Ukrainian Pulmonology Journal最新文献

{"title":"THE HISTORY OF THE STUDY OF PULMONARY EMPHYSEMA AS A NOSOLOGICAL FORM (A LITERATURE REVIEW)","authors":"Y. Feshchenko, M. Polianska, V. I. Korzhov, V. Yachnyk, S. Opimakh","doi":"10.31215/2306-4927-2023-31-1-42-48","DOIUrl":"https://doi.org/10.31215/2306-4927-2023-31-1-42-48","url":null,"abstract":"The issue of the nosology of pulmonary emphysema in adults was uncertain for a long time. According to all international and Ukrainian clinical guidelines and majority of scientific search systems, pulmonary emphysema is considered within the chronic obstructive pulmonary disease (COPD). However, in the International Statistical Classification of Diseases and Related Health Care Problems (ICD), pulmonary emphysema was put into a section separate from COPD. The aim of this study was to follow the history of pulmonary emphysema research in terms of its nosological affiliation according to the literature data. The first publications on pathological inflation of the lungs were dated back to 1679 and 1769. In 1821 the term \"pulmonary emphysema\" was introduced. In the 19th century emphysema was associated with asthma and bronchitis. In the first internationally recognized classification of diseases in 1900, emphysema was associated with asthma. In the period from 1909 till 1948, pulmonary emphysema was classified as a separate nosological form. In the middle of the last century the practitioners from different countries equally used the terms chronic bronchitis, or asthma or emphysema (\"British bronchitis\" and \"American emphysema\"). The grounds of the modern understanding of pulmonary emphysema were created in 1958, when CIBA Guest Symposium experts noted that emphysema was a lung condition characterized by an abnormal increase in the size of the air spaces distal to the terminal bronchioles due to dilatation or destruction of their walls and it is morphological concept. Due to the variety of clinical and pathological syndromes, emphysema could not be considered as a separate entity with homogeneous clinical, radiological or functional signs, therefore, according to CIBA Guest Symposium, it was not possible to use the term \"emphysema\" as the name of the disease. Today, pulmonary emphysema is defined as the destruction of the gas exchange surfaces of the lungs (alveoli), being a pathological concept that describes only one of several structural disorders in patients with COPD. In asthma patients, from the nosological point of view, the presence of pulmonary emphysema indicates an overlap with COPD in one patient. Key words: pulmonary emphysema, chronic obstructive pulmonary disease, nosology, history of medicine.","PeriodicalId":328937,"journal":{"name":"Ukrainian Pulmonology Journal","volume":"24 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"125221373","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"MODERN APPROACHES TO PULMONARY REHABILITATION OF COPD PATIENTS","authors":"V. L. Poberezhets, A. Demchuk, Y. Mostovoy","doi":"10.31215/2306-4927-2021-29-4-19-23","DOIUrl":"https://doi.org/10.31215/2306-4927-2021-29-4-19-23","url":null,"abstract":"V. L. Poberezhets, A. V. Demchuk, Y. M. Mostovoy Abstract Pulmonary rehabilitation (PR) is an effective method to improve the health and quality of life of patients with chronic respiratory diseases. The indications and requirements for performing PR are regulated at the legislative level in conciliatory international and national documents. PR is an integrated approach to the management of COPD patients based on a thorough patient assessment followed by therapy, which includes three components - exercise, education and correction of habits, behavior, and is designed to improve the physical and psychological state of patients with COPD, long-term adherence to a healthy lifestyle. The implementation of PR leads to decrease in symptoms and the frequency of exacerbations of the disease, its systemic manifestations, depression and social isolation of seriously ill patients. For the proper conduct of PR, a multidisciplinary team of specialists is formed which, after a thorough examination of the patient, creates an individual rehabilitation program, teaches him the correct implementation of its components. Modern digital technologies make it possible to carry out PR not only at a rehabilitation center but remotely as well, which makes it more accessible and increases its efficiency. With purpose to assess the adherence of patients with COPD to PR at home and its effectiveness, 72 men with COPD of groups C and D, mean age (68.4 ± 10.3) years, were