Nefrologia English Edition最新文献

{"title":"New perspectives on biomarkers of acute kidney injury: the role of metabolomics.","authors":"Jessy Korina Peña-Esparragoza, José Ángel Lorente, José Luis Izquierdo, Judith Martins","doi":"10.1016/j.nefroe.2025.101329","DOIUrl":"https://doi.org/10.1016/j.nefroe.2025.101329","url":null,"abstract":"","PeriodicalId":31770,"journal":{"name":"Nefrologia English Edition","volume":" ","pages":"101329"},"PeriodicalIF":0.0,"publicationDate":"2025-07-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144675938","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Familial hyperaldosteronism as a cause of secondary hypertension: a case report in pediatric age.","authors":"Ana Roche-Gomez, Cristina Julia Blázquez Gómez, Irene Gómez-Pastrana Pau, Clara María Aymerich de Franceschi, Mar Espino Hernández","doi":"10.1016/j.nefroe.2025.101316","DOIUrl":"https://doi.org/10.1016/j.nefroe.2025.101316","url":null,"abstract":"","PeriodicalId":31770,"journal":{"name":"Nefrologia English Edition","volume":" ","pages":"101316"},"PeriodicalIF":0.0,"publicationDate":"2025-07-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144565283","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cardiovascular reaction to a natural disaster in a pediatric patient. Direct evidence through ambulatory blood pressure monitoring.","authors":"Javier Martín Benlloch, Ana Adell Sales, Ana Ledo García, Pilar Pérez Pintado, Maria Luisa Matoses Ruipérez, Joan Pacheco Campello, Pedro José Ortega López","doi":"10.1016/j.nefroe.2025.101319","DOIUrl":"https://doi.org/10.1016/j.nefroe.2025.101319","url":null,"abstract":"","PeriodicalId":31770,"journal":{"name":"Nefrologia English Edition","volume":" ","pages":"101319"},"PeriodicalIF":0.0,"publicationDate":"2025-07-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144565282","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Glomerular disease in chronic graft versus host disease","authors":"Leticia Peluffo ,&nbsp;Lucía Barceló ,&nbsp;Gabriela Otatti ,&nbsp;Andrés Urrestarazu ,&nbsp;Ruben Coitiño ,&nbsp;Cecilia Baccino ,&nbsp;Sofía San Román ,&nbsp;Agustín Noboa ,&nbsp;Jimena Cabrera ,&nbsp;Haydee Aunchaunya ,&nbsp;Fernanda Varela ,&nbsp;Cecilia Coelho ,&nbsp;Lucía Santini ,&nbsp;Eliana Cabrera ,&nbsp;Paula Gauronas ,&nbsp;Santiago Acle ,&nbsp;Oscar Noboa ,&nbsp;Ricardo Silvariño","doi":"10.1016/j.nefroe.2025.05.002","DOIUrl":"10.1016/j.nefroe.2025.05.002","url":null,"abstract":"<div><div>Allogeneic hematopoietic progenitor cell transplantation is a widely used procedure, and graft-versus-host disease (GVHD) is a common complication. Glomerular involvement due to GVHD is exceptional. Objective: to describe the clinical and histopathological presentation of patients with glomerular disease secondary to GVHD. Materials and methods: a retrospective review of the Uruguayan registry of glomerulopathies was conducted to identify renal biopsies from patients with confirmed GVHD. Results: seven patients were identified, four male, with a median age of 41 years (range 8–58). The most common clinical and analytical presentation was nephrotic syndrome. Histopathological findings included membranous glomerulonephritis (4), segmental and focal sclerohyalinosis (1), membranoproliferative glomerulonephritis (1), and thrombotic microangiopathy (1). All patients were treated with corticosteroids in combination with immunosuppressors, most frequently mycophenolate mofetil and rituximab. Five patients achieved complete remission, one had partial remission, and one did not respond. The combination of corticosteroids with rituximab showed a good response rate in those presenting with podocytopathy in the renal biopsy.