Ukrainian Pulmonology Journal最新文献

{"title":"PROGRESSIVE PULMONARY FIBROSIS IN LIGHT OF THE ATS/ERS/JRS/ALAT 2022 CLINICAL GUIDELINES","authors":"V. Gavrysyuk, Y. Dziublyk, E. Merenkova, O. V. Strafun, O. Bychenko","doi":"10.31215/2306-4927-2022-30-4-51-57","DOIUrl":"https://doi.org/10.31215/2306-4927-2022-30-4-51-57","url":null,"abstract":"Idiopathic pulmonary fibrosis – is a specific form of chronic, progressive, fibrosing interstitial pneumonia of unknown cause, which occurs primarily in 50 years and older patients, limited to the lungs, and is associated with the histopathologic and/or radiologic pattern of usual interstitial pneumonia (UIP). In 2000 American thoracic society (ATS) and European respiratory society (ERS) published the first international; statement on diagnosis and treatment of IPF American Thoracic Society, European Respiratory Society. Idiopathic pulmonary fibrosis: diagnosis and treatment. International consensus statement. In 2011 there was published a new statement on diagnosis and treatment of IPF, approved by Japan respiratory society (JTS) and Latin American thoracis society (ALTS) – An Official ATS/ERS/JRS/AL : Idiopathic Pulmonary Fibrosis: Evidence-based Guidelines for Diagnosis and Management. In 2015 section “Treatment” and in 2018 section “Diagnosis” were revised. It is known that in part of patients with such interstitial lung diseases (ILD) as idiopathic interstitial pneumonia, systemic sclerosis, pneumoconiosis, chronic hypersensitivity pneumonitis, sarcoidosis the disease may acquire a progressive uncontrolled development with the combination of symptoms called progressive pulmonary fibrosis (PPF). At the same time the results of successful use of antifibrotic therapy have been published recently (SENSCIS, INBUILD studies). All this provided the rationale for extended indications for use of antifibrotic therapy to cover other ILDs with the features of PPF. In this connection, ATS, ERS, JRS and ALAT experts published in May 2022 An Official ATS/ERS/JRS/ALAT Clinical Practice Guideline. Idiopathic Pulmonary Fibrosis (an Update) and Progressive Pulmonary Fibrosis in Adults, in which along with the partial changes regarding the principles of diagnosis and treatment of IPF, the definition, diagnosis criteria and management of PPF due to other fibrosing ILDs were presented. The article presents the major statements of new guideline regarding the terminology, diagnosis and treatment of PPF. Key words: progressive pulmonary fibrosis, definition, diagnosis criteria, treatment.","PeriodicalId":328937,"journal":{"name":"Ukrainian Pulmonology Journal","volume":"49 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"126592748","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"THORACIC SURGICAL TREATMENT IN PATIENTS WITH CORONAVIRUS INFECTION","authors":"M. Opanasenko, B. Konik, S. Belokon', O. Tereshkovich, S. M. Shalagai, L. Levanda, M. I. Kalinichenko, V. Lysenko, M. Shamrai, A. M. Stepanyuk, O. Shestakova","doi":"10.31215/2306-4927-2021-29-3-31-35","DOIUrl":"https://doi.org/10.31215/2306-4927-2021-29-3-31-35","url":null,"abstract":"THORACIC SURGICAL TREATMENT IN PATIENTS WITH CORONAVIRUS INFECTION M. S. Opanasenko, B. M. Konik, S. M. Belokon, O. V. Tereshkovich, S. M. Shalagai, L. I. Levanda, M. I. Kalinichenko, V. I. Lysenko, M. U. Shamrai, A. M. Stepanyuk, O. D. Shestakova Abstract Aim. To familiarize physicians of different specialties with thoracic pathology in patients with coronavirus infection (COVID-19). Materials and methods. Since the beginning of the COVID-19 pandemic 63 patients were treated at the department of surgical treatment of tuberculosis and NLD, complicated by purulent-septic infections: 47 (74.6%) — with various complications of coronavirus infection, and 16 (25.4%) — COVID-19 and conditions, requiring thoracic surgery, not associated with COVID-19. Results. Pleural empyema was the most common bacterial complication — 18 (28.5%) cases. Only 6 (9.5%) patients were diagnosed with broncho-pleural fistula, while 12 (19.6%) patients already had a functioning broncho-pleural fistula at the stage of hospitalization. In 15 (23.8%) patients, the destructive cavities remained on admission, and only 3 (4.7%) had isolated pleural empyema without destruction of pulmonary parenchyma (complete scarring of abscesses). 17 (26.9%) patients with empyema underwent videothoracoscopic (VATS) drainage of the pleural cavity with polydrainage and the use of long-term active aspiration in the postoperative period. In 1 (1.5%) case, due to the extremely severe condition of the patient, only drainage of both pleural cavities was performed. 