Mandala of Health最新文献

{"title":"Profil Pasien Hospital-Acquired Pneumonia (HAP) Pasca Kraniotomi di ICU RSUD Prof.Dr.Margono Soekarjo","authors":"Wisnu Budi Pramono, SH.MHum Suryani, Hermin Prihartini","doi":"10.20884/1.mandala.2021.14.2.5160","DOIUrl":"https://doi.org/10.20884/1.mandala.2021.14.2.5160","url":null,"abstract":"Kraniotomi adalah tindakan yang banyak dilakukan di RSUD Prof.DR.Margono Soekarjo (RSMS) dan rentan terkena infeksi nosokomial, salah satunya adalah Hospital-Aqcuired Pneumonia (HAP). Berdasarkan HAP dibagi menjadi dua : pertama HAP karena penggunaan ventilator 48 jam, kedua HAP karena masa rawatan di rumah sakit. Penelitian ini bertujuan untuk mendapatkan profil HAP pasien pasca kraniotomi di ICU RSUP.Prof.Dr.Margono. Jenis penelitian ini adalah deskriptif retrospektif dengan metode non probability sampling. Sampel adalah pasien berusia diatas 18 tahun yang mengalami pneumonia pasca kraniotomi. Data diambil dari ruang IBS,IGD,ICU dan rekam medik RSMS. Hasil insidensi HAP pasca kraniotomi sebesar17%, angka kematian 39%, dengan usia terbanyak diperoleh 51-65 thn (41%), jenis kelamin laki-laki 61%, oprasi emergensi (61%), karna trauma(48%), dengan lama oprasi 2-4 jam(76%), preop GCS <9 (50%), perokok(33%), penyakit paru/trauma paru (13%), diabetes mellitus(9% ),peny jantung (17%), penggunaan ventilator 48 jam 43%, dan kadar albumin <2,5 g/dl (70%). Kuman hasil kultur adalah serretia mercescens (35%). Simpulan: Pasien HAP pasca kraniotomi di ICU RSMS banyak terjadi pada pasien usia 51-65 tahun, laki-laki, menjalani oprasi emergensi dengan penyebab trauma, preoperasi GCS <9, lama oprasi 2-4 jam, memiliki komorbiditas merokok atau diabetes melitus atau penyakit jantung, lama rawatan sebelum HAP > 7 hari, kadar albumin < 2,5 g/dl dengan perkiraan kuman terbanyak adalah serretia mercescens. peny jantung (17%), penggunaan ventilator 48 jam 43%, dan kadar albumin <2,5 g/dl (70%). Kuman hasil kultur adalah serretia mercescens (35%). Simpulan: Pasien HAP pasca kraniotomi di ICU RSMS banyak terjadi pada pasien usia 51-65 tahun, laki-laki, menjalani oprasi emergensi dengan penyebab trauma, preoperasi GCS <9, lama oprasi 2-4 jam, memiliki komorbiditas merokok atau diabetes melitus atau penyakit jantung, lama rawatan sebelum HAP > 7 hari, kadar albumin < 2,5 g/dl dengan perkiraan kuman terbanyak adalah serretia mercescens. peny jantung (17%), penggunaan ventilator 48 jam 43%, dan kadar albumin <2,5 g/dl (70%). Kuman hasil kultur adalah serretia mercescens (35%). Simpulan: Pasien HAP pasca kraniotomi di ICU RSMS banyak terjadi pada pasien usia 51-65 tahun, laki-laki, menjalani oprasi emergensi dengan penyebab trauma, preoperasi GCS <9, lama oprasi 2-4 jam, memiliki komorbiditas merokok atau diabetes melitus atau penyakit jantung, lama rawatan sebelum HAP > 7 hari, kadar albumin < 2,5 g/dl dengan perkiraan kuman terbanyak adalah serretia mercescens. \u0000Kata kunci : kraniotomi, HAP,VAP","PeriodicalId":32014,"journal":{"name":"Mandala of Health","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-12-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43663996","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"KESESUAIAN RENAL RESISTIVE INDEX DENGAN ESTIMATED GLOMELULAR FILTRATION RATE (eGFR) PADA PENYAKIT GINJAL KRONIK","authors":"Hantoro Anggara","doi":"10.20884/1.mandala.2021.14.2.1280","DOIUrl":"https://doi.org/10.20884/1.mandala.2021.14.2.1280","url":null,"abstract":"Penyakit ginjal kronik adalah abnormalitas dari struktur atau fungsi ginjal selama lebih 3 bulan,berdasarkan adanya penyebab, kategori GFR dan albuminuria. Diagnosis gagal ginjal dapat diperiksa secara langsung dan tidak langsung. Pemeriksaan secara langsung dapat dilakukan dengan pemeriksaan biopsi ginjal. Pemeriksaan tidak langsung yaitu dengan pemeriksaan radiologi. Pemeriksaan ultrasonography (USG) adalah salah satu modalitas pemeriksaan radiologi yang sering digunakan untuk