PAIN, JOINTS, SPINE最新文献

{"title":"Sarcopenia and rheumatic diseases: is there any connection?","authors":"M. Dzhus, M. Kulyk, T. Karasevska, H.V. Mostbauer, O. Ivashkivskyi, R.A. Potomka, H. Novytska","doi":"10.22141/pjs.12.4.2022.349","DOIUrl":"https://doi.org/10.22141/pjs.12.4.2022.349","url":null,"abstract":"Sarcopenia is characterized by a loss of skeletal muscle mass, a decrease in muscle strength and/or physical performance, and is one of the main causes for limiting daily activities in the elderly. This is associated with an increased incidence of many adverse events such as dysfunction, falls, frailty, hospitalization, disability, and mortality. Primary (considered as a part of the aging process) and secondary sarcopenia (due to malabsorption, immobility/bed rest, starvation, hypothyroidism, osteoporosis, immune-mediated rheumatic diseases) are united by a chronic inflammatory process of different degrees. Sarcopenia supports one of the most widely accepted theories that low-grade chro­nic inflammation is important in the pathogenesis of many di­seases. For a long time, sarcopenia was considered an age-related disease, but recently it has been reported to be more common in young subjects with autoimmune diseases. In particular, the relationship between sarcopenia and rheumatic diseases such as rheumatoid arthritis has been studied in detail. Although the pathogenesis of sarcopenia in autoimmune diseases is not fully understood, it is believed that a chronic inflammatory process contri­butes to the development of loss of muscle mass and strength, and is different depending on the underlying disease. The definition of sarcopenia varies between studies, which complicates and li­mits direct comparisons. Therefore, in this review, we demonstrate various diagnostic criteria for sarcopenia, focusing on its pre­valence in patients with rheumatic diseases, including rheumatoid arthritis, juvenile idiopathic arthritis, axial spondylitis, psoriatic arthritis, and systemic sclerosis. We developed a structured search strategy for English language publications in PubMed using the term “sarcopenia” in combination with the following keywords: “inflammation”, “diagnosis”, “criteria”, “muscle mass”, “strength”, “outcomes”, “disability”, “mortality”, “pathophysiology”, “rheumatoid arthritis”, “juvenile arthritis”, “axial spondylitis”, “psoriatic arthritis”, “systemic sclerosis”. We focused on clinical trials, meta-analyses and review articles. Articles published only after 2000 year were included, however, we did not include major contributions published before. The search was completed on October 8, 2022.","PeriodicalId":320219,"journal":{"name":"PAIN, JOINTS, SPINE","volume":"18 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-02-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"121698643","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Letter from Deputy Editor-in-Chief Prof. H. Resch","authors":"H. Resch","doi":"10.22141/pjs.12.4.2022.343","DOIUrl":"https://doi.org/10.22141/pjs.12.4.2022.343","url":null,"abstract":"No abstract","PeriodicalId":320219,"journal":{"name":"PAIN, JOINTS, SPINE","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-02-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"122138975","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Arterial stiffness in postmenopausal women with arterial hypertension","authors":"O. Bilovol, І.І. Кniazkova, Т.V. Frolova, O. Tsygankov, А.V. Zhadan","doi":"10.22141/pjs.12.4.2022.348","DOIUrl":"https://doi.org/10.22141/pjs.12.4.2022.348","url":null,"abstract":"Background. It was established that the prevalence of reduced bone mineral density is significantly higher among patients with arterial hypertension compared to healthy subjects. The purpose of the research was to study arterial stiffness and central aortic pressure in women with arterial hypertension combined with osteoporosis. Materials and methods. 88 postmenopausal women with arterial hypertension (average age 62.7 ± 3.8 years) were included in the study, of which 35 women with osteoporosis (OP) according to dual-energy X-ray absorptiometry (DXA) data (group 1) and 33 without it (group 2). The control group consisted of 20 practically healthy women without arterial hypertension and OP. Before the start of the study, the patients did not regularly receive antihypertensive drugs. In addition to conventional studies, daily blood pressure monitoring, applanation tonometry, and DXA were performed. Statistical processing was performed using the Statistica 10.0 software package using standard variational statistics algorithms. Results. It was found that in group 1, the levels of office systolic (SBP) and diastolic blood pressure (DBP) were by 3.7 and 4.9 % (p < 0.05) hi­gher than in group 2. According to daily blood pressure monito­ring, a more pronounced increase in