Indonesian Journal of Rheumatology最新文献_第2页

Characteristics and Treatment Responses of Rheumatoid Arthritis Patients at Dr. Cipto Mangunkusumo National General Hospital Cipto Mangunkusumo 医生国立综合医院类风湿关节炎患者的特征和治疗反应

Indonesian Journal of Rheumatology Pub Date : 2023-12-19 DOI: 10.37275/ijr.v15i2.252

Rudy Hidayat, Sumariyono, RM Suryo, Anggoro Kusumo Wibowo, A. Ariane, Faisal Parlindungan, Johanda Damanik, A. P. Araminta, Article Info

{"title":"Characteristics and Treatment Responses of Rheumatoid Arthritis Patients at Dr. Cipto Mangunkusumo National General Hospital","authors":"Rudy Hidayat, Sumariyono, RM Suryo, Anggoro Kusumo Wibowo, A. Ariane, Faisal Parlindungan, Johanda Damanik, A. P. Araminta, Article Info","doi":"10.37275/ijr.v15i2.252","DOIUrl":"https://doi.org/10.37275/ijr.v15i2.252","url":null,"abstract":"Introduction: Rheumatoid arthritis (RA) is a chronic progressive autoimmune rheumatic disease that primarily affects the joints. The goal of RA treatment is to achieve remission or low disease activity, using a treat-to-target approach. This study aims to explore the characteristics of RA patients and evaluate their treatment responses in Dr. Cipto Mangunkusumo National General Hospital (RSCM). Methods: This cross-sectional study is conducted by collecting demographic and clinical data, as well as interviewing adult patients that have been diagnosed with RA at the Rheumatology Clinic of RSCM and have been on disease-modifying antirheumatic drugs (DMARD) treatment for a minimum of 6 months.Results: A total of 94 patients were included in this study. Subjects were predominantly female (93.6%) and had no formal jobs (64.9%). A majority of RA patients exhibited moderate disease activity (48.9%, based on Disease Activity Score-28 with erythrocyte sedimentation rate [DAS-28 ESR]), with a relatively high level of steroid use (86.2%). Notably, most patients started DMARD treatment more than 2 years after the onset of symptoms (45.7%). The proportion of patients achieving therapy target (remission to low disease activity) was 41.5%, with 13.8% attaining remission. Furthermore, Health Assessment Quality (HAQ) scores were found to be significantly lower among the target-achieving group, indicating better quality of life.Conclusion: Therapy target was achieved in 41.5% of RA patients in RSCM, with 13.8% achieving remission. Further research can be conducted to evaluate factors which may affect treatment response among RA patients.","PeriodicalId":32894,"journal":{"name":"Indonesian Journal of Rheumatology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-12-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138962742","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Indonesian Rheumatology Association (IRA) Recommendations for Diagnosis and Management of Sjogren’s Syndrome 印度尼西亚风湿病学协会（IRA）关于诊断和管理斯约格伦综合征的建议

Indonesian Journal of Rheumatology Pub Date : 2023-12-19 DOI: 10.37275/ijr.v15i2.245

Deddy Nur, Wachid Achadiono, A. Nurudhin, I. N. Suarjana, Lisa Kurnia, Dwi Budi Darmawati, S. Langow, H. Isbagio, H. Kalim, Rudy Hidayat, L. Hamijoyo, Cesarius Singgih, Wahono, Sumariyono, Article Info

{"title":"Indonesian Rheumatology Association (IRA) Recommendations for Diagnosis and Management of Sjogren’s Syndrome","authors":"Deddy Nur, Wachid Achadiono, A. Nurudhin, I. N. Suarjana, Lisa Kurnia, Dwi Budi Darmawati, S. Langow, H. Isbagio, H. Kalim, Rudy Hidayat, L. Hamijoyo, Cesarius Singgih, Wahono, Sumariyono, Article Info","doi":"10.37275/ijr.v15i2.245","DOIUrl":"https://doi.org/10.37275/ijr.v15i2.245","url":null,"abstract":"Background. Sjogren’s syndrome (SS) is a systemic autoimmune disease that affects exocrine glands. Dealing with SS is challenging due to the low level of awareness and knowledge about SS, as well as the difficulty in diagnosing and treating the disease. Diagnosing SS requires many supporting examinations from many medical specialties. Therefore, these recommendations were developed to serve as a guide for health practitioners in diagnosing and treating SS. \u0000Methods. Six selected rheumatologists from the Indonesian Rheumatologist Association (IRA) formulated the recommendations based on key questions formed by a steering committee from IRA. These recommendation materials were taken from several online databases such as PubMed, Science Direct, and Google Scholar. Level of evidence and grades of recommendation were then assigned, and every member of the panellist team will assign a score for level of agreement. \u0000Results. The panel generated a total of 19 recommendations discussing the diagnosis, pharmacological and non-pharmacological therapy, and prognosis for SS. \u0000Conclusion. These recommendations can be used to help clinicians correctly diagnose and choose the most suitable therapy for SS patients. All recommendation statements were created with the consideration of Indonesia’s clinical setting, facility, and drug availability.","PeriodicalId":32894,"journal":{"name":"Indonesian Journal of Rheumatology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-12-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138960678","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Use of Methotrexate for More Than 4 Years Is Not Associated with Liver Fibrosis in Rheumatoid Arthritis Patients 使用甲氨蝶呤超过 4 年与类风湿关节炎患者肝纤维化无关

