Multicenter validation of the Kidney Failure Risk Equation (KFRE) formula in Spanish patients with advanced chronic kidney disease

Q2 Medicine
Beatriz Escamilla-Cabrera , Marco Montomoli , Maria Kislikova , Verónica de la Espada , Alazne Olarte-García , Ana María García-Prieto , Sara Piqueras-Sánchez , Álvaro Álvarez López , Lucía Rodríguez-Gayo , Javier Centellas-Pérez , Hilda Villafuerte , Pedro Barrera Baena
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引用次数: 0

Abstract

Introduction

Chronic kidney disease (CKD) is a prevalent condition that requires reliable tools to predict its progression to end-stage renal disease (ESRD). The KFRE equation, internationally validated, allows for estimating the risk of progression at 2 and 5 years. However, it has not been validated in the Spanish population. This study aims to evaluate the predictive capacity of the KFRE in a cohort of Spanish patients.

Methods

This is a multicenter, observational, and retrospective study conducted in patients with an estimated glomerular filtration rate (eGFR) < 30 ml/min who were followed in nephrology clinics between January 2016 and 2021. A total of 602 patients with clinical and demographic data were included. The predictive capacity of the KFRE, in its 4-variable and 8-variable versions, was evaluated using Cox regression analysis and ROC curves.

Results

Of the 602 patients included, 60% were male. Diabetes was the main etiology. Among the patients who started renal replacement therapy (RRT), 37% did so within two years, and 70% began with hemodialysis. Patients who initiated RRT (50.6%) were younger, had a lower eGFR, and exhibited higher baseline albuminuria. The 4-variable KFRE equation showed an AUC of 0.7639 (95% CI: 0.71−0.81) and demonstrated superior accuracy compared to the 8-variable model.

Conclusions

The KFRE equation, particularly in its 4-variable version, proves to be useful in predicting the progression to ESRD in the Spanish population. However, recalibration is necessary to improve its accuracy in this context.
西班牙晚期慢性肾病患者肾衰竭风险方程(KFRE)公式的多中心验证
慢性肾脏疾病(CKD)是一种普遍的疾病,需要可靠的工具来预测其进展到终末期肾脏疾病(ESRD)。国际认可的KFRE方程可以估计2年和5年的进展风险。然而,它尚未在西班牙人群中得到验证。本研究旨在评估KFRE在西班牙患者队列中的预测能力。方法:这是一项针对肾小球滤过率(eGFR)患者的多中心、观察性和回顾性研究。结果:602例患者中,60%为男性。糖尿病是主要病因。在开始肾脏替代治疗(RRT)的患者中,37%的患者在两年内进行了治疗,70%的患者开始进行血液透析。开始RRT的患者(50.6%)较年轻,eGFR较低,基线蛋白尿较高。4变量KFRE方程的AUC为0.7639 (95% CI: 0.71-0.81),与8变量模型相比,显示出更高的准确性。结论:KFRE方程,特别是它的4变量版本,在预测西班牙人群的ESRD进展方面被证明是有用的。然而,在这种情况下,重新校准是必要的,以提高其准确性。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Nefrologia English Edition
Nefrologia English Edition Medicine-Nephrology
CiteScore
3.00
自引率
0.00%
发文量
67
审稿时长
50 weeks
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