mjl@ lmstnSry@ lTby@最新文献_第3页

Potential linkages between Alzheimer's disease and major depression 阿尔茨海默病与严重抑郁症之间的潜在联系

mjl@ lmstnSry@ lTby@ Pub Date : 2023-01-01 DOI: 10.4103/mj.mj_65_22

F. Raudino

引用次数: 0

Effect of celecoxib alone or in combination of sitagliptin in monoiodoacetate rat model of osteoarthritis 塞来昔布单用或联用西格列汀对单碘乙酸骨关节炎大鼠模型的影响

mjl@ lmstnSry@ lTby@ Pub Date : 2023-01-01 DOI: 10.4103/mj.mj_51_22

Rabab Al-Uqabi, A. Al-Gareeb, Ali K. Al-buhadily

{"title":"Effect of celecoxib alone or in combination of sitagliptin in monoiodoacetate rat model of osteoarthritis","authors":"Rabab Al-Uqabi, A. Al-Gareeb, Ali K. Al-buhadily","doi":"10.4103/mj.mj_51_22","DOIUrl":"https://doi.org/10.4103/mj.mj_51_22","url":null,"abstract":"Background: Osteoarthritis (OA) is considered an attractive research issue; as it is the most common musculoskeletal progressive condition with no cure yet. Aims: To evaluate effect of celecoxib alone or in combination of sitagliptin in monoiodo acetate rat model of OA. Methods: A total of 40 Sprague-Dawley male rats were divided into 4 groups, negative control (n=10), positive control group (OA induced by monoiodoacetate (MIA)) (n=10), celecoxib 50mg/kg (n=10), and celecoxib 50mg/kg plus sitagliptin 20mg/kg group (n=10). Serum levels of inflammatory biomarkers and serum CTX-II were assessed for all groups. Data were analyzed statistically by SPSS version 28.00. Results: group treated with celecoxib showed a significant reduction in the inflammatory biomarkers and CTX-II serum levels compared with the OA group (P<0.01). A significant reduction in CTX-II level in combination treated group relative to celecoxib treated group. Conclusion: Celecoxib imparted anti-inflammatory and cartilage protective effect in OA induced rat model. Sitagliptin combination with celecoxib added an extra cartilage protective effect by reducing cartilage degradation evident by lowering CTX-II serum levels.","PeriodicalId":33069,"journal":{"name":"mjl@ lmstnSry@ lTby@","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44762733","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Evaluation of protective effect of metformin in rats with experimental osteoarthritis 二甲双胍对实验性骨关节炎大鼠保护作用的评价

mjl@ lmstnSry@ lTby@ Pub Date : 2023-01-01 DOI: 10.4103/mj.mj_43_22

Ali K. Al-buhadily, Rabab Al-Uqabi, A. Al-Gareeb

{"title":"Evaluation of protective effect of metformin in rats with experimental osteoarthritis","authors":"Ali K. Al-buhadily, Rabab Al-Uqabi, A. Al-Gareeb","doi":"10.4103/mj.mj_43_22","DOIUrl":"https://doi.org/10.4103/mj.mj_43_22","url":null,"abstract":"Objective: The objective of this study is to evaluate metformin proposed protective effect against the development of osteoarthritis (OA) in rats. Materials and Methods: A total of 40 male Sprague–Dawley rats were included, divided into four groups: negative control (n = 10), positive control (OA induced by monoiodoacetate [MIA]) (n = 10), metformin 200mg/kg group (n = 10) preinduction of OA, and metformin 200 mg/kg group (n = 10) postinduction of OA. Serum C-telopeptide type II collagen (CTX-II), inflammatory biomarkers were evaluated for each group. For data analysis, SPSS version 26.00 was used. Results: Metformin-treated groups showed a significant reduction in inflammatory biomarkers and CTX-II serum levels compared with OA group (P < 0.05). Pretreatment with 200 mg/kg metformin imparted extra cartilage protective effect and further decreased inflammatory cytokines compared to posttreated (P < 0.05). Conclusion: Metformin produced a beneficial protective effect in experimental OA in rats. It attenuates the inflammatory reactions progression by preventing the release of pro-inflammatory cytokines in rats with experimental OA. Furthermore, metformin reduced cartilage degradation evidenced by lowering CTX-II serum levels experimental OA in rats.","PeriodicalId":33069,"journal":{"name":"mjl@ lmstnSry@ lTby@","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44770046","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A pilot study on hypogonadism in male leprosy patients in rural tertiary care hospital in central India 印度中部农村三级护理医院男性麻风病患者性腺功能减退的初步研究

mjl@ lmstnSry@ lTby@ Pub Date : 2023-01-01 DOI: 10.4103/mj.mj_35_23

Pratiksha Sonkusale, S. Kar, A. Deshmukh, Subhor Nandwani, Sangeeta Galui, Aditya Ambulkar

