{"title":"Paradigm shift in the pharmacological treatment of type 2 diabetes mellitus","authors":"T. Lathia","doi":"10.4103/jmgims.jmgims_40_19","DOIUrl":"https://doi.org/10.4103/jmgims.jmgims_40_19","url":null,"abstract":"The options for pharmacological management of type 2 diabetes mellitus have exploded over the last decade or so. Availability of a variety of new drugs, oral as well as injectable, has made the choice of treatment more complex and challenging. Over a decade or so ago, glycemic (glucometabolic) control was the main target of treatment in patients with type 2 diabetes mellitus – usually with metformin, sulfonylureas (SU), thiazolidinediones, and insulin (the traditional quartet). There is conflicting evidence on the cardiovascular (CV) effects of the traditional quartet of drugs. The almost serendipitous benefit of sodium-glucose transporter 2 (SGLT2) inhibitors on CVD and kidney disease in patients with type 2 diabetes mellitus has revolutionized the way we view the treatment of diabetes. . What the physician needs to remember when prescribing this drug is – right patient and right intent.","PeriodicalId":32484,"journal":{"name":"Journal of Mahatma Gandhi Institute of Medical Sciences","volume":"25 1","pages":"11 - 14"},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42012943","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Evidence-based intervention to prevent anemia among women of reproductive age group in developing countries","authors":"M. Zafar","doi":"10.4103/jmgims.jmgims_50_19","DOIUrl":"https://doi.org/10.4103/jmgims.jmgims_50_19","url":null,"abstract":"Background and Objective: Anemia in developing countries is the biggest public health problem. Reproductive age group women have high prevalence. The objective of the present study is to determine the cost-effective intervention for the reduction of anemia among women of reproductive age group. Methodology: A review of the literature was done for identifying various preventive strategies regarding anemia and its implementation barriers in low- and middle-income countries. Google Scholar, PubMed, Web of Science, and Scopus were used as search engines.Results: The result of the review shows that the most cost-effective method for the prevention of anemia among women is iron fortification of food, iron supplementation, community-based health promotion of healthy nutrition. Women empowerment is the best tool for the implementation of all the above method for the prevention of anemia. Conclusion: Community-based intervention is the most effective method for reducing maternal anemia. It includes health promotion and women empowerment. There is a need to develop policies to improve the health promotion activities and involvement of women in society.","PeriodicalId":32484,"journal":{"name":"Journal of Mahatma Gandhi Institute of Medical Sciences","volume":"25 1","pages":"6 - 10"},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42108476","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Assessment of the prevalence of polycystic ovary syndrome among the college students: A case–control study from Kolkata","authors":"M. Chatterjee, S. Bandyopadhyay","doi":"10.4103/jmgims.jmgims_62_19","DOIUrl":"https://doi.org/10.4103/jmgims.jmgims_62_19","url":null,"abstract":"Background: Polycystic ovary syndrome (PCOS) is one of the most common endocrine disorders in women of reproductive age. Of late, the disease is on its rise due to environmental changes as well as lifestyle disorders, affecting 4%–26% of adolescent and young women all over the globe. Initially, this condition is asymptomatic in young girls, progressing toward menstrual irregularities, obesity, hyperandrogenism in late puberty and eventually developing insulin resistance, hypertension, type 2 diabetes, cardiovascular diseases, and infertility around middle age. Aims: Early diagnosis is necessary for early intervention, including lifestyle modifications to prevent the immediate and chronic consequences of PCOS. Materials and Methods: Our study design was of a cross-sectional questionnaire-based survey, conducted from September 2017 to March 2018 to investigate the prevalence of PCOS and its association with body composition variables. The study population comprised randomly chosen students (age group 18–20 years) of all discipline. The data were collected from the students using structured questionnaire with Rotterdam's criteria, and anthropometric measurements were taken using standard techniques. Results: Approximately 28% of the college students were found to be at high risk of developing PCOS. More than 85% of the PCOS cases had oligomenorrhea, 19% were hirsute, 41% had acne, 63% had emotional disturbance, and 22% with a positive family history. Furthermore, the body mass index of the PCOS students demonstrated a trend of Grade 1 obesity than the normal females of the same age group. Conclusion: The present study is an attempt to create increased awareness among the students for early and accurate diagnosis, which is the primary step in managing PCOS.","PeriodicalId":32484,"journal":{"name":"Journal of Mahatma Gandhi Institute of Medical Sciences","volume":"25 1","pages":"28 - 32"},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43393693","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
A. Singh, Maryem Ansari, Ramesh Tanger, Arun Gupta
