Quantum Beam Science最新文献_第5页

The Structure of Liquid and Glassy Carbamazepine. 液态和玻璃态卡马西平的结构

IF 1.4

Quantum Beam Science Pub Date : 2022-12-01 Epub Date: 2022-11-15 DOI: 10.3390/qubs6040031

Chris J Benmore, Angela Edwards, Oliver L G Alderman, Brian R Cherry, Pamela Smith, Daniel Smith, Stephen Byrn, Richard Weber, Jeffery L Yarger

{"title":"The Structure of Liquid and Glassy Carbamazepine.","authors":"Chris J Benmore, Angela Edwards, Oliver L G Alderman, Brian R Cherry, Pamela Smith, Daniel Smith, Stephen Byrn, Richard Weber, Jeffery L Yarger","doi":"10.3390/qubs6040031","DOIUrl":"10.3390/qubs6040031","url":null,"abstract":"<p><p>To enhance the solubility of orally administered pharmaceuticals, liquid capsules or amorphous tablets are often preferred over crystalline drug products. However, little is known regarding the variation in bonding mechanisms between pharmaceutical molecules in their different disordered forms. In this study, liquid and melt-quenched glassy carbamazepine have been studied using high energy X-ray diffraction and modeled using Empirical Potential Structure Refinement. The results show significant structural differences between the liquid and glassy states. The liquid shows a wide range of structures; from isolated molecules, to aromatic ring correlations and NH-O hydrogen bonding. Upon quenching from the liquid to the glass the number of hydrogen bonds per molecule increases by ~50% at the expense of a ~30% decrease in the close contact (non-bonded) carbon-carbon interactions between aromatic rings. During the cooling process, there is an increase in both singly and doubly hydrogen-bonded adjacent molecules. Although hydrogen-bonded dimers found in the crystalline states persist in the glassy state, the absence of a crystalline lattice also allows small, hydrogen-bonded NH-O trimers and tetramers to form. This proposed model for the structure of glassy carbamazepine is consistent with the results from vibrational spectroscopy and nuclear magnetic resonance.</p>","PeriodicalId":31879,"journal":{"name":"Quantum Beam Science","volume":"1 1","pages":""},"PeriodicalIF":1.4,"publicationDate":"2022-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11099869/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69808120","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The ELIMAIA Laser–Plasma Ion Accelerator: Technological Commissioning and Perspectives ELIMAIA激光等离子体离子加速器的技术调试与展望

IF 1.4

Quantum Beam Science Pub Date : 2022-10-09 DOI: 10.3390/qubs6040030

F. Schillaci, L. Giuffrida, M. Tryus, F. Grepl, S. Stanček, A. Velyhan, V. Istokskaia, T. Levato, G. Petringa, G. Cirrone, J. Cupal, L. Koubiková, D. Peceli, J. Jarboe, Tarcio de Castro Silva, M. Cuhra, T. Chagovets, V. Kantarelou, M. Tosca, V. Ivanyan, M. Greplova Zakova, J. Psikal, R. Truneček, A. Cimmino, R. Versaci, Veronika Olšovlcová, D. Kramer, P. Bakule, J. Řídký, G. Korn, B. Rus, D. Margarone

{"title":"The ELIMAIA Laser–Plasma Ion Accelerator: Technological Commissioning and Perspectives","authors":"F. Schillaci, L. Giuffrida, M. Tryus, F. Grepl, S. Stanček, A. Velyhan, V. Istokskaia, T. Levato, G. Petringa, G. Cirrone, J. Cupal, L. Koubiková, D. Peceli, J. Jarboe, Tarcio de Castro Silva, M. Cuhra, T. Chagovets, V. Kantarelou, M. Tosca, V. Ivanyan, M. Greplova Zakova, J. Psikal, R. Truneček, A. Cimmino, R. Versaci, Veronika Olšovlcová, D. Kramer, P. Bakule, J. Řídký, G. Korn, B. Rus, D. Margarone","doi":"10.3390/qubs6040030","DOIUrl":"https://doi.org/10.3390/qubs6040030","url":null,"abstract":"We report on the technological commissioning of the Laser–Plasma Ion Accelerator section of the ELIMAIA user beamline at the ELI Beamlines facility in the Czech Republic. The high-peak, high-average power L3-HAPLS laser system was used with an energy of ~10 J and pulse duration of ~30 fs on target, both in single-pulse and high repetition-rate (~0.5 Hz) mode. The laser pulse was tightly focused to reach ultrahigh intensity on target (~1021 W/cm2) and sustain such laser–plasma interaction regime during high repetition-rate operations. The laser beam, ion beam, and laser–plasma emission were monitored on a shot-to-shot basis, and online data analysis at 0.5 Hz was demonstrated through the full set of used diagnostics (e.g., far and near field, laser temporal diagnostics, X- and gamma-ray detectors, Thomson Parabola ion spectrometer, time-of-flight ion detectors, plasma imaging, etc.). The capability and reliability of the ELIMAIA Ion Accelerator was successfully demonstrated at a repetition rate of 0.5 Hz for several hundreds of consecutive laser shots.","PeriodicalId":31879,"journal":{"name":"Quantum Beam Science","volume":" ","pages":""},"PeriodicalIF":1.4,"publicationDate":"2022-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45656631","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