examined, who were offered to perform PR for 8 weeks at home with a frequency of workouts once a day. We found low adherence of patients with COPD to PR at home (20.8 %). Lung function and the state of skeletal muscles are the determining factors for the successful implementation of PR. Home PR helps improve symptoms in patients with COPD. Key words: COPD, pulmonary rehabilitation.","PeriodicalId":328937,"journal":{"name":"Ukrainian Pulmonology Journal","volume":"25 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"132170734","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"COMPUTED TOMOGRAPHY DENSITOMETRY OF THE LUNGS IN THE ALGORITHM FOR THE DIAGNOSIS OF INTERSTITIAL LUNG DISEASES, INCLUDING OCCUPATIONAL AND ECOLOGICAL DISEASES","authors":"A. Basanets, N. Kurdil","doi":"10.31215/2306-4927-2021-30-1-30-34","DOIUrl":"https://doi.org/10.31215/2306-4927-2021-30-1-30-34","url":null,"abstract":"DENSITOMETRY OF THE LUNGS IN THE ALGORITHM FOR THE DIAGNOSIS OF INTERSTITIAL LUNG DISEASES, INCLUDING OCCUPATIONAL AND ECOLOGICAL DISEASES A. V. Basanets, N. V. Kurdil Abstract Interstitial lung diseases are among the most common diseases of the respiratory system. A significant proportion of them are occupational diseases with pneumoconiosis as the most prevalent condition. Determination of lung density by computed densitometry (CD) allows to quantify the degree of density of lung tissue in a different lung diseases. This review focuses on world and domestic literature on the application of CD for the diagnosis and monitoring of management of interstitial lung diseases such as pulmonary sarcoidosis, pulmonary tuberculosis, idiopathic pulmonary fibrosis, pulmonary embolism, systemic sclerosis, pneumoconiosis, etc. The method of determining of lung density index, its effectiveness depending on the method of CT and the algorithm of examination of the patients are described. Peculiarities of changes in lung density index depending on the form and pathogenesis of the disease, its correlation with lung function and morphological changes have been analyzed. The most reproducible and perfect indicators of CD are those determined by inspiratory CT, which should be taken into account in the further improvement of research protocols. The standardization of the CT imaging protocol should be implemented taking into account the need for possible reduction of the radiation dose. Conclusions. The technique of CD is recognized as a revolutionary diagnostic tool for quantifying the density of the lung parenchyma, which can be effectively used to diagnose and verify the diagnosis of interstitial lung diseases, including occupational diseases. Improving methods of occupational and environmental interstitial lung diseases diagnosing, preventing their progression and development of complications will improve the quality of healthcare service for workers, decrease morbidity, reduce treatment and disability reimbursement costs. Key words: interstitial lung diseases, occupational diseases, computed lung densitometry, computed tomography","PeriodicalId":328937,"journal":{"name":"Ukrainian Pulmonology Journal","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"115541130","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"RESPIRATORY DISEASES CAUSED BY EXPOSURE TO CHEMICAL AIR POLLUTANTS IN TERRITORY OF HOSTILITIES","authors":"M. Prodanchuk, A. Basanets, N. Kurdil","doi":"10.31215/2306-4927-2023-31-1-49-56","DOIUrl":"https://doi.org/10.31215/2306-4927-2023-31-1-49-56","url":null,"abstract":"The problem of the respiratory diseases in the military and civilians caused by exposure to air pollutants on the territory of hostilities is new for Ukraine. Given the variety of sources of air pollution, the combined exposure to diverse hazards, this issue requires careful research and analysis of experience gained in war zones in different countries of the world. Aim: analysis of epidemiological and clinical data on air pollution in the territory of hostilities and its influence on respiratory system of the military and civilians. Materials and methods. Analytical review of scientific publications was carried out using abstract databases of scientific libraries: Pub Med, Medline and text databases of scientific publishing houses Pub Med, Central, BMJ group and other VIP-databases. Results. In addition to explosive gases, atmospheric air pollutants in the territory of hostilities include vehicle exhaust emission, sulfur mustard gas, organic chlorines, pollutants of burn pits: particulate matter, dioxin, n-hexane, benzene, etc., which form a complex combined