PAIN, JOINTS, SPINE最新文献

{"title":"Pedobarography — monitoring method of functional restoration of unstable ankle joint injuries","authors":"V. Sulyma, Yu.O. Filyak, A. Chuzhak","doi":"10.22141/pjs.12.3.2022.338","DOIUrl":"https://doi.org/10.22141/pjs.12.3.2022.338","url":null,"abstract":"The pedobarography method makes it possible to objectify the dynamics of restoring the functional capacity of an injured limb. The value of the method is gaining popularity in determining the functional results of surgical treatment of the patients with ankle joint injuries. The details of pedobarographic monito­ring during the treatment allow to obtain digital indices, which with careful statistical analysis can significantly improve not only the diagnostic process, but also control the process of functional reco­very of the patients with injuries of the lower extremities. Changes in quantitative digital static and dynamic indices of pedobarography mean progress in the functional restoration of the injured limb or the need in the correction of the rehabilitation process. Howe­ver, there is a problem in the interpretation and specification of the known indices and indices in accordance with the pathology. A review of the scientific publications based on the Scopus, Web of Science and The Cochrane Library databases is designed to analyze the possibilities of using the pedobarography method in the diagnosis of ankle joint injuries, tibial bone fractures, which in accordance with quantitative indices make 20-28 % of all fractures of human bones. The kinematic features of the human body in normal and pathological conditions should be carefully analyzed and practically used in the monitoring process of the recovery of wal­king during the rehabilitation period in the patients with ankle joint fractures and not only. Control and detection of the deviations of pedobarographic indices should be analyzed in details with the aim of early detection of an unresolved problem before the appearance of clinical signs of chronic instability. The literature search proves that the analysis of the entire range of static and dynamic indices of pedobarography of damaged and healthy limbs during the period of postoperative recovery of walking makes it possible to evaluate the effectiveness of rehabilitation measures aimed at functional restoration of unstable injuries of the ankle joint.","PeriodicalId":320219,"journal":{"name":"PAIN, JOINTS, SPINE","volume":"96 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-02-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"132418390","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical and laboratory characteristics of patients with articular manifestations of systemic lupus erythematosus","authors":"O. Iaremenko, D. Koliadenko","doi":"10.22141/pjs.12.3.2022.336","DOIUrl":"https://doi.org/10.22141/pjs.12.3.2022.336","url":null,"abstract":"Background. Damage of the joints is one of the typical and often the first signs of systemic lupus erythematosus (SLE), however the peculiarities the of clinical and laboratory changes in patients without articular manifestations (AM) remain insufficiently studied. The purpose was to study the frequency of AM in the patients with SLE and to evaluate its interconnection with clinical and laboratory manifestations of the disease. Materials and methods. 376 patients with SLE were examined. 2 groups were formed: I — with AM presented as arthritis and/or arthralgia at the time of application (n = 316), II — without AM (n = 60). The involvement of various organs and systems, as well as the levels of inflammatory markers and the spectrum of specific autoantibo­dies, were evaluated. Results. Patients with SLE and AM had erythematous rash on the face in the form of a “butterfly” more often than the patients without AM (34.1 vs. 20.0 %, p = 0.04). Serositis was more often observed in patients with AM (39.6 %) compared to the patients without AM (25.4 %, p = 0.048). Nephritis with nephrotic syndrome was 4 times more frequent in patients without arthritis/arthralgia compared to the subjects with AM (10.2 vs. 2.6 %, p = 0.04). The frequency of antiphospholipid syndrome was also significantly higher in patients without AM (25.5 vs. 6.0 %, p < 0.001). The group of the patients with SLE and AM had a hi­gher frequency of Raynaud’s syndrome (27.5 vs. 15.0 %, p = 0.046), lymphadenopathy (50.5 vs. 35.6 %, p = 0.048), heart involvement (62.5 vs. 42.4 %, p = 0.007), weight loss (13.6 vs. 3.8 %, p = 0.04) and positivity for antibodies to dsDNA (65.0 vs. 45.7 %, p = 0.03), than the patients without AM. The median va­lue of SLEDAI was significantly higher in the patients with SLE and AM (11 (6–16) points vs. 7.5 (4–14) points, р = 0.01). Also they received significantly higher doses of oral glucocorticoids (10 (10–20) mg/d in prednisolone equivalent) compared to the subjects without AM (6.25 (3.75–12.5) mg/d, p = 0.01). Conclusions. Rash on the face in the form of a “butterfly”, serositis, heart involvement, lymphadenopathy, Raynaud’s syndrome, weight loss, and