2023 Design of Medical Devices Conference最新文献

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DESIGN OF AN MRI-COMPATIBLE ROBOT FOR IMAGE-GUIDED NEEDLE INSERTION PROCEDURES USING ACTIVE TENDON-DRIVEN NEEDLES 一种mri兼容机器人的设计,用于使用主动肌腱驱动的针头进行图像引导的针头插入过程
2023 Design of Medical Devices Conference Pub Date : 2023-04-17 DOI: 10.1115/dmd2023-2247
Samuel Lafreniere, Olivia Lee Sprouse, Ryan Justin Padilla, B. Konh
{"title":"DESIGN OF AN MRI-COMPATIBLE ROBOT FOR IMAGE-GUIDED NEEDLE INSERTION PROCEDURES USING ACTIVE TENDON-DRIVEN NEEDLES","authors":"Samuel Lafreniere, Olivia Lee Sprouse, Ryan Justin Padilla, B. Konh","doi":"10.1115/dmd2023-2247","DOIUrl":"https://doi.org/10.1115/dmd2023-2247","url":null,"abstract":"\u0000 Visualization and tip tracking of needles inside the body in needle-based interventions are usually challenging using conventional medical imaging modalities such as ultrasound and CT. MRI provides an amazing imaging feedback for the operator to target lesions with a great confidence. However, the needle should be operated teleoperatively using a robot interface. This work introduces a novel design of an MRI-compatible (slave) robot for image-guided needle insertions. The robot is designed with MRI-compatible materials and actuators to enable manual initial positioning inside the MRI bore prior to operation, as well as robotic teleoperation (insertion and actuation) of an active tendon-driven needle towards targets. The range of motion is shown to be appropriate for transperineal prostate interventions such as prostate biopsy and brachytherapy.","PeriodicalId":325836,"journal":{"name":"2023 Design of Medical Devices Conference","volume":"117 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-04-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"125918229","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A LIGHTWEIGHT, FOLDABLE MOTORIZED TRANSPORT CHAIR TO EASE CAREGIVER BURDEN 一种轻便、可折叠的电动运输椅,减轻护理人员的负担
2023 Design of Medical Devices Conference Pub Date : 2023-04-17 DOI: 10.1115/dmd2023-6138
Kimberly Gustafson, W. Durfee, Gregory O. Voss, Andrew H Hansen, G. Goldish
{"title":"A LIGHTWEIGHT, FOLDABLE MOTORIZED TRANSPORT CHAIR TO EASE CAREGIVER BURDEN","authors":"Kimberly Gustafson, W. Durfee, Gregory O. Voss, Andrew H Hansen, G. Goldish","doi":"10.1115/dmd2023-6138","DOIUrl":"https://doi.org/10.1115/dmd2023-6138","url":null,"abstract":"\u0000 As the population ages, the number of caregivers in the Unites States is growing rapidly. The burden on these caregivers is exacerbated by steadily increasing obesity rates, which are highest in adults aged 50 to 70. The Caregiver-Assist Transport Chair (CATC) is designed to address the difficulty many caregivers experience assisting in the transportation of moderate to low mobility care recipients outside of the home for appointments, community engagements, or fresh air excursions. It is not uncommon for the caregiver to be elderly or of a smaller build than the care recipient, increasing the difficulty of pushing a transport chair for extended distances or across uneven or unlevel terrain. The CATC is equipped with intelligent motorized wheels that engage in the forward or reverse directions to maintain a consistently low effort required from the caregiver, independent of the weight of the care recipient. The chair assists on uphill terrain and slows on downhill descents to match the walking speed of the caregiver. In addition, the chair has a drop-down footplate mechanism that eliminates the need for the legs of the care recipient to be lifted onto foot pedals once seated. This footplate also serves as a brake to eliminate safety concerns associated with the chair rolling back as the user transitions between sitting and standing. While the CATC contains motorized elements, unlike a typical motorized wheelchair, it is lightweight, foldable, and easy to maneuver in and out of a vehicle.","PeriodicalId":325836,"journal":{"name":"2023 Design of Medical Devices Conference","volume":"81 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-04-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"132422375","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A CASE STUDY ON ACTIVATION LEVEL OF ROTATOR CUFF MUSCLES USING ELECTROMYOGRAPHY AND ASSOCIATED MUSCLE FORCES 应用肌电图和相关肌肉力量研究肩袖肌的激活水平
