Journal of Medical Science & Research最新文献

{"title":"Evaluation of Risk factors in Newly Diagnosed Stroke Patients","authors":"Kudrat-E-Khuda, Abu Hena Mostofa Kamal, Fakrul Alam, Shamsul Kabir, Kabir Hossain Mollah, Ariful Islam","doi":"10.47648/jmsr.2022.v3302.02","DOIUrl":"https://doi.org/10.47648/jmsr.2022.v3302.02","url":null,"abstract":"Stroke is the major cause of death and disability in the world. The endemicity in Bangladesh is increasing. This hospital-based cross-sectional study was done to assess the risk factors responsible for acute stroke. It was carried out in the Medicine, Neurology, and Neurosurgery department of Holy Family Red Crescent Medical College Hospital, Dhaka from August 2010 to January 2011. A totalof 116 admitted cases were included in this study.During the period of study,16 patientsdied. So, ultimately 100 cases were included in the study. A detailed history was taken,and clinical examination and relevant investigations were done.Out of 116 patients 77(66.4%) were ischemic, 23(19.8%) were haemorrhagic and 16(13.8%) were died. Among them 67(67%) were male and 33(33%) were female. So male to female ratio was 2:1. The age of the patients ranged from 15-96 years.The more than 50 years age group was highest at 49(63.6%) in ischemic, and 41-50 years age group was highest at 10(hemorrhagic) patients. Patients of the sedentary group were more affected in both ischemic 39(50.6%) and hemorrhagic 13(56.5%) strokes. Out of 100 cases, 35(45.5%) were hypertensive in ischemic stroke and 22(94.7%) were hypertensive in haemorrhagic stroke, 21(27.3%) were diabetic in ischemic stroke and 4(17.4%) were diabetic in haemorrhagic stroke, 17(22.1%) were smoker in ischemic stroke and 2(8.7%) were asmoker in haemorrhagic stroke, hyperlipidaemia occurs 17(22.1%) cases in ischemic stroke and 13(56.5%) were in haemorrhagic stroke. Thromboembolic manifestations only occur in 12(52.2%) cases in haemorrhagic stroke patients.","PeriodicalId":315974,"journal":{"name":"Journal of Medical Science & Research","volume":"3 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"127751613","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Microalbuminuria in Non-diabetic Hypertensive Individuals: A Cross Sectional Observation in Dhaka Medical College Hospital","authors":"Md. Abdul Baqui, Nasima Sultana, Md. Anwarul Alam Chowdhury, Syeda Marufa Hasan, K. M. Furkanuddin, Mohammad Abdul Aleem","doi":"10.47648/jmsr.2022.v3302.03","DOIUrl":"https://doi.org/10.47648/jmsr.2022.v3302.03","url":null,"abstract":"The study was conducted to assess the prevalence of microalbuminuria in non-diabetic hypertensive individuals with or without antihypertensive medication(s), attending medicine outpatient department of Dhaka Medical College Hospital. Non-diabetic hypertensive individuals without a history of pre-existing kidney diseases participated in this cross-sectional study. A questionnaire was used for collecting information on demographics, life style and family history of cardiovascular and kidney disease. Spot morning urine samples were collected for albumin estimation. Albuminuria thresholds were evaluated and defined using albumin-creatinine ratio (ACR). A total of 500 non-diabetic hypertensive individuals (310 males, 190 females) aged 52.25+/-7.99 years were enrolled in this study. After excluding 08 persons with macroalbuminuria, microalbuminuria was found in 51 cases (10.37%) [7.68%-13.06%].The prevalence was higher in females than males, ie 11.89% [7.23%- 16.55%] and 9.45% [6.18%-12.72%] respectively. There was no statistical significant difference between the sex groups. Duration of blood pressure showed statistical significant association with the occurrence of microalbuminuria. This suggests that, in Bangladeshi hypertensive individuals microalbuminuria is not uncommon. Further prospective studies with large sample size in different areas of the country are needed to confirm the prevalence of microalbuminuria in such individuals. The causative factors as well as prognostic value of the occurrence of microalbuminuria in this population remain to be determined in prospective cohort studies.","PeriodicalId":315974,"journal":{"name":"Journal of Medical Science & Research","volume":"13 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"114873698","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correlation