anti-dsDNA positivity are significantly more common in SLE patients with AM. Nephritis with nephrotic syndrome and antiphospholipid syndrome occur more often in patients with SLE without AM. Presence of arthritis/arthralgia in patients with SLE is associated with a higher index of disease of activity and the need for higher doses of glucocorticoids.","PeriodicalId":320219,"journal":{"name":"PAIN, JOINTS, SPINE","volume":"6 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-02-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"128572930","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Disuse (post-mobilization) osteoporosis: literature review and clinical case series","authors":"N. Grygorieva, N. Dedukh, M.M. Parubets, M. Bystrytska","doi":"10.22141/pjs.12.3.2022.335","DOIUrl":"https://doi.org/10.22141/pjs.12.3.2022.335","url":null,"abstract":"Background. Disuse (рost-immobilization) osteoporosis is defined as secondary loss of bone mass in case of the absence or insufficient mechanical load on the skeleton. This di­sease can be associated with various risk factors, including long-time bed rest. The purpose of the research was to analyze modern lite­rary data on the mechanisms of development, principles of diagnosis and treatment of disuse osteoporosis and to present own clinical data of disuse osteoporosis in the patients with multiple injuries of the skeleton in the conditions of war in Ukraine. Materials and methods. The review was based on the analysis of literature sources from the PubMed, WOS, Scopus, Google, Google Scholar, Cochrane Library databases for the years 2007–2022. The search was conducted using keywords: disuse osteoporosis, immobilization, bed rest, bone mineral density (BMD), bone remode­ling, regene­ration. Results. The data on the theory of the mechanostat are considered as links in the appearance of disuse osteoporosis. In conditions of immobilization, bone remodeling processes are slowing down. Histomorphometric studies confirm a decrease in trabecular bone density, thickness of the cortical layer, and an increase in its porosity. A change in bone architecture with a biphasic course is observed. Disruption of the synchronicity of remodeling processes with a decrease in the rate of osteoblastoge­nesis and an increase in osteoclastogenesis was noted, and the role of osteocytes as mechanosensors was emphasized. Disuse osteoporosis leads to a violation of biochemical marker of bone meta­bolism. Early laboratory manifestations of bed rest were recorded in the form of a violation of calcium level, an increase in bone resorption markers, while bone formation markers did not change significantly. Bone loss in disuse osteoporosis is manifested by a decrease in BMD indices. The greatest decrease was recorded in the lower extremities’ bones and the vertebrae of the lumbar spine. Modern methods of treatment of disuse osteoporosis involve the use of antiresorptive and osteoanabolic agents but clinical data are limited, which requires multicenter randomized studies. The article presents 3 clinical examples of disuse osteoporosis after gunshot fractures of the lower extremities’ bones.","PeriodicalId":320219,"journal":{"name":"PAIN, JOINTS, SPINE","volume":"75 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-02-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"121578513","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Anti-osteoporotic treatment and COVID-19 risk: is there an association?","authors":"N. Grygorieva, M. Bystrytska, N. Zaverukha, A. Musiienko","doi":"10.22141/pjs.12.2.2022.328","DOIUrl":"https://doi.org/10.22141/pjs.12.2.2022.328","url":null,"abstract":"Introduction. Despite the recent ASBMR, AACE, Endocrine Society, ECTS&NOF guidelines for osteoporosis management in the era of COVID-19 the impact of antiosteoporotic drugs on disease risk and severity is insufficiently studied. The purpose of this study was to assess the COVID-19 risk for the patients receiving the parenteral bisphosphonate or Denosumab treatment, and the severity of its course in patients with systemic osteoporosis. Materials and methods. We performed the phone survey and studied the results of 195 patients (92 % women; mean age – 62.7 ± 10.8 years) with systemic osteoporosis depending on the current use of parenteral antiresorptive drugs (Zoledronic, Ibandronic acids, or Denosumab, n = 125) and compared the results with data of the patients with osteoporosis who did not use any anti-osteoporotic drugs previously (n = 70). Results. The group of patients with COVID-19 included 32.9 % of patients who did not receive previously any anti-osteoporotic treatment and 33.3 % of osteoporotic patients treated with parenteral antiresorptive drugs. The share of the patients taking the Zoledronic acid who fell ill with COVID-19 was 29.2 %, the share of those ta­king the Ibandronic acid was 34.4 %, and the share of those taking Denosumab was 42.9 %. We did not reveal any significant differences in the COVID-19 frequency and severity depending on the presence and type of parenteral