2023 Design of Medical Devices Conference Pub Date : 2023-04-17 DOI: 10.1115/dmd2023-7918
Allyson Mitchell, AmirHossein Majidirad, G. Pujalte
{"title":"A CASE STUDY ON ACTIVATION LEVEL OF ROTATOR CUFF MUSCLES USING ELECTROMYOGRAPHY AND ASSOCIATED MUSCLE FORCES","authors":"Allyson Mitchell, AmirHossein Majidirad, G. Pujalte","doi":"10.1115/dmd2023-7918","DOIUrl":"https://doi.org/10.1115/dmd2023-7918","url":null,"abstract":"\u0000 Rotator cuff tears are among the most common shoulder injuries, making them an attractive topic of study. Yet, there is a lack of clear understanding of attributes associated with deep and superficial muscles when it is intended to study the recovery progress after rehabilitation. Through a systematic approach, this project investigates the activation of rotator cuff muscles using surface electromyography (sEMG) sensors. The team developed a strategic plan to investigate the precision of the NORAXON technology that is utilized in this study to ensure that it is capable of capturing small variations in shoulder motion. This is followed by a reliability analysis to ascertain reproducibility of the experiment. The levels of muscle activities for superficial and deep muscles are monitored to explore the impact of traditionally prescribed arm movements used for the rehabilitation of rotator cuff injuries. Furthermore, an analysis of forces generated in the muscles is done to provide better insight into the activation levels of rotator cuff muscles. The results were promising, with a competent technology and acceptable correlation associated with muscle activities across all subjects. Four common arm movements were studied; scaption generated a significant response in the targeted muscles, particularly of the supraspinatus. Results were conclusive across all subjects, and simulation also supported the experiment showing high activation levels for the supraspinatus. The teres minor also showed a significant contribution when performing external rotation at 90⁰ abduction. The outcome of this study is significant for this ongoing project as it identifies the most impactful exercises that ensure targeted muscles are being triggered. It also lays the groundwork for expanding the project to a clinical study focusing on the most effective arm movements in order to improve rehabilitation process and reduce pertinent cost.","PeriodicalId":325836,"journal":{"name":"2023 Design of Medical Devices Conference","volume":"209 ","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-04-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"133557054","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
DESIGN OF A CUSTOM SENSING AND ACTUATING CUSHION FOR USE IN PRESSURE RELIEF IN WHEELCHAIR USERS 设计一种用于轮椅使用者减压的定制传感和驱动垫
2023 Design of Medical Devices Conference Pub Date : 2023-04-17 DOI: 10.1115/dmd2023-6305
Jason Robinson, Vishakh H. Shewalkar, Isaiah Rigo, Asaiah Rock, Lucy Cinnamon, Daniella Chapman-Rienstra, Jooyoung Hong, Joohyung Kim, Holly M. Golecki
{"title":"DESIGN OF A CUSTOM SENSING AND ACTUATING CUSHION FOR USE IN PRESSURE RELIEF IN WHEELCHAIR USERS","authors":"Jason Robinson, Vishakh H. Shewalkar, Isaiah Rigo, Asaiah Rock, Lucy Cinnamon, Daniella Chapman-Rienstra, Jooyoung Hong, Joohyung Kim, Holly M. Golecki","doi":"10.1115/dmd2023-6305","DOIUrl":"https://doi.org/10.1115/dmd2023-6305","url":null,"abstract":"\u0000 Pressure sores impact a wide range of individuals including wheelchair users. Solutions to address pressure sore prevention are limited. This work is aimed at developing devices to prevent pressure sores in wheelchair users with limited mobility or sensation. Informed by stakeholder input, we present a dynamic cushion design to sense areas of high pressure and actuate to relieve that pressure. We experimented using resistive sensors in a grid formation to map pressure across the seat. To relieve pressure, we propose a grid of custom pneumatic bladders to inflate in response to sensor thresholds. Bladders will inflate to redistribute pressure. After experimenting with a variety of possible bladder geometries, we selected torus-shaped actuators to