among the GCS Score, CT Scan Findings and Early Clinical Outcome of Traumatic Brain Injury- Study of Fifty Cases","authors":"Ahmed Sami-Al-Hasan, Koushik Sikder, Md. Rashidul Hoq, Md.Reazul Alam, Md. Mosharraf Hossain","doi":"10.47648/jmsr.2022.v3302.06","DOIUrl":"https://doi.org/10.47648/jmsr.2022.v3302.06","url":null,"abstract":"Traumatic brain injury (TBI) is defined as an assault to the brain caused by an external physical force that may produce a state of diminished or altered consciousness and consequently, affecting cognitive abilities or physical function. According to the GCS, traumatic brain injuries are classified as mild, moderate or severe. Currently the imaging method of choice for the diagnosis and prognosis of TBI is CT scan. According to the disease profile in SBMCH about 30% patient is admitted in surgery ward in every admission due to traumatic injury. Out of them about 10% have traumatic head injury. The aim of the study was to evaluate an association among the GCS score, CT scan findings and clinical outcome of head injury. It is a prospective observational study at Sher-E-Bangla Medical college Hospital, Barisal. In this study 72% patients were with no CT scan findings (haemorrhagic / nonhaemorghagic). Rest of the patients had CT scan findings (intracerebral haemorrhage, extradural haematoma, subdural hematoma etc.). In severe TBI there was a significant increase in the incidence of CT findings, with a rate of 100% of abnormalities. In this study it was observed that, on admission patients with low GCS (severe TBI) deteriorate more in comparison to moderate and mild TBI on admission. This association is significant (p = .049). Patients in the severe TBI group (according to GCS) showed the highest mortality (2 out of 5). This association is also statistically significant (p = .002).","PeriodicalId":315974,"journal":{"name":"Journal of Medical Science & Research","volume":"12 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"128389673","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficacy of Silicone Sling and Polypropylene (prolene) in Correction of Congenital Blepharoptosis by Frontalis Suspension","authors":"Melia Choudhury, Narayon Chandra Bhowmik, Golam Haider","doi":"10.47648/jmsr.2022.v3302.04","DOIUrl":"https://doi.org/10.47648/jmsr.2022.v3302.04","url":null,"abstract":"Aims & Objective: To compare the cosmetic and functional results of frontalis suspension in congenital blepharoptosis using Silicone sling versus polypropylene. Materials and Methods: A retrospective study, that was conducted at tertiary care hospital from 1st January 2018 to December 2021, thirty two patients with age ranging from 5-50 years, with congenital ptosis having levator function of 4 mm or less were randomly divided into two groups: Group I (which included 16 patients who underwent frontalis brow suspension using silicon rod) and Group II (which consisted of 16 patients who underwent frontalis brow suspension using prolene). After proper pre-operative assessment frontalis brow suspension was performed under general / local anaesthesia. Post-operative cosmetic results, recurrence rates and associated complications were compared between these 2 groups. Final results were taken to be those at 1 month, 6 months' post-operative. Results: The mean age of the silicone group was 26.4 +/- 18.6 years while it was 26.6 +/- 21.4 years for the prolenegroup. There was a male predominant distribution in both groups (9:1 silicone, 7:3 prolene ). The mean late postoperative margin reflex distance (MRD) and palpebral fissure height (PFH) for silicone group was1.76 +/- 1.02, 9.45 +/- 2.34 while for the prolene group was0.65 +/- 0.54 , 6.56 +/- 2.74 respectively . Patients in silicone group had significantly higher PFHs (P<0.0001) and ( P< 0.005) as well as MRDs (P<0.0007) and (P< 0.054) at 6 month and 1 months postoperatively compared to those in prolene group Good cosmetic success graded by lid contour, symmetry, and crease in the silicone group was recorded in 81.25% (13/16), 56.25% (9/16), and 68.75% (11/16) of patients, respectively.In the prolene group, 56.25% (9/16) of patients experienced good outcomes in both contour and symmetry. However, 43.75% (7/16) of this group had good crease outcomes.Frontalis brow suspension showed