pemeriksaan, evaluasi ginjal pada pasien  penyakit ginjal kronik (PGK). Pemeriksaan doppler renal resistive index (RRI) dapat menilai kelainan vaskuler yang terjadi pada ginjal. Penelitian ini bertujuan mengetahui adanya kesesuaian resistive index ginjal dengan estimated glomelular fitration rate (e-GFR) pada penyakit ginjal kronik berdasarkan pemeriksaan USG doppler ginjal. Penelitian ini dilakukan di Bagian Radiologi RS Dr. Wahidin Sudirohusodo Makassar selama Juni-Agustus 2018. Jumlah sampel penelitian sebanyak 32 orang (laki—laki 23 dan perempuan 9 orang dengan rentang umur 18—70 tahun). Rancangan penelitian ini menggunakan kajian potong lintang. Pertama dilakukan perhitungan e-GFR MDRD, kemudian pemeriksaan u!trasonografi Doppler ginjal.  rentang nilai resistive index kedua ginjal 0,58-0,80 dengan nilai rerata 0,72. Rentang nilai e-GFR MDRD 2,43—55,43 ml/mnt/1, 73m2. Data dianalisis dengan uji korelasi Spearman. Hasil penelitian menunjukkan terdapat kesesuaian dengan arah korelasi negatif antara nilai rerata resistive index dengan e-GFR (r=-0,603; p=0,000)","PeriodicalId":32014,"journal":{"name":"Mandala of Health","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-12-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49655033","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"THE INFORMATION ON STATUS OF ANTIBIOTIC RESISTANCE CHANGING THE PERCEPTION AND ATTITUDES OF WISELY ANTIBIOTIC USE IN BANYUMAS DISTRICT COMMUNITIES","authors":"Rahmawati Wulansari, Diyah Woro Dwi Lestari, D. U. Anjarwati, E. Sutrisna","doi":"10.20884/1.mandala.2021.14.2.2280","DOIUrl":"https://doi.org/10.20884/1.mandala.2021.14.2.2280","url":null,"abstract":"The wise use of antibiotics in the Banyumas community is quite alarming. Most of them still buy antibiotics without a doctor's prescription, buy half a prescription and consume antibiotics without finishing it. Good enough knowledge about the dangers of using antibiotics unwisely has not formed a correct perception and attittude of antibiotic use. This study aims to evaluate changes in people's perceptions and attitudes about antibiotic use after being given information related to their resistance status . This research was conducted qualitatively on 10 informants. Retrieval of data through focus group discussion techniques is done before and after providing resistance status information. The results showed that before giving information, perceptions and attitudes towards the use of antibiotics most (80%) of informants were not correct despite having a good level of knowledge. Changes in perceptions and attitudes about the right pattern of antibiotic use wisely occur after being given information about the status of antibiotic resistance they experience. This study can be concluded that the provision of information on the results of the examination of resistance status has a positive effect causing the changing in perception and the right attitude regarding the use of antibiotics wisely in the Banyumas community","PeriodicalId":32014,"journal":{"name":"Mandala of Health","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-12-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41942200","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hubungan Lingkar Pinggang Dengan Kejadian Herniasi Nukleus Pulposus (HNP) di RSUD Margono Soekarjo Purwokerto","authors":"Fatiha Sri utami Tamad, M. Faqih, Massita Dwi Yuliani","doi":"10.20884/1.mandala.2021.14.2.1298","DOIUrl":"https://doi.org/10.20884/1.mandala.2021.14.2.1298","url":null,"abstract":"Latar Belakang : Angka obesitas di beberapa kota di Indonesia mengalami peningkatan sehingga berdampak serius terhadap pembangunan bangsa Indonesiadi bidang kesehatan. Terdapat dua jenis obesitas, yakni obesitas umum dan obesitas sentral. Obesitas sentral dianggap sebagai faktor risiko yang berkaitan erat dengan beberapa penyakit kronis. Cara mengukurnya dengan menggunakan ukuran lingkar pinggang (LP). Dikatakan abnormal jika laki-laki memiliki lingkar pinggang >90 cm, atau perempuan dengan lingkar pinggang >80 cm. Jika seseorang mengalami obesitas sentral maka kelebihan berat badan berpusat di daerah pinggang yang menambah beban vertebra segmen lumbal dan tekanan pada diskus interertebralis sehingga rentan terjadi herniasi pada daerah tersebut. \u0000Tujuan Penelitian : Penelitian ini bertujuan untuk mengetahui apakah terdapat hubungan lingkar pinggang dengan kejadian Herniasi Nukleus Pulposus (HNP) di RSUD Margono Soekarjo Purwokerto. \u0000Metode : Desain penelitian ini adalah observasional analitik dengan pendekatan kasus kontrol. Diagnosis HNP ditegakkan oleh dokter ahli berdasarkan anamnesis, pemeriksaan fisik dan pemeriksaan penunjang (MRI). Hasil penelitian dianalisis dengan Chi Square. \u0000Hasil : Hasil penelitian dengan analisis Chi Square menunjukkan terdapat hubungan lingkar pinggang dengan kejadian Herniasi Nukleus Pulposus (HNP) di RSUD Margono Soekarjo Purwokerto (OR: 0,153; 95% CI:0,071-0,332 : p=0,000) \u0000Kesimpulan : Berdasarkan hasil penelitian, dapat dinyatakan bahwa terdapat hubungan lingkar pinggang dengan kejadian Herniasi Nukleus Pulposus (HNP) di RSUD Margono Soekarjo Purwokerto.","PeriodicalId":32014,"journal":{"name":"Mandala of Health","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-12-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42757690","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"THE EFFECT OF CIPLUKAN EXTRACT (Physalis angulata L.) AS ANTIPSORIATIC AND TO LYMPHOCYTES COUNT OF SKIN TISSUE IN PSORIASIS MICE MODEL","authors":"Putri Nur'afni Sa'adah, Thianti Sylviningrum, Dody Novrial, Fajar Wahyu Pribadi, Wahyu Dwi Kusdaryanto, M. S. Fareza","doi":"10.20884/1.mandala.2021.14.1.4958","DOIUrl":"https://doi.org/10.20884/1.mandala.2021.14.1.4958","url":null,"abstract":"ABSTRACT \u0000Psoriasis is a chronic skin disease in form of papule-shaped lesion and erythematous plaques with thick white scales. The pathogenesis of psoriasis involves IL-23/Th-17 cytokine pathway that contributes the activation of T-lymphocytes and proinflammatory cytokines. Treatment of psoriasis using methotrexate has inhibitory effect of the synthesis of nucleic acid towards T-lymphocytes and keratinocytes. Ciplukan (Physalis angulata L.) has anti-inflammatory potential effect which contains steroid, flavonoid, alkaloid, and physalin that may inhibit lymphocyte activation and proinflammatory cytokine production. The study is used the method of experimental study with post test only with control group design. Thirty five female mices were divided into 7 groups. The parameters of this study is anti-psoriatic (PASI and Baker’s score) and lymphocytes count in psoriasis mice model. The results of Kruskal-Wallis, PASI and Baker’s score showed that p=0,001 (p<0,05) and the result of lymphocytes count using One Way ANOVA showed that p=0,001 (p<0,05). The 800 mg/kgBW dose of ciplukan extract showed the largest decrease on PASI score and lymphocytes count, and the 1200 mg/kgBW dose one showed the largest decrease on the Baker’s score. The present of the 800 mg/kgBW dose of ciplukan extract  gives the most optimal effect in reducing PASI score and skin tissue lymphocytes count in psoriasis mice model that were not significantly different with the treatment control group, while 1200 mg/kgBW dose one gives the most optimal effect in reducing Baker’s score that were significantly different with the treatment control group. \u0000  \u0000Keywords: Ciplukan extract, lymphocytes, methotrexate, Physalis angulata L","PeriodicalId":32014,"journal":{"name":"Mandala of Health","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42239506","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"KARAKTERISTIK HISTOPATOLOGI TUMO KARAKTERISTIK HISTOPATOLOGI TUMOR ORBITA DI RS MATA CICENDO BANDUNG TAHUN 2017-2018","authors":"Tirta Wardana, Raudatul