ternatea) flower as antiobesity. This study is a literature review by searching preceding published articles in Pubmed, ScienceDirect, Cochrane, and Google Scholar journals. The keywords used are (Clitoria ternatea) OR (Bunga Telang) OR (Butterfly pea) AND (Obesity) OR (Antiobesity). Articles are limited by publication period from 2012 to 2022 and then selected based on the criteria. This literature review concluded that the administration of Clitoria ternatea extracts (CTE) can become an alternative antiobesity by inhibiting weight gain, increasing adipose lipolysis, and decreasing the expression of adipogenic and lipogenic proteins.","PeriodicalId":33090,"journal":{"name":"Jurnal Ilmiah Kedokteran Wijaya Kusuma","volume":"68 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136341976","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effect of Spirulina Platensis on Liver Malondialdehyde Levels of Male White Rat Induced by High Dose Paracetamol 螺旋藻对大剂量对乙酰氨基酚诱导的雄性大鼠肝脏丙二醛水平的影响

Jurnal Ilmiah Kedokteran Wijaya Kusuma Pub Date : 2023-09-30 DOI: 10.30742/jikw.v12i2.2700

Anggilia Vanny, Sihning E. J. Tehupuring, Indri Ngesti Rahayu, Roostantia Indrawati

{"title":"Effect of Spirulina Platensis on Liver Malondialdehyde Levels of Male White Rat Induced by High Dose Paracetamol","authors":"Anggilia Vanny, Sihning E. J. Tehupuring, Indri Ngesti Rahayu, Roostantia Indrawati","doi":"10.30742/jikw.v12i2.2700","DOIUrl":"https://doi.org/10.30742/jikw.v12i2.2700","url":null,"abstract":"Paracetamol is widely used in therapy, yet it becomes hepatotoxic agent in a high dose using. The CYP450 enzyme metabolizes a small portion of paracetamol to a reactive substance, NAPQI. High dose of paracetamol causes an extensive increase in NAPQI levels. NAPQI then binds to hepatocytes conditions of oxidative stress. Spirulina platensis contains C-phycocyanin, flavonoids, and phenolics that inhibit lipid peroxidation and reduce oxidative stress. This study aims to determine the effect of Spirulina platensis on MDA levels in the liver tissue of male Wistar rats induced by high dose of paracetamol. This research was experimental with a Randomized Post-test Only Control Group design using 24 white male rats divided into three groups; negative control group (G-), positive control group (G+) was given paracetamol at a dose of 1,250 mg/kg on the 8th day, and treatment group (Gt) was given an amount of Spirulina platensis extract 360 mg/kg BW/day for ten days from 1st until 10th day and paracetamol at a single dose of 1,250 mg/kg BW on the 8th. At the 10th day of the treatment, all groups were terminated for liver tissue collection. TBA test was used to calculate MDA levels. Statistical tests analyzed the results of the data. This statistical tests by SPSS software: MDA levels in the treatment group did not significantly differ (p = 0.144) compared to the negative control group. There was a significant difference of liver tissue MDA levels in the treatment group (p = 0.016) compared to the positive control group. This study concludes that administering Spirulina platensis at a dose of 360 mg/kg/day for ten days can help prevent on increase in tissue MDA levels and maintain liver conditions close to their original state.","PeriodicalId":33090,"journal":{"name":"Jurnal Ilmiah Kedokteran Wijaya Kusuma","volume":"54 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136280294","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Systematic Literature Review of Early Estrogen Exposure and its Relation to Breast Cancer in Woman 早期雌激素暴露与女性乳腺癌关系的系统文献综述

Jurnal Ilmiah Kedokteran Wijaya Kusuma Pub Date : 2023-09-30 DOI: 10.30742/jikw.v12i2.2588

Ni Putu Manik Suryaningsih, Pratika Yuhyi Hernanda, Roethmia Yaniari

{"title":"Systematic Literature Review of Early Estrogen Exposure and its Relation to Breast Cancer in Woman","authors":"Ni Putu Manik Suryaningsih, Pratika Yuhyi Hernanda, Roethmia Yaniari","doi":"10.30742/jikw.v12i2.2588","DOIUrl":"https://doi.org/10.30742/jikw.v12i2.2588","url":null,"abstract":"Breast cancer cell begins in the ductal epithelium and its lobes, where abnormal cell growth that is excessive, uncoordinated, and susceptible to metastasis accumulates. This study set out to find out how far early estrogen exposure influence the risk of having breast cancer in women. This systematic literature review was done by collecting sources related to the investigated variables which are menarche age, age at first birth and hormonal contraception use. We collect from variety of sources such as Google Scholar, PubMed, and Proquest to draw conclusions by grouping the odds ratio (OR) and their 95% CI. Data of the research articles, including author, year, title, and research results in the form of p-value, OR, and 95% CI, were collected from 35 articles published between 2011 and 2022 for this study. The data analysis revealed woman with menarche age at less than 12 years old have more likely to have breast cancer (range of OR 0.80 – 26.8), meanwhile woman who give birth more than 30 years old also have more likely to have breast cancer ( range of OR 1.26 – 6.47) and duration of hormonal contraception use > 5 years were also give more chance to breast cancer development (range OR 0.51 – 9.06). This review analysis highlighted the increased probability in the incidence of breast cancer in woman related to the duration of hormonal contraception use, the age of menarche, and the age at first birth.","PeriodicalId":33090,"journal":{"name":"Jurnal Ilmiah Kedokteran Wijaya Kusuma","volume":"22 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136342362","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Analysis of Association of Dyspareunia in Menopausal Women with The Quality of Sexual Intercourse: Literature Review 绝经期妇女性交困难与性交质量的关系分析:文献综述

