UKRAINIAN JOURNAL OF PERINATOLOGY AND PEDIATRICS最新文献

{"title":"Implementation of the adapted Grifits scale in the Ukrainian pediatric area","authors":"N. Bedrii, O. Yablon","doi":"10.15574/pp.2022.89.17","DOIUrl":"https://doi.org/10.15574/pp.2022.89.17","url":null,"abstract":"Despite of the lot of development assessment tools during last three decades long-term adverse effects of premature infants and techniques determining the extent of violations, no study has provided a comprehensive overview of these tools, as well as their strengths and weaknesses. In the structure of long-term adverse effects of premature birth remains a high frequency of neurological disorders that require further improvement of diagnostic methods and timely correction to improve the prognosis of further development. Purpose - to improve the long-term effects of preterm birth by using an adapted Griffiths scale in preschool children. Materials and methods. An assessment of the psychomotor development of 105 preschool children was estimated. Assessment of psychomotor development was performed using an adapted Griffiths scale and a well-known method. During the study, this category of children was under the supervision of follow-up doctors to systematically assess their health. Dynamic examination was performed during the first year of life once every 3 months, from the second to the sixth year of life - according to the individual rehabilitation plan. Patients (n=105) were divided into 3 groups depending on the severity of disabling pathology. Results. According to the results of the survey, it can be reveal that more than 70% of respondents had the equivalent of delayed psychomotor development of various patterns. Тhe analysis of the assessment of psychomotor development showed that the structure of the causes of delayed psychomotor development in preschool children has the same trend for different methods of examination, however, the Griffiths Adapted Assessment demonstrates more accurate patient-specific outcomes, allows for the rapid detection of long-term adverse effects of preterm birth, recommendations for infants and families to develop an individual rehabilitation and habilitation program, and examinations in dynamics. Conclusions. It has been established that the adapted Griffiths psychomotor development scale is a valid diagnostic tool in the cohort of preschool children in order to determine psychomotor development indicators, calculate the child's intellectual coefficient and form an individual patient profile. The research was carried out in accordance with the principles of the Helsinki Declaration. The study protocol was approved by the Local ethics committee of the participating institution. The informed consent of the patient was obtained for conducting the studies. No conflict of interests was declared by the authors. Key words: early age children, psychomotor development of preschool children, somatoform disorder, follow-up.","PeriodicalId":330226,"journal":{"name":"UKRAINIAN JOURNAL OF PERINATOLOGY AND PEDIATRICS","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-03-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"129134058","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of antiphospholipid antibodies on the risk of implantation failure after in vitro fertilization","authors":"V. Berestoviy, A. Martych, I. Sokol, O. O. Berestoviy, D. Govsieiev","doi":"10.15574/pp.2021.88.14","DOIUrl":"https://doi.org/10.15574/pp.2021.88.14","url":null,"abstract":"Infertility is a unique pathology because it concerns a couple, not one person, and is the cause of a whole range of medical, social, demographic and economic problems. With the active development of assisted reproductive technologies, the demand for solving the problem of infertility has grown significantly. However, the prevalence of infertility remains stable, indicating many «white» spots in the diagnosis and treatment of this pathology and determining the search for new risk factors, diagnostic criteria, and treatment algorithms. Purpose — to analyze the factors that may affect implantation, namely the presence of lupus anticoagulant and antiphospholipid antibodies in women with infertility who have undergone in vitro fertilization. Materials and methods. A survey of 106 women diagnosed with infertility underwent treatment with assisted reproductive technologies in September 2019 — February 2021. The control (1) group consisted of women who received infertility treatment according to the standard scheme: controlled ovarian stimulation, gamete collection, intracytoplasmic sperm injection and embryo transfer. The main (2) group included patients who received aspirin, anticoagulants, and intravenous IgG immunoglobulins in addition to the standard treatment regimen. In