Janah","doi":"10.20884/1.mandala.2021.14.1.4743","DOIUrl":"https://doi.org/10.20884/1.mandala.2021.14.1.4743","url":null,"abstract":"Tumor orbita adalah tumor dalam rongga orbita yang terdiri atas primer, sekunder penyebaran dari struktur sekitar/metastasis Pemeriksaan histopatologi merupakan pemeriksaan goldstandar pada tumor orbita. Penelitian ini bertujuan untuk mengetahuai karakteristik histopatologi tumor orbita di RS mata Cicendo bandung tahun 2017-2018. Penelitian ini merupakan penelitian deskriptif dengan jumlah sampel 760 Data dikumpulkan berdasarkan catatan medis berupa umur, jenis kelamin, mata yang terlibat, lokasi tumor, tindakan, diagnosis klinis, hasil pemeriksaan patologi tumor. Penelitian ini didapatkan hasil umur pasien >45 tahun (43,4%), Mayoritas Laki-laki sebesar 55,4%, mata yang terlibat di mata kiri 51,1%, dengan lokasi terbanyak pada palpebral 36%. Dilakukan tindakan operasi sebanyak (24%). Hasil diagnosis klinis lesi tumor jinak sebesar 68,3% dan lesi tumor ganas sebesar 31,7% dimana limfoma maligna yang paling sering ditemukan. Hasil histopatologis berupa lesi tumor jinak sebesar 71,4% dan lesi tumor ganas sebesar 28,6% dimana squamous cell carcinoma menduduki angka tertinggi sebanyak 50%. Karakteristik histopatologi tumor orbita di RS mata cicendo Bandung didominasi oleh laki-laki, usia >45 tahun pada mata kiri  dan terletak di palpebral dengan hasil diagnosis klinis dan histopatologis tersering adalah lesi /tumor jinak.","PeriodicalId":32014,"journal":{"name":"Mandala of Health","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42481964","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"CORRELATION OF ASPARTATE AMINOTRANSFERASE TO PLATELET RATIO INDEX (APRI) WITH THE DEGREE OF SEVERITY LIVER ORGAN IN CIRRHOSIS HEPATIC PATIENTS","authors":"Mahendra Aulia Rakhman, V. Indriani, Dwi Arini E","doi":"10.20884/1.mandala.2021.14.1.3074","DOIUrl":"https://doi.org/10.20884/1.mandala.2021.14.1.3074","url":null,"abstract":"Background: Cirrhosis hepatic is a chronic liver disease characterized by the replacement of liver tissue into scar tissue resulting in decreased liver function. The patient's diagnosis is gold standard for cirrhosis hepatic by invasive assessment cause tissue damage. The development of the way of diagnosis with secondary markers is APRI score was considered quite good in determining cirrhosis hepatic. On the other to, there is a method for assessing the severity of the liver organ in patients with cirrhosis hepatic using the Child-Pugh score. APRI scores and Child-Pugh scores are based on the calculation of secondary markers caused by hepatocyte cell fungtional damage. This is very useful in the early diagnosis of cirrhosis hepatic patients using simple markers and predicting the severity of the liver organ to assess further prognosis and management. \u0000Objective: To knowing the correlation of APRI index with the degree of severity liver organ in cirrhosis hepatic patients in RSUD Prof. dr. Margono Soekarjo. Specifically, it aims to determine the APRI score and Child-Pugh score in patients with cirrhosis hepatic. \u0000Methods: This study used a cross sectional design with a sample of 31 patients with a diagnosis of cirrhosis hepatic which was selected using a consecutive sampling technique. Primary data were obtained from a one-time blood sampling calculation and secondary data were obtained from medical records from patients with a diagnosis of liver cirrhosis from the physician in charge. Hypothesis analysis using Pearson correlation test. \u0000Resuls: Pearson test results showed a significant difference p = 0.024 (p <0.05) with the strength of the relationship r = 0.404 and the direction of a positive relationship on the correlation of APRI scores and Child-Pugh scores. \u0000Conclusions: There is a significant correlation between APRI scores with the degree of severity liver organ in cirrhosis hepatic patients in RSUD