Precision Radiation Oncology最新文献

{"title":"Dosimetric comparison of lattice radiotherapy across three modern linear accelerator platforms.","authors":"Shijun Li, Qingliang Pang, Bo Li, Jun Lv, Zhuxin Wei, Dawei Zhang, Wen Qin","doi":"10.1002/pro6.70078","DOIUrl":"10.1002/pro6.70078","url":null,"abstract":"<p><strong>Background: </strong>This study aimed to compare the dosimetric characteristics of lattice radiotherapy across different linear accelerator platforms (Versa HD, Halcyon, and NeuRT Aurora) and to evaluate the feasibility of its clinical application.</p><p><strong>Methods: </strong>This study included ten patients with bulky tumors who were eligible for spatially fractionated radiotherapy, including five pelvic cases and five abdominal cases. For each patient, high-dose vertices were contoured within the gross tumor volume using a standardized method, followed by three independently designed treatment plans on the Versa HD, Halcyon, and NeuRT Aurora platforms. The prescribed dose was 2400 cGy in three fractions. Dosimetric evaluation of the target volume included vertex coverage, maximum dose, and the peak-to-valley dose ratio. In addition, a vertex-specific dose analysis was performed to quantify the number of vertices with a D95 of less than 2400 cGy. For organs at risk, the following dosimetric parameters were evaluated: the mean dose to the intra-lattice margin volume, the maximum dose to tissues located more than 2 cm from the vertices, and standard dosimetric parameters for the spinal cord, small bowel, colon, liver, stomach, lungs, and kidneys.</p><p><strong>Results: </strong>All plans demonstrated the characteristic dosimetric features of lattice radiotherapy by establishing alternating high-dose peaks and low-dose valleys within the target volume, while achieving effective protection of surrounding normal tissues without compromising target coverage. Among the three platforms, NeuRT Aurora demonstrated superior performance in dose gradient control and normal tissue protection. The mean peak-to-valley ratios were 6.4, 6.9, and 8.9 for the Versa HD, Halcyon, and NeuRT Aurora platforms, respectively. The maximum dose to tissues located more than 2 cm from the vertices was significantly lower in the NeuRT Aurora plans (1158.6 cGy) than in the Versa HD plans (1280.6 cGy) and Halcyon plans (1257.8 cGy). Consistent with this trend, the NeuRT Aurora plans were also associated with a lower mean dose to the intra-lattice margin volume (792.4 cGy) than the Versa HD (831.4 cGy) and Halcyon (845.7 cGy) plans. For all specific organs at risk, the evaluated dosimetric parameters remained within clinical tolerance limits across the three treatment platforms.</p><p><strong>Conclusions: </strong>This study systematically evaluated lattice radiotherapy plans across three accelerator platforms. Although differences were observed in peak-to-valley ratios and organ-at-risk sparing, all plans met clinical requirements, confirming the overall feasibility of each platform.</p>","PeriodicalId":32406,"journal":{"name":"Precision Radiation Oncology","volume":"10 2","pages":"127-136"},"PeriodicalIF":3.6,"publicationDate":"2026-06-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13292149/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148333215","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Neoadjuvant versus adjuvant chemoradiotherapy for resectable cT3-4a esophageal squamous cell carcinoma: A matched cohort analysis.","authors":"Mingqiang Lin, Yilin Yu, Yibing Hu, Rong Zheng, Jiancheng Li, Qiwei Yao","doi":"10.1002/pro6.70076","DOIUrl":"10.1002/pro6.70076","url":null,"abstract":"<p><strong>Background: </strong>The optimal management of locally advanced resectable esophageal squamous cell carcinoma (ESCC), particularly for cT3-4a disease, remains debated. This study aimed to compare the survival outcomes and toxicity profiles of neoadjuvant chemoradiotherapy (NCRT) and adjuvant chemoradiotherapy (ACRT) in this patient population.</p><p><strong>Methods: </strong>We retrospectively analyzed 223 patients with resectable cT3-4a ESCC who underwent radical surgery combined with NCRT or ACRT. Propensity score matching (PSM) was used to generate 59 balanced pairs for comparative analysis.</p><p><strong>Results: </strong>After matching, the NCRT group demonstrated significantly improved overall survival (OS) compared with the ACRT group, with a median OS of 62 versus 46 months and 5-year OS rates of 66.6% versus 47.5%, respectively (<i>p</i> = 0.023). Despite the longer median progression-free survival (PFS) observed in the NCRT group (53 <i>vs</i>. 