the present study, levels of lupus anticoagulant and antiphospholipid antibodies were determined in both groups. Results. The study found no differences between groups of patients in levels of antibodies (AB) to phospholipids (IgG), beta-2-glycoprotein (IgG, IgM) and lupus anticoagulant (screening, confirmation) in the two groups of patients (p>0.05). Difference in two groups were in levels of AB to beta-2-glycoprotein IgM in controls, on average, 9.42 units/ml (5.86 units/ml — 12.35 units/ml), and in patients of main group — 7.23 units/ml (3.14 units/ml — 10.58 units/ml), p=0.015. One-factor logistic regression models were used to clinically understand the influence of factors associated with the risk of implantation failure. The analysis did not reveal a connection between risk of implantation failure and levels of autoantibodies (aAB) to phospholipids (IgG, IgM), beta-2-glycoprotein (IgG, IgM) and lupus anticoagulant (screening, confirmation) in two groups of patients (p>0.05 in all cases). Conclusions. The presence of aAB and/or antiphospholipid syndrome during the establishment of infertility factors is an essential component of the algorithm for diagnostic search for the cause of infertility and miscarriage. However, based on the obtained data, the presence of aAB in the study does not affect the implantation process nor affects the treatment of infertility. The research was carried out in accordance with the principles of the Helsinki declaration. The study protocol was approved by the Local Ethics Committee of the participating institution. The informed consent of the patient was obtained for conducting the studies. No conflict of interest was declared by the authors. Key ","PeriodicalId":330226,"journal":{"name":"UKRAINIAN JOURNAL OF PERINATOLOGY AND PEDIATRICS","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130743154","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical features of measles in children under 3 years","authors":"Y. Kharchenko, A. Zaretska, H. Pitel, V.Y. Il'ina-Stohnienko, V. A. Tselukh","doi":"10.15574/pp.2021.88.78","DOIUrl":"https://doi.org/10.15574/pp.2021.88.78","url":null,"abstract":"Measles occurs at any age. Outbreaks appear to be exacerbated during periods of low vaccination coverage. In Ukraine in 2016, the level of vaccinations with the first dose was only in 45% of children, and the second — in 31%. Thus, during 2017 only in the Odessa region the number of measles patients reached 1 016. The purpose was to identify the features of the clinical course of measles in young children and infants. Materials and methods. A retrospective study of the medical histories of 111 young children, 68 of them in the first year of life. Results. Measles in children 3 years old retains the typical features of acute onset, manifestations of intoxication (71.82%), fever (99.09%), cough (94.55%), catarrhal phenomena and rash. At the same time, rhinitis (95.59%) and puffiness of the face (100%) are characteristic of children under one year compared with children 1–3 years (51.16% and 58.14%, respectively) p<0.001. Measles severity depends on the age of the child (in children (35.29%) younger than 12 months there was a severe course, and in (55.62%) children younger than 6 months). Complications were found in (44.14%) children. Among them, pneumonia (32.35%) is more common in children under 1 year of age, bronchitis (18.6%) and pneumonia (16.28%) in children aged 1–3 years are approximately the same in frequency. Otitis media (7.35%) was found only in children under 12 months. Conclusions. Thus, the clinical manifestations, severity and complications of measles depend on the age of the child, and the presence of children less than 6 months (28.81%) indicates the existence of a non3immune layer among women of childbearing age. The research was carried out in accordance with the principles of the Helsinki Declaration. The study protocol was approved by the Local ethics committee of the participating institution. The informed consent of the patient was obtained for conducting the studies. No conflict of interest was declared by the authors. Key words: measles, complications, young children, infants.","PeriodicalId":330226,"journal":{"name":"UKRAINIAN JOURNAL OF PERINATOLOGY AND PEDIATRICS","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"128254802","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Changes in systems: lipid and carbohydrate metabolism in pregnant women with different forms of infertility in history","authors":"E. Kolomiiets","doi":"10.15574/pp.2021.88.19","DOIUrl":"https://doi.org/10.15574/pp.2021.88.19","url":null,"abstract":"The most significant changes in lipid and carbohydrate exchange systems were in women with a history of endocrine and combined infertility, which