effect on the respiratory system. The most common chronic respiratory diseases in combat zone are: bronchial asthma, constrictive bronchiolitis, persistent bronchoobstructive conditions, interstitial lung diseases (hypersensitivity pneumonitis, cryptogenic organizing pneumonia (so called deploymentrelated lung diseases). Data on functional, imaging, and pathomorphological biomarkers of chronic respiratory diseases are insufficient and inconsistent. Conclusions: A wide range of air pollutants in the war zone has a combined effect on the health of the military and civilians, leading to the development of inflammatory, allergic, fibrotic, immune-related respiratory diseases. Understanding the mechanism of development of such diseases, determining biomarkers of functional, imaging and pathomorphological signs can be a serious tool in the diagnosis of respiratory diseases in the military and civilian population in the war zone. Key words: respiratory diseases, the territory of military operations, exposure to chemical air pollutants","PeriodicalId":328937,"journal":{"name":"Ukrainian Pulmonology Journal","volume":"4 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"124796050","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"MODERN ASPECTS OF PULMONARY REHABILITATION IN THE CONTEXT OF THE COVID-19 PANDEMIC","authors":"І. А. Iliuk, K. Postovitenko, I. V. Baranova, S. Leshchenko, S. Shevchuk, L. Denyshchych, I. V. Kurilenko, N. Prykhodko","doi":"10.31215/2306-4927-2021-29-3-66-72","DOIUrl":"https://doi.org/10.31215/2306-4927-2021-29-3-66-72","url":null,"abstract":"MODERN ASPECTS OF PULMONARY REHABILITATION IN THE CONTEXT OF THE COVID-19 PANDEMIC І. А. Iliuk, K. P. Postovitenko, I. V. Baranova, S. I. Leshchenko, S. V. Shevchuk, L. P. Denyshchych, I. V Kurilenko, N. M. Prykhodko Abstract It is well known that patients who have had a coronavirus infection need in rehabilitation measures to eliminate the consequences of the disease. However, the data about methods of medical rehabilitation and their effectiveness in such patients are limited, since this disease is new and insufficiently studied. It is believed that medical rehabilitation in COVID-19 convalescents should be comprehensive and aimed at optimizing the patient’s functional capabilities, reducing the cost of treatment, by stabilizing and reducing the systemic manifestations of the disease. This article is devoted to the problem of pulmonary rehabilitation in the context of the COVID-19 pandemic. This area of medicine pursues important goals - reducing the symptoms of the disease, improving the quality of life and increasing the patient’s physical and emotional participation in daily life. The article lists the main methods of pulmonary rehabilitation. The choice the correct methods and personalization of rehabilitation programs, taking into account the individual clinical situation, can prevent the appearance of functional disorders and improve the quality of life of the patients after COVID-19. Key words: COVID-19, pulmonary rehabilitation, quality of life. Ukr. Pulmonol. J. 2020;29(3):66–72:","PeriodicalId":328937,"journal":{"name":"Ukrainian Pulmonology Journal","volume":"111 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"121634002","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"CAUSES OF PULMONARY TUBERCULOSIS RELAPSES","authors":"I. Novozhylova, A. Prykhodko, I. Bushura","doi":"10.31215/2306-4927-2023-31-2-44-49","DOIUrl":"https://doi.org/10.31215/2306-4927-2023-31-2-44-49","url":null,"abstract":"Being a significant source of tuberculosis (TB) spread and the factor adversely affecting its epidemiological parameters, the relapses of TB remain a relevant problem. Aim: to establish the causes of pulmonary TB relapse (PTBR) and to evaluate its significance. Materials and methods – 80 phthisiologists have been interviewed using a special PTBR questionnaire. According to the results, the causes were divided into medical, organizational and social ones. Statistical analysis determined the degree of their significance (low, medium, high). Results. The most significant medical causes of PTBR were inadequate treatment, immunodeficiency, HIV infection, comorbidities, advanced TB, extensive residual lesions, drug adverse reactions. The organizational causes included low coverage of the population with fluorography, lack of follow-up, active detection and prophylaxis of cases in groups of risk, financial and infrastructure difficulties, poor medical-social support and population TB awareness, lack of fast diagnostics, poor management of comorbidities, lack of