Heart Views最新文献

{"title":"Effect of Birth Asphyxia on Neonatal Heart: A Two-dimensional Echocardiography-based Study at a Tertiary Care Center.","authors":"Vikas N Solunke, Monika S Reddy, Shivprasad Mundada","doi":"10.4103/heartviews.heartviews_74_25","DOIUrl":"10.4103/heartviews.heartviews_74_25","url":null,"abstract":"<p><strong>Background: </strong>Perinatal asphyxia is a significant cause of neonatal morbidity and mortality, with potential long-term complications. Timely identification and management are crucial to improving neonatal outcomes. This study aims to assess the maternal and neonatal outcomes of perinatal asphyxia, with a particular focus on echocardiographic findings in term neonates.</p><p><strong>Materials and methods: </strong>This prospective study was conducted between June 2022 and January 2023, enrolling 230 term neonates diagnosed with perinatal asphyxia. Clinical history, physical examination, and two-dimensional echocardiography were performed for each neonate. Neonates with congenital anomalies were excluded. Data were analyzed using SPSS version 15.</p><p><strong>Results: </strong>Out of 230 neonates, 45.23% of those delivered by cesarean section presented with severe hypoxic-ischemic encephalopathy (HIE) III. Meconium-stained liquor was strongly associated with severe HIE, while shock was observed in all HIE III cases. Echocardiographic findings included patent ductus arteriosus (PDA) in 92.3%, persistent pulmonary hypertension (PPHN) in 57.3%, and left ventricular dysfunction in 50.6%. Early neonatal death was reported in 2.6% of cases.</p><p><strong>Conclusion: </strong>Perinatal asphyxia leads to significant cardiovascular and neurological complications. Echocardiographic abnormalities, particularly PDA and PPHN, are commonly observed. Early and accurate diagnosis followed by appropriate management is crucial to improving neonatal survival and outcomes.</p>","PeriodicalId":32654,"journal":{"name":"Heart Views","volume":"27 ","pages":"2"},"PeriodicalIF":0.5,"publicationDate":"2026-08-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13591754/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149018062","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Arrhythmic Burden of Cardiac Amyloidosis: A Comprehensive Review.","authors":"Adel Khalifa Sultan Hamad","doi":"10.4103/heartviews.heartviews_167_25","DOIUrl":"10.4103/heartviews.heartviews_167_25","url":null,"abstract":"<p><p>Cardiac amyloidosis (CA) represents a growing etiology of heart failure (HF) and arrhythmogenesis, driven by the intramyocardial deposition of aberrantly folded proteins, notably immunoglobulin light chains (AL) and transthyretin (ATTR). This infiltrative process compromises myocardial compliance and disrupts the cardiac conduction system, leading to a diverse spectrum of dysrhythmias. The escalating prevalence of CA, particularly within geriatric demographics and individuals with plasma cell dyscrasias, underscores the imperative for refined diagnostic and therapeutic paradigms. The considerable arrhythmic burden in CA significantly contributes to patient morbidity, thromboembolic events, and sudden cardiac death, thus providing the impetus for this comprehensive review. Despite advancements in cardiac imaging and biomarker analysis, detailed electrophysiological characterization and arrhythmia-specific management strategies in CA remain incompletely elucidated. This review aims to provide a comprehensive overview of current evidence related to the arrhythmic features of CA. In addition, it characterizes the electrophysiological consequences of amyloid infiltration, distinguishes arrhythmic profiles between AL and ATTR subtypes, and evaluates diagnostic methods and treatment options to optimize clinical management decision-making. Atrial fibrillation is a prevalent arrhythmia, particularly in wild-type ATTR amyloidosis. In contrast, AL amyloidosis, characterized by direct myocyte cytotoxicity and accelerated disease progression, frequently manifests with ventricular arrhythmias and conduction disturbances. Ultimately, arrhythmias in CA are multifactorial, necessitating a subtype-specific approach to diagnosis and treatment. Risk stratification, integrating electrocardiographic, imaging, biomarker, and genetic data, is crucial for guiding patient management. Future directions involve personalized treatment frameworks leveraging multiomics integration, remote rhythm monitoring, and artificial intelligence-driven predictive modeling to advance precision electrophysiology in systemic amyloidosis.