UKRAINIAN JOURNAL OF PERINATOLOGY AND PEDIATRICS最新文献

{"title":"COVID-19 in children: multisystem inflammatory syndrome","authors":"I. Avramenko, N. S. Kosmynina, M. Stasiv, V. Mishchuk","doi":"10.15574/pp.2022.90.17","DOIUrl":"https://doi.org/10.15574/pp.2022.90.17","url":null,"abstract":"Unlike adults, children are less likely to get infected SARS-CoV-2, their disease has a mild form and fatal cases are rather rare. However, a new disease associated with SARS-CoV-2, the multisystem inflammatory syndrome (MIS-C), has been described in children. Most children with MIS-C in the world are blacks or asians. Purpose - to analyze of peculiarities of MIS-C in children of Lviv Region. Materials and methods. We have analyzed medical records of 16 children who were treated in Communal Non-Commercial Establishment of Lviv Regional Council «Lviv Regional Children Clinical Hospital «OKHMATDYT» in the period from September 2020 to January 2021 with the diagnosis of MIS-C, associated with SARS-CoV-2. Results. MIS-C was diagnosed in 16 children (average age was 8,2±0,065 years, girls:boys = 1:0,6). None of our patients was the «primary source of SARS-CoV-2» in the household but contracted coronavirus disease after a contact with the sick relatives. The disease occurred in 4 (25%) children against the background of acute coronavirus disease, in 4 (25%) more children during the first month and 8 (50%) children more than a month after acute SARS-CoV-2 infection. All children has febrile fever and general weakness. Besides, in most of the patients clinical progression of MIS-C was characterized by typical skin rashes and conjunctivitis (13 children - 81,5%), facial swelling and edema of distal parts of extremities (11 children - 68,75%). Muscle pain was present in 9 (56%) children, hyperesthesia - in 4 (25%) children, gastrointestinal symptoms - in 8 (50%) our patients. Myocarditis was diagnosed in 4 (25%) children, linear dilatation of coronary arteries (2 children - 12,5%) and small aneurysms (1 child - 6,25%) - in 3 (18,75%) our patients. All these changes returned to normal 1 month after discharge from the hospital. Conclusions. The syndrome of multisystem inflammatory response before the 48th day after acute coronavirus disease and is characterized by typical clinical course. Treatment with human immunoglobulin at the dose of 1-2 g/kg, glucocorticosteroids at the dose of 1-2 mg/kg, aspirin 3-5 mg/kg against the background of antibacterial therapy is effective for the prevention of changes in the coronary arteries and for the recovery of all patients. The research was conducted in accordance with the principles of bioethics set out in the WMA Declaration of Helsinki and Universal Declaration on Bioethics and was approved by the Commission on Ethics of Scientific Research, Experimental Developments and Scientific Works of Danylo Halytsky Lviv National Medical University. The informed consent of the patients was obtained for conducting the studies. No conflict of interests was declared by the authors. Keywords: COVID-19, pediatric inflammatory multisystem syndrome, pediatric multisystem inflammatory disease, COVID-19 related, MIS-C associated with COVID-19, PIMS-TS.","PeriodicalId":330226,"journal":{"name":"UKRAINIAN JOURNAL OF PERINATOLOGY AND PEDIATRICS","volume":"29 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"132827078","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Appendicular cancer: relevance, diagnosis, treatment, prognosis. Results of an in-house clinical observation","authors":"V. Dronova, O. Dronov, O. Mokryk, P. Bakunets, Y. Bakunets, R. S. Tesluk","doi":"10.15574/pp.2022.90.65","DOIUrl":"https://doi.org/10.15574/pp.2022.90.65","url":null,"abstract":"The article is devoted to cancer of the appendix, which is extremely rare. The incidence of worm cancer is 0.5% of all forms of colon cancer. According to the histological classification there are 7 forms of this malignant pathology: neuroendocrine tumor, mucinous cystadenoma, mucinous cystadenocarcinoma, adenocarcinoma of the colon, goblet cell cancer, ring cell adenocarcinoma, paraganglioma. The article highlights the risk factors for appendicular cancer. Clinical manifestations, diagnostic criteria and treatment tactics of this type of colon neoplasm are described in detail. Data on 5-year survival and prognosis in this type of oncological pathology are given. The results of the patient’s own clinical observation of worm cancer are described in detail. Purpose - in view of the rare occurrence of apendicularis cancer to make a clinical case of its treatment in the department of operative gynecology of SI «Institute of Pediatrics, Obstetrics and Gynecology named after academician O.M. Lukyanova of the NAMS of Ukraine» for