42 months), the difference in the 5-year PFS rate was not statistically significant (56.7% <i>vs</i>. 44.4%; <i>p</i> = 0.113). Furthermore, the two groups exhibited similar profiles of treatment-related adverse events (all <i>p</i> > 0.05). Multivariable analysis identified treatment strategy, body mass index (BMI), and clinical nodal (cN) status as independent predictors of OS (all <i>p</i>  < 0.01). A novel prognostic score (PS) integrating BMI and cN status effectively stratified patients into distinct risk categories, with higher scores predicting poorer prognosis but not in the neoadjuvant subgroup.</p><p><strong>Conclusions: </strong>For patients with resectable cT3-4a ESCC, NCRT provides superior OS compared to ACRT, with similar PFS and toxicity. These findings support the prioritization of NCRT for this disease stage; however, larger randomized trials are warranted to optimize patient selection.</p>","PeriodicalId":32406,"journal":{"name":"Precision Radiation Oncology","volume":"10 2","pages":"155-164"},"PeriodicalIF":3.6,"publicationDate":"2026-05-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13292158/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148333292","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A new perspective on radiotherapy in the comprehensive treatment of cancer.","authors":"Yingze Ma, Hongxuan Yu, Shijie Shang, Shixin Shan, Dawei Chen","doi":"10.1002/pro6.70073","DOIUrl":"10.1002/pro6.70073","url":null,"abstract":"<p><p>Radiotherapy (RT) has become an indispensable part of modern cancer treatment owing to its efficacy, precision, and safety. With continuous advances in clinical practice, the role of RT in comprehensive cancer treatment has been repositioned. Through a combination of chemotherapy, targeted therapy, and immunotherapy, RT can achieve multiple therapeutic goals, including disease cure, symptom relief, improved quality of life, and prolonged survival. Therefore, understanding the development of RT, its mechanisms, technological innovations, combined therapeutic strategies, and prospects is essential for advancing tumor treatment and improving patient survival.</p>","PeriodicalId":32406,"journal":{"name":"Precision Radiation Oncology","volume":"10 2","pages":"165-183"},"PeriodicalIF":3.6,"publicationDate":"2026-05-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13292160/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148333256","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Skeletal muscle status and malnutrition as predictors of short-term radiotherapy response and oral mucositis in head and neck cancer.","authors":"Haomiao Zhang, Xiaonan Hu, Junying Zhao, Mingxin Zhang, Yang You, Wencheng Shao, Lili Yu","doi":"10.1002/pro6.70072","DOIUrl":"10.1002/pro6.70072","url":null,"abstract":"<p><strong>Objective: </strong>This study aimed to investigate whether baseline skeletal muscle status and malnutrition in patients with locally advanced head and neck cancer (HNC) are associated with short-term treatment outcomes and acute radiation oral mucositis (OM).</p><p><strong>Methods: </strong>We retrospectively analyzed data from 68 patients with stage III-IV HNC treated at a single center with definitive radiotherapy (66-70 Gy) with or without chemotherapy (induction and/or concurrent) between July 2021 and July 2023. Malnutrition was diagnosed using the Global Leadership Initiative on Malnutrition (GLIM) criteria and Patient-Generated Subjective Global Assessment (PG-SGA). Short-term response was assessed at first post-treatment imaging after radiotherapy according to RECIST 1.1, and OM severity was graded using World Health Organization criteria. Univariate and multivariate logistic regression analyses evaluated the correlation between short-term response and grades III-IV OM.</p><p><strong>Results: </strong>Of the 68 patients, 32.4% had a lower skeletal muscle index (SMI), 26.5% had lower hand grip strength (HGS), 20.6% (GLIM) and 58.8% (PG-SGA) had malnutrition. At the end of treatment, 64.7% of the patients achieved partial remission, and 35.3% achieved a stable condition. Low HGS was associated with low short-term efficacy (<i>OR</i> = 0.31, 95% <i>CI</i> = 0.10-0.95, <i>p</i> = 0.040); however, this difference did not reach statistical significance in the multivariate model. A total of 41.2% of patients had Grade III-IV OM; however, OM was not significantly associated with low SMI, HGS, or malnutrition.