Yemeni Journal for Medical Sciences最新文献_第6页

Evaluation of Immune Response to Hepatitis B Vaccine among Malnourished Children in Yemen 也门营养不良儿童对乙肝疫苗免疫反应的评价

Yemeni Journal for Medical Sciences Pub Date : 2015-12-17 DOI: 10.20428/yjms.9.1.a2

Fuad A. Alsamei, A. Elagib, Najla Al-Sonboli, Fawzi A. Alkumaim, Nader S. Alsayaad, Abdulmalik T. Aldobibi

{"title":"Evaluation of Immune Response to Hepatitis B Vaccine among Malnourished Children in Yemen","authors":"Fuad A. Alsamei, A. Elagib, Najla Al-Sonboli, Fawzi A. Alkumaim, Nader S. Alsayaad, Abdulmalik T. Aldobibi","doi":"10.20428/yjms.9.1.a2","DOIUrl":"https://doi.org/10.20428/yjms.9.1.a2","url":null,"abstract":"Objectives: To determine the coverage rate of hepatitis B virus (HBV) vaccine and to evaluate the immune response to HBV vaccine by measuring hepatitis B surface antibody (anti-HBs) among malnourished under-five-year old children.Methods: A cross-sectional study was conducted in two tertiary hospitals in Yemen; Al-Sabeen Maternity and Child Hospital in Sana’a and the Yemeni-Swedish Hospital in Taiz city in the period from March 2014 to Dec. 2014. The target population was malnourished children aged from 6 to 59 months old with a history of three HBV vaccine doses in infancy. According to the World Health Organization’s definition of malnutrition, 121 malnourished children were enrolled in the study. Data of malnourished children were collected using a pre-designed, pre-tested questionnaire. Two milliliters of venous blood were taken, and anti-HBs was then tested by enzyme linked immunosorbent assay. An anti-HBs level of at least 10 IU/L was considered a successful response to the vaccine.Results: The coverage rate of HBV vaccine among malnourished children was 89.3%, being higher among girls (52.1%) than boys (37.2%). Response to HBV vaccine (≥10 IU/L) was observed in 72.2% (78/108) of children while 27.8% (30/108) of children failed to respond to the vaccine, with a statistically significant difference (p <0.001).Conclusions: A good HBV vaccine coverage rate was found among malnourished Yemeni children, with a moderate rate of protection. Therefore, re-vaccination or administration of booster doses to a substantial proportion of vaccinated children should be considered.","PeriodicalId":32479,"journal":{"name":"Yemeni Journal for Medical Sciences","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2015-12-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67544444","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Malaria Research Priorities in Yemen: Paving the Way for Malaria Elimination 也门的疟疾研究重点:为消除疟疾铺平道路

Yemeni Journal for Medical Sciences Pub Date : 2015-12-17 DOI: 10.20428/yjms.9.1.e

Rashad Abdul‑Ghani

引用次数: 5

Comparative Analysis of Five Brands of Lisinopril Tablets in Yemeni Market 也门市场5个品牌赖诺普利片的比较分析

Yemeni Journal for Medical Sciences Pub Date : 2014-12-01 DOI: 10.20428/yjms.v8i1.780

Othman G.Q.

{"title":"Comparative Analysis of Five Brands of Lisinopril Tablets in Yemeni Market","authors":"Othman G.Q.","doi":"10.20428/yjms.v8i1.780","DOIUrl":"https://doi.org/10.20428/yjms.v8i1.780","url":null,"abstract":"Background: In poor countries such as Yemen, the cost of drugs is a factor affecting the patient’s decision to buy it and generic medicines are introduced as cheaper alternatives to the high cost brands. However, it has been believed that generic medicines are inferior in quality compared to the branded medicines. Thus, the aim of the present study is to investigate the physicochemical equivalence of five brands of tablets containing Lisinopril (antihypertensive) sourced from different retail pharmacy outlets in the Yemeni market. Methods: The quality and physicochemical equivalence of five different brands of Lisinopril tablets were assessed. The assessment included the evaluation of uniformity of weight, friability, crushing strength, disintegration and dissolution tests as well as chemical assay of the tablets. Results: Results obtained showed that all five brands of the Lisinopril 5 mg tablets passed the British Pharmacopoeia (BP) standards for uniformity of weight, the crushing strength/hardness test and the friability test. All the brands passed the disintegration test and standard assay of content of active ingredients Conclusion: The five brands of Lisinopril 5mg tablets that were analysed passed all the BP quality specifications and were physically and chemically equivalent. All tested formulations were found to be equivalent.","PeriodicalId":32479,"journal":{"name":"Yemeni Journal for Medical Sciences","volume":"85 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2014-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67544822","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A Ten Year Descriptive Study of Adult Leukaemia at Al-Jomhori Teaching Hospital in Sana'a, Yemen 也门萨那Al-Jomhori教学医院成人白血病十年描述性研究

Yemeni Journal for Medical Sciences Pub Date : 2014-11-28 DOI: 10.20428/yjms.v8i1.678

J. Al-Ghazaly, W. Al-Dubai, M. Abdullah, Altaf Al-Mahagri, Leila Al-Gharasi

{"title":"A Ten Year Descriptive Study of Adult Leukaemia at Al-Jomhori Teaching Hospital in Sana'a, Yemen","authors":"J. Al-Ghazaly, W. Al-Dubai, M. Abdullah, Altaf Al-Mahagri, Leila Al-Gharasi","doi":"10.20428/yjms.v8i1.678","DOIUrl":"https://doi.org/10.20428/yjms.v8i1.678","url":null,"abstract":"Background: There is scarcity of data of the epidemiology of leukaemia in Arab countries including Yemen. Understanding patterns of leukaemia underpins epidemiology and can provide insight into disease etiology. The aim of this research is to determine the epidemiologic pattern of adult leukaemia in Yemen.Methods: The research is a descriptive cross-sectional study. We analyzed the data of 702 adult patients with leukaemia, who were newly diagnosed over a ten-year period between October 1999 and October 2009 at the referral haematology centre in Sana’a at Al-Jomhori Teaching Hospital, according to type of leukaemia, age, sex, geographic distribution and time of diagnosis.Results: Acute Myeloid Leukaemia (AML) was found to be the most common (45.1%) followed by Chronic Myeloid Leukaemia (CML) (26.5%), Acute Lymphoid Leukaemia (ALL) (17.7%) and Chronic Lymphoid Leukaemia (CLL) (10.7%), respectively. There was an almost equal prevalence of AML and CML for males and females but males had significantly more cases of ALL and CLL (p =0.008). A significant variation in geographic pattern showed that the highest number of cases is seen the Central mountainous region and the least number of cases in the South-eastern region which is coastal and lowland (p<0.001). The seasonal variation showed that higher number of ALL cases was seen in the summer months (33%) compared with other seasons (21% in the spring, 24.2% in autumn and 21.8% in winter).Conclusions: The pattern of adult leukaemia in Yemen is different from that seen in western countries which could be attributed to different environmental exposure. The geographic pattern indicates a possible role of certain environmental factors which warrant further investigations. The pattern of seasonal variation needs further studies for evaluating the seasonality. ","PeriodicalId":32479,"journal":{"name":"Yemeni Journal for Medical Sciences","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2014-11-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67544767","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3