Jurnal Ilmiah Kedokteran Wijaya Kusuma Pub Date : 2023-09-30 DOI: 10.30742/jikw.v12i2.2678

Farizah El Husna, Ni Luh Ayu Sri Antari Putri, Eka Wahyu Dewangga, Radina Dewi Sariva Y., Gegel Purnomo Wicaksono, Andiani Falah

{"title":"Analysis of Association of Dyspareunia in Menopausal Women with The Quality of Sexual Intercourse: Literature Review","authors":"Farizah El Husna, Ni Luh Ayu Sri Antari Putri, Eka Wahyu Dewangga, Radina Dewi Sariva Y., Gegel Purnomo Wicaksono, Andiani Falah","doi":"10.30742/jikw.v12i2.2678","DOIUrl":"https://doi.org/10.30742/jikw.v12i2.2678","url":null,"abstract":"In postmenopausal women, sexual function may worsen with increasing menopausal status. Dyspareunia is a common complaint that is experienced by women who have experienced menopause and this also causes a decrease in the quality of sexual intercourse in women who have experienced menopause. The aim of this study is to determine the relationship between dyspareunia in menopausal women and the quality of sexual intercourse. This research method uses a literature review. Literature review means reviewing various types of literature, both national journals and international journals obtained from an academic database on Google Scholar, PubMed NCBI, and Science Direct from 2013 to 2023, without language restrictions, and full-text research journals with the keywords that related between “Dyspareunia”, “Quality of Sexual Intercourse”, and “Menopause Women”. Data were obtained from twenty-two research journals that met the inclusion criteria. Results showed that overall the article supports the effect of dyspareunia in postmenopausal women on the quality of sexual intercourse. All of the 22 articles show a relationship between dyspareunia in postmenopausal women and the quality of sexual intercourse. As a conclusion, dyspareunia experienced by postmenopausal can lead to a decrease in the quality of sexual intercourse in postmenopausal women. These findings may contribute to the development of a valid association of dyspareunia in menopausal women with the quality of sexual intercourse.","PeriodicalId":33090,"journal":{"name":"Jurnal Ilmiah Kedokteran Wijaya Kusuma","volume":"68 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136341971","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Prophylactic Effect of Eucheuma spinosum on Total Blood Cholesterol Levels in Rattus norvegicus Dexamethasone-Induced 棘真菊对地塞米松诱导褐家鼠血总胆固醇水平的预防作用

Jurnal Ilmiah Kedokteran Wijaya Kusuma Pub Date : 2023-09-30 DOI: 10.30742/jikw.v12i2.2649

Josefus Kristoforus Kresno Widjojo, Fitri Handajani, Duti Sriwati Aziz, Peppy Nawangsasy

{"title":"The Prophylactic Effect of Eucheuma spinosum on Total Blood Cholesterol Levels in Rattus norvegicus Dexamethasone-Induced","authors":"Josefus Kristoforus Kresno Widjojo, Fitri Handajani, Duti Sriwati Aziz, Peppy Nawangsasy","doi":"10.30742/jikw.v12i2.2649","DOIUrl":"https://doi.org/10.30742/jikw.v12i2.2649","url":null,"abstract":"Hyperlipidemia is one of the main risk factors for heart disease caused by the formation of atherosclerosis. Eucheuma spinosum contains a natural antioxidant flavonoid, which has an antiatherogenic effect that can inhibit the formation of cholesterol in the liver so that it can prevent the development of atherosclerosis. This study aims to determine the effect of prophylactic administration of Eucheuma spinosum on the total cholesterol levels of Rattus novergicus induced by dexamethasone. This study was an experimental design with a post-test-only control group design. This study would use 24 white male Rattus norvegicus divided into three groups; a negative control group (K-) without treatment, a positive control group (K+) induced dexamethasone 8 mg/Kg BW on day 14 until day 20, treatment group (KP) given Eucheuma spinosum extract 200 mg/Kg BW on day 8 until day 20 as Prophylactic and on day 14 until day 20 induced dexamethasone 8 mg/Kg BW. After completing the treatment period, all groups were terminated and taken total calculation of cholesterol levels through the aorta of rats. Data was analyzed statistically computerized. The results of the study of total cholesterol levels that used Kruskal-Wallis test showed differences between groups (p<0.001). There was a decrease in total cholesterol levels in the treatment group (p<0.024) compared with the positive control group. The administration of Eucheuma spinosum extract as a prophylactic dose of 200 mg/Kg BW for 14 days could reduce the total cholesterol level of Rattus norvegicus induced by dexamethasone compared to those not given Eucheuma spinosum extract.","PeriodicalId":33090,"journal":{"name":"Jurnal Ilmiah Kedokteran Wijaya Kusuma","volume":"25 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136280461","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0