Indonesian Journal of Rheumatology Pub Date : 2023-12-19 DOI: 10.37275/ijr.v15i2.246

Tati Muliani, L. Hamijoyo, N. Agustanti

{"title":"Use of Methotrexate for More Than 4 Years Is Not Associated with Liver Fibrosis in Rheumatoid Arthritis Patients","authors":"Tati Muliani, L. Hamijoyo, N. Agustanti","doi":"10.37275/ijr.v15i2.246","DOIUrl":"https://doi.org/10.37275/ijr.v15i2.246","url":null,"abstract":"Background. Methotrexate is an anchor drug in the management of rheumatoid arthritis (RA). However, the association between methotrexate and development of liver fibrosis remains a subject of controversy. Non-invasive methods to assess liver fibrosis, such as the FIB-4 score, have been developed. RA patients on methotrexate therapy should be monitored for any signs of liver fibrosis. This study aims to investigate the correlation between methotrexate cumulative dose and the FIB-4 score in rheumatoid arthritis patients who received methotrexate therapy to assess the hepatotoxic effects of methotrexate. \u0000Methods. This cross-sectional study involved rheumatoid arthritis patients who received methotrexate therapy at Dr. Hasan Sadikin General Hospital Bandung from September 2022 to November 2022. Clinical data, laboratory tests (including platelet values and liver function test), and cumulative methotrexate doses were extracted from medical records. Data were analyzed using the Spearman correlation test. \u0000Results. This study involved 100 subjects aged between 22-82 years, comprising 93% women and 7% men. The median FIB-4 score was 0.73 (0.24-6.80), while the median methotrexate cumulative dose was 2477.5 mg, with a range of 1005-10400 mg. The results showed that correlation coefficient between the FIB-4 score and methotrexate cumulative dose in rheumatoid arthritis patients was -0.089 (p=0.378). \u0000Conclusion. There is no significant correlation between FIB-4 score and cumulative dose of methotrexate in rheumatoid arthritis patients. The use of methotrexate in RA patients over 4 years is relatively safe as it does not increase the risk of liver fibrosis.","PeriodicalId":32894,"journal":{"name":"Indonesian Journal of Rheumatology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-12-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138960714","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effect of Vitamin D Supplementation on Regulatory T Cells of Systemic Lupus Erythematosus: A Systematic Review 补充维生素 D 对系统性红斑狼疮调节性 T 细胞的影响：系统综述

Indonesian Journal of Rheumatology Pub Date : 2023-12-19 DOI: 10.37275/ijr.v15i2.251

R. U. Partan, K. Murti, Zen Hafy, Article Info, Yuniza Yuniza

引用次数: 0

Comparison of the Effectiveness of Chewing Manalagi Apples (Malus sylvestris) and Green Melon (Cucumis melo L.) as Self-Cleansing Regarding Changes in the Debris Index on Dentistry Students of Universitas Prima Indonesia 比较咀嚼马纳拉基苹果（Malus sylvestris）和青瓜（Cucumis melo L.）作为自我清洁剂对印度尼西亚第一大学牙科学生碎屑指数变化的效果

Indonesian Journal of Rheumatology Pub Date : 2023-11-28 DOI: 10.37275/ijr.v13i3.267