optimize durability, stability, and increase breathability in the final design. Given the ability to fabricate custom bladders and program controls, the proposed device can be tailored to users’ specific needs. While static cushion solutions exist on the market, our custom design allows users to dynamically alleviate pressure eliminated the need to constantly readjust position and ultimately reduce time spent treating sores.","PeriodicalId":325836,"journal":{"name":"2023 Design of Medical Devices Conference","volume":"2 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-04-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"132878404","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A COMPARISON OF THE PRESSURE FAILURE OF TWO COLORECTAL ANASTAMOSES STAPLING TECHNIQUES 两种结直肠吻合器加压失败的比较
2023 Design of Medical Devices Conference Pub Date : 2023-04-17 DOI: 10.1115/dmd2023-8985
Youssef Fahmy, M. Trabia, Brian Ward, L. Gallup, Whitney Elks
{"title":"A COMPARISON OF THE PRESSURE FAILURE OF TWO COLORECTAL ANASTAMOSES STAPLING TECHNIQUES","authors":"Youssef Fahmy, M. Trabia, Brian Ward, L. Gallup, Whitney Elks","doi":"10.1115/dmd2023-8985","DOIUrl":"https://doi.org/10.1115/dmd2023-8985","url":null,"abstract":"\u0000 Anastomotic leakage (AL) is a serious complication that effects thousands of patients undergoing colorectal surgery annually. Stapling is generally used to perform anastomoses. Two common anastomosis techniques are the End to End (EE), and End to Side (ES). Currently there is no experimental approach to compare the effectiveness of these two techniques against AL. This work proposes an ex-vivo experimental setup of burst testing of anastomoses using porcine tissues. Twelve pigs were used with three specimens harvested from the colon of each of them: EE, ES, and a control specimen. Failure of the anastomoses were monitored, and the corresponding leakage pressures were recorded. Preliminary results indicated that ES led to higher strength than EE.","PeriodicalId":325836,"journal":{"name":"2023 Design of Medical Devices Conference","volume":"5 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-04-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"128794874","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
CONVECTION ENHANCED THERMO-CHEMOTHERAPY CATHETER SYSTEM: PRE-510(K) CLEARANCE PROTOCOL DEVELOPMENT: FLUID PERFORMANCE TESTING 对流增强热化疗导管系统:pre-510 (k)清除协议开发:流体性能测试
2023 Design of Medical Devices Conference Pub Date : 2023-04-17 DOI: 10.1115/dmd2023-3181
Brianna E. Morales, Christopher G. Rylander
{"title":"CONVECTION ENHANCED THERMO-CHEMOTHERAPY CATHETER SYSTEM: PRE-510(K) CLEARANCE PROTOCOL DEVELOPMENT: FLUID PERFORMANCE TESTING","authors":"Brianna E. Morales, Christopher G. Rylander","doi":"10.1115/dmd2023-3181","DOIUrl":"https://doi.org/10.1115/dmd2023-3181","url":null,"abstract":"\u0000 Our lab is developing a novel device, the convection-enhanced thermo-chemotherapy catheter system (CETCS), to improve drug dispersal around a glioblastoma. To help prepare the device for clinical trials, we were advised to first prepare and receive 510(k)-clearance. The 510(k)-clearance process includes proving the novel device is substantially equivalent to a previously cleared predicate device. For the CETCS device, we have identified the Cleveland Multiport Catheter (CMC) as our predicate device. In this work, we test infusion pump flow rate, high-pressure flow rate, and microneedle tip deflection; each with respect to infusion and aspiration. The CMC’s 510(k) summary sheet provided guidelines for the test protocols to follow. If the CMC’s 510(k) summary did not state a metric, we set the metric based on the CETCS device specifications. Replicating or exceeding the threshold passing criteria set by the CMC device or the CETCS specifications demonstrates that CETCS is substantially equivalent to the predicate device for those specific metrics.","PeriodicalId":325836,"journal":{"name":"2023 Design of Medical Devices Conference","volume":"81 6 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-04-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"116349423","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