is explained by their presence of risk factors, namely age, PCOS, an increased frequency of somatic pathology (metabolic syndrome, obesity, insulin resistance) complicated by the course of pregnancy. Purpose — to study changes in systems: lipid and carbohydrate metabolism in pregnant women with various forms of infertility. Materials and methods. Changes in systems were studied: lipid and carbohydrate metabolism in 127 pregnant women with various types of infertility. The distribution of pregnant women to groups is based on infertility factor: group I — 35 pregnant women with a history of endocrine infertility, group II — 37 pregnant women with a history of infertility of trumpe-peritoneal genesis, group III — 30 pregnant women with a history of combined infertility: trumpe-peritoneal genesis with endocrine, control group (IV) — 25 healthy pregnant women who did not have a history of infertility. To assess metabolic disorders, all women were measured for BP, blood levels were determined: glucose and HOMA (Homeostasis Model Assesment) index, triglycerides and high3density lipoproteins. Used: immunochemiluminescent, enzymatic colorimetric and kinetic enzymatic method. The validity for relative values was evaluated by the Fisher angular transform method. Results. Examining plasma glucose measurement data in women with different types of infertility by groups in the I and III trimesters found that in the I group, increased rates were in 5 (14.3%) patients in the I trimester and in 9 (25.7%) in the III trimester; in group III, 3 (10%) patients in the I trimester and 10 (33.3%) in the III trimester; while elevated blood sugar levels in group II women were in 3 (10%) patients in the I trimester and 10 (33.3%) in the III trimester, and in group IV none had elevated glucose levels in the I trimester and in 1 (8%) patient it increased in the III trimester. Determining the HOMA index in women with different types of infertility by groups in the I and III trimesters found that in the I group, increased rates were in 4 (11.4%) patients in the I trimester and in 5 (14.3%) in the III trimester; in group III in 3 (10%) patients in the I trimester and in 4 (13.3%) in the III trimester; while the indicator of the HOMA index in group II women did not change, both in the I trimester and III trimester and amounted to — 1 (2.7%), and in group IV no one had an increased HOMA index, both in the I trimester and III trimester. Analyzing high3density lipoprotein (HDL) measurement data in women with different types of infertility by groups in the I and III trimesters, it turned out that in the I group, 2 (5.7%) patients in the I trimester and 4 (11.4%) in the III trimester had increased rates; in group III in 3 (10.0%) patients in the I trimester and in 6 (20.0%) in the III trimester; while the HDL in women of group II did not cha","PeriodicalId":330226,"journal":{"name":"UKRAINIAN JOURNAL OF PERINATOLOGY AND PEDIATRICS","volume":"63 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"124781693","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Immunopathological value of interleukin-1β and interleukin-10 in lark fluid in children under 15 months","authors":"G.V. Velieva, M. Sultanova, S. Guseynova","doi":"10.15574/pp.2021.88.32","DOIUrl":"https://doi.org/10.15574/pp.2021.88.32","url":null,"abstract":"Purpose — to determinate local immunity of the organ of vision in dacryocystitis in children under 15 months, study the effect of a microbiological preparation containing Escherichia Coli and Enterococcus faecalis (probiotics — Symbioflor) on it, as well as determinate the effectiveness of treatment with these drugs. Materials and methods. Were studied immunograms in children under 15 months of age. Lacrimal fluid was collected using microcapillary pipettes to collect biological fluid. The study patients had not previously received any eye drops one week prior to tear collection and no therapeutic treatment. We examined 74 children, divided according to age, gender and diagnosis into two groups: group 1 (healthy). 18 somatically relatively healthy children without identified ophthalmological problems; group 2 (patients) — 56 somatically relatively healthy children with a confirmed diagnosis of neonatal dacryocystitis Each group is divided into three groups (up to 6 months, 7–12 months, 13–15 months). All patients underwent general clinical laboratory research. Results and conclusions. In patients with neonatal dacryocystitis, the content of IL-1β in the lacrimal fluid is significantly higher than normal values, and IL-10 is below the age norm. The use of probiotics makes it possible to stabilize the content of IL-1β in the tears of patients with dacryocystitis of newborns. The use of this class of drugs does not affect the composition