{"title":"[Radiation-induced hemorrhagic cystitis-possible treatment options!]","authors":"P Nuhn, J Thüroff","doi":"10.1007/s00120-022-01844-1","DOIUrl":"https://doi.org/10.1007/s00120-022-01844-1","url":null,"abstract":"<p><p>Radiation-induced hemorrhagic cystitis is a late-onset complication of radiation therapy of the pelvis with an incidence rate of approximately 5-10%. The severity of hematuria can vary from mild hematuria to more severe bleeding with clot formation and urinary retention to intractable life-threatening bleeding when blood transfusions fail to keep pace with blood loss. Management of radiation-induced hemorrhagic cystitis is based on the presenting symptoms after ruling out urinary tract infection or a tumor. In cases with mild or moderate gross hematuria, hydration can be sufficient to prevent clot formation. In emergency cases, evacuation of clots and continuous bladder irrigation with isotonic saline is required, and in cases with persistent bleeding, transurethral fulguration is also required. Unfortunately, radiation-induced hemorrhagic cystitis can lead to persistent or intermittent hematuria. In these cases, intravesical instillation of astringent agents or hyperbaric oxygen therapy can alleviate symptoms. In emergency cases, transarterial embolization or surgical ligation of vesical arteries may be necessary. In rare refractory cases, urinary diversion with or without cystectomy should be performed.</p>","PeriodicalId":319655,"journal":{"name":"Urologie (Heidelberg, Germany)","volume":" ","pages":"614-621"},"PeriodicalIF":0.6,"publicationDate":"2022-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40583614","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Juliane Putz, Angelika Borkowetz, Gina Benita Schlumberger, Johannes Huber, Christian Thomas
{"title":"[Relevance of water-related rehabilitation measures for stoma patients : Results of a pilot project and review of the literature].","authors":"Juliane Putz, Angelika Borkowetz, Gina Benita Schlumberger, Johannes Huber, Christian Thomas","doi":"10.1007/s00120-021-01737-9","DOIUrl":"https://doi.org/10.1007/s00120-021-01737-9","url":null,"abstract":"<p><strong>Background: </strong>The creation of a skin stoma after exenterative pelvic surgery drastically affects the physical health of patients. Being concerned with aesthetic and functional aspects, patients tend to not participate in offers for water-related rehabilitation, especially water gymnastics and swimming.</p><p><strong>Objective: </strong>The aim of the pilot project \"UROAquaFIT\" was to evaluate the feasibility of water-related rehabilitation for patients after cystectomy with incontinent urinary diversion.</p><p><strong>Methods: </strong>Patients after radical cystectomy with incontinent urinary diversion were offered the possibility to participate in the water-based rehabilitation program \"UROAquaFIT\". Split into small groups, a water gymnastics course took place under the guidance of a physiotherapist and a stoma therapist as well as under medical supervision. Data on quality of life and a personal assessment were collected using a questionnaire before and 6 months after the course. In addition, a MEDLINE-based search for aqua gymnastics in oncology was conducted.</p><p><strong>Results and conclusion: </strong>All participants reported the course as being positive and enriching. The participants' well-being and self-esteem improved. Therefore, water gymnastics can be a highly effective method for rehabilitation of patients with incontinent urinary diversion. In addition, it improves the physical health of those affected and thus expands the possibilities for social reintegration. This form of therapy should be standard in the rehabilitation of patients with incontinent urinary diversion.</p>","PeriodicalId":319655,"journal":{"name":"Urologie (Heidelberg, Germany)","volume":" ","pages":"622-628"},"PeriodicalIF":0.6,"publicationDate":"2022-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39931042","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"[Systematic action-Emergencies in systemic cancer therapy!]","authors":"Martin Bögemann","doi":"10.1007/s00120-022-01835-2","DOIUrl":"https://doi.org/10.1007/s00120-022-01835-2","url":null,"abstract":"<p><strong>Background: </strong>A multitude of treatment options for the systemic treatment of urologic cancer have become available in recent years. In addition to classical chemotherapy or androgen-deprivation therapy, other approaches like targeted therapies (e.g., tyrosine kinase inhibitors), checkpoint inhibitors, and new approaches like radioligand therapies are increasingly used. Whether treating their own patients or caring for patients who receive these compounds from other physicians in the field, urologists will inevitably be confronted with adverse events associated with these diverse therapies. This development will continue to grow as new compounds are continuously being registered and even new drug classes are being developed. Therefore, every urologist should know the basics regarding prophylaxis, control of adverse events, and especially management of emergency situations associated with systemic treatment in uro-oncology.