Pigment InternationalPub Date : 2022-05-01DOI: 10.4103/pigmentinternational.pigmentinternational_76_20
Kakar Shruti, Suggu Ramu, Bhalla Mala
{"title":"Mosaic neurofibromatosis type 1 or segmental neurofibromatosis: what is in the name?","authors":"Kakar Shruti, Suggu Ramu, Bhalla Mala","doi":"10.4103/pigmentinternational.pigmentinternational_76_20","DOIUrl":"https://doi.org/10.4103/pigmentinternational.pigmentinternational_76_20","url":null,"abstract":"","PeriodicalId":32636,"journal":{"name":"Pigment International","volume":"1 1","pages":"137 - 138"},"PeriodicalIF":0.0,"publicationDate":"2022-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75721734","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pigment InternationalPub Date : 2022-05-01DOI: 10.4103/pigmentinternational.pigmentinternational_81_21
A. Arora, M. Bhalla
{"title":"Newer indications of tranexamic acid in dermatology beyond melasma: a review","authors":"A. Arora, M. Bhalla","doi":"10.4103/pigmentinternational.pigmentinternational_81_21","DOIUrl":"https://doi.org/10.4103/pigmentinternational.pigmentinternational_81_21","url":null,"abstract":"Tranexamic acid (TXA) is an antifibrinolytic agent approved for use to control bleeding during surgery and after trauma. It has been used in dermatology as a therapeutic and prophylactic agent in angioedema since 1970s but its recently discovered role in melasma has made it the current molecule of interest. At present TXA is being widely researched for multiple indications in view of its role in reducing melanogenesis and angiogenesis in skin. Various case reports and clinical trials have been published over the last few years describing its role in postinflammatory hyperpigmentation, dermal melanosis, rosacea, telangiectasia, and even as an antiaging agent. We present this review here summarizing the various publications for the aforementioned indications.","PeriodicalId":32636,"journal":{"name":"Pigment International","volume":"71 1","pages":"70 - 81"},"PeriodicalIF":0.0,"publicationDate":"2022-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75587534","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pigment InternationalPub Date : 2022-05-01DOI: 10.4103/pigmentinternational.pigmentinternational_80_20
A. Chaudhary, Shitij Goel, Tunika Arora
{"title":"Tamoxifen-induced lichen planus pigmentosus − case report","authors":"A. Chaudhary, Shitij Goel, Tunika Arora","doi":"10.4103/pigmentinternational.pigmentinternational_80_20","DOIUrl":"https://doi.org/10.4103/pigmentinternational.pigmentinternational_80_20","url":null,"abstract":"Lichen planus pigmentosus is characterized by slaty-gray pigmentation, predominantly on sun-exposed sites. It is considered to be a type IV hypersensitivity reaction to unknown antigen with lichenoid inflammation which may lead to melanin incontinence and superficial dermal pigmentation. This report presents a rare case of lichen planus pigmentosus caused due to tamoxifen intake.","PeriodicalId":32636,"journal":{"name":"Pigment International","volume":"40 1","pages":"134 - 136"},"PeriodicalIF":0.0,"publicationDate":"2022-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75565488","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pigment InternationalPub Date : 2022-05-01DOI: 10.4103/pigmentinternational.pigmentinternational_69_20
K. Phan, S. Shumack, Monisha Gupta
{"title":"Association between vitiligo and risk of suicide and suicidal ideation: systematic review and meta-analysis","authors":"K. Phan, S. Shumack, Monisha Gupta","doi":"10.4103/pigmentinternational.pigmentinternational_69_20","DOIUrl":"https://doi.org/10.4103/pigmentinternational.pigmentinternational_69_20","url":null,"abstract":"Background: Vitiligo is an autoimmune skin disorder characterized by patches of depigmentation due to loss of melanocytes. Vitiligo is associated with significant psychosocial burden, with prior studies showing links with psychiatric comorbidities such as depression. Few studies have evaluated the relationship between vitiligo and suicidal ideation and suicide attempts. We aimed to investigate the underlying prevalence and risk of suicidal ideation or suicide attempts among patients with vitiligo. Materials and Methods: A systematic search of PubMed, MEDLINE, Embase, and the Cochrane Library was conducted. Cross‐sectional, case–control or cohort studies that assessed the prevalence of suicidal ideation or suicide attempts among patients with vitiligo were