</div></div>","PeriodicalId":31770,"journal":{"name":"Nefrologia English Edition","volume":"45 5","pages":"Pages 381-387"},"PeriodicalIF":0.0,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144095083","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A predictive model of non-diabetic kidney disease in patients with diabetes mellitus and chronic kidney disease. A Spanish multi-center study","authors":"Sheila Bermejo ,&nbsp;Ester González ,&nbsp;Katia López-Revuelta ,&nbsp;Meritxell Ibernon ,&nbsp;Diana López ,&nbsp;Adoración Martín-Gómez ,&nbsp;Rosa Garcia-Osuna ,&nbsp;Tania Linares ,&nbsp;Montserrat Díaz ,&nbsp;Nàdia Martín ,&nbsp;Xoana Barros ,&nbsp;Helena Marco ,&nbsp;Maruja Isabel Navarro ,&nbsp;Noemí Esparza ,&nbsp;Sandra Elias ,&nbsp;Ana Coloma ,&nbsp;Nicolás Roberto Robles ,&nbsp;Irene Agraz ,&nbsp;Esteban Poch ,&nbsp;Lida Rodas ,&nbsp;María José Soler","doi":"10.1016/j.nefroe.2025.04.004","DOIUrl":"10.1016/j.nefroe.2025.04.004","url":null,"abstract":"<div><h3>Aims</h3><div>Kidney biopsy is increasing in patients with diabetes and around 50–60% of patients with diabetes have non-diabetic kidney disease (NDKD). Identifying NDKD is crucial since these patients have a better renal prognosis and survival compared to patients with diabetic nephropathy (DN). The objective of this study is to provide a clinical practice tool for through a predictive model of NDKD.</div></div><div><h3>Material and methods</h3><div>Observational and multicenter Spanish study of the pathological results of kidney biopsies in patients with diabetes from 2002 to 2014. A logistic regression analysis and the probability of presenting NDKD was calculated using a punctuation score.</div></div><div><h3>Results</h3><div>A total of 832 patients with diabetes and renal biopsy were analyzed. An accurate risk-predictive model for NDKD was developed with five top-ranked non-invasive clinical variables (age, serum creatinine, presence of diabetic retinopathy, microhematuria and peripheral vascular disease) obtaining a score for each one allowing for a proper prediction of NDKD.</div></div><div><h3>Conclusions</h3><div>In our study, we developed a risk-stratification score to calculate the probability of NDKD. This could be in a next future a useful tool for the clinical indication of renal biopsy in patients with diabetes and kidney disease.</div></div>","PeriodicalId":31770,"journal":{"name":"Nefrologia English Edition","volume":"45 5","pages":"Pages 360-368"},"PeriodicalIF":0.0,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144262752","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Characterization of recurrent UMOD variants (p.C255Y y p.Q316P) in a Galician cohort: genotype-phenotype correlation and clinical implications","authors":"Eloísa Sánchez-Cazorla ,&nbsp;Borja Temes-Álvarez ,&nbsp;Pilar Oliveros-Martínez ,&nbsp;Pedro Fortes-González ,&nbsp;María García-Murias ,&nbsp;Ana Barcia de la Iglesia ,&nbsp;Noa Carrera ,&nbsp;Miguel Ángel García-González ,&nbsp;Grupo GalERH","doi":"10.1016/j.nefroe.2025.04.007","DOIUrl":"10.1016/j.nefroe.2025.04.007","url":null,"abstract":"<div><h3>Background</h3><div>The <em>UMOD</em> gene encodes the uromodulin protein, which plays a crucial role in renal function. Genetic alterations affecting its correct function are mainly related to Autosomal Dominant Tubulointerstitial Kidney Disease (ADTKD), progressive renal failure and hyperuricaemia, among other variable clinical phenotypes. In the Galician population there are recurrent mutations in this gene, this study aims to phenotypically characterize the recurrent variants to improve the prognosis and management strategies of affected patients.</div></div><div><h3>Methods</h3><div>In a Galician population characterized by high genetic conservation, a retrospective cohort study was conducted with 37 patients from 15 families carrying recurrent variants in <em>UMOD</em> (p.C255Y and p.Q316P, from transcript NM_001008389.3). Clinical data were collected, including renal function, hyperuricemia, hypertension and presence of renal cysts. Genomic analyses were performed by NGS and Sanger sequencing, variant classification were conducted according to ACMG guidelines. Statistical comparisons were performed using Mann-Whitney, Chi-square and Fisher tests, with Benjamini-Hochberg correction for multiple testing.</div></div><div><h3>Results</h3><div>The cohort included 28 carriers of p.C255Y and 9 of p.Q316P genetic variants. Both variants affect highly conserved domains with low tolerance to amino acid changes, which alters protein function and has clinical effects in patients. Hyperuricemia was observed in 76% of p.C255Y carriers and 50% of p.Q316P carriers, while interestingly only the first variant was associated with episodes of gout. Renal cysts and hypertension were identified in about half of the patients, independently of variant type. Kaplan–Meier curves suggested an earlier progression to hyperuricemia and advanced chronic kidney disease (CKD) in p.C255Y carriers, although without reaching statistical significance.