1 (1.5%) patient with bilateral pleural empyema died of progressive respiratory and cardiovascular failure. Nonspecific exudative pleurisy was diagnosed in 8 (12.6%) patients after coronavirus infection. Spontaneous pneumothorax without development of pleural empyema was diagnosed in 7 (11.1%) patients and in 3 (4.7%) cases pneumo hemothorax occurred. in 2 (3.1%) cases there was a need for parietal pleurectomy (there was a significant area of detachment of the visceral pleura and the impossibility of imposing intracorporeal sutures). All patients were discharged from the hospital with recovery. 6 (9,5 %) patients with necrotizing pneumonia comprised a challenging group of patients with large, treatment-resistant cavities. In 4 (6.3%) cases antibacterial therapy was ineffective, so transthoracic cavity drainage was performed. All 6 patients underwent radical resection interventions following long pre-operative period: 3 (4.7%) cases - pleurolobectomy, 2 (3.1%) — sublobar resection and 1 (1.5%) - resection of the 6th segment of right lung). Conclusions. Pulmonary purulent-destructive COVID-19 complications may occur much more rarely if timely treatment was used. Videothoracoscopic intervention is a preferred option of treatment of these conditions. Key words: COVID-19, thoracic pathology pneumohemothorax, pleurodesis. Ukr. Pulmonol. J. 2021;29(3):31–35:","PeriodicalId":328937,"journal":{"name":"Ukrainian Pulmonology Journal","volume":"32 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"127138350","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"BEST CLINICAL PRACTICE OF MANAGEMENT OF SIDE EFFECTS OF BPAL REGIMEN (CLINICAL CASE)","authors":"N. Lytvynenko, M. Pogrebna, L. Protsyk, Y. Senko, V. Davydenko, L. Shcherbakova, O. Chobotar","doi":"10.31215/2306-4927-2022-30-2-72-74","DOIUrl":"https://doi.org/10.31215/2306-4927-2022-30-2-72-74","url":null,"abstract":"New 6-months regimen based on bedaquiline, pretomanid and linesolid (BPaL), evaluated in TB-PRACTECAL clinical trial, is one of modern treatments for extensively drug resistant tuberculosis. Patients on BPaL should be carefully observed for side effects, especially liver toxicity, myelosuppression, peripheral and optic neuropathy, QT-interval prolongation and pancreatitis. A clinical case of extensively drug resistant tuberculosis with the outcomes of BPaL regimen treatment on the backgrounds of side effects is presented in current report. This case demonstrates that timely and thorough monitoring of side effects allows to preserve the BPaL regimen modality, regardless the occurrence of several adverse effects in one person and to complete the prescribed course of treatment, which resulted in cure. Key words: extensively drug resistant tuberculosis, BPaL regimen of treatment, saide effects.","PeriodicalId":328937,"journal":{"name":"Ukrainian Pulmonology Journal","volume":"22 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"122144129","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"BARRIERS IN ACHIEVING ASTHMA CONTROL IN CLINICAL PRACTICE DURING THE COVID-19 PANDEMIC","authors":"Y. Feshchenko, M. Polianska, S. Opimakh, S. Moskalenko, I. Zvol","doi":"10.31215/2306-4927-2023-31-2-5-12","DOIUrl":"https://doi.org/10.31215/2306-4927-2023-31-2-5-12","url":null,"abstract":"The main goals of bronchial asthma (BA) treatment are to achieve good symptoms control and to minimize future risk of asthma-related mortality, exacerbations, persistent airflow limitation and adverse effects of therapy. Despite the availability of effective treatments for asthma the real life asthma control is lower than expected. The aim of this study was to evaluate the barriers in achieving asthma control in clinical practice during the COVID-19 pandemic according to the literature data. There are both general and COVID-19-related barriers in achieving the goals of asthma treatment. In most patients, the causes for the lack of asthma control are incorrect inhaler technique, poor adherence to treatment, overuse of short-acting bronchodilators, comorbidities, the influence of adverse environmental conditions and psychosocial factors. The COVID-19 pandemic has affected the asthma control through quarantine restrictions and the influence of post-acute COVID-19 disorders. On the one hand, quarantine restrictions had a positive effect on the asthma course: there was a decrease in the seasonal respiratory viral infections and the asthma exacerbations frequency. On the other hand, asthma patients were significantly affected by the pandemic due to a high level of anxiety, stress and limited