significantly good cosmetic and functional results using silicone tube (93%) as compared to prolene (69%). Conclusion: The established treatment for ptosis with poor levator function is frontalis sling suspension surgery. The upper ptotic lid is attached to the frontalis muscle and the lid is elevated actively on elevating brow. The use of silicone rod in tarsofrontalis sling surgery for congenital ptosis repair is a safe and effective surgery, with few complications and easy removal and adjustment.","PeriodicalId":315974,"journal":{"name":"Journal of Medical Science &amp; Research","volume":"355 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"122174738","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of Gastro-protective Activity of Red-cabbage Against Indomethacin Induced Ulcer in Rats","authors":"Umma Taj Lovely, Md. Faizul Ahasan, Eliza Omar","doi":"10.47648/jmsr.2022.v3302.05","DOIUrl":"https://doi.org/10.47648/jmsr.2022.v3302.05","url":null,"abstract":"Background and objective: The red cabbage (Brassica oleracea Linn var. capitata) is a leafy green biennial plant that contains beta-carotene, vitamin C and fibre. It is used in cooking for its nutritional value and has known anti-inflammatory activity.This study compared the antiulcerogenic activity of Aqueous Extract of Brassica (AEB) oleracea var. capitata with Misoprostol.Materials and Method: Acute gastric ulcers were induced in albino rats by the oral administration of indomethacin. The gastroprotective potential of the AEB(250,500 and 1000 mg/kg body weight) was compared with Misoprostol (100?g/kg body weight). Results:A significant reduction in the mean number of lesions was observed in high dose AEB (0.83 +/- 0.75) compared with indomethacin (4.00 +/- 1.26). Mean number of lesions were similar in misoprostol groups (1.50 +/- 0.55) and medium dose AEB (1.77 +/- 0.41).No significant reduction in the mean number of lesions was observed in low dose AEB (3.00 +/- 0.63) compared with indomethacin (4.00 +/- 1.26). Inhibition percentage was maximum in high dose AEB (97.71%) and minimum in low dose AEB (28.08%).Conclusions: The AEB demonstrated good antiulcerogenic activities which justify the inclusion of this plant in the management of gastric disorders. Further experiments are underway to determine which anti-ulcer mechanisms involved in gastroprotection.","PeriodicalId":315974,"journal":{"name":"Journal of Medical Science &amp; Research","volume":"28 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"133004947","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bacteriological profile of Tracheal aspirate and their Antimicrobial Sensitivity Pattern in a Tertiary Care Hospital in Dhaka city","authors":"Begum T, Ferdous J, Ullah M B, Murshed M, Shahnaz S","doi":"10.47648/jmsr.2022.v3302.01","DOIUrl":"https://doi.org/10.47648/jmsr.2022.v3302.01","url":null,"abstract":"Background: The majority of nosocomial infections are seen in intensive care units and they course with higher rates of mortality and morbidity worldwide. Objectives: To identify the current microbial isolates and their antimicrobial susceptibility pattern from the tracheal aspirate culture in a tertiary care hospital in Dhaka city.Materials and Method: This retrospective study was conducted in the department of Microbiology at Holy Family Red Crescent Medical College Hospital, Dhaka from January 2020 to June 2021 for a period of one and a half years. Written consent was taken from the corresponding authority.A total of 109 samples were collected from tracheal aspirates of the patients who were admitted to the hospital with the critically ill patients in intensive care units.Microsoft Excel software was used for data analysis.Results: A total of 109 samples were analyzed. Of them, the predominant populations were male 73(66.97%) and the remaining were female 36(33.03%). Out of 109 samples, 70 (64.22%)was culture positive. Culture negative was 39 (35.78%). The majority of isolates were Gram-negative bacteria. Among them, predominant bacteria wereKlebsiella spp. 43(61.43%) followed by Acinetobacter spp 19(27.15%), Pseudomonas spp. 05(07.14%) & Gram-positive isolates waswereaph. Aureus 03(04.28%). Klebsiella species showed higher sensitivity totigecycline 97.67%, colistin 93.02%, amikacin 65.11% and meropenem 37.20% & gentamicin 