</p><p><strong>Conclusion: </strong>Baseline skeletal muscle status and malnutrition did not consistently predict short-term treatment outcomes or severe radiation-induced OM in patients with locally advanced HNC. However, these results suggest a potential relationship between low HGS and treatment response. Further research with larger sample sizes and longitudinal evaluations is needed to clarify muscle and nutritional status impact on multidimensional outcomes in this patient population.</p>","PeriodicalId":32406,"journal":{"name":"Precision Radiation Oncology","volume":"10 2","pages":"147-154"},"PeriodicalIF":3.6,"publicationDate":"2026-04-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13292236/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148333272","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Advances in mucosal injury mechanisms in radiation-induced esophagitis associated with thoracic radiotherapy.","authors":"Hao Zhang, Liangxue Luo, Chaofen Zhao, Bibo Wu, Jing Zhang, Lingfeng Liu, Bing Lu, Shengfa Su","doi":"10.1002/pro6.70071","DOIUrl":"10.1002/pro6.70071","url":null,"abstract":"<p><p>Radiotherapy has emerged as a cornerstone modality in the management of malignant tumors. Its evolution from a localized intervention to a radical curative strategy has been particularly pronounced in lung cancer, where its role has shifted from symptom palliation to survival prolongation. Radiation esophagitis (RE) is one of the most common acute adverse effects of thoracic radiotherapy, particularly in patients with lung cancer. In the early phase of RE, the predominant features include reactive oxygen species-mediated DNA damage and disruption of the epithelial barrier. The inflammatory phase is characterized by nuclear factor kappa B activation, edema, and pain. During the dysregulated repair phase, impaired regeneration of the esophageal mucosal epithelium, compounded by microbiota imbalance, further exacerbates tissue injury. In the late phase, transforming growth factor beta-driven fibrosis may culminate in stricture or fistula formation. Clinically, the condition primarily manifests as dysphagia and odynophagia. The prevention and management of RE remain significant clinical challenges. This review examines key issues related to RE within the context of precision radiotherapy, with particular emphasis on its incidence and current management strategies.</p>","PeriodicalId":32406,"journal":{"name":"Precision Radiation Oncology","volume":"10 2","pages":"242-253"},"PeriodicalIF":3.6,"publicationDate":"2026-04-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13292155/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148333163","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Boron-10 carriers and their applications in boron neutron capture therapy.","authors":"Dachao Tang, Mengqi Shi, Zhichen Mao, Weiya Chen, Xiaoling Li, Xiao Yan Zhao, Zhigang Liu, Xiao Xu","doi":"10.1002/pro6.70061","DOIUrl":"10.1002/pro6.70061","url":null,"abstract":"<p><p>Boron neutron capture therapy (BNCT) has emerged as a promising therapeutic modality in cancer treatment, demonstrating the ability to selectively eliminate cancer cells through the ¹⁰B(n,α)⁷Li nuclear reaction with minimal side effects on normal tissues. As a binary, target-specific therapeutic modality for malignancies, BNCT critically depends on novel boron delivery carriers that exhibit high tumor affinity and prolonged intratumoral retention. Although several boron carriers have received Food and Drug Administration approval for clinical investigation, leading carriers such as L-p-boronophenylalanine (BPA) and sodium borocaptate (BSH) continue to require high infusion doses and exhibit limited tumor selectivity and affinity, short systemic half-lives, and limited in vivo stability. These challenges have stimulated extensive global research into novel boron-10 carriers and innovative carrier platforms, including amino acids, sugars, porphyrin derivatives, nucleotides, and a variety of nanocarrier systems. This review provides a systematic classification of high-abundance boron-10 carriers, critically examines radio-boron research, and evaluates the potential integration of BNCT into clinical diagnostics and advanced cancer treatment protocols. By detailing the current status of novel boron-10 carriers, this review further aims to elucidate critical challenges and opportunities in BNCT drug development, ultimately providing a theoretical foundation for next-generation BNCT interventions.