</div></div><div><h3>Conclusions</h3><div>Recurrent <em>UMOD</em> mutations in a Galician cohort revealed shared clinical features, including hyperuricemia and CKD progression, with phenotypic variability influenced by age and additional genetic modifiers. The findings highlight the prognostic value of genotype-phenotype correlations and the need for tailored clinical management in ADTKD patients.</div></div>","PeriodicalId":31770,"journal":{"name":"Nefrologia English Edition","volume":"45 5","pages":"Pages 369-380"},"PeriodicalIF":0.0,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144019131","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Renal involvement due to pigment casts in a patient with sickle cell disease, not everything is focal and segmental glomerulosclerosis","authors":"Lina M. Garzón ,&nbsp;Edgar H. Dominguez ,&nbsp;Nancy Janeth Vargas ,&nbsp;Luz M. Mejía","doi":"10.1016/j.nefroe.2025.04.011","DOIUrl":"10.1016/j.nefroe.2025.04.011","url":null,"abstract":"<div><div>Sickle cell disease, is a genetic disorder caused by a mutation in the HBB gene, affecting the β-globin and resulting in the formation of sickle hemoglobin. The disease can affect the kidney through various mechanisms, including vaso-occlusion, ischemia–reperfusion, endothelial dysfunction, and hemolysis-induced renal injury. This article describes the case of a 41-year-old woman with sickle cell disease who presented with a hemolytic crisis, developed acute kidney injury (AKI), 8<!--> <!-->g of proteinuria in 24<!--> <!-->h, and required renal support therapy. A renal biopsy was performed, revealing focal segmental glomerulosclerosis (FSGS), severe acute tubular necrosis, interstitial fibrosis with moderate tubular atrophy, and pigment casts. Thus, histochemistry was performed with a positive reaction for iron with evidence of intraluminal and cytoplasmic granular deposits in the proximal tubules compatible with hemosiderin and negative for hemoglobin. The case of this patient with sickle cell disease and AKI illustrates the importance of considering hemoglobin cast nephropathy as a potential cause.</div></div>","PeriodicalId":31770,"journal":{"name":"Nefrologia English Edition","volume":"45 5","pages":"Pages 410-414"},"PeriodicalIF":0.0,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144262755","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Magnitude of chronic kidney disease in Spain","authors":"Rafael Santamaria ,&nbsp;Carlos Escobar ,&nbsp;Unai Aranda ,&nbsp;Beatriz Palacios ,&nbsp;Margarita Capel ,&nbsp;Ignacio Hernández ,&nbsp;Ana Cebrián ,&nbsp;Roberto Alcázar ,&nbsp;Manuel Gorostidi","doi":"10.1016/j.nefroe.2025.04.009","DOIUrl":"10.1016/j.nefroe.2025.04.009","url":null,"abstract":"","PeriodicalId":31770,"journal":{"name":"Nefrologia English Edition","volume":"45 5","pages":"Pages 415-417"},"PeriodicalIF":0.0,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144262756","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Improvement in the detection, diagnosis, and early treatment of chronic kidney disease in Spain. The IntERKit project","authors":"José Luis Górriz ,&nbsp;Fran Adán Gil ,&nbsp;Manuel A. Botana López ,&nbsp;Antonio Buño Soto ,&nbsp;Francisco José Campos Cabrera ,&nbsp;Angeles Cisneros ,&nbsp;Silvia Cobo Guerrero ,&nbsp;María Dolores Conejos ,&nbsp;Isabel Egocheaga Cabello ,&nbsp;M. Concepción Fernández Planelles ,&nbsp;Lisardo García-Matarín ,&nbsp;Natalia Jiménez ,&nbsp;Juan Carlos Julián Mauro ,&nbsp;David León Jiménez ,&nbsp;Daniel Martínez Gamote ,&nbsp;Pilar Mazón Ramos ,&nbsp;Alberto Ortiz ,&nbsp;Gemma Palau ,&nbsp;Julia Quevedo Rivera ,&nbsp;J. Emilio Sánchez-Álvarez ,&nbsp;Roser Vallés Fernández","doi":"10.1016/j.nefroe.2025.05.001","DOIUrl":"10.1016/j.nefroe.2025.05.001","url":null,"abstract":"<div><div>Chronic kidney disease (CKD) is a real public health problem. It is estimated that by 