{"title":"Neurothekeoma of the scalp in a child: A rare case","authors":"A. Singh, Maryem Ansari, Ramesh Tanger, Arun Gupta","doi":"10.4103/jmgims.jmgims_6_19","DOIUrl":"https://doi.org/10.4103/jmgims.jmgims_6_19","url":null,"abstract":"Neurothekeoma (NT) is a rare, benign tumor that is derived from peripheral nerve sheath cells. There are less than 300 cases reported in the literature to date. Historically, this tumor has been subclassified as myxoid (classic), mixed, or the cellular type, depending on the amount of myxoid stroma and cellularity. Here, we present a case of NT (mixed type) of the scalp in a 3-year-old female child. The tumor was completely excised. No recurrence was detected in the past 3 months after the local excision.","PeriodicalId":32484,"journal":{"name":"Journal of Mahatma Gandhi Institute of Medical Sciences","volume":"25 1","pages":"48 - 49"},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41453543","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"The Nobel prize in physiology or medicine 2019","authors":"Gupta Op","doi":"10.4103/JMGIMS.JMGIMS_2_20","DOIUrl":"https://doi.org/10.4103/JMGIMS.JMGIMS_2_20","url":null,"abstract":"• According to Alfred Nobel’s will the bulk of his fortune should be divided into five parts and to be used for prizes in physics, chemistry, physiology or medicine, literature and peace. • The first Nobel Prizes were awarded in 1901. • In the late 1960s, Sveriges Riksbank (Sweden's central bank) established the Economic Sciences Prize in memory of Alfred Nobel. • The Nobel Prizes are announced at the beginning of October every year. In 2019, 15 men and women were awarded a Nobel Prize. • The Economic Sciences Prize is awarded at the same time as the Nobel Prize, as part of the same ceremony on 10 December every year.","PeriodicalId":32484,"journal":{"name":"Journal of Mahatma Gandhi Institute of Medical Sciences","volume":"25 1","pages":"57 - 58"},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70803352","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Medical jousting: Think well before speaking","authors":"A. Agrawal, V. Thawani","doi":"10.4103/jmgims.jmgims_63_19","DOIUrl":"https://doi.org/10.4103/jmgims.jmgims_63_19","url":null,"abstract":"","PeriodicalId":32484,"journal":{"name":"Journal of Mahatma Gandhi Institute of Medical Sciences","volume":"25 1","pages":"50 - 51"},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70803885","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Cryptococcus laurentii: An unusual cause for atypical pneumonia in hematological malignancy","authors":"Sunita Kabi, Swati Jain, B. Swain, N. Sharma","doi":"10.4103/jmgims.jmgims_65_18","DOIUrl":"https://doi.org/10.4103/jmgims.jmgims_65_18","url":null,"abstract":"Cryptococcus laurentii, one of the nonneoformans Cryptococcus is a known biopesticide to control fruit rot, previously considered to be nonpathogenic to humans, is now have been reported as a cause of opportunistic infections. Here, we present a case of pulmonary cryptococcosis due to C. laurentii in a patient with chronic lymphocytic leukemia and prolymphocytic leukemia. Sputum microscopy showed Gram-positive spherical capsulated budding yeast cells, culture of which revealed it as C. laurentii. The patient was promptly put on fluconazole, but he died on the subsequent day after initiation of therapy. A high index of suspicion and improvement of techniques of culture and identification is essential for early diagnosis and treatment of unusual fungal infections.","PeriodicalId":32484,"journal":{"name":"Journal of Mahatma Gandhi Institute of Medical Sciences","volume":"25 1","pages":"45 - 47"},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43526081","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Comment on: Knowledge and attitude regarding Zika virus disease among junior residents of a tertiary care hospital in Delhi, India","authors":"H. Esmaily, Elmira Niknami, A. Saffaei","doi":"10.4103/jmgims.jmgims_31_19","DOIUrl":"https://doi.org/10.4103/jmgims.jmgims_31_19","url":null,"abstract":"","PeriodicalId":32484,"journal":{"name":"Journal of Mahatma Gandhi Institute of Medical Sciences","volume":"25 1","pages":"52 - 52"},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43326622","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Illness divinized","authors":"M. Mishra","doi":"10.4103/jmgims.jmgims_68_19","DOIUrl":"https://doi.org/10.4103/jmgims.jmgims_68_19","url":null,"abstract":"","PeriodicalId":32484,"journal":{"name":"Journal of Mahatma Gandhi Institute of Medical Sciences","volume":"25 1","pages":"55 - 55"},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42614380","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Determinants of surgically induced menopause in rural North Karnataka","authors":"Sudhirgouda Patil, N. Tyagi, J. Prasad","doi":"10.4103/jmgims.jmgims_47_19","DOIUrl":"https://doi.org/10.4103/jmgims.jmgims_47_19","url":null,"abstract":"Objective: The objective of the study was to quantify the effect of surgically induced menopause (SIM) on quality of life as assessed by religion, body mass index (BMI), sexual problem, menstrual history, blood spotting after intercourse, menopausal symptoms, and psychological disorder in the age group of 40–55 years of women. Materials and Methods: In this cross-sectional study, 712 rural women, comprising of 40 women (aged 40–55 years) with SIM, were surveyed, by inverse cluster sampling with proportional to population size. The aim was to study SIM and its determinants; menopause anthropometric data, menopause symptoms, and associated psychosocial symptoms. The data was analyzed using bivariate and multivariate techniques. Results: Around 6.4% of Hindu women had SIM, followed by Muslim (6.2%) and others (1.1%). SIM was significantly high in BMI group <25. The differences of SIM in regularity of menstruation were significant. Similar results were observed in sexual problem, menstrual flow, blood spotting after intercourse, blood spotting between periods, pain in periods, physical and mental exhaustion, heart discomfort, sleep problem, irritability, and dryness of the vagina. The sexual activity significantly hampered after SIM, further, unadjusted Odds Ratios (ORs) were not in line with adjusted OR. With regularity of menstruation problem, the SIM increases significantly, as indicated by adjusted and unadjusted ORs, the similar results were seen by menstrual flow and blood spotting after intercourse. The SIM by adjusted and unadjusted ORs was similar in other determinants. The Logistic regression model has been calibrated for sensitivity and specificity above 90% and accuracy as high as 97.8%. The modulated probabilities have been provided for the users of the model. Conclusion: The results of the bivariate analysis of surgical menopause by its covariates and regression model constructed are valuable for health-care providers, as reference for diagnosis, and to pacify patients for consequences of the prognosis.","PeriodicalId":32484,"journal":{"name":"Journal of Mahatma Gandhi Institute of Medical Sciences","volume":"25 1","pages":"33 - 38"},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46877933","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}