closed-type hospitals, stigma of TB patients, imperfect legislative base. The list of social causes consisted of low compliance to therapy, poor living and working conditions, low sanitary culture, migration of population and low social support. Among the significant (1-3 ratings) of social causes of RTBL respondents are: interrupted treatment (91,2 %), low commitment to treatment (83,7 %) and poor working conditions (71,2 %); p <0.05, among the average significant-unsatisfactory financial conditions, stay in prison and unemployment (65,0–35,0 %); p >  0,05, among others – careless attitude to one’s own health, low sanitary culture of the population, loneliness, low informative level of social institutions, migration of the population, homelessness, bad habits, poor nutrition, stress. Conclusions. The most significant medical factors of RTB development are: inadequate treatment of TB, immunodeficiency states, HIV infection, concomitant diseases, abandoned TB, major residual changes, side effects of medicines; organizational: low coverage of fluorography, lack of dispensary and active detection and prevention of TB in risk groups, financial and infrastructure difficulties, insufficient medical and social support, inaccessibility of rapid diagnosis absence of closed-type hospitals, stigma patients with TB, imperfect legislative framework; social: the disadvantage of treatment, unsatisfactory social and living conditions, low sanitary culture, population migration, social insecurity. Since the most threatening causes of PTBR were the limitations with the treatment of the newly detected TB cases we proposed considering “completion of the treatment course” as a conditionally effective treatment outcome and continue follow-up until final cure confirmation. Identifying a significant number of organizational limitations, as indicated by phthisiologists, raises the doubts about the transfer of out-patient","PeriodicalId":328937,"journal":{"name":"Ukrainian Pulmonology Journal","volume":"332 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"129760120","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"REFRACTORY SARCOIDOSIS: DEFINITION, DIAGNOSTIC CRITERIA, PREVALENCE","authors":"V. Gavrysyuk, E. Merenkova, Y. Dziublyk, N. Morska, N. Pendalchuk, A. Yachnik, N. Vlasova, O. V. Strafun, O. Bychenko","doi":"10.31215/2306-4927-2022-30-2-23-30","DOIUrl":"https://doi.org/10.31215/2306-4927-2022-30-2-23-30","url":null,"abstract":"Refractory pulmonary sarcoidosis is a variant of sarcoidosis defined as a condition in which glucocorticosteroids (GCS) in maintenance dose less than 10 mg daily (prednisolone equivalent) and methotrexate (MTX) including their combination are not sufficient to achieve clinical remission of the disease. Aim of study — retrospective evaluation of the prevalence of refractory pulmonary sarcoidosis based on assessment of outcomes of GCS and immunosuppressive therapy in patients with newly diagnosed disease. Materials and methods. We examined 250 patients with pulmonary sarcoidosis (main group), 106 male (42,4 %) and 144 female (57,6 %), mean age 44 years (22–74). Stage ІІ was diagnosed in 237 (94,8 %) patients, stage ІІІ — in 13 (5,2 %). GCS therapy was conducted using methylprednisolone (MP) in 190 patients (Group 1 - GCS) according to statements of National clinical recommendations “Sarcoidosis” (2014). Initial dose of MP was 0,4 mg/kg daily during 4 weeks with subsequent tapering to maintenance dose of 0,1 mg/kg by the end of 6th month. MTX monotherapy (15 mg once a week) was conducted in 60 patients with contraindications or serious side effects of MP (Group 2 - MTX). In case of progression or lack of positive response to GCS (improvement) after 6 months of treatment, patients were switched to combination therapy: MP 12 mg daily plus MTX 10 mg weekly. Patients without contraindications or serious adverse effects of MP, failed on initially prescribed MTX, were also switched to combination therapy. Those cases, in which the progression or stabilization of disease was observed despite 6 months of combined therapy, were considered as refractory. For comparison of categorial data, presented as absolute value and percentage, χ2 Pearson’s test was used. All measurements were bilateral with the level of significance p < 0,05. Results. Resistance to GCS therapy (progression or stabilization on therapy) were observed in 55 (28,9 %) patients; cases of treatment failure were observed much more rarely (7 patients — 11,7 %; χ2 =7,302; р = 0,007), mainly in cases with macronodular parenchyma lesions. Considering combination therapy