</p>","PeriodicalId":32654,"journal":{"name":"Heart Views","volume":"27 ","pages":"5"},"PeriodicalIF":0.5,"publicationDate":"2026-08-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13591758/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149018105","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Basal Left Ventricular Aneurysm in Hypertrophic Cardiomyopathy: An Unusual Case Report.","authors":"Mehmet Uğur Çaliskan, Ceren Yagmur Dogru Yilmaz","doi":"10.4103/heartviews.heartviews_164_25","DOIUrl":"10.4103/heartviews.heartviews_164_25","url":null,"abstract":"<p><p>Hypertrophic cardiomyopathy (HCM) is a genetic cardiac disease associated with an increased risk of sudden cardiac death. Left ventricular (LV) apical aneurysms may develop in patients with HCM and are linked to an adverse prognosis. We present the case of a 68-year-old woman with HCM who was found to have aneurysmal dilatation of the LV basal segments on transthoracic echocardiography. Coronary angiography revealed no obstructive epicardial coronary artery disease. Unlike the typical apical aneurysm pattern, this case highlights a basal segment aneurysm in HCM and underscores the importance of careful echocardiographic evaluation in the diagnosis and follow-up of these patients.</p>","PeriodicalId":32654,"journal":{"name":"Heart Views","volume":"26 4","pages":"287-289"},"PeriodicalIF":0.5,"publicationDate":"2026-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13142814/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147843668","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Managing Feeding Refusal as an Unusual Presentation of Severe Atrioventricular Valve Regurgitation in a PostFontan Patient with Down Syndrome.","authors":"Mohamed Metwally Abdelaal, Mustafa Alqbandi","doi":"10.4103/heartviews.heartviews_133_25","DOIUrl":"10.4103/heartviews.heartviews_133_25","url":null,"abstract":"<p><strong>Background: </strong>Feeding refusal is an uncommon and often overlooked manifestation of hemodynamic deterioration in patients with Fontan physiology.</p><p><strong>Case presentation: </strong>We report a child with trisomy 21 and unbalanced atrioventricular septal defect who presented several years after Fontan completion with progressive feeding refusal and ascites. Comprehensive evaluation revealed severe atrioventricular valve regurgitation without Fontan pathway obstruction. Medical optimization resulted in clinical improvement, and surgical valve repair was planned.</p><p><strong>Conclusion: </strong>Feeding refusal may represent an early clinical clue of Fontan failure. Prompt recognition and multidisciplinary management are essential to optimize outcomes in this high-risk population.</p>","PeriodicalId":32654,"journal":{"name":"Heart Views","volume":"26 4","pages":"281-283"},"PeriodicalIF":0.5,"publicationDate":"2026-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13142805/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147843676","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bridging the Gap: Primary Care Physicians as Partners in Heart Failure Early Detection.","authors":"Juan Sebastián Therán León, Carlos Enrique Arenas","doi":"10.4103/heartviews.heartviews_166_25","DOIUrl":"10.4103/heartviews.heartviews_166_25","url":null,"abstract":"","PeriodicalId":32654,"journal":{"name":"Heart Views","volume":"26 4","pages":"313-314"},"PeriodicalIF":0.5,"publicationDate":"2026-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13142803/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147843695","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Alternating Right and Left Bundle Branch Block: Management in a Patient with Cardiac Amyloidosis.","authors":"Avitasha Darshni, Mohammad Paymard","doi":"10.4103/heartviews.heartviews_91_25","DOIUrl":"10.4103/heartviews.heartviews_91_25","url":null,"abstract":"<p><p>Alternating