{"title":"塞来昔布单用或联用西格列汀对单碘乙酸骨关节炎大鼠模型的影响","authors":"Rabab Al-Uqabi, A. Al-Gareeb, Ali K. Al-buhadily","doi":"10.4103/mj.mj_51_22","DOIUrl":null,"url":null,"abstract":"Background: Osteoarthritis (OA) is considered an attractive research issue; as it is the most common musculoskeletal progressive condition with no cure yet. Aims: To evaluate effect of celecoxib alone or in combination of sitagliptin in monoiodo acetate rat model of OA. Methods: A total of 40 Sprague-Dawley male rats were divided into 4 groups, negative control (n=10), positive control group (OA induced by monoiodoacetate (MIA)) (n=10), celecoxib 50mg/kg (n=10), and celecoxib 50mg/kg plus sitagliptin 20mg/kg group (n=10). Serum levels of inflammatory biomarkers and serum CTX-II were assessed for all groups. Data were analyzed statistically by SPSS version 28.00. Results: group treated with celecoxib showed a significant reduction in the inflammatory biomarkers and CTX-II serum levels compared with the OA group (P<0.01). A significant reduction in CTX-II level in combination treated group relative to celecoxib treated group. Conclusion: Celecoxib imparted anti-inflammatory and cartilage protective effect in OA induced rat model. Sitagliptin combination with celecoxib added an extra cartilage protective effect by reducing cartilage degradation evident by lowering CTX-II serum levels.","PeriodicalId":33069,"journal":{"name":"mjl@ lmstnSry@ lTby@","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Effect of celecoxib alone or in combination of sitagliptin in monoiodoacetate rat model of osteoarthritis\",\"authors\":\"Rabab Al-Uqabi, A. Al-Gareeb, Ali K. Al-buhadily\",\"doi\":\"10.4103/mj.mj_51_22\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Background: Osteoarthritis (OA) is considered an attractive research issue; as it is the most common musculoskeletal progressive condition with no cure yet. Aims: To evaluate effect of celecoxib alone or in combination of sitagliptin in monoiodo acetate rat model of OA. Methods: A total of 40 Sprague-Dawley male rats were divided into 4 groups, negative control (n=10), positive control group (OA induced by monoiodoacetate (MIA)) (n=10), celecoxib 50mg/kg (n=10), and celecoxib 50mg/kg plus sitagliptin 20mg/kg group (n=10). Serum levels of inflammatory biomarkers and serum CTX-II were assessed for all groups. Data were analyzed statistically by SPSS version 28.00. Results: group treated with celecoxib showed a significant reduction in the inflammatory biomarkers and CTX-II serum levels compared with the OA group (P<0.01). A significant reduction in CTX-II level in combination treated group relative to celecoxib treated group. Conclusion: Celecoxib imparted anti-inflammatory and cartilage protective effect in OA induced rat model. Sitagliptin combination with celecoxib added an extra cartilage protective effect by reducing cartilage degradation evident by lowering CTX-II serum levels.\",\"PeriodicalId\":33069,\"journal\":{\"name\":\"mjl@ lmstnSry@ lTby@\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2023-01-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"mjl@ lmstnSry@ lTby@\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.4103/mj.mj_51_22\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"mjl@ lmstnSry@ lTby@","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.4103/mj.mj_51_22","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Effect of celecoxib alone or in combination of sitagliptin in monoiodoacetate rat model of osteoarthritis
Background: Osteoarthritis (OA) is considered an attractive research issue; as it is the most common musculoskeletal progressive condition with no cure yet. Aims: To evaluate effect of celecoxib alone or in combination of sitagliptin in monoiodo acetate rat model of OA. Methods: A total of 40 Sprague-Dawley male rats were divided into 4 groups, negative control (n=10), positive control group (OA induced by monoiodoacetate (MIA)) (n=10), celecoxib 50mg/kg (n=10), and celecoxib 50mg/kg plus sitagliptin 20mg/kg group (n=10). Serum levels of inflammatory biomarkers and serum CTX-II were assessed for all groups. Data were analyzed statistically by SPSS version 28.00. Results: group treated with celecoxib showed a significant reduction in the inflammatory biomarkers and CTX-II serum levels compared with the OA group (P<0.01). A significant reduction in CTX-II level in combination treated group relative to celecoxib treated group. Conclusion: Celecoxib imparted anti-inflammatory and cartilage protective effect in OA induced rat model. Sitagliptin combination with celecoxib added an extra cartilage protective effect by reducing cartilage degradation evident by lowering CTX-II serum levels.