outcomes and MTX monotherapy treatment failure among patients with contraindications and serious adverse effects of GCS therapy, a refractory pulmonary sarcoidosis was registered in 27 (10,8 %) patients. Conclusion. Outcomes of GCS and MTX therapy in patients with newly diagnosed pulmonary sarcoidosis, conducted according to the international and national standards, confirmed the refractory pulmonary sarcoidosis in 10,8 % of cases, which corresponded to foreign literature data. Key words: refractory pulmonary sarcoidosis, diagnosis, prevalence, methylprednisolone, methotrexate.","PeriodicalId":328937,"journal":{"name":"Ukrainian Pulmonology Journal","volume":"24 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"128074305","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"LABORATORY DIAGNOSTIC ALGORITHMS FOR COVID-19","authors":"I. Dziublyk, O. Bororova, G. Kapitan, O. Yakovenko","doi":"10.31215/2306-4927-2022-30-2-63-71","DOIUrl":"https://doi.org/10.31215/2306-4927-2022-30-2-63-71","url":null,"abstract":"The novel coronavirus SARS-CoV-2 causes respiratory diseases in humans, in particular acute respiratory disease COVID-19 (Coronavirus disease 2019), and can be transmitted from person to person. Specific antiviral therapy has not been developed completely. Various vaccines are widely introduced in the world. Non-specific prophylaxis, aimed at preventing the spread of the SARS-CoV-2 virus, is carried out in relation to the source of the infectious agent (patient or virus carrier), the mechanisms of transmission of the virus and the protection of contact person. During a pandemic, testing for SARS-CoV-2 is a very important part of the first line defense of the population from COVID-19 in any country of the world. It is timely testing that makes it possible to identify and isolate an infected person, slow down the transmission of coronavirus and provide targeted care to the patients. Diagnostic testing for SARS-CoV-2 is considered a very important component of the overall COVID-19 prevention and control strategy. WHO strongly recommends to test individuals suspected of having a COVID-19 immediately or as early as possible to confirm or rule out SARS-CoV-2 infection. The rapid spread of COVID-19 poses a whole list of critical tasks in front of healthcare professionals, the solution of which is closely related to the introduction of effective etiological diagnostics, including the use of rapid tests. For the safe and high-quality use of rapid tests, it is important to have a basic understanding of how they work, what are their advantages and disadvantages, what are the algorithms for their use, where is their place in the etiological diagnosis of COVID-19, and how to record correctly the results and to draw conclusions. The article sets out the requirements for the use of rapid tests based on immunochromatographic analysis and the procedure for testing for COVID-19 based on WHO materials, analysis of domestic and foreign scientific publications, regulatory documents and orders of the Ministry of Health of Ukraine. Key words: COVID-19, SARS-CoV-2, diagnostics, rapid tests, nucleic acid amplification method.","PeriodicalId":328937,"journal":{"name":"Ukrainian Pulmonology Journal","volume":"81 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130082860","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"CYTOPROTECTIVE THERAPY FOR PATIENTS WITH RESPIRATORY PATHOLOGY: PROPERTIES OF EKTOIN","authors":"S. Zaikov, A. Bogomolov, L. V. Mikheĭ","doi":"10.31215/2306-4927-2021-29-4-48-56","DOIUrl":"https://doi.org/10.31215/2306-4927-2021-29-4-48-56","url":null,"abstract":"CYTOPROTECTIVE THERAPY FOR PATIENTS WITH RESPIRATORY PATHOLOGY: PROPERTIES OF EKTOIN S. V. Zaikov, A. E. Bogomolov, L. V. Mikhei Abstract In light of the often irrational use of antibiotics, the growing problem of antibiotic resistance of respiratory pathogens and certain imperfections in the management of patients with acute and chronic rhinosinusitis, acute and chronic bronchitis, exacerbations of chronic obstructive pulmonary disease, there is always a need to seek for a new (non-antibacterial) methods of treatment to increase the effectiveness of therapy in these categories of patients. Probably, cytoprotection may also become one of these methods. Aim — to analyze the results of ectoine use as a respiratory cytoprotector. Material and methods. Analysis of available scientific publications on the use of ectoine in medical practice has been done. Conclusions. Ectoin is a natural molecule of extremolyte that strengthens the bonds and the number of neighboring