average daily SBP and DBP by 4.1 and 6.6 % (p < 0.05) was observed in group 1 compared to group 2. It was found that in group 1, compared to the control group and group 2, an increase in pulse wave velocity was detected by 37.2 and 26.4 %, respectively. Conclusions. In women with postmenopau­sal osteoporosis in combination with arterial hypertension according to data of office measurement, daily monitoring blood pressure and data of applanation tonometry, blood pressure levels and parameters of arterial stiffness were significantly higher than in patients with arterial hypertension without osteoporosis.","PeriodicalId":320219,"journal":{"name":"PAIN, JOINTS, SPINE","volume":"41 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-02-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"115474162","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of alfacalcidol on bone regeneration in senile rats","authors":"F. Klymovytskyy, V. Klymovytskyy, N. Dedukh","doi":"10.22141/pjs.12.4.2022.346","DOIUrl":"https://doi.org/10.22141/pjs.12.4.2022.346","url":null,"abstract":"Background. Among the drugs that have a pleiotropic effect on bone, attention is drawn to alfacalcidol – the precursor of the active form of D-hormone. There are studies that have revealed distinctive features of the effect of alfacalcidol on bone regeneration in osteoporosis and in young animals. The purpose was to study bone regeneration after treatment with alfacalcidol in senile animals. Materials and methods. A transcortical defect from the lateral to the medial femur was modeled in rats aged 24 months in the area of the metadiaphysis. A treatment with alfacalcidol was carried out from the 2-nd day and for 10 and 30 days before the animals was withdrawn from the experiment. Histological study of bone regeneration with morphometric analysis of tissues in the areas of callus had been performed. Results. On the 10-th day of the treatment with alfacalcidol in senile animals, connective tissue, osteoid and coarse-fibrous trabecular bone with a high density of osteoblasts were located in the defect area. On the 30-th day in treated animals, the bone tissue of the callus was mature; its area was larger than in untreated animals. In the area of cancellous bone there is a network of newly formed bone trabeculae. Destructive manifestations around the defect were reduced in animals treated with alfacalcidol. In untreated animals there was no dense bone fusion with cortex fragments; trabeculae of cancellous bone were intermittent. In the lateral part of the callus, the area of bone tissue was reduced compared to the medial part. Conclusions. Treatment of animals with alfacalcidol accelerates the formation of bone tissue in the defect and reduces destructive manifestations around the defect compared to untreated animals.","PeriodicalId":320219,"journal":{"name":"PAIN, JOINTS, SPINE","volume":"59 5","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-02-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"131638966","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Letter from Editor Prof. N. Grygorieva","authors":"N. Grygorieva","doi":"10.22141/pjs.12.4.2022.342","DOIUrl":"https://doi.org/10.22141/pjs.12.4.2022.342","url":null,"abstract":"No abstract","PeriodicalId":320219,"journal":{"name":"PAIN, JOINTS, SPINE","volume":"10 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-02-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"125395929","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical features of joint damage in patients with diabetes mellitus","authors":"V. Orlenko","doi":"10.22141/pjs.12.3.2022.337","DOIUrl":"https://doi.org/10.22141/pjs.12.3.2022.337","url":null,"abstract":"Background. The development of diabetes-associa­ted osteoarthritis is a complex and multifactorial process that depends on the type and compensation of diabetes mellitus (DM). Currently, the data about the role of various risk factors in the development of joint damage among the patients with DM are extremely contradictory. The purpose of the research was to study the clinical characteristics and risk factors of diabetes-associated osteoarthritis in the patients with type 1 DM (T1DM) and type 2 DM (T2DM). Materials and methods. 