</p><p><strong>Objectives: </strong>To provide an overview of typical emergency situations and their management in genitourinary cancers.</p><p><strong>Methods: </strong>Summary of common uro-oncological emergency situations associated with systemic therapy.</p><p><strong>Results: </strong>The urologist requires expert knowledge in the management of emergencies within systemic treatment of genitourinary cancers like neutropenic fever during chemotherapy, hand-foot syndrome with tyrosine kinase inhibitors, immune-related adverse events, but also of side effects occurring in patients treated by other physicians, e.g., during radioligand therapies administered by nuclear physicians.</p><p><strong>Conclusions: </strong>Basic knowledge on the typical side effects and emergencies that are associated with compounds used in the treatment of genitourinary cancers is essential. Continuous medical education to be able to handle the new developments in this rapidly evolving field is mandatory.</p>","PeriodicalId":319655,"journal":{"name":"Urologie (Heidelberg, Germany)","volume":" ","pages":"587-595"},"PeriodicalIF":0.6,"publicationDate":"2022-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9128322/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40583612","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"[Prophylaxis of nausea and vomiting after medical cancer treatment : Guidelines on supportive treatment-Part II].","authors":"Hartmut Link","doi":"10.1007/s00120-022-01848-x","DOIUrl":"https://doi.org/10.1007/s00120-022-01848-x","url":null,"abstract":"<p><p>The frequency and severity of nausea and/or vomiting in patients receiving anticancer drugs are influenced by numerous factors, e.g., by the specific therapeutic agent, the dosage, the schedule and the form of administration. They are also influenced by individual factors of the patients, e.g., young age, female gender, previous cancer treatment, low or no alcohol consumption, morning sickness, travel sickness and states of anxiety. The emetogenicity of parenteral and oral medications is classified into high, moderate and minimal. For prophylaxis of highly emetogenic chemotherapy (HEC), neurokinin‑1 receptor antagonists (NK1-RA), 5‑hydroxytryptamine‑3 receptor antagonists (5-HT3-RA), dexamethasone (DEX) and olanzapine (OLANZ) are used in combination. For moderate emetogenicity DEX and 5‑HT3-RA are used together for prophylaxis of acute emesis and for low emetogenicity a monotherapy with 5‑HT3-RA, DEX or metoclopramide is used. For minimal emetogenicity routine prophylaxis is not necessary. Standards are also prescribed for delayed emesis and oral anticancer medications. Guideline-conform prophylaxis is an indispensable component of medical oncological treatment.</p>","PeriodicalId":319655,"journal":{"name":"Urologie (Heidelberg, Germany)","volume":" ","pages":"667-680"},"PeriodicalIF":0.6,"publicationDate":"2022-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40583616","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
A. Cox, A. Hofmann, C. Neissner, C. Federle, W. Rösch
{"title":"Trampolinspringen-induzierte Makrohämaturie","authors":"A. Cox, A. Hofmann, C. Neissner, C. Federle, W. Rösch","doi":"10.1007/s00120-022-01825-4","DOIUrl":"https://doi.org/10.1007/s00120-022-01825-4","url":null,"abstract":"","PeriodicalId":319655,"journal":{"name":"Urologie (Heidelberg, Germany)","volume":"100 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-04-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"122681319","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
V. Krieg, Vanessa Brandes, C. Lindemann, F. Moll, J. Leissner
{"title":"Seltene Ursache eines perinephritischen Abszesses","authors":"V. Krieg, Vanessa Brandes, C. Lindemann, F. Moll, J. Leissner","doi":"10.1007/s00120-022-01808-5","DOIUrl":"https://doi.org/10.1007/s00120-022-01808-5","url":null,"abstract":"","PeriodicalId":319655,"journal":{"name":"Urologie (Heidelberg, Germany)","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-04-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"124370164","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}