ITINERARY PREDICTIVE ANALYTICS: AI BASED SOFTWARE AS A MEDICAL DEVICE TO PREDICT PATIENTS’ FIRST VISIT ITINERARY FOR HEALTHCARE ADMINISTRATION 行程预测分析:基于人工智能的软件作为一种医疗设备,用于预测患者的首次就诊行程,以供医疗管理部门使用
2023 Design of Medical Devices Conference Pub Date : 2023-04-17 DOI: 10.1115/dmd2023-1597
S. Damani, K. Gopalakrishnan, Keirthana Aedma, Pratyusha Muddaloor, V. Chandrasekhara, Alexander J. Ryu, Christopher A. Aakre, S. P. Arunachalam
{"title":"ITINERARY PREDICTIVE ANALYTICS: AI BASED SOFTWARE AS A MEDICAL DEVICE TO PREDICT PATIENTS’ FIRST VISIT ITINERARY FOR HEALTHCARE ADMINISTRATION","authors":"S. Damani, K. Gopalakrishnan, Keirthana Aedma, Pratyusha Muddaloor, V. Chandrasekhara, Alexander J. Ryu, Christopher A. Aakre, S. P. Arunachalam","doi":"10.1115/dmd2023-1597","DOIUrl":"https://doi.org/10.1115/dmd2023-1597","url":null,"abstract":"\u0000 Majority of hospitals still utilize manual methods for patient scheduling and predicting future appointments, resulting in longer wait times, hospital burnout and inadequate use of resources. A variety of avenues have been explored, including priority patient routing, tele-health, neural networks for improving ER efficiency, predicting no-shows, consultation duration variations, and optimizing operating room utilization. Addressing this issue, a study was conducted using 700 pre-visit notes of pancreatic patients to determine the requirement of endoscopic or biliary procedure. Through natural language processing and traditional or transfer learning algorithms, data could directly be sent to EPIC for nurses to assess in further decision making. Performance of the models was above average with the transfer learning method outperforming the traditional method. Although limited by less dataset and fewer circumstances to test the models on, the results exposed potential for future development with the possibility of patients reporting their chief concerns, in turn analyzed by algorithms, ultimately creating a smooth and effective patient itinerary.","PeriodicalId":325836,"journal":{"name":"2023 Design of Medical Devices Conference","volume":"77 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-04-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"116358578","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
HAND MOVEMENT GLOVE FOR CHILD WITH TITINOPATHY 为患有视网膜病变的儿童准备的手部运动手套
2023 Design of Medical Devices Conference Pub Date : 2023-04-17 DOI: 10.1115/dmd2023-9287
Hannah Bass, C. Foster, Akshaya Santhanaraj, Shourya Kumar
{"title":"HAND MOVEMENT GLOVE FOR CHILD WITH TITINOPATHY","authors":"Hannah Bass, C. Foster, Akshaya Santhanaraj, Shourya Kumar","doi":"10.1115/dmd2023-9287","DOIUrl":"https://doi.org/10.1115/dmd2023-9287","url":null,"abstract":"\u0000 Patients with titinopathy or hand paralysis often lack quality, low cost therapeutic tools to aid in gaining hand strength and range of motion. As a result, our team sought to develop a way to increase flexion and passive motion in the hand of a patient with titinopathy in order to gain functionality. This paper outlines the design and development of a novel therapeutic glove for a 4 year old boy with a neuromuscular disease that prevents him from flexing the two distal joints of his fingers.\u0000 The team has developed a low-cost hand movement glove (HMG) to be used as a supplement to traditional physical therapy. The device utilizes a motor-cable system secured to each finger, allowing for independent and synchronized flexion of each finger. Phase I of prototyping resulted in a working model to assess the finger movement mechanism and overall wearability of the device. Phase II utilized an Arduino Uno microcontroller, circuit switch, PCA9685 driver board, micro servo motors, a cotton woven glove, and 3-D printed components to characterize a more robust model allowing independent flexion of each finger.\u0000 Initial testing has proven the device’s ability to achieve physiologically relevant degrees of flexion in each finger. Upon completion of further testing, we anticipate this device having a profound impact as an additional tool utilized in the patient’s physical therapy regimen to allow for regained flexion at both proximal and distal interphalangeal joints.","PeriodicalId":325836,"journal":{"name":"2023 Design of Medical Devices Conference","volume":"3 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-04-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"126101635","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