of the tears of healthy children, no changes are observed. The use of probiotics can be recommended in the complex treatment of neonatal dacryocystitis, since the drug is safe and helps to stabilize the local immunity of the conjunctival cavity. The research was carried out in accordance with the principles of the Helsinki Declaration. The study protocol was approved by the Local ethics committee of the participating institution. The informed consent of the patient was obtained for conducting the studies. No conflict of interest was declared by the authors. Key words: interleukin-1β, interleukin-10, regulation of inflammation.","PeriodicalId":330226,"journal":{"name":"UKRAINIAN JOURNAL OF PERINATOLOGY AND PEDIATRICS","volume":"8 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"121217262","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Congenital nephrotic syndrome in the practice of a neonatologist (clinical case)","authors":"O. Koloskova, L. Kolyubakina, O. Vlasova, N. Kretsu, I. Lastivka, L. F. Balytska","doi":"10.15574/pp.2021.88.72","DOIUrl":"https://doi.org/10.15574/pp.2021.88.72","url":null,"abstract":"Congenital nephrotic syndrome (CNS) is an inherited disease that is caused by gene mutations and is inherited by an autosomal-recessive mechanism. In most cases, it is associated with genetically mediated defects in the components of the glomerular filtration barrier, especially nephrine and podocytes, with a typical histological picture of diffuse mesenteric sclerosis or focal-segmental glomerulosclerosis. According to genetic research, the primary CNS caused by gene mutations in one of the five genes (NPHS1, NPHS2, WT1, LAMB2, PLCE1) or chromosomal abnormalities. Secondary CNS is combined with other diseases of systemic or renal origin. The onset of the disease manifestation is possible in the antenatal period or during the first three months of life. CNS is manifested by significant hypoproteinemia, proteinuria and diffuse edema. Treatment of congenital nephrotic syndrome is mainly symptomatic therapy, such as: control of edema, azotemia, thyroid function, prevention and treatment of secondary complications (infections and thrombosis). Molecular genetic testing is the «gold» standard for genotyping of this disease. The course of СNS is unfavorable due to the rapid development of end3stage chronic renal failure. The purpose of article is to expand the knowledge of pediatricians and neonatologists about the clinical, laboratory, instrumental and pathomorphological features of Finnish type of СNS in the neonatal age. Clinical case. The article presents clinical, laboratory, instrumental, pathomorphological and molecular-genetic features of the Finnish type of CNS with the manifestation in the early neonatal period. Conclusions. The example of this case shows the necessity of a comprehensive approach at the examination of children suffered from CNS to verify the type of disease, determine the prognosis and treatment tactics. The research was carried out in accordance with the principles of the Helsinki declaration. The informed consent of the patient was obtained for conducting the studies. No conflict of interest was declared by the authors. Key words: congenital nephrotic syndrome, newborn, molecular genetic testing.","PeriodicalId":330226,"journal":{"name":"UKRAINIAN JOURNAL OF PERINATOLOGY AND PEDIATRICS","volume":"29 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"122269713","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical and therapeutic aspects of sickle cell disease in three clinical cases","authors":"S. Aggoune","doi":"10.15574/pp.2021.88.66","DOIUrl":"https://doi.org/10.15574/pp.2021.88.66","url":null,"abstract":"One of the reasons of high pediatric mortality in developing countries, sickle cell disease is gradually emerging and is becoming a public health problem in many countries where it is rife. In Algeria the incidence is 2.7%. The management of sickle cell disease is increasingly better codified now thanks to better knowledge of the condition. It takes into account not only currently accepted universal principles but also the realities specific to our country. Purpose: to share with health care professionals our therapeutic attitude during main acute complications as well as during the inter3critical phase of sickle cell disease in Algerian children. Clinical cases. In this article, we presented three clinical cases concerning two adolescents and a two3year3old infant, carriers of major sickle cell syndrome, who were hospitalized for severe forms. Conclusions. Providing right care for children with sickle cell disease could help prevent or improve many complications associated with this disease and allow them to lead healthier and more productive lives. Our patients were