Susiani Tarigan, Firdha Muharraran, Alisya Anjani

{"title":"Comparison of the Effectiveness of Chewing Manalagi Apples (Malus sylvestris) and Green Melon (Cucumis melo L.) as Self-Cleansing Regarding Changes in the Debris Index on Dentistry Students of Universitas Prima Indonesia","authors":"Susiani Tarigan, Firdha Muharraran, Alisya Anjani","doi":"10.37275/ijr.v13i3.267","DOIUrl":"https://doi.org/10.37275/ijr.v13i3.267","url":null,"abstract":"Introduction: Problems regarding dental and oral health have an important influence on overall health. Accumulation of food waste is a key factor in this influence on dental and oral health, and poor oral hygiene can cause periodontal problems and dental tissue disorders. This study aimed to compare the effectiveness of chewing manalagi apples and green melons in cleaning dental debris on dentistry students of Universitas Prima Indonesia. Methods: The research used various materials such as disclosing solutions to identify debris, biscuits chewed by the samples, and two types of fruit, namely manalagi apples and green melons. The research design involved a pre-test and post-test with an experiment for the sample group, without a comparison group. Results: The study showed that consuming manalagi apples was more effective in cleaning dental debris than green melons. This difference is significant with a value of p = 0.000. Conclusion: Manalagi apples have better potential to improve self-cleaning of the oral cavity, which contributes to overall dental and oral health.","PeriodicalId":32894,"journal":{"name":"Indonesian Journal of Rheumatology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-11-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139224824","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Embryonal Rhabdomyosarcoma: Rare Case Reports with Middle Ear Location 胚胎性横纹肌肉瘤:中耳少见病例报告

Indonesian Journal of Rheumatology Pub Date : 2023-11-03 DOI: 10.37275/ijr.v13i3.264

Runky Pebranka, None Salmiah Agus, None Yessy Setiawati

{"title":"Embryonal Rhabdomyosarcoma: Rare Case Reports with Middle Ear Location","authors":"Runky Pebranka, None Salmiah Agus, None Yessy Setiawati","doi":"10.37275/ijr.v13i3.264","DOIUrl":"https://doi.org/10.37275/ijr.v13i3.264","url":null,"abstract":"Background: Patients with embryonal rhabdomyosarcoma (EMRS) are dominated by boys. The peak incidence occurs in the small age group from one year to 4 years. Approximately 35% of all pediatric RMS occur in the head and neck. Case presentation: A 3-year-old male patient came to the ear, nose, throat-head neck (ENT-HNS) polyclinic at Dr. M. Djamil General Hospital Padang on February 25th, 2021, with complaints of a lump appearing in his right ear canal for 4 months. The patient also complained of slanting on the right side of his face and pain in his right ear since 2 weeks ago. History of bleeding from the ear 1 week ago. On the examination of House-Brackmann, the patient obtained a category House-Brackmann V. Histopathological results, microscopically visible pieces of tissue with part of the surface covered with keratinized squamous epithelium, part of the surface not keratinized. There are dense groups consisting of a proliferation of cells with round, oval nuclei, small to medium size, little cytoplasm, some cells with pleomorphic nuclei, hyperchromatic, irregular nuclear membranes, lots of eosinophilic cytoplasms, with the appearance of \"tadpole”, atypical mitoses may be found. The underlying tissue stroma appears myxoid. Among them, fibrotic connective tissue septa containing partially hyperemic capillaries are visible. Necrotic areas and clusters of PMN leukocytes and cellular debris were also seen. This description is consistent with EMRS. Conclusion: The patient was diagnosed with right middle ear EMRS stage III with right peripheral facial nerve paresis House-Brackmann V.","PeriodicalId":32894,"journal":{"name":"Indonesian Journal of Rheumatology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-11-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135873423","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Critical Care Management of Myasthenic Crisis: A Case Report 重症肌无力危象的重症监护管理1例报告

Indonesian Journal of Rheumatology Pub Date : 2023-11-02 DOI: 10.37275/ijr.v13i3.263

Liliriawati Ananta Kahar

引用次数: 0

Post Operative Management in Intensive Care of Obstructive Jaundice caused by Choledocholithiasis: A Case Report 胆总管结石致梗阻性黄疸重症监护术后处理1例

Indonesian Journal of Rheumatology Pub Date : 2023-10-09 DOI: 10.37275/ijr.v13i3.257

Liliriawati Ananta Kahar, None Wiwi Monika Sari

{"title":"Post Operative Management in Intensive Care of Obstructive Jaundice caused by Choledocholithiasis: A Case Report","authors":"Liliriawati Ananta Kahar, None Wiwi Monika Sari","doi":"10.37275/ijr.v13i3.257","DOIUrl":"https://doi.org/10.37275/ijr.v13i3.257","url":null,"abstract":"Introduction: Gallstones are a very common problem in the global population. 10%-25% of affected people may have specific symptoms, and 1%-2% of them may experience major complications. Case presentation: 83-year-old female patient complained of yellow in her eyes and skin. Patients also felt pain in the right upper abdomen. Laboratory examination revealed increased bilirubin serum. Abdominal Ultrasound examination showed Obstruction of the Bilier Ductus caused by a stone at ductus sisticus and sludge of the gallbladder. The patient was diagnosed with Jaundice obstruction caused by obstruction of the bile ducts due to a stone at the ductus sisticus with a history of nephrectomy, Hypertension, and type 2 diabetes. The patient underwent Laparoscopic cholecystectomy, ERCP, and stent biller, After the procedure, the patient was admitted to the intensive care unit. Conclusion: Understanding the patient's comprehensive medical and surgical history is fundamental in understanding the postoperative patient in the intensive care unit. Adequate resuscitation is necessary for good clinical perfusion and physiological stability of the patient.","PeriodicalId":32894,"journal":{"name":"Indonesian Journal of Rheumatology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135045098","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Correlation between Uric Acid Levels and the Severity of Psoriasis Vulgaris Patients 尿酸水平与寻常型银屑病患者病情严重程度的相关性