30.23%. Other drugs showed wer sensitivity to axicillin/clavulenic acid 18.60%, and ciprofloxacin 18.60% , trimethoprim/ sulfamethoxazole 09.30%, ceftazidime & cefuroxime 04.65% and lowest sensitivity shown in ceftriaxone 02.32%. Acinetobacter speciesshowed higher sensitivityin colistin at 100% and tigecycline at 47.36%. Other drugs like amikacinand trimethoprim/ sulfamethoxazole 15.78% and the lowest sensitivity were shown in meropenem 10.52% and high resistance in gentamycin, ceftriaxone, ceftazidime, and ciprofloxacin.Pseudomonas spp. showed the highest sensitivity 60.00% to piperacillin-tazobactam, amikacin, imipenem, meropenem, and gentamycin, 40.00% to ciprofloxacin, 20.00% to ceftazidime & cefepime.All the isolate of Staph. aureus was the highest sensitive 100% to vancomycin and linezolid, 66.66% sensitive to amikacin, trimethoprim/ sulfamethoxazole, tetracycline, and gentamicin, 33.33% showed lower sensitivityto amoxicillin/ clavulanic acid, cloxacillin and ciprofloxacin.Conclusion:This study aimed to investigate thedistribution of pathogenic microorganisms isolated from tracheal aspirate and their antibiotic sensitivity profile in intensive care units. A periodic review of the bacteriological profile and antibiotic sensitivity pattern is highly essential for the clinician to treat critically ill patients in ICU. Antibiotic policy & infection control programs should be included in every hospital to reduce this drug resistance.","PeriodicalId":315974,"journal":{"name":"Journal of Medical Science &amp; Research","volume":"989 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"123317843","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Histopathological Pattern of Primary Glomerulonephritis - A Single Center Experience","authors":"Shaheen Sikder, Faijul Islam, Mahmudur Rahman, Ehteshamul Hoque","doi":"10.47648/jmsr.2022.v3201.04","DOIUrl":"https://doi.org/10.47648/jmsr.2022.v3201.04","url":null,"abstract":"lomerulonephritis is the most common cause of chronic kidney disease in our country like in other developing countries. The incidence and histological pattern of primary GN in our countare is inadequately described. This cross-sectional prospective study was conducted at the nephrology unit in Holy Family Red Crescent Medical College Hospital, a tertiary care teaching hospital in Dhaka, Bangladesh starting from January 2019 - December 2019 including all patients with suspected primary GN who underwent kidney biopsies. Total 35 biopsies were performed. M: F 1.3:1 .Mean age was 33.71+_12.2 yrs. Membranoproliferative GN (34.28%) was the most common cause followed by mesangioproliferative (22.85%), IgA nephropathy (17.14%), membranous (11.42%), FSGS ( 11.42%) and minimal change disease (2.8%). Among 35 cases, 20 had proliferative verity. In immunofluroscence study, 19 had mild to marked deposits of immunoglubulin. 5.71% had post-biopsy complication which was not significant enough. As the sample size was small so needs more studies in large to get the specific epidemiological patterns of primary GN.","PeriodicalId":315974,"journal":{"name":"Journal of Medical Science &amp; Research","volume":"9 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"127412520","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association and Outcome of ABO-Rh Blood Group among 294 COVID-19 Patients admitted in A Dedicated Hospital","authors":"Perveen RA, Nasir M, Pervin S, Zahan T, Farha N","doi":"10.47648/jmsr.2022.v3201.01","DOIUrl":"https://doi.org/10.47648/jmsr.2022.v3201.01","url":null,"abstract":"Aim: The rapid global spread of the novel corona virus SARS-CoV-2 has strained healthcare and testing resources, making the identification and prioritization of individuals most at-risk became a critical challenge. Recent evidence suggests blood type may affect the risk of severe COVID-19.Method: In this cross-sectional observational study, among 1348 admitted patients in Holy Family Red Crescent Medical College who tested positive for RT-PCR, 294 patients were included with known blood type to assess the association between ABO and Rh blood types and demographic profile, co-morbidities, clinical outcomes, and changes in the biomarkers. Result: among 294 patients admitted to the hospital with COVID-19, the mean age was 48 to 49 years. Out of all patients, 211 were male, and 