presented late. These cases revealed the problematic nature of early diagnosis, regular follow-up and early detection of complications in SCD patients especially with asymptomatic osteonecrosis of the femoral head. The research was carried out in accordance with the principles of the Helsinki declaration. The informed consent of the patients was obtained for conducting the studies. No conflict of interest was declared by the author. Keywords: sickle cell disease, acute anemia, stroke, osteonecrosis.","PeriodicalId":330226,"journal":{"name":"UKRAINIAN JOURNAL OF PERINATOLOGY AND PEDIATRICS","volume":"84 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134302480","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Тhe problem of the origin and prevalence of halitosis in teenagers and young adults who smoke","authors":"I. Lisecka, M. Rozhko","doi":"10.15574/pp.2021.88.39","DOIUrl":"https://doi.org/10.15574/pp.2021.88.39","url":null,"abstract":"Today, halitosis is a common pathology, which ranks third among dental diseases and remains a serious medical and dental problem. Smoking due to its high prevalence and harmful effects on the health of adolescents and young people is a major problem, both in our country and abroad, due to the widespread spread of this harmful habit. The impact on the organs of the oral cavity, the development of pathological conditions, including halitosis, depends on the intensity, duration and type of smoking, as well as on individual morphofunctional features of oral tissues that are genetically determined. It is known that smoking adversely affects the biophysical properties of oral fluid, non3specific protective factors, immune responses, the condition of the oral mucosa, impairs hygiene, etc., which together leads to quantitative and qualitative changes in microbial biofilm and can cause halitosis. Purpose — to study the prevalence of halitosis in adolescents and adolescents who smoke. Materials and methods. Were examined, conducted a questionnaire, which included the presence of bad breath and the causes of its occurrence, determining the state of oral hygiene using the Green Vermilion index, hardware diagnostic test for halitosis with a Tanita halimmeter «Breath Alert» for 114 adolescents and young people aged 15 to 24, who were divided into groups: Group I involved 26 people who regularly smoke traditional cigarettes; to the second group — 22 people who regularly smoke electronic cigarettes (Vapi); to group III — 23 people who regularly smoke tobacco heating devices (IQOS); to group IV — 43 people without a bad habit of smoking. Results. Analysis of oral hygiene in the respondents showed that the structure of the OHI-S index showed the worst performance in adolescents and adolescents who smoke traditional cigarettes and looked like this: in the first group of respondents found poor oral hygiene OHI-S was equal to (1.77±0.02) points. The state of hygiene of RP in adolescents and adolescents who smoke alternative cigarettes corresponded to a satisfactory level, which was confirmed by the value of the OHI-S index, respectively, in subjects of group II — (1.53±0.01) and in subjects of group III — (1.46±0.02) points. In the surveyed group IV, the state of hygiene of the RP was also satisfactory, but the index was much lower — (0.87±0.03) points. As for the registration of unpleasant odor, the hardware diagnostic test mainly revealed halitosis in persons of group I, namely in 64% of persons. In the rest of the examined halitosis was detected much less often: in persons of group II — in 12%, in persons of group III — in 8%, in persons of group IV — in 2%. It should be noted that moderate halitosis was detected only in persons of group I — 26%, mild halitosis was registered in 38%. Mild halitosis was reported in the remaining comparison groups. Conclusions. Halitosis is an important and urgent medical and social problem, as it was found in almost half of the sur","PeriodicalId":330226,"journal":{"name":"UKRAINIAN JOURNAL OF PERINATOLOGY AND PEDIATRICS","volume":"5 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"121245809","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Contraverted questions of management of pregnancy with immune thrombocytopenia","authors":"O.M. Naumchyk, I. Davydova, A.Iu. Lymanska","doi":"10.15574/pp.2021.88.52","DOIUrl":"https://doi.org/10.15574/pp.2021.88.52","url":null,"abstract":"Among autoimmune cytopenias during pregnancy, immune thrombocytopenia (ITP) occurs most often. Thrombocytopenia (TP), a decrease in platelet count less than 150x109/l, occurs in 5 to 12% of pregnancies. Immune thrombocytopenia is a diagnosis of exclusion and requires differential diagnosis primarily with gestational TP. Preconception counseling is extremely important in ITP to develop