access to routine medical care. Health disorders in post-COVID-19 period negatively affect the control of BA. After recovery from acute COVID-19 a proportion of asthma patients experienced poorer control and required increased asthma maintenance therapy. Approaches to improving asthma control include adherence to established asthma management guidelines, patient and healthcare professional education, regular asthma monitoring and assessment, review of inhaler technique, provision of a written asthma action plan, use of digital technologies. Key words: bronchial asthma, asthma control, COVID-19.","PeriodicalId":328937,"journal":{"name":"Ukrainian Pulmonology Journal","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130462556","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"POSSIBILITIES OF NONTRADITIONAL MEDICINE IN ADDITIONAL TREATMENT FOR INFLAMMATORY DISEASES OF THE RESPIRATORY TRACT","authors":"O. Rechkina, O. V. Strafun, М. О. Polianska, М. Р. Budyonna","doi":"10.31215/2306-4927-2021-29-4-64-68","DOIUrl":"https://doi.org/10.31215/2306-4927-2021-29-4-64-68","url":null,"abstract":"POSSIBILITIES OF NONTRADITIONAL MEDICINE IN ADDITIONAL TREATMENT FOR INFLAMMATORY DISEASES OF THE RESPIRATORY TRACT O. О. Rechkina, O. V. Strafun, М. О. Polianska, М. Р. Budyonna Abstract Oxidative stress plays an important role іn the pathogenesis of airway inflammatory diseases. Multivitamin preparations containing antioxidants, nutritional supplements are significant support in the fight against oxidative stress. The healing properties of one such supplement, badger fat, have been known for centuries. It is used in folk medicine as a natural and effective agent with bactericidal, anti-inflammatory, immunostimulating and general strengthening effects. The main active components of badger fat include unsaturated fatty acids and vitamins, especially A, E and D. Vitamins of these groups enhance the anti-inflammatory effect of unsaturated fatty acids, and also exhibit high antioxidant activity, while unsaturated fatty acids (including omega-3, omega-6), help to improve metabolic processes and tissue trophism, exhibiting anti-inflammatory and antioxidant effects. The article presents the characteristics of the dietary supplement “Borsukovy zhyr”, the results of studies of its effectiveness and tolerability in the complex treatment of chronic bronchitis and AE COPD, as a component of therapy of adults and children with bronchopulmonary diseases, showing its effectiveness, safety and good tolerability. The supplement can be used in the complex treatment of bronchopulmonary pathology in both adults and children as a safe source of fat-soluble vitamins and polyunsaturated fatty acids. Key words: oxidative stress, antioxidants, dietary supplement, badger fat.","PeriodicalId":328937,"journal":{"name":"Ukrainian Pulmonology Journal","volume":"59 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"133718840","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"THE CASE OF COVID-19 WITH ATYPICAL PULMONARY LESIONS AND A LIFETIME HISTOLOGICAL EXAMINATION","authors":"О. Rekalova, I. Liskina, E. M. Maetnyi, M. Kulyk","doi":"10.31215/2306-4927-2021-29-3-41-47","DOIUrl":"https://doi.org/10.31215/2306-4927-2021-29-3-41-47","url":null,"abstract":"THE CASE OF COVID-19 WITH ATYPICAL PULMONARY LESIONS AND A LIFETIME HISTOLOGICAL EXAMINATION О. M. Rekalova, I. V. Liskina, E. M. Maetnyi, M. I. Kulyk Abstract The case of atypical destructive pulmonary lesions associated with the COVID-19 is presented in 42 years old man without significant comorbidity. COVID-19 was not confirmed by naso-pharyngeal smear PCR test at 7th and 28th days of the disease, and by serum SARS-CoV-2 antibody at 11th and 29th day. Chest computed tomography demonstrated the pattern of bilateral multifocal pneumonia with infiltration and cavitation in the acute phase. The video-thoracoscopic edge resection of S5 of the left lung was performed on the 34th day of the disease. Mosaic lung lesions were revealed at histological examination: poorly delimited focal infiltrates, severe productive-necrotic inflammation of the microcirculatory vessels, plasma and red blood cell diapedesis, macrophages reaction, disthelectasis zones, microcysts. The development of cysts of various size could be a consequence of post-inflammatory scaring emphysema and distelectasis with dilatation of vessels with a damaged wall. IgG antibodies to the nucleocapsid protein of SARS-Cov-2 were detected in blood at day 62 after the onset of the disease. Thus, the patient was diagnosed with moderate COVID-19 with destructive pneumonia, not