Precision Radiation Oncology最新文献_第4页

Low versus high dose of postoperative radiotherapy for locally advanced esophageal squamous cell carcinoma: a propensity score‐matched analysis 局部晚期食管鳞状细胞癌术后低剂量与高剂量放疗的倾向评分匹配分析

Precision Radiation Oncology Pub Date : 2023-04-19 DOI: 10.1002/pro6.1192

Qiwei Yao, Hongying Zheng, Shuyun Huang, M. Lin, Jun Yang, Jiancheng Li

引用次数: 0

Application of radiomics in lung immuno‐oncology 放射组学在肺部免疫肿瘤学中的应用

Precision Radiation Oncology Pub Date : 2023-04-04 DOI: 10.1002/pro6.1191

Weisi Yan, C. Quan, Mourad Waleed, Jianda Yuan, Zheng Shi, Jun Yang, Qiuxia Lu, J Zhang

{"title":"Application of radiomics in lung immuno‐oncology","authors":"Weisi Yan, C. Quan, Mourad Waleed, Jianda Yuan, Zheng Shi, Jun Yang, Qiuxia Lu, J Zhang","doi":"10.1002/pro6.1191","DOIUrl":"https://doi.org/10.1002/pro6.1191","url":null,"abstract":"Radiomics is a rapidly evolving field of research that extracts and analyzes quantitative features within medical images. Those features are termed as radiomic features that can characterize a tumor in a comprehensive and quantitative manner with regard to its internal structure and heterogeneity. Radiomic features can be used, alone or in combination with demographic, histological, genomic, or proteomic data, for predicting prognosis or treatment response. Immunotherapy, or immune‐oncology, is the study of cancer treatment by taking advantage of the body's immune system to prevent, control, and eliminate cancer. In this review, we first provide a brief introduction to both radiomics and immune‐oncology in lung cancer. Then, we discuss the need for developing immune‐oncology biomarkers, and the advantages of radiomics in identifying biomarkers related to immunotherapy. We also discuss potential areas in and out of tumors, such as the intra‐tumoral hypoxic region and tumor microenvironment, where radiomic markers might be extracted, as well as a potential application of radiomic biomarkers in clinical lung cancer management. Finally, we present radiation and immune modulation in non‐small cell lung cancer, clinical trials and their design to incorporate radiomic biomarkers, and radiomics‐guided precision radiation therapy.","PeriodicalId":32406,"journal":{"name":"Precision Radiation Oncology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-04-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47406940","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Evaluating bone marrow dosimetry with the addition of bone marrow structures to the medical internal radiation dose phantom 在医用内部辐射剂量体模中添加骨髓结构评估骨髓剂量测定

Precision Radiation Oncology Pub Date : 2023-03-01 DOI: 10.1002/pro6.1189

K. Ferrone, C. Willis, F. Guan, Jingfei Ma, Leif E. Peterson, S. Kry

引用次数: 1

Definitive chemoradiotherapy in elderly patients with esophageal cancer: Safety and outcome 老年癌症食管癌最终放化疗的安全性和疗效

Precision Radiation Oncology Pub Date : 2023-03-01 DOI: 10.1002/pro6.1190

I. Kiladze, Lika Chkhaidze, A. Iovashvili, E. Natelauri, B. Sokurashvili, E. Mariamidze, N. Kacheishvili, B. Jeremic

引用次数: 0

Dosimetric response of Gafchromic^™ EBT-XD film to therapeutic protons. Gafchromic的剂量反应™ EBT‐XD薄膜治疗质子

Precision Radiation Oncology Pub Date : 2023-03-01 Epub Date: 2023-03-02 DOI: 10.1002/pro6.1187

Fada Guan, Xiaochun Wang, Ming Yang, Emily Draeger, Dae Han, Kiminori Iga, Fanqing Guo, Luis Perles, Yuting Li, Narayan Sahoo, Radhe Mohan, Zhe Chen