bundle branch block (ABBB) is a phenomenon described by the presence of both right bundle branch block (RBBB) and left bundle branch block (LBBB) in the same individual at different points in time. We present the case of a 74-year-old male with known cardiac amyloid who was managed in hospital for an ABBB in the context of an accidental fall. Serial electrocardiograms (ECGs) revealed transient alternating RBBB and LBBB. The patient underwent dual-chamber permanent pacemaker implantation. This case reviews the management of alternating bundle brunch blocks and highlights the complexities of treating conduction disease in patients with cardiac amyloid.</p>","PeriodicalId":32654,"journal":{"name":"Heart Views","volume":"26 4","pages":"290-292"},"PeriodicalIF":0.5,"publicationDate":"2026-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13142810/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147843727","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Time to Thrombolysis in Left-sided Prosthetic Valve Thrombosis: Reaffirming the Critical Window.","authors":"Fidel M Caceres-Loriga, Humberto Morais","doi":"10.4103/heartviews.heartviews_146_25","DOIUrl":"10.4103/heartviews.heartviews_146_25","url":null,"abstract":"","PeriodicalId":32654,"journal":{"name":"Heart Views","volume":"26 4","pages":"311-312"},"PeriodicalIF":0.5,"publicationDate":"2026-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13142807/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147843696","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Can QRISK-3 and PREVENT Predict Premature Acute Coronary Syndrome in Adults under 40 Years? The Insights from Predicting the Risk of Acute Coronary Syndrome under 40 (PRACS-40) Study.","authors":"Abhishek Jharia, Shishir Soni, Lalit Jain, Jaya Upadhyay","doi":"10.4103/heartviews.heartviews_171_25","DOIUrl":"10.4103/heartviews.heartviews_171_25","url":null,"abstract":"<p><strong>Background: </strong>The occurrence of acute coronary syndrome (ACS) among individuals under 40 years has increased markedly, yet current atherosclerotic cardiovascular disease risk prediction models are primarily validated in older adults, leading to underrecognition of risk and missed prevention in the young.</p><p><strong>Objectives: </strong>The objectives of this study were to evaluate cardiovascular risk factors (CVRFs) in young adults with ACS and to assess the applicability and correlation of QRISK-3 and PREVENT risk prediction scores in this demographic.</p><p><strong>Methods: </strong>In this single-center observational study, 250 patients (<40 years of age) with ACS were assessed for the CVRFs; demographic, metabolic, and lifestyle profiles, echocardiographic and coronary angiographic (CAG) findings; and risk scores. The correlation between QRISK-3 and PREVENT models was assessed in the 30-40-year age subgroup.</p><p><strong>Results: </strong>The cohort (mean age: 35.1 ± 4.0 years; 93.2% of males) demonstrated a high prevalence of tobacco use (smoking - 40.8% and smokeless tobacco - 76.8%) and diabetes (26.8%). ST-segment-elevated myocardial infarction represented 63.6% of cases, and single-vessel disease predominated on CAG. The mean QRISK-3 10-year and 30-year estimates were 1.53+1.64 and 11.76+7.21, respectively. A strong correlation was observed between QRISK-3 and PREVENT for both 10-year (<i>r</i> = 0.714, <i>P</i> < 0.001) and 30-year (<i>r</i> = 0.868, <i>P</i> < 0.01) risk estimates in the 30-40-year age group. Smokeless tobacco users exhibited shorter sleep duration and lower 30-year QRISK scores compared with nonusers (<i>P</i> < 0.001).</p><p><strong>Conclusions: </strong>Premature ACS links to modifiable factors such as tobacco and poor lifestyle. Standard models underpredict short-term risk but align well with long-term; integrating lifetime estimates and region-specific behaviors (e.g., smokeless tobacco) could improve prediction and enable earlier interventions.