{"title":"A pilot study on hypogonadism in male leprosy patients in rural tertiary care hospital in central India","authors":"Pratiksha Sonkusale, S. Kar, A. Deshmukh, Subhor Nandwani, Sangeeta Galui, Aditya Ambulkar","doi":"10.4103/mj.mj_35_23","DOIUrl":"https://doi.org/10.4103/mj.mj_35_23","url":null,"abstract":"Background: Leprosy is a chronic granulomatous infectious disease caused by Mycobacterium leprae. Besides the skin and peripheral nerves, it also involves many internal organs. Testicular involvement is mainly seen in leprosy. Hypogonadism in males with leprosy can occur due the involvement of testis. Aim: The aim was to evaluate the gonadal function impairment in males with leprosy and to analyze the relation of follicle-stimulating hormone (FSH), luteinizing hormone (LH), and testosterone to the activity, duration, and disease classification in Central India. Patients and Methods: This was a prospective observational pilot study. We evaluated 30 patients of leprosy. They were subjected to careful history taking, dermatological and genital examination, assessment of FSH, LH, and testosterone levels, and slit skin smear for acid-fast bacilli. Diagnosis of leprosy was confirmed histopathologically. The collected data were encoded and entered electronically in a computer excel worksheet 2010 version. The statistical analysis was performed using SPSS version 17.0 for Windows. Pearson correlation coefficient was used to establish relationship between different variables. P ≤ 0.05 was considered statistically significant. Results: A positive correlation was found between FSH and LH hormones which was highly significant, whereas there was a negative correlation between testosterone and FSH and LH levels. There was a positive correlation between age, duration of disease, and reaction in leprosy with those of FSH and LH levels. There was a positive correlation between disease activity bacillary index (BI) and FSH, LH and a negative correlation between BI and testosterone. Conclusion: It is recommended that lepromatous leprosy patients should be routinely screened for hypogonadism using FSH, LH, and testosterone levels.","PeriodicalId":33069,"journal":{"name":"mjl@ lmstnSry@ lTby@","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44621717","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Caudal septal deviation surgical techniques 尾间隔偏曲手术技术

mjl@ lmstnSry@ lTby@ Pub Date : 2023-01-01 DOI: 10.4103/mj.mj_8_23

Nasir Hassen

{"title":"Caudal septal deviation surgical techniques","authors":"Nasir Hassen","doi":"10.4103/mj.mj_8_23","DOIUrl":"https://doi.org/10.4103/mj.mj_8_23","url":null,"abstract":"Background: Caudal septal repair is hard to confront in otolaryngology and plastic surgeon, due to cartilage memory. It causes nasal obstruction or esthetical problems to the nasal base and columella. Although different modalities have been described for the treatment of this abnormality, these techniques not only improve the function but also preserve or improve the appearance of the nose. Objective: The objective was to discuss the different surgical conservative procedures that can be used to treat alterations of the caudal septum and change the position of the cartilage in the midline and find which is the best. Patients and Methods: A descriptive study was conducted on 40 patients who aged 20–40 years, had attended the Otolaryngology Outpatient Clinic in Al Karama Teaching Hospital, Baghdad, Iraq, between October 2016 and March 2020, and with a history of obstructed nose; conservative nasal septal surgery was done for them depending on the severity. Results: Regarding the result of the type of surgery, the patients were satisfied with their esthetic and functional perfection; patients with preoperative nasal obstruction reported improved breathing. In scoring technique with (NOSE) score pre and postoparative results were 58.21 and 22.66, in reshaping technique were 60.66 and 17.21 as a pre and postoparative results and in batten graft the results were 62.34 and 20.26 as a pre and postoparative results alternatively. Reshaping and batten graft techniques are better results than the scoring technique. Conclusion: The study outcomes that the approaches for improvement of caudal septal deviation are safe and effective. The approach of surgery will depend on the severity of the deviation.","PeriodicalId":33069,"journal":{"name":"mjl@ lmstnSry@ lTby@","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47134392","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Correlation of NF-kB serum level with the expression pattern of microrna-221 in a sample of hcv-exposed Iraqi patients 伊拉克hcv暴露患者血清NF-kB水平与microrna-221表达模式的相关性