{"title":"Dosimetric response of Gafchromic™ EBT-XD film to therapeutic protons.","authors":"Fada Guan, Xiaochun Wang, Ming Yang, Emily Draeger, Dae Han, Kiminori Iga, Fanqing Guo, Luis Perles, Yuting Li, Narayan Sahoo, Radhe Mohan, Zhe Chen","doi":"10.1002/pro6.1187","DOIUrl":"10.1002/pro6.1187","url":null,"abstract":"EBT-XD model of Gafchromic™ films has a broader optimal dynamic dose range, up to 40 Gy, compared to its predecessor models. This characteristic has made EBT-XD films suitable for high-dose applications such as stereotactic body radiotherapy and stereotactic radiosurgery, as well as ultra-high dose rate FLASH radiotherapy. The purpose of the current study was to characterize the dependence of EBT-XD film response on linear energy transfer (LET) and dose rate of therapeutic protons from a synchrotron. A clinical spot-scanning proton beam was used to study LET dependence at three dose-averaged LET (LETd) values of 1.0 keV/µm, 3.6 keV/µm, and 7.6 keV/µm. A research proton beamline was used to study dose rate dependence at 150 Gy/second in the FLASH mode and 0.3 Gy/second in the non-FLASH mode. Film response data from LETd values of 0.9 keV/µm and 9.0 keV/µm of the proton FLASH beam were also compared. Film response data from a clinical 6 MV photon beam were used as a reference. Both gray value method and optical density (OD) method were used in film calibration. Calibration results using a specific OD calculation method and a generic OD calculation method were compared. The four-parameter NIH Rodbard function and three-parameter rational function were compared in fitting the calibration curves. Experimental results showed that the response of EBT-XD film is proton LET dependent but independent of dose rate. Goodness-of-fit analysis showed that using the NIH Rodbard function is superior for both protons and photons. Using the \"specific OD + NIH Rodbard function\" method for EBT-XD film calibration is recommended.","PeriodicalId":32406,"journal":{"name":"Precision Radiation Oncology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10586355/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49417719","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Adding the X‐ray Bragg reflection physical process in crystal to the Geant4 Monte Carlo simulation toolkit, part I: reflection from a crystal slab 将晶体中的X射线布拉格反射物理过程添加到Geant4蒙特卡罗模拟工具包中，第一部分:晶体板的反射

Precision Radiation Oncology Pub Date : 2023-02-26 DOI: 10.1002/pro6.1188

F. Guan, Makoto Asai, D. Bartkoski, Michael Kleckner, Ze’ev Harel, M. Salehpour

{"title":"Adding the X‐ray Bragg reflection physical process in crystal to the Geant4 Monte Carlo simulation toolkit, part I: reflection from a crystal slab","authors":"F. Guan, Makoto Asai, D. Bartkoski, Michael Kleckner, Ze’ev Harel, M. Salehpour","doi":"10.1002/pro6.1188","DOIUrl":"https://doi.org/10.1002/pro6.1188","url":null,"abstract":"X‐ray diffraction from a solid crystal shows the wave nature of photons. It is an important electromagnetic (EM) physics process when X‐ray photons interact with a crystal. Bragg diffraction, often called Bragg reflection, is a special case of the general form of X‐ray diffraction, known as Laue diffraction. When the Bragg's law is met, the incident photon beam is reflected from the crystal plane behaving as a specular reflection at the Bragg angle. However, the Bragg reflection physical process has not been integrated into the general‐purpose Monte Carlo simulation toolkit Geant4 for particle physics. In the current study, we developed a new EM physical process class “G4CrystalBraggReflection” and a new EM physical model class “G4DarwinDynamicalModel” for modeling the Bragg reflection physical process within a crystal. We added the Bragg reflection physical process to the EM physics category of Geant4. The preliminary results of photon tracking in a silicon crystal slab have shown the feasibility of simulating the Bragg reflection process in addition to the standard EM processes in the framework of Geant4.","PeriodicalId":32406,"journal":{"name":"Precision Radiation Oncology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-02-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42770143","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Radiotherapy of early‐stage breast cancer 癌症早期乳腺癌的放射治疗