556subjects were examined, who were divided into groups according to the type of DM, the presence, and the degree of severity of diabetes-associated osteoarthritis. Results. In the group of the subjects with T1DM, dia­betes-associated osteoarthritis was diagnosed in 185 (74.5 %) patients, and in patients with T1DM, joint damage was diagnosed in 241 (78.2 %) persons. It was established that in the vast majority of the patients, diabetes-associated osteoarthritis was loca­lized in the joints of the upper limbs. Oligoarthritis was frequent of the patients with T1DM, while polyarthritis is more common in patients with T2DM. It has been established that the probability of diabetes-associated osteoarthritis developing in patients with T1DM probably increases after the age of 35, with a body mass index (BMI) of more than 25.0 kg/m2, a level of glycated hemoglobin (HbA1c) of more than 8.0 %, and duration of DM of more than 28 years, and in the patients with T1DM, it develops more often among the patients after the age of 61 years, with HbA1c higher than 8.2 %, BMI 27.9 kg/m2 and higher, and duration of DM more than 14 years. Conclusions. Measures to prevent diabetes-associated osteoarthritis in patients with DM should be based on long-term compensation of the underlying disease and maintenance of the optimal body mass.","PeriodicalId":320219,"journal":{"name":"PAIN, JOINTS, SPINE","volume":"15 4 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-02-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"124251572","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Report from the research conference with international participation “Osteoporosis — actual multidisciplinary problem” (OsteoHub, online, November 17–18, 2022)","authors":"No Authors","doi":"10.22141/pjs.12.3.2022.340","DOIUrl":"https://doi.org/10.22141/pjs.12.3.2022.340","url":null,"abstract":"No abstract","PeriodicalId":320219,"journal":{"name":"PAIN, JOINTS, SPINE","volume":"44 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-02-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"124159292","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Abstracts of the scientific conference with international participation “Osteoporosis — actual multidisciplinary problem” (November 17–18, 2022)","authors":"No Authors","doi":"10.22141/pjs.12.3.2022.341","DOIUrl":"https://doi.org/10.22141/pjs.12.3.2022.341","url":null,"abstract":"No abstract","PeriodicalId":320219,"journal":{"name":"PAIN, JOINTS, SPINE","volume":"48 11 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-02-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"115941835","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Letter from Editor-in-Chief","authors":"N. Grygorieva","doi":"10.22141/pjs.12.3.2022.334","DOIUrl":"https://doi.org/10.22141/pjs.12.3.2022.334","url":null,"abstract":"No abstract","PeriodicalId":320219,"journal":{"name":"PAIN, JOINTS, SPINE","volume":"689 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-02-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"115117448","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Calcium-phosphate ceramics in spine surgery: features of regeneration and use","authors":"V. Shapovalov, N. Dedukh, M. Shymon","doi":"10.22141/pjs.12.3.2022.339","DOIUrl":"https://doi.org/10.22141/pjs.12.3.2022.339","url":null,"abstract":"The review is based on the analysis of 53 literature sour­ces from PubMed, Google, Google Scholar, and Cochrane Library. Among the substitutes for autogenous bone grafts in spine surgery, ceramic biomaterials are the largest studied group, among which certain niche is occupied by calcium phosphate ceramics (CPCs). Hydroxylapatite, tricalcium phosphate and biphasic ceramics with all parts of hydroxylapatite and tricalcium phosphate are widely used in spine surgery. The advantage of using CPCs is their biocompa­tibility, osteoconductivity, osteoinductivity, osteoimmunomodulation and the ability to stimulate angiogenesis — the main components that ensure bone regeneration. In the given review, the peculiarities of regeneration in the interface “ceramic material — bone tissue” depending on the composition, surface structure, and crystallinity of the material are noted. The positive results of the experimental studies led to the use of CPCs in the clinic. CPCs with auto­genous bone grafts are successfully used in posterior and posterolateral lumbar spondylodesis, which allows reducing significantly the volume of autologous bone. A new direction is the development of non-metallic combined cages, which are used to perform anterior cervical discectomy and spondylodesis. The composition of these cages includes various polymers in combination with CPCs and bone autogenous graft to ensure high-quality spondylodesis, reduce of stress-shiel­ding and subsidence of the cage. A special approach requires the study of degradation and resorption by osteoclasts of various CPCs in order to control and synchronize the process of “resorption — bone formation”. Among the issues for the further research, the molecular mechanisms of osteoimunomodulation and factors that stimulate osseointegration and osteoinduction in the management of reparative osteogenesis should be further explored.","PeriodicalId":320219,"journal":{"name":"PAIN, JOINTS, SPINE","volume":"5 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-02-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"115420581","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}