Virtual Angstrom-Beam Electron Diffraction Analysis for Zr80Pt20 Metallic Glasses Zr80Pt20金属玻璃的虚拟埃束电子衍射分析

IF 1.4

Quantum Beam Science Pub Date : 2022-09-22 DOI: 10.3390/qubs6040028

A. Hirata

引用次数: 0

A Solar-Rechargeable Radiation Dosimeter Design for Radiation Hazard Zone Located with LoRa Network 利用LoRa网络定位辐射危险区的太阳能可充电辐射剂量计设计

IF 1.4

Quantum Beam Science Pub Date : 2022-09-19 DOI: 10.3390/qubs6030027

Cheng-Yan Guo, Tzu-Lu Lin, Tung-Li Hsieh

引用次数: 0

Transmission Bender as an Analyzer Device for MIEZE 传动弯管机作为MIEZE的分析装置

IF 1.4

Quantum Beam Science Pub Date : 2022-08-02 DOI: 10.3390/qubs6030026

J. Jochum, J. Cooper, Lukas M. Vogl, P. Link, O. Soltwedel, P. Böni, C. Pfleiderer, C. Franz

引用次数: 2

Further Optimized Design of a Nested Rotate Sextupole Permanent Magnet Lens for the Focusing of Pulsed Neutrons 用于脉冲中子聚焦的嵌套旋转六极永磁透镜的进一步优化设计

IF 1.4

Quantum Beam Science Pub Date : 2022-07-26 DOI: 10.3390/qubs6030025

Taisen Zuo, Zhanjiang Lu, C. Deng, Songwen Xiao, Yongcheng He, Zhe-xi He, Xiong Lin, Changli Ma, Zehua Han, He Cheng

引用次数: 1

Blue Diode Laser Welding of Commercially Pure Titanium Foils 商用纯钛箔的蓝光二极管激光焊接

IF 1.4

Quantum Beam Science Pub Date : 2022-07-18 DOI: 10.3390/qubs6030024

T. Pasang, P. Lin, W. Misiolek, Jianjin Wei, S. Masuno, M. Tsukamoto, Eiji Hori, Yuji Sato, Y. Tao, Danang Yudhistiro, S. Yunus

{"title":"Blue Diode Laser Welding of Commercially Pure Titanium Foils","authors":"T. Pasang, P. Lin, W. Misiolek, Jianjin Wei, S. Masuno, M. Tsukamoto, Eiji Hori, Yuji Sato, Y. Tao, Danang Yudhistiro, S. Yunus","doi":"10.3390/qubs6030024","DOIUrl":"https://doi.org/10.3390/qubs6030024","url":null,"abstract":"The need for thin foil welding is increasing significantly, particularly in the electronic industries. The technologies that are currently available limit the joining processes in terms of materials and their geometries. In this paper, a series of trials of fusion welding (bead-on- plate) of commercially pure titanium (CPTi) foils were conducted using a blue diode laser (BDL) welding method. The power used was 50 W and 100 W for 0.1 mm and 0.2 mm thick foils, respectively. Following welding, various samples were prepared to examine the weld profiles, microstructures, hardness, tensile strength, and fracture surface characteristics. The results showed that the base metal (BM) had an annealed microstructure with equiaxed grains, while the weld zones contained martensite (α’) with large grains. The hardness increased in both regions, from around 123 HV to around 250 HV, in the heat-affected zone (HAZ) and fusion zone (FZ) areas. The tensile tests revealed that the strengths of the welded samples were slightly lower than the unwelded samples, i.e., UTS = 300–350 MPa compared with 325–390 MPa for the unwelded samples. Fracture took place within the BM area. All of the samples, welded and unwelded, showed identical fracture mechanisms, i.e., microvoid coalescence or ductile fracture. The weld zone experienced very small strains (elongation) at fracture, which indicates a good weld quality.","PeriodicalId":31879,"journal":{"name":"Quantum Beam Science","volume":" ","pages":""},"PeriodicalIF":1.4,"publicationDate":"2022-07-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49520457","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Laser Cleaning as Novel Approach to Preservation of Historical Books and Documents on a Paper Basis 激光清洗作为纸质历史文献保护的新途径

IF 1.4

Quantum Beam Science Pub Date : 2022-06-30 DOI: 10.3390/qubs6030023

V. Parfenov, A. Galushkin, T. Tkachenko, V. Aseev

引用次数: 1

Demonstration of Neutron Phase Imaging Based on Talbot–Lau Interferometer at Compact Neutron Source RANS 基于Talbot–Lau干涉仪的紧凑型中子源RANS中子相位成像演示

IF 1.4

Quantum Beam Science Pub Date : 2022-06-01 DOI: 10.3390/qubs6020022

H. Takano, Yanlin Wu, T. Samoto, A. Taketani, Takaoki Takanashi, C. Iwamoto, Y. Otake, A. Momose

引用次数: 0

Effects of Energetic Carbon-Cluster Ion Irradiation on Lattice Structures of EuBa2Cu3O7−x Oxide Superconductor 高能碳簇离子辐照对EuBa2Cu3O7−x氧化物超导体晶格结构的影响