Indonesian Journal of Rheumatology Pub Date : 2023-08-28 DOI: 10.37275/ijr.v13i3.248

Pristia Widya, N. Mulianto

{"title":"Correlation between Uric Acid Levels and the Severity of Psoriasis Vulgaris Patients","authors":"Pristia Widya, N. Mulianto","doi":"10.37275/ijr.v13i3.248","DOIUrl":"https://doi.org/10.37275/ijr.v13i3.248","url":null,"abstract":"Introduction: Psoriasis vulgaris (PV) is a recurrent chronic inflammatory skin disease characterized by erythematous, scaly, well-defined plaques with the greatest predilection, generally in the areas of the elbows, knees, scalp, and lower back. The psoriasis area and severity index (PASI) is one of the most widely used evaluation tools to determine the development of psoriasis vulgaris in a patient. Hyperuricemia is the dominant risk factor for PV when compared to other known risk factors, such as obesity or metabolic syndrome. This study aimed to determine whether there is a relationship between serum uric acid levels and the severity of PV based on the PASI score. \u0000Methods: Cross-sectional study with one-time sampling conducted from December 2021 to February 2022 in psoriasis vulgaris patients who came to the Dermatology and Venereology clinic at Dr. Moewardi General Hospital, Surakarta, Indonesia. All data were statistically analyzed using SPSS 26. Variables, including age, gender, disease duration, body mass index, and uric acid levels, were subjected to univariate analysis. Bivariate analysis was then followed by a parametric test. The p-value <0.05 was considered significant. \u0000Results: There were 36 patients during the study period. The average uric acid level was 6.0135, with an average PASI score of 10.6388. The relationship between uric acid levels and the severity of psoriasis vulgaris was found to be significant, with a value of p = 0.025. \u0000Conclusion: There is a significant relationship between uric acid levels and the severity of psoriasis vulgaris, where the higher the uric acid level, the more severe the severity of psoriasis vulgaris.","PeriodicalId":32894,"journal":{"name":"Indonesian Journal of Rheumatology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-08-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46943365","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Single Case Experience of Immunosuppressant Administration to Systemic Sclerosis-ILD Patients with Aspergilloma 免疫抑制剂治疗系统性硬化症- ild伴曲霉菌瘤患者的单例体会

Indonesian Journal of Rheumatology Pub Date : 2022-07-12 DOI: 10.37275/ijr.v14i1.197

Wilujeng Anggraini, Perdana Rahman

{"title":"Single Case Experience of Immunosuppressant Administration to Systemic Sclerosis-ILD Patients with Aspergilloma","authors":"Wilujeng Anggraini, Perdana Rahman","doi":"10.37275/ijr.v14i1.197","DOIUrl":"https://doi.org/10.37275/ijr.v14i1.197","url":null,"abstract":"Background: Systemic sclerosis (SSc) is a chronic autoimmune disease that still poses a great challenge to clinicians. SSc is characterized by immune dysregulation and progressive fibrosis that typically affects variable internal organ involvement such as lungs. Interstitial lung disease (ILD) is a common manifestation of SSc and a leading cause of death. The immunosuppressive drug is the main treatment to suppress the inflammation process in SSc. \u0000Case presentation: In this case we report a 40-year-old female to suffer ILD-SSc. According to High-Resolution Computed Tomography (HRCT) thorax, we found that it was interstitial lung disease with aspergilloma. She got methylprednisolone 3x8 mg and azathioprine 2x50 mg. At the end of the treatment, the patient showed improvement in her clinical condition and showed no worsening condition in the HRCT evaluation for her fungal aspergilloma. \u0000Conclusion: Systemic sclerosis (SSc) is a rare autoimmune disease involving the skin and internal organs. The immunosuppressive agent is still the drug of choice for most autoimmune diseases. Immunosuppressive may promote fungal growth and have been associated with increased risk in most serious fungal diseases including aspergilloma.","PeriodicalId":32894,"journal":{"name":"Indonesian Journal of Rheumatology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-07-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47892145","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0