ARRHYTHMIC SUDDEN DEATH SURVIVAL PREDICTION MODEL FOR HYPERTROPHIC CARDIOMYOPATHY PATIENTS: AN INTERPRETABLE MACHINE LEARNING ANALYSIS 肥厚性心肌病患者心律失常猝死生存预测模型:可解释的机器学习分析
2023 Design of Medical Devices Conference Pub Date : 2023-04-17 DOI: 10.1115/dmd2023-2989
N. Farahani, Moein Enayati, Andredi Pumarejo, Mateo Alzate Aguirre, Christopher G. Scott, Konstantinos C. Siontis, Martijn Bos, J. Geske, M. Ackerman, Adelaide M. Arruda-Olson
{"title":"ARRHYTHMIC SUDDEN DEATH SURVIVAL PREDICTION MODEL FOR HYPERTROPHIC CARDIOMYOPATHY PATIENTS: AN INTERPRETABLE MACHINE LEARNING ANALYSIS","authors":"N. Farahani, Moein Enayati, Andredi Pumarejo, Mateo Alzate Aguirre, Christopher G. Scott, Konstantinos C. Siontis, Martijn Bos, J. Geske, M. Ackerman, Adelaide M. Arruda-Olson","doi":"10.1115/dmd2023-2989","DOIUrl":"https://doi.org/10.1115/dmd2023-2989","url":null,"abstract":"\u0000 Hypertrophic Cardiomyopathy (HCM) is an inheritable heart disease with the highest rate of sudden cardiac death (SCD) in young adults. Implantable Cardioverter Defibrillator (ICD) therapy is recommended for HCM patients at high risk for SCD. Reviewing the recent clinical literature revealed the potential to improve the selection of candidates for ICD implantation. The current study uses information extracted from echocardiography reports to evaluate HCM patients with ICD and aims to provide a comparative insight into patients who benefited the most from the device therapy, including shock and anti-tachycardia pacing (ATP). The proposed interpretable machine learning approach has used the XGboost algorithm. The model’s performance was considered satisfactory, as evidenced by an accuracy score of 81% and an area under the receiver operating characteristic curve (AUC) value of 69% and SHapley Additive exPlanations (SHAP) identified common properties of HCM patients in each category and provided high-level reasoning and foundation for a clinical decision support tool.","PeriodicalId":325836,"journal":{"name":"2023 Design of Medical Devices Conference","volume":"17 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-04-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"124648692","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
EXTRACELLULAR FLOW PATTERNS SURROUNDING A BREAST CANCER CELL DURING TRANSPORT IN A MICROCHANNEL 乳腺癌细胞在微通道中运输过程中的细胞外流动模式
2023 Design of Medical Devices Conference Pub Date : 2023-04-17 DOI: 10.1115/dmd2023-7947
Lahcen Akerkouch, Trung Le, Amanda Haage, Aaron Vanyo
{"title":"EXTRACELLULAR FLOW PATTERNS SURROUNDING A BREAST CANCER CELL DURING TRANSPORT IN A MICROCHANNEL","authors":"Lahcen Akerkouch, Trung Le, Amanda Haage, Aaron Vanyo","doi":"10.1115/dmd2023-7947","DOIUrl":"https://doi.org/10.1115/dmd2023-7947","url":null,"abstract":"\u0000 We performed the transport of a breast cancer cell (MB231-TGFb) in a microvessel using high-resolution simulations. Using open-source imaging software Slicer3D and Meshmixer, the 3D surface mesh forming the cell membrane was reconstructed from confocal microscopic images. The Dissipative Particle Dynamics method is used to model the cell membrane. The extracellular fluid flow is modeled with the Immersed Boundary Method to solve the governing equations of the blood plasma. The unsteady flow is applied at the inlet of the microchannel with an oscillatory pattern. Our results showed that the extracellular flow patterns are highly dependent on the waveform profile. The oscillatory flow showed the creation of vortices that influence the cellular deformations in the microchannel. These results could have implications on the destination of the cancer cells during transport in physiological flows.","PeriodicalId":325836,"journal":{"name":"2023 Design of Medical Devices Conference","volume":"63 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-04-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"121094810","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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