Lukas Koch, R Fink-Puches, L Cerroni, A Aigelsreiter, B Sadoghi
{"title":"[Orchiectomy due to early syphilis].","authors":"Lukas Koch, R Fink-Puches, L Cerroni, A Aigelsreiter, B Sadoghi","doi":"10.1007/s00120-022-01776-w","DOIUrl":"https://doi.org/10.1007/s00120-022-01776-w","url":null,"abstract":"<p><p>Granulomatous and abscessing testicular inflammations are important differential diagnoses of testicular tumors. Infectious orchitis should always be considered in unclear testicular masses with negative tumor markers. We report the case of a 45-year-old man with abscessing orchitis due to early syphilis diagnosed after orchiectomy with the suspicion of a seminoma.</p>","PeriodicalId":319655,"journal":{"name":"Urologie (Heidelberg, Germany)","volume":" ","pages":"767-769"},"PeriodicalIF":0.6,"publicationDate":"2022-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39801708","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Eva Erne, Nicole Anderle, Christian Schmees, Arnulf Stenzl
{"title":"[Patient-derived microtumors : Potential for therapeutic response prediction-a case study].","authors":"Eva Erne, Nicole Anderle, Christian Schmees, Arnulf Stenzl","doi":"10.1007/s00120-022-01851-2","DOIUrl":"https://doi.org/10.1007/s00120-022-01851-2","url":null,"abstract":"<p><strong>Background: </strong>In view of continued development of new oncological approaches, there is a high demand for personalized tumor therapy. However, fast and effective functional platforms for the prediction of individual patient response to drug therapy are largely unavailable. Various promising approaches have already been described for three-dimensional cell culture models, which represent cellular complexity and almost identical structures of the original tumor tissue.</p><p><strong>Objectives: </strong>Based on a case report, we show the capability and results of a novel test system using patient-derived microtumors (PDMs) and autologous tumor-infiltrating lymphocytes (TILs) for the prediction of response to cancer therapy.</p><p><strong>Methods: </strong>We established PDMs and TILs from primary tumor tissue of a renal cell carcinoma metastasis. Using immunohistochemistry and multiplex florescence-activated cell sorting (FACS ) analyses, the PDMs and TILs were characterized regarding to histology and immunophenotype. Tumor-specific cytotoxicity of standard of care and investigational compounds were assessed. The results were compared to the patient's individual in vivo response to therapy.</p><p><strong>Conclusion: </strong>The cytotoxicity assay of PDMs and TILs showed a significant therapeutic response (p = 0.0004) to therapy with a programmed cell death protein 1 (PD-1) inhibitor and lenvatinib compared to the control. The in vitro results correlated positively with the in vivo data. In the future, patient-derived models could predict response to cancer therapy and may help to optimize treatment decision-making.</p>","PeriodicalId":319655,"journal":{"name":"Urologie (Heidelberg, Germany)","volume":" ","pages":"739-744"},"PeriodicalIF":0.6,"publicationDate":"2022-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40581108","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Paulo Leonardo Pfitzinger, Regina Johanna Franziska Stredele, Lennert Eismann, Katja Lellig, Kristina Becker, Martina Heinrich, Christiane Zeller, Kristina Lisec, Dirk-André Clevert, Thomas Pfluger, Christian Stief, Birgit Kammer
{"title":"[Special diagnostics in pediatric urology-Ultrasound, VCUG, CT and MRI : Part 1: tips for the practice].","authors":"Paulo Leonardo Pfitzinger, Regina Johanna Franziska Stredele, Lennert Eismann, Katja Lellig, Kristina Becker, Martina Heinrich, Christiane Zeller, Kristina Lisec, Dirk-André Clevert, Thomas Pfluger, Christian Stief, Birgit Kammer","doi":"10.1007/s00120-022-01869-6","DOIUrl":"https://doi.org/10.1007/s00120-022-01869-6","url":null,"abstract":"<p><p>The diagnostics and treatment of pediatric urology patients in the clinical routine can be extremely challenging. In comparison to adult patients, congenital diseases, more time consuming examinations and limited options in addition to the parents' expectations must be taken into account in the diagnostic work up. In this first of two parts we will delve into ultrasound diagnostics as the cornerstone in the diagnostic pathway of children with hydronephrosis ans take a closer look on contrast enhanced ultrasound (CEUS). Conventional voiding cystourethrography still plays a major role in the diagnostic pathway of vesicoureteric reflux and will be treated in this article. Computed tomography should only be considered in pediatric patients in rare cases, always taking radiation into critical account. Magnetic resonance imaging provides an excellent anatomical overview without exposing the child to unnecessary radiation. This article provides an overview on the diagnostic imaging studies in pediatric urology and brings tips for the diagnostic evaluation.</p>","PeriodicalId":319655,"journal":{"name":"Urologie (Heidelberg, Germany)","volume":" ","pages":"782-791"},"PeriodicalIF":0.6,"publicationDate":"2022-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40581112","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}