PAIN, JOINTS, SPINE最新文献

{"title":"The role of regulatory micro-RNAs in inflammatory processes and production of tumor necrosis factor-alpha in patients with rheumatoid arthritis","authors":"","doi":"10.22141/pjs.13.1.2023.353","DOIUrl":"https://doi.org/10.22141/pjs.13.1.2023.353","url":null,"abstract":"Background. Micro-RNAs are fundamental agents of post-transcriptional control of gene expression. In recent years many works have appeared on the possible role of micro-RNAs in rheumatoid arthritis (RA). Studies of the role of micro-RNA and the relationship with the synthesis of tumor necrosis factor-α (TNF-α) are very promising for understanding the pathogenesis and treatment of RA and other autoimmune diseases. The purpose of the research was to study the role of regulatory micro-RNAs in inflammatory processes and the possible connection with the production of TNF-α in patients with RA. Materials and methods. 29 patients with active RA and 20 healthy individuals (control) were examined. All subjects were examined for 16 micro-RNAs. The choice of micro-RNA was based on previous studies and theoretical conclusions (according to the ­miRWalk database). Rheumatoid factor, the level of antibodies to cyclic peptides containing citrulline, C-reactive protein (СRP), le­vels of TNF-α (serum, spontaneous, and stimulated) were determined in the blood of patients. Results. Statistical analysis de­monstrated significant overexpression of miR-221, miR-203, miR-146b, miR-132, ­miR-21 and miR-17-3p and inhibition of miR-223 synthesis in RA patients. The activation of TNF-α synthesis at rest and the increased production of TNF-α by mononuclear cells after stimulation in RA were shown. Differences in the levels of relative expression of some micro-RNAs between seropositive and seronegative groups of RA patients were found, but only hyperexpression of miR-155 was highly reliable. For the first time, a possible relationship between TNF-α production and miR-29 and miR-155 micro-RNAs, as well as a correlation between miR-16, miR-99b and miR-203 and CRP levels, was revealed. Conclusions. The obtained data on the profile of micro-RNAs in RA makes it possible to distinguish the most “interesting” micro-RNAs for further study of pathogenesis, their role in inflammation, to study the choice of TNF-α inhibitors, and predicting the effectiveness of that treatment.","PeriodicalId":320219,"journal":{"name":"PAIN, JOINTS, SPINE","volume":"26 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-04-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130068748","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Some clinical factors of aseptic instability of the knee joint endoprosthesis","authors":"","doi":"10.22141/pjs.13.1.2023.355","DOIUrl":"https://doi.org/10.22141/pjs.13.1.2023.355","url":null,"abstract":"Background. Conducting clinical studies to determine the factors determining the aseptic instability of knee joint endoprosthesis components is an urgent issue in modern orthopedics. The aim of the study was to determine some clinical factors of aseptic instability of knee joint endoprosthesis components. Materials and methods. Comprehensive research was conducted on 285 patients who underwent primary knee arthroplasty between 2010 and 2021, including 85 patients with clinical and radiological signs of aseptic instability of knee arthroplasty components (AIKAC). Also, 200 patients made up a control group with no signs of AIKAC instability observed. Clinical research methods included general, and special orthopedic methods of studying local changes in the knee joint. They included measurement of body mass index (BMI), overloading of the knee joint due to work, previous surgical interventions and early postoperative complications of primary arthroplasty, and presence of angular deformities in the knee joint. For the clinical assessment of the knee joint of patients after knee arthroplasty, we used our own point assessment of the state of the knee joint. Results. It was determined that significant factors for the development of instability of components of the knee joint endoprosthesis are both directly related to the patient (increase in BMI, difficult working conditions, the presence of operative interventions on the knee joint), and factors related to errors du­ring the primary total arthroplasty (residual deformities of the knee joint and early postoperative complications). Conclusions. We determined important factors of aseptic instability of the knee joint in the patients after arthroplasty. Taking into account the results of this study will