the formation of alertness of physicians to this pathology. There were outlined risk factors of apendicular cancer development. There were described in detail clinical manifestations, diagnostic criteria and treatment tactics of this type of colon cancer. There were given the data of 5-year survival rate and prognosis of this kind of oncologic pathology. Separately, there were described in detail the results of the in-house clinical monitoring of cancer of the worm gastrointestinal tract in a female patient. The research was carried out in accordance with the principles of the Helsinki Declaration. The informed consent of the patient was obtained for conducting the studies. No conflict of interests was declared by the authors. Keywords: cancer of the appendicular process, 5-year survival, prognosis, risk factors.","PeriodicalId":330226,"journal":{"name":"UKRAINIAN JOURNAL OF PERINATOLOGY AND PEDIATRICS","volume":"15 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"133248526","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Tetrallogy of Fallot and hypertrophic cardiomyopathy. Unusual association","authors":"A. Malska, O. Kuryliak","doi":"10.15574/pp.2022.90.59","DOIUrl":"https://doi.org/10.15574/pp.2022.90.59","url":null,"abstract":"Tetrallogy of Fallot (ToF) is the most widespread congenital heart defect characterized by a wide anatomic spectrum and clinical manifestations, which depend on the degree of stenosis of the pulmonary artery, and can be associated with chromosomal abnormalities. Hypertrophic cardiomyopathy (HCM) is a rare genetic disorder that often occurs in the autosomal-dominant type and has a high risk of cardiac death and is associated with abnormalities in certain gene loci. Clinical case. We present this rare association in a 9-month-old girl, without previous history of heart defect, who was admitted to intensive care unit with a clinical presentation of severe hypoxic spell. A rare case of the combination of ToF and HCM has been reported in a 9-month-old child admitted to the reanimation department of the Lviv Regional Children’s Clinical Hospital «OKHMATDYT» for malignant and cyanotic attacks. The girl was hospitalized for reanimation in a jaundice-cyanotic crisis with a saturation rate of 44%. On examination, a pronounced sciatica, pallor and cyanosis of the lips were detected. Auscultatively, the heart tones were rhythmic, muffled, the heart rate - 202 beats per second, systolic murmur was detected on the left side of the chest 5/6 on the Levine scale. Electrocardiogram showed signs of systolic hypertension and hypertrophy of the right ventricle. 2D-echocardiographic examination revealed hypertrophy of the left and right ventricular walls and interventricular septum as well as signs of ToF. On the magnetic resonance imaging the diagnosis was confirmed. After the stabilization of the general condition the child was transported to the Center of Pediatric Cardiology and Cardiac Surgery in Kyiv for surgical treatment, where it was recommended to continue the medical treatment with beta-blockers. After 2 months, the 1-year-old child was operated on routinely - radical correction of ToF, the post-operative state was good. Conclusions. Association of ToF and HCM is extremely rare. ToF is often associated with chromosomal aberration, while hypertrophic cardiomyopathy associates with certain gene loci. Surgical treatment of ToF associated with HCM differs greatly from surgical treatment of usual ToF and physiology of both conditions have to be considered prior to the surgery, as combination of ToF and HCM is associated with high postoperative mortality, as the LVOT progresses and increased risk of development of ventricular arrhythmias and heart failure develops. The association between ToF and HCM is extremely rare. ToF is associated with chromosomal abnormalities, whereas HCM is associated with abnormalities in certain gene loci. The prognosis for patients with TF and HCM is associated with high postoperative mortality due to progression of obstruction of the left ventricular tract, development of ventricular arrhythmias and cardiovascular failure during the postoperative period. The research was carried out in accordance with the principles of the Helsinki ","PeriodicalId":330226,"journal":{"name":"UKRAINIAN JOURNAL OF PERINATOLOGY AND PEDIATRICS","volume":"6 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"126798949","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reproductive losses in Ukraine: current situation","authors":"R. Marushko, O. Dudina, T. Marushko","doi":"10.15574/pp.2022.89.5","DOIUrl":"https://doi.org/10.15574/pp.2022.89.5","url":null,"abstract":"During the transformation of society, accompanied not only by socio-economic