</p>","PeriodicalId":32654,"journal":{"name":"Heart Views","volume":"26 4","pages":"272-280"},"PeriodicalIF":0.5,"publicationDate":"2026-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13142811/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147843743","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Revisiting Digitoxin in Patients with Heart Failure and Reduced Ejection Fraction Trial: Lessons on Statistical Power.","authors":"Alaa Rahhal, Ashfaq Patel","doi":"10.4103/heartviews.heartviews_157_25","DOIUrl":"10.4103/heartviews.heartviews_157_25","url":null,"abstract":"","PeriodicalId":32654,"journal":{"name":"Heart Views","volume":"26 4","pages":"309-310"},"PeriodicalIF":0.5,"publicationDate":"2026-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13142806/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147843714","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"iCARDIO Alliance Global Implementation Guidelines on Heart Failure 2025.","authors":"Vijay Chopra, Muhammad Shahzeb Khan, Magdy Abdelhamid, William T Abraham, Offer Amir, Stefan D Anker, John J Atherton, Fernando Bacal, Ralph Stephan von Bardeleben, Dulce Brito, Lucrecia Maria Burgos, Javed Butler, Maria Rosa Costanzo, Albertino Damasceno, Justin A Ezekowitz, Ishaque Hameed, Sivadasanpillai Harikrishnan, Tiny Jaarsma, Anuradha Lala, Ileana L Piña, Clara Saldarriaga, David Sim, John R Teerlink, Nqoba Tsabedze, Hiroyuki Tsutsui, Jing Yu, Yuhui Zhang, Mohammad Zubaid, Nikhil Balankhe, Juan Esteban Gomez-Mesa, James L Januzzi, Marvin Konstam, Rhonda Monroe, Elijah Ogola, Vinayagam Palaniappan, Mark C Petrie, Fausto J Pinto, Girish C Rajadhyaksha, Amina Rakisheva, Carlos E Ramos, Victor Rossel, Naoki Sato, P Christian Schulze, Andrew Sindone, Hadi N Skouri, Harriette G C Van Spall, Aistė Štaraitė, Lynne Warner Stevenson, Kadhim Sulaiman, Tzung-Dau Wang, Michael Böhm, Andrew J S Coats, Shelley Zieroth","doi":"10.4103/heartviews.heartviews_37_26","DOIUrl":"10.4103/heartviews.heartviews_37_26","url":null,"abstract":"<p><p>Inconsistencies in healthcare access, varying infrastructure, resource constraints and diverse local practices as well as practical and political issues restrict the global applicability of currently available guidelines. There is a need for universal recommen- dations that address the unique challenges faced by patients and healthcare providers worldwide. Our iCARDIO Alliance Global Implementation Guidelines emphasize the incorporation of novel therapies, while integrating standard of care with the most up-to-date evidence to enable clinicians to optimize patient care. This document is about heart failure (HF), including acute and chronic heart failure, heart failure with reduced ejection fraction and heart failure with preserved ejection fraction as well as cardiomyopathies. Context-specific recommendations tailored to individual patient needs are highlighted providing a thorough evaluation of the risks, benefits, and overall value of each therapy, aiming to establish a standard of care that improves patient outcomes and reduces the burden of hospitalization in this susceptible population. These guidelines provide evidence-based recommendations that represent a group consensus considering the many other published guidelines that have reviewed many of the issues discussed here, but they also make new recommendations where new evidence has recently emerged. Most importantly these guidelines also provide recommendations on a number of issues where resource limitations may put constraints on the care provided to HF patients. Such \"economic adjustment\" recommendations aim to provide guidance for situations when \"Resources are somewhat limited\" or when \"Resources are severely limited\". Hence, this document presents not only a comprehensive but also concise update to HF management guidelines thereby aiming to provide a unified strategy for the pharmacological, non-pharmacological, invasive and interventional management of this significant global health challenge that is applicable to the needs of healthcare around the globe.</p>","PeriodicalId":32654,"journal":{"name":"Heart Views","volume":"26 4","pages":"227-259"},"PeriodicalIF":0.5,"publicationDate":"2026-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13142816/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147843685","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}