improve the diagnosis and treatment of aseptic instability of the knee joint.","PeriodicalId":320219,"journal":{"name":"PAIN, JOINTS, SPINE","volume":"155 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-04-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"122475204","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Blackout in Ukraine and challenges regarding the storage of immunobiological drugs","authors":"","doi":"10.22141/pjs.13.1.2023.351","DOIUrl":"https://doi.org/10.22141/pjs.13.1.2023.351","url":null,"abstract":"An undeclared war has been going on in Ukraine for more than one year. Defeated at the front, Russia resorted to massive shelling of energy facilities with the aim of leaving Ukrainians wit­hout electricity and heat during the winter. As reported, since October 10, the Russians have fired more than a thousand missiles and drones at Ukrainian energy facilities. The shelling on November 23, 2022 led to a system crash — a blackout occurred. For the first time in the history of Ukraine, all of the country’s nuclear power units were shut down. In conditions of lack of light and non-wor­king refrige­rating chambers, the storage conditions of thermolabile immunobiological drugs became a new test for the medical community and patients. As you know, immunobiological drugs, which are widely used in the treatment of various rheumatological disea­ses, require strict storage conditions in the temperature range from +2 to +8 °С. Under blackout conditions, it is difficult for Ukrainian patients to maintain optimal storage conditions for these drugs. The analysis of the studies showed that the majority of patients do not comply with the requirements for the storage of thermolabile drugs, even with the constant presence of light and electricity. Experts indicate that more and more thermolabile drugs are becoming available, and in most cases, these medications are dispensed to ambulatory patients. More thermolabile drugs are becoming avai­lable, and in most cases, these medications are dispensed to ambulatory patients. However, there is no regulation once medications are dispensed to patients and little is known with regard to what happens during transport and home sto­rage. Previous studies suggest that these drugs are improperly stored. Future studies should focus on clinical consequences and possible solutions. It is recommended for Ukrainians to follow the rules and conditions of sto­rage of heat-labile medicinal products during blackouts/emergency and stabilization blackouts.","PeriodicalId":320219,"journal":{"name":"PAIN, JOINTS, SPINE","volume":"7 3 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-04-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"117320225","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The efficacy of combined treatment of secondary hyperthyroidism in pre-dialysis chronic kidney disease patients","authors":"","doi":"10.22141/pjs.13.1.2023.356","DOIUrl":"https://doi.org/10.22141/pjs.13.1.2023.356","url":null,"abstract":"Background. It is well known that chronic kidney di­sease (CKD) patients develop mineral and bone disturbances which lead to the development of renal osteodystrophy and its complications. Secondary hyperthyroidism is the main reason for the deve­lopment of mineral and bone disoders in these patients. The purpose of the study was to evaluate the efficacy of combined therapy with Alfacalcidol and Quercetin in the treatment of secondary hyperthyroidism in pre-dialysis CKD patients. Materials and me­thods. 61 patients with CKD 3 and 4 stages aged 20–78 years were included in the study. Patients were divided into 2 groups: 35 patients received combined treatment with Alfacalcidol and Quercetin granules, and 26 patients received standard treatment with calcium carbonate. Indices of calcium, phosphorus, magnesium, and alkaline phosphatase were analyzed by photocolometry method and parathyroid hormone (PTH) by immune assay method. Statistical analysis was performed in the Statistica 5.0 program (StatSoft Inc., USA). Results. It was shown that intake of Alfacalcidol (0,25–0,5 mcg daily) and Quercetin granules 1.0 g three times per day provided normalization of calcium-phosphorous homeostasis, correction of hyperthyroidism but also has pronounced analgesic effect as compared with patients receiving monotherapy with calcium carbonate. Conclusions. Combined treatment with Alfacalcidol and Quercetin granules in predialysis CKD patients with se­condary hyperthyroidism leads to calcium and phosphorus metabolism normalization, correction of secondary hyperthyroidism, and