Precision Radiation Oncology Pub Date : 2023-01-29 DOI: 10.1002/pro6.1183

Cedric X. Yu

引用次数: 2

Clinical outcomes after salvage external beam radiotherapy combined with interstitial brachytherapy for locally advanced, recurrent endometrial cancer 挽救性外束放疗联合间质近距离放疗治疗局部晚期复发性癌症的临床疗效

Precision Radiation Oncology Pub Date : 2023-01-24 DOI: 10.1002/pro6.1185

Asma Waheed, R. Banerjee, T. Meyer, S. Quirk, C. Doll, P. McGeachy, T. Phan, M. Roumeliotis, K. Martell

{"title":"Clinical outcomes after salvage external beam radiotherapy combined with interstitial brachytherapy for locally advanced, recurrent endometrial cancer","authors":"Asma Waheed, R. Banerjee, T. Meyer, S. Quirk, C. Doll, P. McGeachy, T. Phan, M. Roumeliotis, K. Martell","doi":"10.1002/pro6.1185","DOIUrl":"https://doi.org/10.1002/pro6.1185","url":null,"abstract":"Salvage external beam radiation therapy (EBRT) followed by interstitial brachytherapy is commonly used to treat patients with vaginal recurrence of endometrial cancer. The evidence for this is typically limited to case series treating small volumes of disease. For the present study, 12 consecutive patients with locally advanced, biopsy‐proven vaginal recurrence after surgically treated endometrial cancer who received salvage EBRT (45 Gy in 25 daily fractions to microscopic disease and 55–57.5 Gy to gross nodal disease) with magnetic resonance‐guided interstitial brachytherapy (20–21 Gy in 3 fractions over 2 days) were retrospectively reviewed. The median tumor size of recurrent disease on magnetic resonance imaging was 5 (3–6) cm. Three (25%) tumors involved the bladder wall, three (25%) involved the urethra, and four (33%) extended to the pelvic sidewall. Four (25%) patients had gross nodal disease. On follow‐up, no (0%) patient developed local recurrence. One patient (8%) developed nodal recurrence outside of the radiotherapy treatment volume and then distant metastases, and one patient (8%) developed distant metastasis 2.5 years post‐treatment and subsequently died from the disease. No (0%) other deaths were reported. Zero patients (0%) developed grade ≥4 bowel or bladder toxicity. These data support EBRT with interstitial brachytherapy using modern techniques for locally advanced, vaginal recurrences of endometrial cancer.","PeriodicalId":32406,"journal":{"name":"Precision Radiation Oncology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-01-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48354527","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Impact of dose calculation accuracy on inverse linear energy transfer optimization for intensity‐modulated proton therapy 剂量计算精度对调强质子治疗逆线性能量传递优化的影响

Precision Radiation Oncology Pub Date : 2022-12-08 DOI: 10.1002/pro6.1179

Mei Chen, W. Cao, P. Yepes, F. Guan, F. Poenisch, Cheng Xu, Jiayi Chen, Yupeng Li, Ivan Vazquez, Ming Yang, X. Zhu, Xiaodong Zhang

引用次数: 2

Stereotactic body radiotherapy compared with video‐assisted thoracic surgery after propensity‐score matching in elderly patients with pathologically‐proven early‐stage non‐small cell lung cancer 经病理证实的早期非小细胞肺癌癌症老年患者倾向评分匹配后立体定向放疗与视频辅助开胸手术的比较

Precision Radiation Oncology Pub Date : 2022-12-01 DOI: 10.1002/pro6.1175

Xiao‐ye Liu, Miao Gao, Ze‐yuan Cheng, Zheng‐Kun Cai, Lu Yu, Geng‐Min Niu, Jun-yi Li, Yu-Lin Bai, Shu‐Zhou Zhao, Yong-chun Song, Xiao-Guang Wang, Yang Dong, Xuyao Yu, Z. Tao, Z. Yuan

引用次数: 0