included. DerSimonian and Laird random‐effects models were utilized to calculate the pooled prevalence and odds ratios. Results: From systematic review, we identified seven studies included for analysis. A total of 12,043 vitiligo cases were compared with 87,053,333 controls. The pooled proportion of suicidal ideation in vitiligo was 15.2% compared to 2.0% in the control group (P < 0.001). The proportion of suicide attempts/suicides was also higher for vitiligo compared to controls (3.2% vs. 2.1%, P < 0.001). Moderate‐to‐high heterogeneity was observed between the studies. Conclusion: Our data further provide evidence of the significant impact vitiligo has on self-esteem and psychological burden. Patients with vitiligo were significantly more likely to have suicidal ideation. Clinicians should actively evaluate patients with vitiligo for signs/symptoms of suicidal ideation and provide appropriate referrals to manage their psychiatric symptoms accordingly.","PeriodicalId":32636,"journal":{"name":"Pigment International","volume":"34 1","pages":"127 - 130"},"PeriodicalIF":0.0,"publicationDate":"2022-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89683455","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pigment InternationalPub Date : 2022-05-01DOI: 10.4103/pigmentinternational.pigmentinternational_38_20
K. Rambhia, S. Hajare, J. Mukhi, R. Singh
{"title":"The mystery of brown shawl over back: a rare case of giant plexiform neurofibroma underlying a giant café-au-lait macule","authors":"K. Rambhia, S. Hajare, J. Mukhi, R. Singh","doi":"10.4103/pigmentinternational.pigmentinternational_38_20","DOIUrl":"https://doi.org/10.4103/pigmentinternational.pigmentinternational_38_20","url":null,"abstract":"Neurofibromatosis is a rare autosomal dominant disorder characterized by café-au-lait macules and cutaneous neurofibromas. Café-au-lait spots are sharply defined, light-brown colored homogenous macules observed in more than 90% of cases. Plexiform neurofibromas are benign tumors originating from nerve sheath cells, subcutaneous or visceral peripheral nerves involving multiple fascicles often described on palpation as a bag of worms. We describe a case of 25-year-old male who presented with a giant plexiform neurofibroma underlying a giant café-au-lait macule.","PeriodicalId":32636,"journal":{"name":"Pigment International","volume":"6 1","pages":"131 - 133"},"PeriodicalIF":0.0,"publicationDate":"2022-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89992491","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pigment InternationalPub Date : 2022-05-01DOI: 10.4103/pigmentinternational.pigmentinternational_58_20
Y. Bhat, F. Shah, Insha Latif, Najm-u Saqib, A. Shah, Yaqzata Bashir, Rita T Devi, U. Dar, Masarat Naushad, I. Hassan, K. Krishan
{"title":"Role of dermoscopy in the assessment of difficult to diagnose cases of pigmentary dermatoses: study from a tertiary care hospital","authors":"Y. Bhat, F. Shah, Insha Latif, Najm-u Saqib, A. Shah, Yaqzata Bashir, Rita T Devi, U. Dar, Masarat Naushad, I. Hassan, K. Krishan","doi":"10.4103/pigmentinternational.pigmentinternational_58_20","DOIUrl":"https://doi.org/10.4103/pigmentinternational.pigmentinternational_58_20","url":null,"abstract":"Background: Pigmentary disorders are a common skin affliction causing great distress and anguish among those affected. Dermoscopy is a noninvasive diagnostic modality which has great potential in the diagnosis of these disorders. Objectives: To assess the dermoscopic features relevant to the diagnosis of pigmentary dermatoses in patients presenting to our tertiary care hospital. Methods: This was a cross-sectional study conducted in patients presenting to pigmentary dermatoses clinic of our hospital over a period of 1 year. A comprehensive evaluation with special emphasis on dermoscopy was performed in all patients. The dermoscope used was DL3N Dermlite (10X). Additional investigations were carried out as deemed necessary to clinch a final diagnosis. Results: The study included a total of 200 cases with 90 males and 110 females, with age ranging from 6 months to 69 years and a mean age of 24.43 ± 17.07 years. The pigmentary dermatoses encountered were divided into three groups − disorders of hypopigmentation, facial melanoses, and other pigmentary disorders. Dermoscopic findings most relevant to diagnosis were compiled and tabulated. Conclusion: Dermoscopy played a significant role to rule out ominous diagnosis with accuracy comparable to histopathology, when carried out by an expert. The need for an invasive procedure such as skin biopsy was evaded in a number of cases.","PeriodicalId":32636,"journal":{"name":"Pigment International","volume":"71 1","pages":"93 - 106"},"PeriodicalIF":0.0,"publicationDate":"2022-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91051201","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pigment InternationalPub Date : 2022-05-01DOI: 10.4103/pigmentinternational.pigmentinternational_17_20