decline, but also by unfavorable indicators of population reproduction, the issue of reducing reproductive losses and maintaining the viability of offspring at all stages of ontogenesis. Purpose - to investigate the condition and dynamics of the main components of reproductive losses in Ukraine. Materials and methods. A comprehensive retrospective analysis and assessment of the dynamics of reproductive losses and their main components in Ukraine for the period 2000-2021 according to the State Statistics Service of Ukraine and the State Institution «Center for Medical Statistics of the Ministry of Health of Ukraine». Methods of system approach, bibliographic, structural-logical, epidemiological analysis of statistical data processing, graphic image are applied. Results. A continuous study of the dynamics of reproductive loss at the population level showed a positive trend in the number of total reproductive losses - 86.1 per 1,000 live births in 2000 and 57.0‰ in 2021, OR with 95% CI 0.63 (0.62-0.65), p<0.0001, in violation of the trend of gradual decline of this indicator by its growth in 2005 up to 72.1‰, in connection with the preparation of perinatal facilities for the transition to the WHO criteria for perinatal period, live births and stillbirths. The downward trend was characteristic of prenatal losses - spontaneous (spontaneous) abortions, and medical legal abortions in the period from 12 to 22 weeks of pregnancy, the number of which decreased from 68.8 per 1,000 live births in 2000 to 43.2‰ in 2021, OR with 95% CI 0.63 (0.59-0.67), p<0.0001, and deaths in the first year of life - from 11.9‰ to 7.2‰, respectively, OR with 95% CI 0.7 (0.66-0.74), p<0.0001. At the same time, the stillbirth rate tended to increase - from 5.4‰ to 6.6‰, OR with 95% CI 1.23 (0.9-1,3), p<0.0001, against the background of a steady increase in the share of antenatal fetal death from 85.3% in the structure of stillbirth in 2001 up to 94.5% in 2021. It is established that in Ukraine in the structure of registered total reproductive losses during the entire observation period prenatal losses up to 22 weeks of gestation amounted to a total of 74.1%, of which spontaneous abortions 57.9%, medical legal abortions from 12 to 22 weeks 16.2% of pregnancies and 25.9% of feto-infantile losses, of which 15.7% died in the first year of life and 10.2% were stillborn. In the dynamics of the XXI century, the share of medical legal abortions in the period from 12 to 22 weeks of pregnancy decreased 3 times and those who died in the first year of life by 7.3%. The trend to increase the proportion was stillborn by 87.1% and spontaneous abortions by 29.6%. Conclusions. The situation with the state and dynamics of the main components of reproductive losses in Ukraine in the XXI makes it appropriate to further develop the family planning service, the formation of a comprehensive medical and social program to corr","PeriodicalId":330226,"journal":{"name":"UKRAINIAN JOURNAL OF PERINATOLOGY AND PEDIATRICS","volume":"56 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-03-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"128337322","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Risk factors of gastrointestinal food allergy in young children","authors":"M. H. Horianska","doi":"10.15574/pp.2022.89.22","DOIUrl":"https://doi.org/10.15574/pp.2022.89.22","url":null,"abstract":"Purpose - to study risk factors of gastrointestinal food allergy (GIFA) in young children. Materials and methods. 68 young children with GIFA and 22 children of the same age with an unencumbered individual allergy history were examined. A study of children perinatal, family and individual allergy history was conducted, and a survey was conducted on the state of parents’ health. The vitamin D supply of children was determined by quantifying of serum 25-hydroxycalciferol (25(OH)D) concentration by using an immunochemical analyzer. Results. Anamnestic risk factors that showed a significant association with the development of GIFA in young children and reliably differed from the control group were: complicated obstetric history, medical treatment of mothers during pregnancy, early artificial feeding, burdensome family allergy history and gastrointestinal diseases presence in parents. Insufficient supply of vitamin D was in 79.4% of patients with GIFA compared with 13.6% of children in the control group. The average serum 25(OH)D value in children with GIFA was 34.18±1.7 ng/ml, which is significantly lower than in the control group (40.2±2.3 ng/ml; p<0,05), which may be an additional factor in the development and severity of the disease. Conclusions. Risk factors of gastrointestinal food allergy have been identified, which will improve the prevention, early