anti-osteoporotic therapy. Additionally, there were no differences depen­ding on the patients' age, gender, obesity, and other osteoporosis risk factors. The risk of COVID-19 in the patients with systemic osteoporosis did not differ depending on antiresorptive drug use, amounting (odds ratio (OR) 95 % CI) 1.1 (0.6-2.0), or on the use of the definite anti-osteoporotic drug (for the Zoledronic acid – 0.9 (0.4-2.0), the Ibandronic acid – 1.1 (0.5-2.3), and for the Denosumab – 1.6 (0.5-5.2). Conclusions. Parenteral anti-osteoporo­tic drugs (Zoledronic acid, Ibandronic acid, or Denosumab) do not have any influence on COVID-19 frequency and severity and can be recommended for the continuation of the treatment of patients with osteoporosis.","PeriodicalId":320219,"journal":{"name":"PAIN, JOINTS, SPINE","volume":"42 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-11-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134090723","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Osteoarthritis and intestinal microbiota: pathogenetic significance of the joint — gut — microbiome axis","authors":"I. Golovach, D. Rekalov","doi":"10.22141/pjs.12.2.2022.332","DOIUrl":"https://doi.org/10.22141/pjs.12.2.2022.332","url":null,"abstract":"Introduction. Osteoarthritis (ОА) is a disease leading to joint degeneration, accompanied by constant pain, inflammation, and functional failure of the joints. Although many factors contribute to the development of ОА, the gut microbiome has recently emerged as an important pathogenic factor in ОА initiation and progression. The purpose of the study was to analyze modern literature data regarding the link between the gut microbiome and ОА. Materials and me­thods. The available data of clinical studies and scientific reviews were analyzed, and modern meta-analyses on the influence of gut microbiota on the development and progression of ОА were evaluated. Results. Gut microbiota is responsible for a number of metabolic, immunolo­gical, and structural and neurological functions, potentially elucida­ting the heterogeneity of OA phenotypes and formation of individual features of the course of the disease. Numerous studies support the hypothesis of the existence of a gut – joint axis and the interaction between gut microbiota and OA-relevant risk factors. The proposed concept begins with intestinal disruption and dysbacteriosis, disruption of microbiota homeostasis, continuous changes in microbial composition and genomic plasticity for optimal adaptation of bacteria to the host environment, accompanied by both adaptive and innate immune responses due to translocation of bacteria and bacterial products into the bloodstream to the joint. This cascade ultimately leads to inflammation in the joint and contributes to the development and progression of OA. Interpretion of the potential mechanisms of OA pathogenesis is essential for the development of new preventive and disease-modifying therapeutic interventions. In addition, gut microbiota is also a potential biomarker related to inflammation and gut dysbiosis to predict the progression of ОА and monitor the effectiveness of therapeutic interventions. Conclusions. In this review, we summarized research data that are supporting the hypothesis of a “joint – gut – microbiota axis” and the interaction between gut microbiota and the OA-relevant factors, including age, gender, metabolism, obesity.","PeriodicalId":320219,"journal":{"name":"PAIN, JOINTS, SPINE","volume":"62 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-11-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"122015279","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The impact of gait on hip joint formation in patients with cerebral palsy","authors":"M. Yatsuliak, S. Martsyniak, V. Filipchuk","doi":"10.22141/pjs.12.2.2022.330","DOIUrl":"https://doi.org/10.22141/pjs.12.2.2022.330","url":null,"abstract":"Introduction. The influence of the gait on the hip joint formation in patients with infantile cerebral palsy (CP) is an actual object of scientific research. The purpose of the research was to study the correlations between walking and clinical and roentge­nometric parameters of the hip joint in the patients with CP. Materials and methods. There were examined 39 patients with CP and pathology of the hip joints (70 joints), who had been treated at the National Research Institute of Traumatology and Orthopedics for the period from 2018 to 2022. The patients had been divided into 2 groups depending on the ability to walk. We had performed a clinical and roentgenogramometric examination of the hip joints in positioning according to our own method and the standard anterior-posterior radiological position. All patients underwent a clinical assessment of femoral torsion using the Ruwe method. To assess the relationships between the studied indices Spearman's correlation analysis was performed. Results. The positive influence of gait on the hip joint formation had been revealed. The average va­lues of the hip clinical and roentgenometric parameters in patients