associated with bacterial / mycobacterial / fungal infection, and with vasculitis, and probable microthrombosis of lung vessels, followed by resolution and development of minor residual fibrotic and emphysematous focci. Key words: COVID-19, atypical pulmonary lesions, lung cavitation, lifetime histological examination, morphological changes in the lungs. Ukr. Pulmonol. J. 2021;29(3):41–47.","PeriodicalId":328937,"journal":{"name":"Ukrainian Pulmonology Journal","volume":"60 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"116605128","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"CASE OF THORACIC ACTINOMYCOSIS IN A CHILD","authors":"E. Rechkina, N. V. Promskaya, I. Liskina, O. Kravtsova","doi":"10.31215/2306-4927-2021-29-3-48-52","DOIUrl":"https://doi.org/10.31215/2306-4927-2021-29-3-48-52","url":null,"abstract":"A. Rechkina, N. V. Promskaya, I. V. Liskina, O. M. Kravtsova Abstract The article presents a rare clinical case of a complex way of diagnosis and treatment of thoracic actinomycosis with lung and chest soft tissues lesions in 12 years old child. About six months passed from the time of the first complaints until the final clinical diagnosis was made. This delay led to significant destructive changes in the lungs and adjacent soft tissues. During this time, the child went through all stages of health care. Differential diagnosis with lung neoplasm was performed. The diagnosis was verified by histological and immunohistochemical studies. The biopsy material revealed separately rounded dense clusters of fungi, which morphologically most corresponded to actinomycetes. The treatment consisted of two stages (inpatient and outpatient), which lasted more than three months. Significant clinical and radiological improvement has been achieved. The child continues treatment on an outpatient basis under the regular supervision of a pulmonologist. Key words: thoracic actinomycosis, diagnosis, treatment, children. Ukr. Pulmonol. J. 2021;29(3):48–52.","PeriodicalId":328937,"journal":{"name":"Ukrainian Pulmonology Journal","volume":"116 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"129149540","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"MODIFICATION OF CLINICAL COURSE OF CHRONIC OBSTRUCTIVE PULMONARY DISEASE: A MYTH OR ESSENTIAL REALITY OF PRESENT?","authors":"Y. Feshchenko, M. M. Ostrovskiy, I. Makoyda","doi":"10.31215/2306-4927-2022-30-1-47-51","DOIUrl":"https://doi.org/10.31215/2306-4927-2022-30-1-47-51","url":null,"abstract":"MODIFICATION OF CLINICAL COURSE OF CHRONIC OBSTRUCTIVE PULMONARY DISEASE: A MYTH OR ESSENTIAL REALITY OF PRESENT? Y. I. Feshchenko, M. M. Ostrovskiy, I. Y. Makoyda Abstract Chronic obstructive pulmonary disease (COPD) remains in the top chart of respiratory diseases affecting mankind, being the most prevalent pulmonary condition and one of major cause of death. Bronchial tree and alveolar structures remodeling, hyperproduction of phlegm, persisting inflammation, microcirculation disturbances, hypoxia, bad habits are the list of factors, leading (if left uncontrolled) to initiation or progression of COPD and development of its complications. Timely diagnostics and management of COPD aimed on preventing of a galloping progression of the disease, is a leading point of interest for healthcare practitioners. Modification of COPD clinical course is one of outcomes to be reached by a physician in cooperation with a patient. Use of original mucolytic erdosteine, which possesses pleiotropic effects, counteracts multiple pathological mechanisms. Breaking disulfide bonds of glycoproteins improves sputum viscosity and makes phlegm easier to cough up. Anti-oxidant effect is mediated by suppression of lipids peroxidation and alfa1-antitrypsin inactivation, as well as increasing of glutathione level in bronchoalveolar lavage fluid. Important effect is a suppression of pro-inflammatory cytokines synthesis (IL-6, IL-8) and modification of inflammation activity. Data from randomized clinical trial RESTORE have demonstrated the potency of erdosteine 300 mg twice daily taken 1 year as add-on to maintenance COPD therapy in terms of reduction of duration, rate and severity of exacerbations. DELFI clinical study (2020) has confirmed the confidence of leading chest physicians and hospitals of Europe in this molecule. Key words: chronic obstructive pulmonary disease, erdosteine, modification of course.","PeriodicalId":328937,"journal":{"name":"Ukrainian Pulmonology Journal","volume":"39 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"123696247","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"MODERN METHODS OF