diagnosis and treatment of gastrointestinal allergic disease. The research was carried out in accordance with the principles of the Helsinki declaration. The study protocol was approved by the Local ethics committee of the participating institution. The informed consent of the patient was obtained for conducting the studies. No conflict of interests was declared by the author. Key words: gastrointestinal food allergy, risk factor, vitamin D, young children.","PeriodicalId":330226,"journal":{"name":"UKRAINIAN JOURNAL OF PERINATOLOGY AND PEDIATRICS","volume":"106 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-03-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"117220374","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Rubinstein-Taybi syndrome in neonatal practice (case report)","authors":"Z. Kocherha, B. Pavlykivska, L.S. Harkot, Yuliia Dmytruk, O. Pavlykivska","doi":"10.15574/pp.2022.89.31","DOIUrl":"https://doi.org/10.15574/pp.2022.89.31","url":null,"abstract":"The article presents data on a rare genetic disease - Rubinstein-Taybi syndrome. The disease incidence is 1: 25000-1: 30000. Parents’ lifestyle has no influence on the birth of a child with Rubinstein-Taybi syndrome. The risk of having a second child with the same pathology is 0.1%. The syndrome is characterized by the presence of deformed digits, distinctive facial features and mental retardation. Clinical signs of the disease occur as a result of mutation in the gene encoding a specific GreB protein. This gene is localized on the chromosome 16. The article reports on the main phenotypic deviations and analyzes the literature data on somatic and neurological pathologies. The syndrome is characterized by a combination of delayed physical and psychomotor development, progressive intellectual disability, characteristic craniofacial dysmorphism, deformity of digits (namely broad, short and wide distal phalanges of the thumbs and big toes, sometimes distal phalanges of other fingers and toes), abnormalities of the cardiovascular, respiratory and urogenital systems. The article presents primary data on the diagnosis of Rubinstein-Taybi syndrome in a child of neonatal age. The boy’s parents, young people, and the newborn’s sister, aged 3, are healthy. No phenotypic manifestations of skeletal dysplasia were detected. The relatives’ hereditary history is negative. We have observed the following facial dysmorphia: low forehead, low hair growth line, high-arched eyebrows, moon-shaped face, hypertelorism, downward slanted eyes, «beaked» nose, hypoplastic nasal wings, moderate retrognathia, high narrow palate, dysplastic, small, low-lying auricles. Broad terminal phalanges of thumbs and big toes, as well as valgus deformity of the thumbs were observed. The child was diagnosed with an open aortic duct and congenital choanal atresia on the right. Thus, a severe disabling pathology in a child born to apparently healthy parents indicates a sporadic de novo mutation. The research was carried out in accordance with the principles of the Helsinki declaration. The informed consent of the patient was obtained for conducting the studies. No conflict of interests was declared by the authors. Key words: Rubinstein-Taybi syndrome, craniofacial abnormalities, digit abnormalities, newborns.","PeriodicalId":330226,"journal":{"name":"UKRAINIAN JOURNAL OF PERINATOLOGY AND PEDIATRICS","volume":"5 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-03-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"132380979","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Creation of mental maps - innovative way of organizing information during study","authors":"I. Lisetska, Y.M. Volyak","doi":"10.15574/pp.2022.89.45","DOIUrl":"https://doi.org/10.15574/pp.2022.89.45","url":null,"abstract":"Reforming higher education, including medical, involves the introduction of the latest educational technologies, which allows to prepare future doctors who can synthesize the acquired theoretical and practical material to correctly diagnose and choose treatment, make decisions in non-standard situations, ie, develop in them clinical thinking. It is established that the information provided in the text version is assimilated by about 70% of students, while the text is supplemented by diagrams, drawings, tables - about 95% of students. In addition, on the one hand it allows to cover the entire structure of the submitted material, on the other hand - reveals the specifics and features of each element in particular. One of the modern innovative ways of organizing information during learning is mental maps - a technique of visualization of thinking; method of recording, using lists and diagrams (for example, «trees» or charts). Mental maps are widely