has an analgesic effect.","PeriodicalId":320219,"journal":{"name":"PAIN, JOINTS, SPINE","volume":"80 6","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-04-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"113970012","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The positive effect of JAK inhibitor tofacitinib in the treatment of primary Sjögren’s syndrome: a clinical case","authors":"","doi":"10.22141/pjs.13.1.2023.357","DOIUrl":"https://doi.org/10.22141/pjs.13.1.2023.357","url":null,"abstract":"Primary Sjögren’s syndrome (pSS, Sjögren’s disease) is a systemic autoimmune disease which develops in previously healthy individuals and characterized by damage to exocrine glands, mainly lacrimal and salivary glands, with gradual formation of their secretory insufficiency and various systemic manifestations. According to EULAR recommendation (2019) therapeutic management of pSS bases on symptomatic treatment of sicca syndrome and broad-spectrum immunosuppression for systemic manifestations. The perspective group for the treatment of autoimmune disease is Janus kinase inhibitors, which can block the signals from biologically active molecules (interferons, erythropoietins and cytokines) and providing a response to these target cell signals. Therefore, the use of JAK inhibitors in patients with pSS requires clinical confirmation of effectiveness. The article described the clinical case of the positive effect of tofacitinib with methotrexate combination in the treatment of patient with pSS. A 55-year-old female with sicca syndrome (confirmed by Schirmer’s test), arthralgia, low-grade fever, weight loss and a positive test for the detection of specific antibodies (SS-A/Ro > 240 units/ml, SS-B/La 94 units/ml) was diagnosed with pSS. The total score of EULAR Sjögren’s syndrome disease activity index (ESSDAI) was 9 (activity grade II). The treatment included symptomatic methods of sicca syndrome correcting (replacement therapy with artificial tear preparations and chewing gums with xylitol) in combination with immunosuppressive therapy. The addition of tofacitinib 5 mg twice daily to methotrexate (10 mg weekly) has been shown to significantly reduce disease activity after 6 months of treatment (ESSDAI = 0).","PeriodicalId":320219,"journal":{"name":"PAIN, JOINTS, SPINE","volume":"32 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-04-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"126990750","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Letter from the member of Editorial Board Prof. Mário Rui Mascarenhas","authors":"","doi":"10.22141/pjs.13.1.2023.359","DOIUrl":"https://doi.org/10.22141/pjs.13.1.2023.359","url":null,"abstract":"No abstract","PeriodicalId":320219,"journal":{"name":"PAIN, JOINTS, SPINE","volume":"35 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-04-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"129517063","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The musculoskeletal system diseases in pregnant women with high infection risk and the single nucleotide rs1544410 polymorphism of the calcitriol receptor gene","authors":"","doi":"10.22141/pjs.13.1.2023.354","DOIUrl":"https://doi.org/10.22141/pjs.13.1.2023.354","url":null,"abstract":"Background. The problem of vitamin D (VD) deficiency in the population, in general, and in pregnant women, in particular, and related diseases, including the musculoskeletal system, remains one of the most widespread medical and social problems of our time. The purpose was to determine the frequency of musculoskeletal diseases in pregnant females at high infection risk (HIR) with impaired vitamin D status and single-nucleotide Bsml polymorphism of its receptor gene. Materials and methods. Fifty-six pregnant women (main group) with HIR and 40 healthy pregnant women (control group) had been examined. The level of 25-hydroxyvitamin D (25(OH)D) in blood was determined by the enzyme-linked immunosorbent assay, and real-time polymerase chain reaction was used to detect the mutant version of Bsml (rs1544410) polymorphism of the gene that is encoding vitamin D receptors (VDR). Statistical processing of the results was done using the resource www.socscistatistics.com. Results. HIR was due to the presence of chronic kidney diseases, carriers of pathogens of the TORCH group of infections and conditionally pathogenic microflora in the urogenital tract. The level of 25(OH)D was lower than the generally accepted optimal level in 76.8 and 15 % of pregnant women, in the main and control groups, respectively (F = 0.03; p = 0.0001). Carriers of the