mjl@ lmstnSry@ lTby@ Pub Date : 2023-01-01 DOI: 10.4103/mj.mj_20_22

Shaima’a R. Al-Salihy, R. Al-Shawk, Safaa A. Al-Waysi, M. Rasheed

{"title":"Correlation of NF-kB serum level with the expression pattern of microrna-221 in a sample of hcv-exposed Iraqi patients","authors":"Shaima’a R. Al-Salihy, R. Al-Shawk, Safaa A. Al-Waysi, M. Rasheed","doi":"10.4103/mj.mj_20_22","DOIUrl":"https://doi.org/10.4103/mj.mj_20_22","url":null,"abstract":"Background: Hepatitis C virus (HCV) has the ability to change cellular messenger RNA transcription and translation by stimulating the synthesis of cellular microRNAs (miRNAs) that impair immune response and facilitate viral reproduction. One of the most important members of the immune response against HCV is nuclear factor-kappa B (NF-κB), which is regulated by cellular miRNAs. Aims: we aimed to investigate the correlation of NF-κB serum level with circulatory miRNA-221 (miR-221) fold change in HCV-exposed individuals. Materials and Methods: Serum level of NF-κB in 88 samples (22 patients with persistent HCV infection, 22 individuals with spontaneous HCV virus clearance, 22 individuals treated with direct-acting antivirals (DAAs) drugs, and 22 uninfected apparently healthy blood donors as control) was measured by enzyme-linked immunosorbent assay. Reverse transcriptase–polymerase chain reaction was used to quantify the expression fold of circulatory miR-221. Results: The results showed that there was a significant decrease in the mean level of NF-κB at P < 0.000 among HCV-exposed patients (2.0058 ng/ml) as compared to the control group (2.9841 ng/ml). The mean fold change of miR-221 was significantly upregulated about six more times among HCV-exposed patients (mean = 6.3545) compared to the control group (mean = 1.1864). Furthermore, the mean ± standard deviation of miR-221 fold change in patients with persistent HCV infection was significantly higher compared to patients cured after DAA therapy (P = 0.048), there was a weak negative correlation (r = −0.246, P = 0.021) between NF-κB serum level and miR-221 folding level. Conclusion: HCV infection disrupts NF-κB activation, resulting in dysregulation of miR-221 that persists long after the virus has been cleared. Thus, quantification of serum NF-κB and miR-221in HCV-exposed patients could be used as noninvasive prognostic marker during long-term follow-up. Furthermore, a miRNAs profile analysis can help distinguish HCV-exposed from healthy individuals.","PeriodicalId":33069,"journal":{"name":"mjl@ lmstnSry@ lTby@","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47134819","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Vagal nerve stimulation for refractory epilepsy: Eight years of experience on 183 Iraqi patients 迷走神经刺激治疗难治性癫痫：183例伊拉克患者的8年经验

mjl@ lmstnSry@ lTby@ Pub Date : 2023-01-01 DOI: 10.4103/mj.mj_14_22

Mohamed Al Tamimi, AhmedA Salam Al Atraqchi, Ahmed Tahseen, Hayder Qatran

{"title":"Vagal nerve stimulation for refractory epilepsy: Eight years of experience on 183 Iraqi patients","authors":"Mohamed Al Tamimi, AhmedA Salam Al Atraqchi, Ahmed Tahseen, Hayder Qatran","doi":"10.4103/mj.mj_14_22","DOIUrl":"https://doi.org/10.4103/mj.mj_14_22","url":null,"abstract":"Background: Vagus nerve stimulation has been broadly known as one of treatment lines for refractory epilepsy, especially in poor applicants for resection surgeries or in whom resection has failed. Its use for different seizure-types control is increasing. Aims: We aimed to assess the efficacy of Vagal nerve stimulation (VNS) therapy outcome predictive aspects utilizing subgroup analysis. Materials and Methods: From 2008 until 2016, 183/190 refractory epilepsy cases with specific inclusion criteria were selected. All underwent pre- and postimplantation assessment of response utilizing Engel criteria and Chalfont seizure severity scoring system for 2 years. Descriptive and statistical data analysis was accomplished for the data of age at epilepsy start and VNS insertion, seizures nature, device stimulation parameters, and peri-surgical antiepileptic medicines. Results: At 12 months follow-up period (29.5%), patients were assigned to a Class I and II outcome (representing very good seizure outcome) especially among patients with G. T. C seizure. 38.8% had a “worthwhile” improvement and consigned as Class III outcome mostly among P. S. G patients. The response was better at 24 months' follow-up period. Patients <10 years of age with pre surgery mean duration of epilepsy of 10 (+5) years and mean age at onset of epilepsy of 7 (+5) years showed better response. Mean seizure frequency reduction was 69.8% (+18). Conclusions: Stimulation parameters needed was lower for class I and II with significant reduction of required anti-epileptic drugs (AED). Our study may help to provide response predictive characteristics.","PeriodicalId":33069,"journal":{"name":"mjl@ lmstnSry@ lTby@","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45700179","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cardiovascular health in turner syndrome: Manifestations, endocrine, and metabolic risk factors with a look at clinical practice 特纳综合征的心血管健康：临床实践中的表现、内分泌和代谢危险因素

mjl@ lmstnSry@ lTby@ Pub Date : 2022-07-01 DOI: 10.4103/mj.mj_13_22

W. Abdullah, Abdulameer Jawad al-Gburi, Saba Younis Al-Obaidi

引用次数: 0

C-reactive protein in elderly and pregnant COVID-19 cases: A new role for an old marker 老年人和孕妇新冠肺炎病例中的C反应蛋白：一种旧标志物的新作用

mjl@ lmstnSry@ lTby@ Pub Date : 2022-07-01 DOI: 10.4103/mj.mj_54_22

E. Ali, D. Salman, Wassan Nori

引用次数: 2

Siblings with dyschromatosis universalis hereditaria a rare case report 同胞遗传性普遍性色素沉着病一例罕见病例报告

mjl@ lmstnSry@ lTby@ Pub Date : 2022-07-01 DOI: 10.4103/mj.mj_9_22

P. Kumari, Sonia Jain, Pratiksha Sonkusale, A. Deshmukh

引用次数: 0