Egyptian Journal of Basic and Clinical Pharmacology最新文献_第2页

Assessment of the Effect of HMGCR Variant Alleles on Response to Atorvastatin Treatment in Type 2 Diabetic Egyptian Patients 埃及2型糖尿病患者HMGCR变异等位基因对阿托伐他汀治疗反应的评估

Egyptian Journal of Basic and Clinical Pharmacology Pub Date : 2019-02-27 DOI: 10.32527/2019/101390

Sara Bakr Abd El-Kader, A. Guemei, M. Barakat, I. Diab, M. Megallaa

{"title":"Assessment of the Effect of HMGCR Variant Alleles on Response to Atorvastatin Treatment in Type 2 Diabetic Egyptian Patients","authors":"Sara Bakr Abd El-Kader, A. Guemei, M. Barakat, I. Diab, M. Megallaa","doi":"10.32527/2019/101390","DOIUrl":"https://doi.org/10.32527/2019/101390","url":null,"abstract":"Use of 3 hydroxyl-3-methylglutaryl-3-coenzyme A reductase (HMGCR) inhibitors, or statins, reduces the progress and the complications of diabetes mellitus by modifying the lipid profile. The aim of this study was to assess the association between variation in statin response and the single-nucleotide polymorphism (SNP) rs12916 C/T in the gene encoding HMGCR, a rate limiting enzyme in cholesterol synthesis and the target enzymatic reaction of statins. A total of 96 Egyptian patients with type 2 diabetic dyslipidemia were treated with atorvastatin 20 mg/day for 3 months. Total cholesterol, triglyceride, low density lipoprotein–cholesterol (LDL-C), high density lipoprotein–cholesterol (HDL-C) plasma concentrations were measured at baseline and at the end of the treatment period together with genetic screening for SNP rs 12916 C/T. It was found that individuals with the CC genotype showed a mean reduction in LDL-C level of about 31.57 ± 87.52 mg/dl (p=0.24), while the reduction in the CT and TT genotypes was 28.50 ± 72.74 mg/dl (P=0.04) and 26.15 ± 101.45 mg/dl (p=0.06), respectively. It is concluded that there is no significant association between this SNP rs12916 C/T and response to atorvastatin therapy in type 2 dyslipidemic diabetic Egyptian patients.","PeriodicalId":32679,"journal":{"name":"Egyptian Journal of Basic and Clinical Pharmacology","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-02-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42261068","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Isoquercetin Could Protect Against Ovariectomy-Induced Neuronal Changes in Rats 异槲皮素对去卵巢大鼠神经元变化的保护作用

Egyptian Journal of Basic and Clinical Pharmacology Pub Date : 2019-02-23 DOI: 10.32527/2019/101405

Heba A. Elnoury

{"title":"Isoquercetin Could Protect Against Ovariectomy-Induced Neuronal Changes in Rats","authors":"Heba A. Elnoury","doi":"10.32527/2019/101405","DOIUrl":"https://doi.org/10.32527/2019/101405","url":null,"abstract":"Menopause occurs gradually and is characterized by increased susceptibility to developing mood disorders. Several studies have suggested that oxidative stress is implicated in the subsequent mood changes. It has been reported that quercetin glycosides may be effective due to their antioxidant abilities. The present work aimed to find out whether quercetin able to act against ovariectomy consequences and possible underlying mechanism(s). Animals were randomly divided into six groups of eight rats each. Group (1) Control group (2) Sham operated group (3) Ovariectomized (OVX) group (4) OVX-Isoquercetin-treated (10 mg/kg, i.p., dissolved in a DMSO/saline solution) group (5) OVX-estrogen-treated (subcutaneous implant of pellets (Innovative Research of America, Toledo, OH) containing 17β-estradiol (1.5 mg/8 wk) group (6) OVX-Isoquercetin-estrogen treated group. The treatments were initiated two week after both ovariectomy and sham operations and continued for four consecutive weeks. Tested parameters: oxidative stress markers (MDA, GSH, SOD), inflammatory cytokines (TNF-α, IL-6) and brain monoamines (dopamine, nor epinephrine, 5-HT). Results: Isoquercetin either alone or in combination with estrogen can improve: oxidative stress markers (MDA, GSH, SOD), inflammatory cytokines (TNF-α, IL-6) and brain monoamines (dopamine, nor epinephrine, 5-HT). Combination of both isoquercetin & estrogen gives the best results in most of the tested parameters especially in normalizing IL-6 level. Concerning serotonin estrogen was as good as the combined drugs. Conclusion: Isoquercetin has an additive role with estrogen to maintain healthy brain tissue for production of normal monoamine levels.","PeriodicalId":32679,"journal":{"name":"Egyptian Journal of Basic and Clinical Pharmacology","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-02-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47214407","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

Prophylactic and Ameliorative Effect of N-Acetylcysteine on Doxorubicin-Induced Neurotoxicity in Wister Rats n-乙酰半胱氨酸对阿霉素致Wister大鼠神经毒性的预防和改善作用

Egyptian Journal of Basic and Clinical Pharmacology Pub Date : 2019-01-25 DOI: 10.32527/2019/101396