heterozygous genotype A/G were 67.7 % of pregnant women with HIR compared to 35 % of the control group (odd ratio (OR) = 3.95; 95% confidence interval (CI): 2.19–7.1; χ2 = 20.88, p = 0.00001), and the G/G genotype was inherent in 19.6 and 47.5 % of women, respectively (OR = 0.27; 95% CI 0.15–0.51;  p = 0.00006). A third of pregnant women from the main group had a history of musculoskeletal diseases (32.14 %) versus 12.5 % in control group (OR = 3.15; 95% CI: 1.54–6.46); 71.4 % of pregnant women with HIR were carriers of A/G genotype (OR = 9.79; 95% CI: 5.10–18.82). Conclusions. The share of vitamin D deficiency/insufficiency in pregnant women with HIR is almost 77 %. The general somatic history of these women is characterized by a high frequency of the kidney diseases (37.5 %) and musculoskeletal diseases (32.1 %). Two-thirds of pregnant women with HIR, as well as with musculoskeletal diseases, are carriers of the heterozygous Bsml of polymorphic genotype A/G of the VDR gene, which probably causes a higher risk of the development of pathology in conditions of calcitriol deficiency. Studying VD status, the genetic personification of disease risks, and correction of modified factors in time, in particular, VD deficiency is seen as a promising direction for improving perinatal outcomes and the quality of life of pregnant women in general, but further research is required.","PeriodicalId":320219,"journal":{"name":"PAIN, JOINTS, SPINE","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-04-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"129067341","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bone mineral density and other risk factors in children and adolescents with low-energy fractures of long bones","authors":"F.Х. Umarov, Z. Matanov","doi":"10.22141/pjs.12.4.2022.345","DOIUrl":"https://doi.org/10.22141/pjs.12.4.2022.345","url":null,"abstract":"Background. There are an increasing number of children and adolescents with reduced age-related rate of bone mass accumulation, low bone mineral density (BMD) and low-energy fractures. This problem is widely discussed in the scientific literature. Purpose of the study was to assess the BMD in children and adolescents with low-energy fractures of long bones and to investigate some biochemical parameters of bone metabolism. Materials and methods. Body mass index (BMI), bone densitometry, levels of vitamin D, calcium, phosphorus and alkaline phosphatase in blood serum of 230 children and adolescents with low-energy fractures of long bones, aged 6 to 17 years, who underwent treatment due to the fractures were studied. Results. Fractures occurred predominantly in 41.3 % of the humerus and 43 % of the forearm bones. 20 % of children and adolescents had abnormal BMI values. Low BMD values in 86 of 230 examinees were detected in the lumbar spine, of which only 66 (76.7 %) had BMD abnormalities in the hip. In assessing vitamin D status, 19.3 % of the girls and 9.2 % of the boys had normal vitamin D values. A decrease in calcium level and an increase in alkaline phosphatase in blood serum were found. In terms of BMD and vitamin D status, the dependence of boys was statistically significant in the elementary and high school groups, while in girls it was only in the elementary school group. A direct link between low BMD and vitamin D has been established. Conclusions. Low BMD, vitamin D, impaired calcium-phosphorus metabolism and obesity in children and adolescents may be considered predictors of fracture occurrence.","PeriodicalId":320219,"journal":{"name":"PAIN, JOINTS, SPINE","volume":"47 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-02-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"126329759","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Management of osteoporosis during martial law: the experience of the Ukrainian Center of Osteoporosis and the challenges of war","authors":"N. Grygorieva, M. Bystrytska, Vas.V. Povorozniuk","doi":"10.22141/pjs.12.4.2022.344","DOIUrl":"https://doi.org/10.22141/pjs.12.4.2022.344","url":null,"abstract":"Background. Russian aggression has had a critical impact on the provision of medical care to the patients in Ukraine, in general, and to the patients with osteoporosis and its complications, in particular. Destruction of hospitals, limited access to emergency and planned medical care, and increased workload on some hospitals due to a significant number of refugees and internally displaced persons are only some of the problems faced by the Ukrainian medical community. The purpose of the study was to analyze the peculiarities