{"title":"阿尔茨海默病与严重抑郁症之间的潜在联系","authors":"F. Raudino","doi":"10.4103/mj.mj_65_22","DOIUrl":null,"url":null,"abstract":"Alzheimer's disease (AD) and major depression (MD) are frequent diseases with a significant impact on the quality of life, and epidemiological studies show a correlation between early depressive episodes and AD. Although apparently different, they nonetheless maintain significant similarities, such as the common genetic substrate, involvement of similar structures, and a number of common pathogenetic hypotheses. This in-depth literature review aims at highlighting possible linkages between the two diseases: A chronic inflammatory process that selectively alters the blood–brain barrier in certain regions can be hypothesized.","PeriodicalId":33069,"journal":{"name":"mjl@ lmstnSry@ lTby@","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Potential linkages between Alzheimer's disease and major depression\",\"authors\":\"F. Raudino\",\"doi\":\"10.4103/mj.mj_65_22\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Alzheimer's disease (AD) and major depression (MD) are frequent diseases with a significant impact on the quality of life, and epidemiological studies show a correlation between early depressive episodes and AD. Although apparently different, they nonetheless maintain significant similarities, such as the common genetic substrate, involvement of similar structures, and a number of common pathogenetic hypotheses. This in-depth literature review aims at highlighting possible linkages between the two diseases: A chronic inflammatory process that selectively alters the blood–brain barrier in certain regions can be hypothesized.\",\"PeriodicalId\":33069,\"journal\":{\"name\":\"mjl@ lmstnSry@ lTby@\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2023-01-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"mjl@ lmstnSry@ lTby@\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.4103/mj.mj_65_22\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"mjl@ lmstnSry@ lTby@","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.4103/mj.mj_65_22","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Potential linkages between Alzheimer's disease and major depression
Alzheimer's disease (AD) and major depression (MD) are frequent diseases with a significant impact on the quality of life, and epidemiological studies show a correlation between early depressive episodes and AD. Although apparently different, they nonetheless maintain significant similarities, such as the common genetic substrate, involvement of similar structures, and a number of common pathogenetic hypotheses. This in-depth literature review aims at highlighting possible linkages between the two diseases: A chronic inflammatory process that selectively alters the blood–brain barrier in certain regions can be hypothesized.
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