used during the learning process, for example to process and organize information, keep notes of practical classes conducting practical classes and lectures, create lecture presentations, activate the creative component to generate new ideas, brainstorming and more. Mind maps can be created both by drawing and using computer programs such as Google (www.coggle.it), Freemind, MindMeister (www.mindmeister.com) etc. Therefore, to better absorb information, improve the preparation of students for final certification and further professional activities, it is advisable to use a variety of modern educational technologies, including the creation of mental maps that develop thinking, memory and imagination, as well as creativity that promotes effective formation of professional competencies in students. The research was carried out in accordance with the principles of the Helsinki declaration. The study protocol was approved by the Local ethics committee of the participating institution. The informed consent of the patient was obtained for conducting the studies. No conflict of interests was declared by the authors. Key words: mental map, learning technology, information, educational process","PeriodicalId":330226,"journal":{"name":"UKRAINIAN JOURNAL OF PERINATOLOGY AND PEDIATRICS","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-03-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"129756106","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Serum cystatin C as a marker of renal dysfunction in children with juvenile idiopathic arthritis","authors":"S. Samsonenko, T. Borуsova","doi":"10.15574/pp.2022.89.26","DOIUrl":"https://doi.org/10.15574/pp.2022.89.26","url":null,"abstract":"An accurate assessment of the estimated glomerular filtration rate (eGFR) is important for early detection of chronic kidney disease, control of nephrotoxicity, and dose adjustment of drugs. To date, there has been only one cohort retrospective study of the prevalence of chronic kidney disease in children with juvenile idiopathic arthritis (JIA). Purpose - to determine the level of serum cystatin C and, on its basis, the state of eGFR depending on the form of the clinical course, degree of activity, methods of treatment of JIA in children. Materials and methods. 80 children with JIA were examined. The content of serum cystatin C was determined by enzyme-linked immunosorbent assay. The Hoek formula was used to calculate eGFR based on the level of cystatin C in blood serum. Results. A decrease in eGFR below 90 ml/min/1.73m2 to 63.08 ml/min/1.73m2 based on serum cystatin C was found in 41.3% of children with JIA. The variant of the clinical course of JIA does not affect the concentration of serum cystatin С and the level of eGFR. Meanwhile, a high degree of risk of developing a decrease in eGFR in children with polyarthritis was established - 72.7% versus 48.9% (OR=2.78; CI: 1.07-7.24; p<0.04). Elevated serum cystatin С levels and decreased eGFR are associated with the degree of JIA activity and its duration. A decrease in eGFR is observed in all children with high activity of JIA, 71.4% - with low activity, 28.3% - in remission. A low risk of developing a decrease in eGFR in children in remission of JIA was established - 51.5% versus 91.5% (OR=0.10; CI: 0.03-0.34; p<0.001). The duration of the active stage of JIA ≥4 years negatively affects the level of eGFR, which leads to a high risk of developing a decrease in eGFR - 39.4% versus 17% (OR=3.17; CI: 1.13-8.9; p<0.04). A high risk of developing a decrease in eGFR was established in children with JIA who received non-steroidal anti-inflammatory drugs (NSAIDs) at the time of the examination - 54.5% versus 8.5% (OR=12.9; CI: 3.76-44.25; p<0.001). The use of immunobiological therapy is associated with a low risk of developing a decrease in eGFR - 9.1% versus 46.8% (OR=0.11; CI: 0.03-0.42; p<0.001). Conclusions. Renal dysfunction was found in 41.3% of children with JIA. Its development is affected by high activity of JIA, duration of the active stage of JIA ≥4 years, and treatment with NSAIDs. The study was carried out in accordance with the principles of the Helsinki Declaration. The study protocol was approved by the Local Ethics Committee of the institution specified in the work. Informed consent was obtained from the parents of the children for the research. No conflict of interests was declared by the authors. Key words: juvenile idiopathic arthritis, renal dysfunction.","PeriodicalId":330226,"journal":{"name":"UKRAINIAN JOURNAL OF PERINATOLOGY AND PEDIATRICS","volume":"5 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-03-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"128763383","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Phenotypic