</p>","PeriodicalId":32406,"journal":{"name":"Precision Radiation Oncology","volume":"10 2","pages":"205-241"},"PeriodicalIF":3.6,"publicationDate":"2026-04-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13292174/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148333207","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Combining radiotherapy with CAR-T cell therapy for solid tumors: Challenges, mechanisms, and future directions.","authors":"Leran Qiu, Xingyu Zhou, Jiao Xue, Xiaokang Zhang, Songbing Qin","doi":"10.1002/pro6.70058","DOIUrl":"10.1002/pro6.70058","url":null,"abstract":"<p><p>Chimeric antigen receptor (CAR)-T cell therapy has achieved significant success in treating hematological malignancies. However, compared to its efficacy against hematologic cancers, the application of CAR-T cell therapy for solid tumors still faces several challenges. Radiotherapy, an important component in the treatment of solid tumors, has recently attracted widespread attention because of its immunomodulatory effects. Combined radiotherapy may overcome the limitations of CAR-T cell therapy for solid tumors. This review discusses the theoretical foundations of combined radiation therapy and CAR-T cell therapy, along with preclinical and clinical research progress. Additionally, this study provides an innovative exploration of key factors to be considered when combining these two therapies. These factors include radiation dose, mode, radiation type, and timing and scheduling of the combined treatment. This review offers new perspectives on future research directions and highlights critical issues that remain to be addressed.</p>","PeriodicalId":32406,"journal":{"name":"Precision Radiation Oncology","volume":"10 2","pages":"192-204"},"PeriodicalIF":3.6,"publicationDate":"2026-04-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13292151/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148333180","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Segmentation influence on the generalizability of the overall survival models in CT-based oropharyngeal carcinoma patients.","authors":"Yongqiang Wang, Xuhua Xiao, Jiang Zhang, Xinzhi Teng, Bing Li, Kangdong Liu, Jing Cai, Hong Ge","doi":"10.1002/pro6.70056","DOIUrl":"10.1002/pro6.70056","url":null,"abstract":"<p><strong>Objectives: </strong>To evaluate the impact of tumor volume segmentation variability on the repeatability of radiomic features (RFs) and to determine how RF repeatability influences the generalizability of radiomic models for predicting overall survival (OS) in patients with oropharyngeal carcinoma (OPC).</p><p><strong>Methods: </strong>We retrospectively analyzed CT images from 1017 patients with oropharyngeal carcinoma across three institutions. Perturbation methods were applied to simulate variations in gross tumor volume segmentation. RFs were extracted from both the original images and Laplacian of Gaussian-filtered images using different perturbation masks. RF repeatability was quantified using intra-class correlation coefficients (ICC). Repeatable RFs were progressively incorporated into the modeling process according to different ICC thresholds to assess the influence of feature repeatability on model generalizability.</p><p><strong>Results: </strong>Incorporation of RFs with ICC values between 0.7 and 0.8 improved the AUC index of the two-year and three-year OS models in external validation cohorts. Using an ICC threshold of 0.7, RFs were classified into high- and low-repeatability groups, and OS models were trained and validated using the training, internal testing, and external validation cohorts. Across all cohorts, the OS model trained with high-repeatability RFs demonstrated significantly superior performance compared to the model trained with low-repeatability RFs.</p><p><strong>Conclusion: </strong>The findings demonstrate that selecting RFs with ICC values greater than 0.7 substantially enhances both the generalizability and predictive performance of CT-based radiomic models for patients with OPC. This study further underscores the importance of considering RF repeatability, particularly in the presence of tumor volume segmentation variability, to improve the robustness and clinical reliability of radiomic models.