an individual pregnancy management plan. Prediction and calculation of antero-, perinatal and obstetric risks for the fetus and pregnant woman should be performed repeatedly during pregnancy. The choice of the time of initiation of therapy and the type of medication is not clear due to the specificity of the drugs and the possible impact on the fetus. The issue of neonatal severe thrombocytopenia and hemorrhagic complications that may occur at the antenatal stage in some cases is not explained by maternal immune thrombocytopenia, and fetal3neonatal alloimmune thrombocytopenia (FNAT). An unambiguous guide to the prevention and management of cases with FNAT has not been developed at present. We have highlighted current global trends on this issue. Pregnant women with severe TP are a group of high perinatal risk, pregnancy and childbirth should take place in a maternity hospital of III level with the involvement of a multidisciplinary team and an individual plan of pregnancy management, development of delivery and management of postpartum and neonatal periods. The research was carried out in accordance with the principles of the Helsinki declaration. The study protocol was approved by the Local Ethics Committee of the participating institution. The informed consent of the patient was obtained for conducting the studies. No conflict of interest was declared by the authors. Key words: immune thrombocytopenia, pregnancy, fetal-neonatal alloimmune thrombocytopenia, gestational thrombocytopenia.","PeriodicalId":330226,"journal":{"name":"UKRAINIAN JOURNAL OF PERINATOLOGY AND PEDIATRICS","volume":"118 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"122061877","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Modern strategies of prophylaxis of chasse of cervix of the uterus. Realities of present time (literature review)","authors":"V. Kondratiuk, N.Ie. Horban, N. Koblosh","doi":"10.15574/pp.2021.88.60","DOIUrl":"https://doi.org/10.15574/pp.2021.88.60","url":null,"abstract":"The role of human papilloma virus in the development of cervical cancer and other diseases of the anogenital area is proven and well known. Despite this, there is an annual increase in the incidence of cervical cancer. Cervical cancer screening is a population-based set of organizational and medical measures aimed at early detection of precancerous and tumorous diseases of the cervix and to reduce mortality in this group of patients. After the discovery of the viral nature of cervical cancer and the introduction of a number of methods to detect human papilloma virus — HPV testing has become important. Diagnosis of cancer in the early stages increases the likelihood of an effective response to organ-sparing surgical treatment, increases the patient's chances of survival and allows the use of less expensive treatments. HPV screening is sensitive not only to the detection of precancerous diseases, but also significantly reduces the incidence and mortality from cervical cancer, which is the main indicator of its effectiveness. However, specific antiviral treatments for human papillomavirus have not been developed, and vaccination is the only effective way to prevent cervical cancer and other associated diseases. The prevalence of papillomavirus infection has increased more than 10-fold in the last decade. One of the key points in cervical cancer prevention is vaccination. Routine HPV vaccination is recommended at the age of 11–12 years and can also be given from the age of 9; vaccination is recommended for all people under the age of 26 who did not pass the procedure on time; when vaccinating persons <15 years of age, it is recommended to administer the vaccine according to a 2-dose schedule. Individuals with human immunodeficiency virus and other immunosuppressed conditions should receive a 3-dose vaccination. In countries where human papillomavirus vaccination is widely used, the incidence rates show a decrease in the incidence of cervical cancer. The coronavirus pandemic threatens to disrupt vaccination against human viral papilloma in low- and middle-income countries, which negatively affects the strategy to eliminate cervical cancer. The WHO Global Response to the COVID Pandemic has been a catalyst for innovation and adaptation at the health system level that can be used to improve access to and dissemination of information in the context of HPV vaccination and cervical cancer screening. No conflict of interest was declared by the authors. Key words: human papilloma virus, cervical cancer, vaccination, cornavirus disease.","PeriodicalId":330226,"journal":{"name":"UKRAINIAN JOURNAL OF PERINATOLOGY AND PEDIATRICS","volume":"131 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"128067978","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}