with CP who do not walk were significantly higher compared to those of subjects who walk. Correlation analysis revealed the relationship between walking and the studied parameters of the hip joint (cervical-diaphyseal angle, femoral torsion, acetabular angle, Sharp angle, Reimers index, the center edge angle of Wiberg) in both settings, as well as walking and other factors (age, level lesion, GMFCS scale (II-IV level), congenital dysplasia of the hip joints in the history). At the same time, there was no found any dependence between gait and adductor myotomy in the history. Conclusions. A significant influence of the gait on the following para­meters of the hip joint was established: the true cervical-diaphyseal angle (p = 0.00001) in positioning according to our own me­thod, femoral torsion (p = 0.01), acetabular angle (standard setting) (p = 0.00001), Sharpe angle (standard setting) (p = 0.018), Reimers index (standard setting) (p = 0.00007), center edge angle of Wiberg (standard setting) (p = 0.001) and lack of statistical signi­ficance of the influence of the adductor myotomy factor in history (p = 0.11) on the walking function.","PeriodicalId":320219,"journal":{"name":"PAIN, JOINTS, SPINE","volume":"21 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-11-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"125269331","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Quality of life in patients with ankylosing spondylitis with anemic syndrome assessed according to the ASQoL questionnaire, the relationship with the course of the disease","authors":"S. Shevchuk, O. Zviahina, О.S. Zviahin, Y. Bezsmertnyi, I. Segeda","doi":"10.22141/pjs.12.2.2022.329","DOIUrl":"https://doi.org/10.22141/pjs.12.2.2022.329","url":null,"abstract":"Introduction. Anemia, as a frequent comorbid pathology, increases the severity of the course, reduces the quality of life (QoL), and worsens the prognosis in patients with ankylosing spondylitis (AS). However, studies examining the impact of anemia on the course of the disease and QoL assessed using the ASQoL questionnaire are currently insufficient. The purpose was to analyze the QoL indices according to the ASQoL questionnaire in AS patients with anemia and to evaluate its dependence on gender, as well as the form and course of the disease. Materials and me­thods. 118 patients with AS and 26 practically healthy subjects, representative of age and gender, had been examined. QoL index was assessed using the ASQoL questionnaire. Results. QoL index in AS patients according to the ASQoL questionnaire was 8.96 ± 0.41 points. In AS patients with anemic syndrome, the QoL parameter was 11.85 ± 0.74 points, QoL index in AS patients without anemia was 7.88 ± 0.44 points. Patients with a peripheral form of AS and anemia have worse QoL index according to ASQoL scores (12.13 ± 0.94), compared to the subjects with a central form of AS and anemia (10.42 ± 1.21). Also, the worst indices of QoL were established in patients with anemia of chronic disease (ACD) (16.27 ± 0,44) and ACD with iron deficiency (11.50 ± 0.92). In the subjects with iron deficiency anemia (IDA), the indices of QoL did not significantly differ from parameters of the patients without anemia (7.16 ± 0.52). Disease activity and the presence of anemic syndrome have a reliable (p < 0.05) direct correlation (IL-6: r = 0.62; CRP: r = 0.68; BASDAI: r = 0.5; ASDAS: r = 0.25) with deterioration of QoL index according to ASQoL. Conclusions. Аnemia is a frequent comorbid pathology in patients with AS and worsens the QoL indices of the patients. The degree and pathogenetic type of anemia (in particular, ACD) is closely correlated with the lower QoL index of patients with AS.","PeriodicalId":320219,"journal":{"name":"PAIN, JOINTS, SPINE","volume":"21 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-11-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"125630943","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Arterial stiffness, vascular calcification and osteoporosis — common mechanisms of interaction (literature review)","authors":"O. Nishkumay, H.V. Mostbauer, O.O. Alekseenko, K.I. Moskalenko, P. Lazarev, M. Shevchuk","doi":"10.22141/pjs.12.2.2022.333","DOIUrl":"https://doi.org/10.22141/pjs.12.2.2022.333","url":null,"abstract":"Introduction. The problem of cardiovascular morbidity and mortality remains an urgent issue of modern medicine, and arterial stiffness is its independent predictor. Lively discussions about the correct approach to the prevention and treatment of comorbid conditions – increased vascular stiffness as an influential factor of the cardiovascular events and decreased bone mineral density (osteoporosis), primarily arise against the background of the need and safety of calcium and vitamin D supplements. The purpose was to search for literature data as for possible common pathogenetic links in the progression of arterial stiffness and the development of osteoporosis in order to assess the safety of the use of drugs to prevent osteoporotic fractures. Results. Analysis of literature