</p>","PeriodicalId":32406,"journal":{"name":"Precision Radiation Oncology","volume":"10 1","pages":"7-18"},"PeriodicalIF":3.6,"publicationDate":"2026-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13097530/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147783336","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical outcomes of thoracic radiotherapy in combination with chemoimmunotherapy in elderly patients with extensive-stage small cell lung cancer.","authors":"Jinmin Han, Wencai Zheng, Jie Jiang, Huan Shi, Chengxin Liu","doi":"10.1002/pro6.70051","DOIUrl":"10.1002/pro6.70051","url":null,"abstract":"<p><strong>Purpose: </strong>We evaluated the effect of thoracic radiotherapy (TRT) on extensive-stage small-cell lung cancer (ES-SCLC) in elderly patients (aged ≥ 60 years) in the era of immunotherapy (IO) and analyzed the prognostic factors to guide personalized treatment.</p><p><strong>Methods: </strong>The clinical data of 178 elderly patients were reviewed. Kaplan-Meier curves were generated to estimate the survival rates. Multivariate prognostic analyses were performed using Cox proportional hazards models.</p><p><strong>Results: </strong>The mOS in the CRT-IO group was superior to that in the CT-IO group (22.0 vs. 14.7 months, <i>p</i> = 0.014). In addition, the mPFS in the CRT-IO group was significantly longer than that in the CT-IO group (11.2 vs. 7.0 months, <i>p</i> = 0.023). The mOS in the CRT-IO group was better than that in the CRT group; however, the difference was not statistically significant (22.0 vs. 17.3 months, <i>p</i> = 0.103). Overall survival was the longest in the CRT-IO group, followed by the CRT and CT-IO groups.Patients in the low-dose group had longer survival times than those in the high-dose group; however, this difference was not statistically significant (all <i>p</i> > 0.05).Multivariate analysis suggested that a KPS (Karnofsky performance status) score ≥ 80 (<i>p</i> = 0.003) was a good predictor of longer OS, whereas liver metastasis (<i>p</i> = 0.004) was associated with shorter OS.</p><p><strong>Conclusions: </strong>CRT-IO should be prioritized as a treatment for elderly patients with ES-SCLC with good performance status and liver metastasis. However, CRT could be a viable option for patients with a compromised performance status or for whom economic factors are a concern.</p>","PeriodicalId":32406,"journal":{"name":"Precision Radiation Oncology","volume":"10 1","pages":"39-47"},"PeriodicalIF":3.6,"publicationDate":"2026-03-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13097688/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147783288","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"MRI-based qualitative, quantitative, and radiomics/deep learning methods for assessing treatment response after neoadjuvant chemoradiotherapy in patients with locally advanced rectal cancer.","authors":"Shuang Chen, Lin Liu, Guangwei Tian, Ruimei Chai","doi":"10.1002/pro6.70055","DOIUrl":"10.1002/pro6.70055","url":null,"abstract":"<p><p>Neoadjuvant chemoradiotherapy (nCRT) followed by total mesorectal excision is standard treatment for locally advanced rectal cancer (LARC). This approach allows a subset of patients to achieve a pathological complete response (pCR), thereby improving surgical outcomes, anal preservation rates, and disease-free survival. An accurate preoperative assessment of pCR is crucial for guiding treatment decisions. Magnetic resonance imaging (MRI), owing to its superior soft-tissue contrast and spatial resolution, has become the preferred noninvasive modality for assessing nCRT efficacy. Advances in functional MRI (fMRI) techniques include diffusion-weighted imaging, derived sequences, perfusion-weighted imaging, and neuro-fMRI. fMRI sequences provide not only a qualitative assessment but also quantitative parameters derived from various imaging principles, thereby significantly enhancing the clinical utility of MRI. Beyond conventional and functional MRI, this field is rapidly evolving with the integration of radiomics and deep learning approaches. Radiomics involves the high-throughput extraction of minimal quantitative features from medical images, which can reveal tumor heterogeneity and phenotypic characteristics that are invisible to the human eye. This review summarizes current research and future perspectives on MRI-based qualitative, quantitative, radiomic, and deep-learning approaches for assessing nCRT efficacy in patients with LARC.</p>","PeriodicalId":32406,"journal":{"name":"Precision Radiation Oncology","volume":"10 1","pages":"102-115"},"PeriodicalIF":3.6,"publicationDate":"2026-03-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13097691/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147783309","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}