Walaa I. Mohammed, R. Radwan, H. Elsayed

{"title":"Prophylactic and Ameliorative Effect of N-Acetylcysteine on Doxorubicin-Induced Neurotoxicity in Wister Rats","authors":"Walaa I. Mohammed, R. Radwan, H. Elsayed","doi":"10.32527/2019/101396","DOIUrl":"https://doi.org/10.32527/2019/101396","url":null,"abstract":"Doxorubicin (DOX) is an anthracycline antibiotic and a quinone-containing chemotherapeutic drug used for various types of cancers. However, as with most anticancer drugs, it causes many toxic effects, one of them is cognitive impairment. The present study investigated the prophylactic and ameliorative effect of n-acetylcysteine (NAC) against DOX-induced neurotoxicity in rats. Rats were divided into four groups. Control group: rats received saline. NAC treated group: rats received NAC (100 mg/kg, p.o.) daily for 35 days. DOX-treated group: rats received DOX (4 mg/kg, i.p.) for four weeks on day 7, 14, 21 and 28. DOX+NAC treated group 1: rats received NAC (100 mg/kg, p.o.) daily for 35 days and DOX (4 mg/kg, i.p.) for four weeks on day 7, 14, 21 and 28). DOX+NAC treated group 2: rats received NAC (100 mg/kg, p.o.) daily started at the 7th day of the experiment till the end of the experiment and DOX (4 mg/kg, i.p.) for four weeks on day 7, 14, 21 and 28. The present results showed a significant reduction in the body weight, which was associated with a significant increase in brain to body weight ratio in DOX-treated rats. Tumor necrosis factor (TNF-α) level, malondialdehyde (MDA) and total protein levels were significantly elevated. Whilst, reduced glutathione (GSH) and glutathione peroxidase (GPx) levels were significantly decreased. Moreover, there were histopathological abnormalities in the brain tissue of DOX-treated rats, as most of the neurons degenerated and the blood vessels surrounded with wide perivascular spaces. In addition, the neuropil was vacuolated. The present study demonstrated that NAC has a neuroprotective effect on the brain damage induced by DOX, through inhibition of inflammation and oxidative stress. This neuroprotective effect was more pronounced in DOX+NAC treated group 1, as it produced a significant increase in brain GSH and GPx levels and more improvement in the histopathological abnormality compared to DOX+NAC treated group 2.","PeriodicalId":32679,"journal":{"name":"Egyptian Journal of Basic and Clinical Pharmacology","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-01-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44778100","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 8

It is Personal – or not! 这是个人的——或者不是!

Egyptian Journal of Basic and Clinical Pharmacology Pub Date : 2019-01-23 DOI: 10.32527/2019/101416

P. Devchand

引用次数: 0

Ginseng Nanoparticles Protect Against Methotrexate-Induced Testicular Toxicity in Rats 人参纳米颗粒对甲氨蝶呤诱导大鼠睾丸毒性的保护作用

Egyptian Journal of Basic and Clinical Pharmacology Pub Date : 2019-01-22 DOI: 10.32527/2019/101397

Madonna E. F. Kamel, H. Mohammad, C. Maurice, Magda M. Hagras

{"title":"Ginseng Nanoparticles Protect Against Methotrexate-Induced Testicular Toxicity in Rats","authors":"Madonna E. F. Kamel, H. Mohammad, C. Maurice, Magda M. Hagras","doi":"10.32527/2019/101397","DOIUrl":"https://doi.org/10.32527/2019/101397","url":null,"abstract":"Testicular toxicity of methotrexate (MTX) is a clinically important adverse effect. Ginseng has been demonstrated to stimulate spermatogenesis, prevent chemotherapy-induced testicular injury and to possess antiapoptotic and antioxidant actions. Owing to its low bioavailability, ginseng was formulated to nanoform in the current study. As there is no available data about the protective effects of ginseng or ginseng nanoparticles against MTX-induced testicular toxicity, this study was initiated. Seventy-two male rats were enrolled. Rats were given either ginseng (5oo mg/kg/day), or ginseng nanoparticles (125 and 250 mg/kg/day) orally for 28 consecutive days. Rats received a single dose of MTX (20 mg/kg) intraperitoneally on day 25. Ginseng and ginseng nanoparticles pre-treatment in rats significantly alleviated the testicular histopathological effects induced by MTX. Also, they significantly restored the impaired spermatogenesis induced by MTX via significantly increasing the Johnsen's tubular biopsy score (JTBS). Ginseng and ginseng nanoparticles treatment prior to MTX administration in rats significantly ameliorated MTX-induced testicular apoptosis by significantly decreasing the percentage of caspase-3-immunostained testicular area. Ginseng and ginseng nanoparticles pretreatment caused nonsignificant increase in serum testosterone levels that were significantly decreased by MTX. The results indicate that ginseng and ginseng nanoparticles protect against MTX-induced testicular toxicity in rats, which is suggested to be through inhibition of MTX-induced testicular apoptosis. The protective effect of ginseng nanoparticles was supposed to be better than ginseng in the given doses.","PeriodicalId":32679,"journal":{"name":"Egyptian Journal of Basic and Clinical Pharmacology","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-01-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42857288","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 10

Tryptophan Metabolism: A Versatile Area Providing Multiple Targets for Pharmacological Intervention. 色氨酸代谢：为药理学干预提供多个靶点的多功能领域。

Egyptian Journal of Basic and Clinical Pharmacology Pub Date : 2019-01-01 DOI: 10.32527/2019/101415

Abdulla Abu-Bakr Badawy

引用次数: 0

Challenges Facing Scientific Research in Developing Countries: 3. An Attempt at Offering Remedies and Solutions 2 .发展中国家科研面临的挑战;提供补救和解决办法的尝试

Egyptian Journal of Basic and Clinical Pharmacology Pub Date : 2019-01-01 DOI: 10.32527/2019/101412

M. Badr

引用次数: 0