ETIOLOGICAL DIAGNOSING OF ACUTE COMMUNITY-ACQUIRED LOWER RESPIRATORY TRACT INFECTIONS","authors":"O. Bororova, Y. Dziublyk, V. Iachnyk","doi":"10.31215/2306-4927-2021-29-3-58-65","DOIUrl":"https://doi.org/10.31215/2306-4927-2021-29-3-58-65","url":null,"abstract":"MODERN METHODS OF ETIOLOGICAL DIAGNOSING OF ACUTE COMMUNITY-ACQUIRED LOWER RESPIRATORY TRACT INFECTIONS O. L. Bororova, Y. O. Dziublyk, V.A. Iachnyk Abstract The review presents the possibilities presented by various methods of etiological diagnostics used in pulmonology. The main method of diagnosing acute community-aquired lower respiratory tract infections is the microbiological approach which includes microscopy of patient’s material with Gram staining, cultures on nutrient media, isolation of culture, identification and determination of susceptibility of a microorganism to antibiotics. But unfortunately the etiologocal factor cannot be detected in about half of patients. Recently, the popularity of molecular methods of etiological diagnosis has grown. They are characterized by greater sensitivity to microbiological methods and allow to get results faster. Molecular diagnostic tests are divided into four categories depending on the mechanism based on them: immunoassay, hybridization methods, amplification and sequencing methods. Among the tests based on the principles of immunoassay, noteworthy are rapid tests, which are most consistent with the idea of an ideal diagnostic tool in the field of laboratory medicine. They are fast, simple, cheap, highly sensitive and highly specific. However, as the appearance of specific antibodies in the body takes some time, the results of tests based on immunoassay remain positive for several weeks after the delayed episode of acute community-acquired lower respiratory tract infection, so they have diagnostic value only in the presence of clinical manifestations of the disease. The genetic approach allows the detection of infectious agents in the early stages of the disease, when serological and immunological methods are ineffective. Tests based on nucleic acid amplification, including PCR, have also become increasingly common recently. These methods should be used for the diagnosis of atypical pathogens and respiratory viruses, because their cultivation in culture is difficult. Sequencing and mass spectrometry methods are being actively developed, but there are limitations that prevent their use in everyday clinical practice. So the combination of microbiological approach with molecular diagnostic methods is the most optimal for the identification of the causative agent of acute community-acquired lower respiratory tract infections and the use of targeted etiotropic treatment. Key words: acute community-acquired lower respiratory tract infections, etiological diagnosis, microbiological, serological, immunological, molecular genetic methods, ICA, PCR, sequencing, mass spectrometry. Ukr. Pulmonol. J. 2021;29(3):58–65","PeriodicalId":328937,"journal":{"name":"Ukrainian Pulmonology Journal","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"124658305","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"ASTHMA AS A MASK OF ALLERGIC BRONCHOPULMONARY ASPERGILLOSIS: DIAGNOSIS AND TREATMENT","authors":"O. Rekalova","doi":"10.31215/2306-4927-2021-29-4-57-63","DOIUrl":"https://doi.org/10.31215/2306-4927-2021-29-4-57-63","url":null,"abstract":"ASTHMA AS A MASK OF ALLERGIC BRONCHOPULMONARY ASPERGILLOSIS: DIAGNOSIS AND TREATMENT O. M. Rekalova Abstract Asthma is a heterogeneous diseases with multiple phenotypes, 5–10 % of which are associated with severe course of disease, resistant to standard therapy. Allergic bronchopulmonary aspergillosis (ABPA), being a separate disease (ICD-10: B44.9 — aspergillosis unspecified), may mimic asthma. A literature review of major statements regarding ABPA, focusing on definition, pathogenesis, diagnostic criteria, association of different forms of asthma with fungal sensitization and Th2-response, stage, radiological picture, diagnostic algorithm in asthma and cystic fibrosis, characteristics of major applicable lab tests, principles and algorithm of treatment of ABPA patients, and treatment prospects. Lung radiological data using computer modeling from patient with ABPA (clinical case) has been presented as an illustration. Key words: allergic bronchopulmonary aspergillosis (ABPA), asthma, diagnosis, treatment. Ukr. P","PeriodicalId":328937,"journal":{"name":"Ukrainian Pulmonology Journal","volume":"47 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"121545695","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}