sourses had showed that possible osteogenic factors affecting arterial stiffness may be: secondary hyperparathyroidism, disbalance of the RANK/RANKL/OPG system, inhibition of vitamin K-dependent matrix proteins (Gla-protein), osteopontin, etc. Conclusions. Today, there are many hypotheses confirming the possible influence of osteogenic factors on vascular stiffness and arterial calcification. Therefore, the search for sensitive markers and the development of screening protocols for the patients with risk factors for both osteoporosis and vascular changes are extremely relevant. A special issue is the possibility of using monotherapy for these comorbid pathologies, which can safely and efficiently influence the prevention of complications – both low-energy osteoporotic fractures and cardiovascular catastrophes. This will be the focus of our further research.","PeriodicalId":320219,"journal":{"name":"PAIN, JOINTS, SPINE","volume":"38 3","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-11-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"133170051","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Paraneoplastic arthritis — at the crossroads of rheumatology and oncology","authors":"Y. Yehudina, S. Trypilka","doi":"10.22141/pjs.12.1.2022.325","DOIUrl":"https://doi.org/10.22141/pjs.12.1.2022.325","url":null,"abstract":"Paraneoplastic arthritides (PA) are a group of inflammatory arthropathies associated with latent or manifest malignancy, localized in a distant site in relation to the primary focus and caused by immune-mediated mechanisms. Although the pathogenesis of PA is unknown, immune-mediated mechanisms can cause paraneoplastic syndrome with a dominant feature of polyarthritis. Arthritis can be both the initial manifestation of the disease, and it can manifest itself some time before the oncological process. Common forms of PA include paraneoplastic oligo/polyarthritis; hypertrophic osteoarthropathy; remitting seronegative symmetric synovitis with pitting edema; palmar fasciitis and pancreatic panniculitis associated with pancreatic carcinoma. The purpose of this review article was to describe the clinical characteristics, diagnostic assessment and treatment of paraneoplastic arthritis, and highlight the challenges that healthcare professionals may face in order to distinguish these conditions from other autoimmune rheumatic diseases. Further research is needed to understand the mechanisms associated with PA and to develop new diagnostic biomarkers.","PeriodicalId":320219,"journal":{"name":"PAIN, JOINTS, SPINE","volume":"15 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-10-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"128514264","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mathematical model of the bone biological age based on the bone mineral density and quality indicex and Ukrainian FRAX model","authors":"N. Grygorieva, H. Dubetska, N. Koshel, A. Pisaruk, I. Antoniuk-Shcheglova","doi":"10.22141/pjs.12.1.2022.324","DOIUrl":"https://doi.org/10.22141/pjs.12.1.2022.324","url":null,"abstract":"Background. It is well-known that with aging there is a loss of bone mass and its strength, which leads to the development of osteoporosis and its complications. The aim of the study was to create a modern mathematical model for determining the biolo­gical age of the bone system, taking into account indices of bone mineral density (BMD) and quality and the FRAX® questionnaire. Materials and methods. 77 women and 44 men aged 30 to 90 years without any significant somatic pathology were included in the study. Patients were divided into 4 age groups: 30–44 years old — young, 45–59 years — mature, 60–74 years — old age and 75–90 years — senile age. We measured the parameters of BMD in the different areas of the skeleton by means of the dual-photon X-ray absorptiometry (DXA, “Prodigy”). The 10-year probability of major osteoporotic and hip fractures was measured using the Ukrainian version of the FRAX®. Statistical analysis was performed in the Statistica 7.0 program (StatSoft Inc., USA). Results. The dependence of the indices of BMD and bone quality, risk of osteoporotic fractures on age and the need for their early determination in young people to predict the risk of osteoporosis and its complications have been proven. The coefficient of determination of the R2 model was 0.62, which indicates that 62 % of the variance of the “Age” can be explained by the predictors included in the model (DXA and FRAX indices); adjusted R2 index was 0.59 (p < 0.001), which indicates high significance of the model. Conclusions. The developed model for estimating the bone biological age has high accuracy and can be used to assess the risk of osteoporosis and its complications in young people for the purpose of predicting the disease.","PeriodicalId":320219,"journal":{"name":"PAIN, JOINTS, SPINE","volume":"10 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-10-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"127471684","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}