water molecules, organizes water from a chaotic fluid into a structured Ectoin® Hydro Complex, which surrounds mucous cells with a protective layer of water and leads to barrier protection of the mucous membrane. The natural molecule of ectoine has anti-inflammatory, membrane-stabilizing and cytoprotective properties. Ectoin is used for barrier protection and recovery of the mucous membrane of the respiratory tract in acute and chronic diseases of the upper and lower respiratory tract. Efficacy and safety of ectoine, including its long-term use, werev proved by the results of preclinical and clinical studies. Key words: cytoprotective therapy, ectoine, respiratory pathology","PeriodicalId":328937,"journal":{"name":"Ukrainian Pulmonology Journal","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"131157616","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"CLINICAL AND LABORATORY FEATURES OF CORONAVIRUS DISEASE AND RISK FACTORS OF LETHAL OUTCOME IN PATIENTS WHO REQUIRED HOSPITALIZATION DURING THE THIRD WAVE OF COVID-19 IN UKRAINE: A SINGLE-CENTER RETROSPECTIVE STUDY","authors":"Т. Pertseva, K. Gashynova, V. V. Rudakova, V. V. Rodionova, V. Dmytrychenko, O. Kovalenko, O. V. Kravets, N. O. But, N. V. Laksha, L. A. Hlyniana, O. F. Mykhailenko, S. P. Novikov","doi":"10.31215/2306-4927-2022-30-4-6-18","DOIUrl":"https://doi.org/10.31215/2306-4927-2022-30-4-6-18","url":null,"abstract":"CLINICAL AND LABORATORY FEATURES OF CORONAVIRUS DISEASE AND RISK FACTORS OF LETHAL OUTCOME IN PATIENTS WHO REQUIRED HOSPITALIZATION DURING THE THIRD WAVE OF COVID-19 IN UKRAINE: A SINGLE-CENTER RETROSPECTIVE STUDY Т. О. Pertseva, K. Y. Gashynova, V. V. Rudakova, V. V. Rodionova, V. V. Dmytrychenko, O. Y. Kovalenko, O. V. Kravets, N. O. But, N. V. Laksha, L. A. Hlyniana, O. F. Mykhailenko, S. P. Novikov Abstract August 2021 in Ukraine marked the beginning of the third wave of COVID-19, catastrophic in terms of hospitalization and mortality, when, according to the Ministry of Health, the Delta strain was the dominant variant of the virus. By that time, it had already been established that clinical characteristics of patients and levels of inflammatory markers differed between Delta and non-Delta variants. The aim of the study was to analyze the anthropometric, clinical, anamnestic and laboratory characteristics of patients with COVID-19 who required hospitalization during the third wave of the epidemic in Ukraine, in order to determine the risk predictors of fatal outcome. Materials and methods. The study was a single-center retrospective analysis conducted on an original cohort of 632 patients who were admitted with confirmed COVID-19 to Public Non-profit Organization “City Clinical Hospital № 4” Dnipro City Council during August-October 2021. The following data were obtained and analyzed from the medical records of the studied patients: degree of severity at the time of admission according to the COVID-19 Severity Index, demographic characteristics, comorbidity, presentation, vital signs and laboratory parameters at admission, results of chest computed tomography, treatment options and the outcomes. Results. The patients’ median age was 63 years, 38,8 % were male. Hospital mortality rate was 23,58%. The median of bed count days — 9 [6, 12]. Fever (76,3 %), dyspnea (85,4 %), cough (53,3 %) and fatigue (49,5 %) were the most common clinical manifestations on admission. The percentage of patients with comorbidities was significantly higher among deceased (96,0 % vs. 56,1 %). The most prevalent were cardio- and neurometabolic comorbidities. The median SpO2 on admission was significantly lower among deceased — 86 [75, 90]. There were 25,44 % and 57,23 % of all hospitalized patients who received ICU care and oxygen therapy, respectively. The regression analysis revealed the age older than 57 years (HR 3,198, 95 % CI 1,992–5,134), neuromuscular symptoms (HR 2,033, 95 % CI 1,358–3,045) and chest pain (HR 1,867, 95 % CI 1,055–3,306), the presence of co-morbidity (HR 26,678, 95% CI 8,498–83,750), primarily arterial hypertension (HR 3,945, 95 % CI 2,725–5,712), coronary heart disease (HR 7,619, 95% CI 5,155–11,259), heart failure (HR 2,823, 95% CI 2,020–3,944), diabetes (HR 2,966, 95 % CI 2,095–4,200), arrhythmia (HR 2,247, 95 % CI 1,524–3,312), cerebrovascular diseases (HR 2,746, 95% CI 1,725–4,372) were reliable predictors of fatal outcome in COVID-19. At","PeriodicalId":328937,"journal":{"name":"Ukrainian Pulmonology Journal","volume":"604 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"123237643","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}