of providing diagnostic and advisory care at the Ukrainian Scientific and Medical Center of Osteoporosis (Kyiv) during martial law in order to determine the main challenges associated with military aggression and the possibilities of their elimination. Materials and me­thods. In a retrospective analysis of the data, the Center’s activity during 2019–2022 was evaluated depending on the month and year of the observation, the age and gender of the examinees, and type of the patients’ visit (on-line or off-line). Results. The analysis confirmed the decrease in dual-energy X-ray absorptiometry (DXA) procedures and consultations of various specialists from the beginning of martial law in Ukraine. The resumption of the Center’s work, despite difficulties related to logistical and other reasons, took place after 2 weeks in the on-line format and in 1.5 months after the start of martial law (off-line). Despite the decrease in the number of DXA procedures (by 84.3 % in April and 24.7 % in May 2022 compared to the indices in the same months in 2019) and off-line consultations (by 93.6 % in March, 66 % in April, and 11.2 % in May 2022 compared to the indices of 2019) during the martial law, the Center’s work was characterized by the implementation of on-line consultations, the share of which in the first months after the russian invasion was 66–100 % of all consultations. Conclusions. Well-established work using teleme­dicine allows maintaining the provision of medical care to the patients with osteoporosis and its complications at an appropriate level despite the challenges associa­ted with martial law.","PeriodicalId":320219,"journal":{"name":"PAIN, JOINTS, SPINE","volume":"42 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-02-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"128848250","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Conservative treatment of patients with secondary adhesive capsulitis","authors":"S. Strafun, S. Bohdan, L. Yuriychuk, O. Strafun","doi":"10.22141/pjs.12.4.2022.347","DOIUrl":"https://doi.org/10.22141/pjs.12.4.2022.347","url":null,"abstract":"Background. Secondary adhesive capsulitis, similar to idiopathic one, is accompanied by thickening of the glenohumeral joint capsule and loss of its elasticity. Nonoperative ma­nagement of secondary adhesive capsulitis associated with shoulder soft tissue injuries, impact of prolonged immobilization or surgical treatment still remains controversial. Capsular distension with steroids as in idiopathic adhesive capsulitis is often not used for one reason or another. The purpose: to compare the results of conservative treatment in patients with secondary adhesive capsulitis who underwent or not capsular distension with steroids during the treatment. Materials and methods. From 2015 to 2021 at the Department for Microsurgery and Reconstructive-Recovery Surgery of Upper Limb of the State Institution “Institute of Traumatology and Orthopaedics of the National Academy of Medical Sciences of Ukraine” (Kyiv) and Ivano-Frankivsk Regional Clinical Hospital, we have conduc­ted conservative treatment for 825 patients with various soft tissue pathology of the shoulder joint complicated by secondary adhesive capsulitis. All patients were divided into two groups: first one — conservative treatment, second one — conservative treatment with intraarticular injections (capsular distension) with steroids. In our study, we evaluated the function of the shoulder joint using the Constant Shoulder Score (CSS) and visual analog scale (VAS) before treatment and after 3 and 6 months. Results. Patients from first group (conservative treatment wi­thout distension intraarti­cular injections) had worse average functional results 3 month after starting treatment according to CSS (p = 0.13) and VAS (p = 0.24) compared to subjects of second group. Six months after the start of treatment, patients from first group had significantly worse results by CSS and VAS than those from group 2, where distension intraarticular injections were performed (p = 0.03 and p = 0.06, respectively). Conclusions. Conservative treatment of patients with secondary adhesive capsulitis of the shoulder joint should be comprehensive, differentiated and include both non-drug treatment methods and distension intraarticular injections with long-acting steroids.","PeriodicalId":320219,"journal":{"name":"PAIN, JOINTS, SPINE","volume":"133 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-02-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"114302677","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}