Prof. dr. Margono Soekarjo. The average APRI score in patients cirrhosis hepatic is 3, 107. The Child-Pugh score for the degree of severity liver organ is 8 or in the category of Child-Pugh B or moderate category.","PeriodicalId":32014,"journal":{"name":"Mandala of Health","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46195245","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"PENGARUH BERKUMUR DENGAN LARUTAN PROBIOTIK TERHADAP KADAR IgA DALAM SALIVA","authors":"Recita Indraswary, Hilma Yunita Nurenda, Helmi Faturrahman","doi":"10.20884/1.mandala.2021.14.1.4754","DOIUrl":"https://doi.org/10.20884/1.mandala.2021.14.1.4754","url":null,"abstract":"ABSTRACT \u0000Saliva contains IgA which acted as the first line of defense against a pathogen in the oral cavity. IgA salivary in the elderly have decreased which caused prone to oral infection. The alternative way to increased salivary IgA levels was by gargling a probiotic solution. Gargling was a mechanical stimulation to increase the flow rate of saliva. Probiotic contains bacteria which can give advantage for the human body. Probiotics can stimulate the immune system to increased IgA levels. The purpose of this study was to determine the effect of gargling probiotic solutions on salivary IgA levels in the elderly. \u0000This study used a quasi-experimental pre and post-test design group. The number of samples was 11 people. Each sample was instructed to gargling probiotic solution 10 ml every morning and evening along with their saliva was taken before and after gargle the probiotic solution. Data analysis was done using a paired t-test. \u0000The result showed the mean of salivary IgA levels before gargling probiotic solution were 206.6818±25.17419 and salivary IgA levels after gargling probiotic solution were 223.4091±12.52042. Based on the paired t-test got a value of p=0.059 (>0.05) means there is no significant difference. \u0000The conclusion of this study was gargling probiotic solution can increase salivary IgA but is not statistically significant. \u0000Keywords: Salivary IgA, probiotic solution, elderly","PeriodicalId":32014,"journal":{"name":"Mandala of Health","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44168945","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"THE EFFECT OF CIPLUKAN EXTRACT (Physalis angulata L.) TO THE NUMBER OF FIBROBLASTS IN IMIQUIMOD INDUCES PSORIASIS MICE MODEL","authors":"Irse Priyaganda Bani Musa, Thianti Sylviningrum, Dody Novrial, M. S. Fareza","doi":"10.20884/1.mandala.2021.14.1.4763","DOIUrl":"https://doi.org/10.20884/1.mandala.2021.14.1.4763","url":null,"abstract":"Imiquimod induces activation of Th17 cells and dendritic cells that play a role in psoriasis. Ciplukan extract ( Physalis angulata L.) contains steroid compounds, flavonoids, alkaloids, and saponins such as Physalin B, Physalin F, Physalin G which have anti-inflammatory activity in psoriasis pathophysiology. This research is an experimental research with post test only with control group design. Thirty five female mice were divided into 7 groups. Group A: negative control, group B: positive control, group C induced by imiquimod and given with ciplukan extract 400 mg/kg BW for 7 days, group D induced by imiquimod and given with ciplukan extract 800 mg/kg BW for 7 days, group E induced imiquimod and given with ciplukan extract 1,200 mg/kg BW for 7 days, group F induced by imiquimod and given with methotrexate 1 mg/kg BW for 7 days, and group G induced by imiquimod and given with a combination of ciplukan extract 1,200 mg/kgBW and methotrexate 1mg/kgBW for 7 days. 7 days. The number of fibroblast cells was counted on the fifteenth day by taken a sample of mouse skin and made histological preparations and then counted manually used a microscope. The mean number of fibroblast cells in groups A, B, C, D, E, F, and G were 21.6±2.3, respectively; 39.2±5.5; 30.6±1.3; 24.0±2.8; 24.8±2.9; 28,4±3,0;28,2±3,2 . The results of the test One Way ANOVA showed a value of p = 0.000 (p < 0.05), so that the results are significant. \u0000  \u0000Keywords: ciplukan extract, fibroblast, methotrexate , Physalis angulata \u0000 ","PeriodicalId":32014,"journal":{"name":"Mandala of Health","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45408504","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"PERBANDINGAN INDEKS ASPARTATE AMINOTRANSFERASE TO PLATELET RATIO INDEX (APRI) PADA PASIEN SIROSIS HEPATIS DAN KARSINOMA HEPATOSELULER","authors":"Muhammad Rifqi Fauzan Nurkamal, Vitasari Indriani, Ika Murti Harini","doi":"10.20884/1.mandala.2021.14.1.3070","DOIUrl":"https://doi.org/10.20884/1.mandala.2021.14.1.3070","url":null,"abstract":"ABSTRAK \u0000Sirosis hepatis dianggap sebagai kondisi sebelum terjadinya karsinoma hepatoseluler. Sirosis hepatis dan karsinoma hepatoseluler perlu dideteksi lebih awal dengan menggunakan indeks sederhana karena prognosisnya yang buruk. APRI merupakan indeks yang dapat membantu diagnosis fibrosis dan sirosis secara signifikan. Hasil penelitian sebelumnya melaporkan adanya perbedaan signifikan pada rerata indeks APRI yang diambil dari data rekam medis pasien sirosis hepatis dan karsinoma hepatoseluler. Penelitian ini mengkaji rerata indeks APRI dari hasil pemeriksaan laboratorium pasien yang baru terdiagnosis sirosis hepatis dan karsinoma hepatoseluler. Untuk mengetahui perbandingan indeks APRI pada pasien sirosis hepatis dan karsinoma hepatoseluler. Penelitian analitik observasional dengan pendekatan cross sectional dilakukan pada 11 pasien sirosis hepatis dan 11 pasien karsinoma hepatoseluler yang baru terdiagnosis di RSUD Prof. Dr. Margono Soekarjo. Pengambilan data dilakukan dengan teknik consecutive sampling pada sampel darah pasien yang kemudian dikirim ke laboratorium Patologi Klinik. Analisis hipotesis menggunakan uji T tidak berpasangan. Rerata indeks APRI pada pasien sirosis hepatis adalah 0,79 ± 0,60. Rerata indeks APRI pada pasien karsinoma hepatoseluler adalah 7,27 ± 7,11. Terdapat perbedaan bermakna pada indeks APRI antara pasien sirosis hepatis dan karsinoma hepatoseluler dengan nilai p = 0,00 (p < 0,05). Terdapat perbedaan rerata pada indeks APRI antara pasien sirosis hepatis dan karsinoma hepatoseluler. \u0000Kata Kunci: APRI, karsinoma hepatoseluler, sirosis hepatis \u0000  \u0000ABSTRACT \u0000Hepatic cirrhosis was considered as a condition before the occurrence of hepatocellular carcinoma. Hepatic cirrhosis and hepatocellular carcinoma needed to be detected earlier using a simple index because of their poor prognosis. APRI was an index that could helped diagnosing fibrosis and cirrhosis significantly. The results of previous studies reported a significant difference in the mean of APRI taken from the medical record data of hepatic cirrhosis and hepatocellular carcinoma patients. This study investigated the mean of APRI from laboratory results of newly diagnosed patients with hepatic cirrhosis and hepatocellular carcinoma. To determine the comparison of the APRI in patients with hepatic cirrhosis and hepatocellular carcinoma. An analytic observational study with cross sectional model was conducted among 11 hepatic cirrhosis and 11 hepatocellular carcinoma patients which newly diagnosed in Prof. Dr. Margono Soekarjo General Hospital. Data collection was performed by consecutive sampling method on the patient's blood sample which was then sent to the laboratory of Clinical Pathology. Hypothesis was analysed using independent t-test. The mean of APRI in hepatic cirrhosis patients is 0.79 ± 0.60. The mean of APRI in hepatocellular carcinoma patients is 7.27 ± 7.11. There is a significant difference of the APRI between the hepatic cirrhosis and hepatocellul","PeriodicalId":32014,"journal":{"name":"Mandala of Health","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45937314","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}