2040, approximately one in five adults will develop CKD, and that by 2050 it will be the third cause of death in Spain. However, CKD is clearly underdiagnosed, with low screening figures in the population at risk, often delaying its identification until advanced stages of the disease, which worsens prognosis and increases associated costs. In addition, drugs are now available that have been shown to reduce the progression of CKD and the risk of developing vascular complications. In this context, the early detection, diagnosis, and initial management of CKD by health organizations should become a priority, as this would reduce the burden of the disease substantially. Since this pathology is oligo, or paucisymptomatic in the initial stages, a proactive attitude is required from the health professional to detect, diagnose, and treat it early. Several publications have shown that, to date, neither the detection of CKD nor its initial management are optimal. The IntERKit project emerged with the aim of improving the early detection, diagnosis, and initial management of CKD by promoting collaboration with health organizations through tools easily implemented by these organizations. The IntERKit project provides healthcare organizations with a structured framework to optimize early management of CKD efficiently, achieving a real, measurable, sustainable, and scalable impact, which can evolve depending on the results obtained.</div></div>","PeriodicalId":31770,"journal":{"name":"Nefrologia English Edition","volume":"45 5","pages":"Pages 351-359"},"PeriodicalIF":0.0,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144175124","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Multicenter validation of the Kidney Failure Risk Equation (KFRE) formula in Spanish patients with advanced chronic kidney disease","authors":"Beatriz Escamilla-Cabrera ,&nbsp;Marco Montomoli ,&nbsp;Maria Kislikova ,&nbsp;Verónica de la Espada ,&nbsp;Alazne Olarte-García ,&nbsp;Ana María García-Prieto ,&nbsp;Sara Piqueras-Sánchez ,&nbsp;Álvaro Álvarez López ,&nbsp;Lucía Rodríguez-Gayo ,&nbsp;Javier Centellas-Pérez ,&nbsp;Hilda Villafuerte ,&nbsp;Pedro Barrera Baena","doi":"10.1016/j.nefroe.2025.05.003","DOIUrl":"10.1016/j.nefroe.2025.05.003","url":null,"abstract":"<div><h3>Introduction</h3><div>Chronic kidney disease (CKD) is a prevalent condition that requires reliable tools to predict its progression to end-stage renal disease (ESRD). The KFRE equation, internationally validated, allows for estimating the risk of progression at 2 and 5 years. However, it has not been validated in the Spanish population. This study aims to evaluate the predictive capacity of the KFRE in a cohort of Spanish patients.</div></div><div><h3>Methods</h3><div>This is a multicenter, observational, and retrospective study conducted in patients with an estimated glomerular filtration rate (eGFR)<!--> <!-->&lt;<!--> <!-->30<!--> <!-->ml/min who were followed in nephrology clinics between January 2016 and 2021. A total of 602 patients with clinical and demographic data were included. The predictive capacity of the KFRE, in its 4-variable and 8-variable versions, was evaluated using Cox regression analysis and ROC curves.</div></div><div><h3>Results</h3><div>Of the 602 patients included, 60% were male. Diabetes was the main etiology. Among the patients who started renal replacement therapy (RRT), 37% did so within two years, and 70% began with hemodialysis. Patients who initiated RRT (50.6%) were younger, had a lower eGFR, and exhibited higher baseline albuminuria. The 4-variable KFRE equation showed an AUC of 0.7639 (95% CI: 0.71−0.81) and demonstrated superior accuracy compared to the 8-variable model.</div></div><div><h3>Conclusions</h3><div>The KFRE equation, particularly in its 4-variable version, proves to be useful in predicting the progression to ESRD in the Spanish population. However, recalibration is necessary to improve its accuracy in this context.</div></div>","PeriodicalId":31770,"journal":{"name":"Nefrologia English Edition","volume":"45 5","pages":"Pages 388-396"},"PeriodicalIF":0.0,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144200248","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}