features of immunocompetent cells in I-II pregnancy trimesters in women with anamnese infertility","authors":"L. Tumanova, E. Kolomiiets","doi":"10.15574/pp.2022.89.11","DOIUrl":"https://doi.org/10.15574/pp.2022.89.11","url":null,"abstract":"It is impossible to solve the socio-economic problem of increasing the birth rate in Ukraine without determining the mechanisms of pregnancy disorders, among which immune ones occupy an important place, and developing individualized scientifically based therapy schemes. Purpose - to determine the characteristics of levels of immunocompetent blood cells based on the CD phenotype in women with a history of infertility at different stages of pregnancy. Materials and methods. With a FACSCan cell cytofloorimeter (Becton Dickinson, USA) and a test of Becton Dickinson systems (USA) determined using monoclonal antibodies (MCAs) to differentiated lymphocyte antigens, and activation markers (HLA-DR, CD25, CD69) or having inhibitory properties (CD158a) relative levels of immunocompetent cells 436 non-pregnant (reference group n) and 514 pregnant women with a history of infertility at different dates of the I and II trimesters of pregnancy (groups a-e). Results. Against the background of reduced lymphocyte count and increased blood granulocytes in pregnant women, a significantly high relative level of T-L and T-cytotoxic subpopulations were found with their activation (CD3+CD8+HLA-DR+- and CD3+CD8+Cd In this gestation period there is also an increase as the number of T-helpers (CD3+CD4+-L), and their activation with expression on the membranes of HLA-DR- and CD25-molecules. In the first 10 weeks of pregnancy, a decrease in the expression of inhibitory molecules CD158a (KIR2DL1) on NK T CD3+CD4+CD56+-cl and the relative level of B-lymphocytes (CD19+), as well as their subpopulations B-1a (CD19+CD5+) from 8 to 28 weeks was noted. Conclusions. The peculiarities of the levels of peripheral blood immune system cells according to their CD phenotypes make it possible to observe the dynamics of the most important of them (CD3+CD8+HLA-DR+-, CD3+CD8+CD56+-, CD. The research was carried out in accordance with the principles of the Helsinki declaration. The study protocol was approved by the Local ethics committee of the participating institution. The informed consent of the patient was obtained for conducting the studies. No conflict of interests was declared by the authors. Key words: CD-phenotype, immunocompetent cells, pregnant women, history of infertility, flow cytometry.","PeriodicalId":330226,"journal":{"name":"UKRAINIAN JOURNAL OF PERINATOLOGY AND PEDIATRICS","volume":"7 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-03-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"115068171","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Syndrome of muscle weakness and myalgia in pediatric practice on clinical examples","authors":"O. Oshlyanska, A. Artsymovych, T. G. Nadtochiy","doi":"10.15574/pp.2022.89.35","DOIUrl":"https://doi.org/10.15574/pp.2022.89.35","url":null,"abstract":"The article presents data on the main causes of muscle weakness in children and discusses the clinical features of diseases that may be accompanied by muscle weakness. Emphasis is placed on the possibilities of differential diagnosis of muscle weakness syndrome in children through the use of various methods of examination. The algorithm of differential diagnostic search at muscular weakness is offered. The possibility of its application in pediatric practice is demonstrated on clinical examples. Despite certain common features in the onset of the disease in the presented cases, a detailed examination makes it possible to distinguish between congenital and acquired causes of muscle damage and refer the patient for appropriate treatment. It should be noted that muscle weakness is a fairly common symptom in a child. More often it is not associated with damage to the muscles themselves. The causes of chronic weakness differ significantly in children of all ages. In a child with clinical signs of muscle weakness, it is necessary to conduct a thorough examination, aimed primarily at excluding various serious diseases. The research was carried out in accordance with the principles of the Helsinki Declaration. The informed consent of the patient was obtained for conducting the studies. No conflict of interests was declared by the authors. Key words: children, muscle weakness, differential diagnosis.","PeriodicalId":330226,"journal":{"name":"UKRAINIAN JOURNAL OF PERINATOLOGY AND PEDIATRICS","volume":"117 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-03-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"117274234","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}