Jyoti Budhwar, S. Malhotra
{"title":"Efficacy of autologous melanocytic transplantation by flip-top technique in patients of stable vitiligo","authors":"Jyoti Budhwar, S. Malhotra","doi":"10.4103/pigmentinternational.pigmentinternational_17_20","DOIUrl":"https://doi.org/10.4103/pigmentinternational.pigmentinternational_17_20","url":null,"abstract":"Background: Vitiligo is an acquired disorder of depigmentation. Various surgical modalities are recommended for quicker resolution of lesions in stable cases. Aim and objectives: To study the efficacy of flip-top technique of autologous melanocytic transplantation in a series of 30 patients with stable vitiligo. Materials and Methods: Thirty patients with stable vitiligo, not responding to adequate trial of medicines were taken in this prospective study. After doing complete investigations, including coagulogram, they were subjected to Flip-top technique of autologous melanocytic transplantation, then 15 patients were put on PUVASOL and 15 patients were exposed to sunlight alone for 3 months. Digital photographs were taken at every sitting. An analysis was performed using the Wilcoxon signed-rank test and Mann--Whitney tests and grading was done for response. Results: Satisfactory cosmetic results were obtained in all cases with 26 patients achieving more than 25% of repigmentation and only 4 patients achieving less than 50% or above repigmentation. Colour match was good with minimal complications. Conclusion: Flip-top technique of autologous melanocytic transplantation appears to be a promising option for patients with stable recalcitrant vitiligo.","PeriodicalId":32636,"journal":{"name":"Pigment International","volume":"46 1","pages":"107 - 114"},"PeriodicalIF":0.0,"publicationDate":"2022-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90784734","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pigment InternationalPub Date : 2022-01-01DOI: 10.4103/pigmentinternational.pigmentinternational_51_20
Veena
{"title":"Dyschromatosis universalis hereditaria with keratoacanthoma: a rare presentation","authors":"Veena","doi":"10.4103/pigmentinternational.pigmentinternational_51_20","DOIUrl":"https://doi.org/10.4103/pigmentinternational.pigmentinternational_51_20","url":null,"abstract":"Dyschromatosis Universalis hereditaria is a rare pigmentary disorder presenting with dyschromia of skin involving trunk and extremities arranged in mottled manner lesions, usually present in the first few years of life. Herein, we report this extremely rare case of dyschromatosis universalis hereditaria in a middle-aged male with a family history of dyschromia in his younger sister, now presenting to us with a keratoacanthoma.","PeriodicalId":32636,"journal":{"name":"Pigment International","volume":"19 1","pages":"55 - 58"},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73894124","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pigment InternationalPub Date : 2022-01-01DOI: 10.4103/pigmentinternational.pigmentinternational_11_20
S. Gupta, Sushantika Kumari
{"title":"Congenital hairy melanocytic nevus over eye","authors":"S. Gupta, Sushantika Kumari","doi":"10.4103/pigmentinternational.pigmentinternational_11_20","DOIUrl":"https://doi.org/10.4103/pigmentinternational.pigmentinternational_11_20","url":null,"abstract":"A ten year old boy presented with black hairy nevus over left eyelid since birth.He did not have any complains of vision. The nevus was progressing in size encroaching over upper eyelid with minute papules in eyelid margin. It was diagnosed as congenital hairy melanocytic nevus clinically. His parents were advised laser therapy after he reaches maturity as a management option. The location of the nevus made it worth reporting.","PeriodicalId":32636,"journal":{"name":"Pigment International","volume":"26 1","pages":"65 - 66"},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84987687","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}