83 were female, with a ratio of 1: 2.54. The highest numbers of patients were between 50-59 years. The highest percentage of diabetic patients were present in the AB blood group (54%), and hypertensive patients in the O and Rh-negative blood group (40.29%, 60%) which were statistically not significant. Other than that, COPD, IHD, and CKD were observed. Symptoms of patients were categorized as inflammatory and neurological. Shortness of breath (52.41%), fever (38.43%), and cough (28.23%) were observed among inflammatory symptoms, which were statistically significant and lethargy (16.25%) was only remarkable neurological involvement. Among all ABO blood groups, 'A' blood group of patients, present with a higher percentage of both inflammatory and neurological symptoms. Among the Rh blood group, Rh-negative patients did not present with diarrhea, sore throat, lethargy, anosmia, and loss of taste. Changes in biomarkers levels were also observed in all blood groups. Conclusion: COVID-19 patients with blood group A or B are at increased risk of disease severity with the highest number of co morbidities and symptoms compared with patients with blood group O or AB.","PeriodicalId":315974,"journal":{"name":"Journal of Medical Science &amp; Research","volume":"3 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"133951841","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Maternal and Foetal outcome of Pregnancy with Diabetes Mellitus: A Hospital Based Cross-sectional Study","authors":"Suha Jesmin, Shiffin Rijvi, Ruma Sengupta","doi":"10.47648/jmsr.2022.v3201.03","DOIUrl":"https://doi.org/10.47648/jmsr.2022.v3201.03","url":null,"abstract":"Background: Prevalence of pregnancy with diabetes mellitus is increasing worldwide, poses a greater risk of maternal and foetal complications. Considering the scarcity of data in our country context, we conducted to evaluate the pregnancy outcome of diabetic mothers in a tertiary care hospital. Methods: This hospitalbased cross-sectional study was conducted at the Obstetrics and Gynaecology ward, BIRDEM general Hospital following ethical approval. Total 214 diabetic mothers admitted for delivery were included in this study, wherein 102 had overt diabetes mellitus (ODM) and rest 112 had gestational diabetes mellitus (GDM). Informed written consent was ensured prior to participation. A semi-structured questionnaire was used during data collection. Collected information was recorded in separate case record form. Analysis was performed using the statistical package for social science (SPSS) version 24. Results: The mean age of all study mother was 28.82+/-5.06 (SD) years ranging from 18-43 years. There was no significant difference in baseline data between ODM and GDM mothers (p>0.05). Diabetic mother with HbA1C >5.9% had significantly higher incidence of pre-term labour (51.26% vs 25.26%), caesarian section (87.39% vs 75.79%), polyhydramnios (10.95% vs 1.05%), foetal macrosomia (6.72% vs 1.05%) and NICU admission of baby (16.81% vs 7.37%) compared to diabetic mother with HbA1C ?5.9%. However, no significant differences were observed between ODM and GDM groups regarding any pregnancy outcome (p>0.05). Conclusion: Uncontrolled glycaemia is associated with pre-term delivery, caesarian section, polyhydramnios, macrosomia and NICU admission. However, further multicentre studies are recommended.","PeriodicalId":315974,"journal":{"name":"Journal of Medical Science &amp; Research","volume":"40 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"124537326","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"C-Reactive Protein And Lipid Profile In Ischemic Heart Disease A Cross-Sectional Analytical Study","authors":"Begum FA, Khan EH, Rahman MMU, Yeasmin F, Alam MA","doi":"10.47648/jmsr.2022.v3201.02","DOIUrl":"https://doi.org/10.47648/jmsr.2022.v3201.02","url":null,"abstract":"Inflammation plays a major role in the initiation, progression & destabilization of atheroma. C-reactive protein (CRP) is a sensitive marker of inflammation, and elevated levels have been associated with future risk of myocardial infarction (MI). Risk of coronary heart disease & other forms of atherosclerotic vascular disease rises with plasma cholesterol concentration & in particular the ratio of total cholesterol to high density lipoprotein (HDL-C) cholesterol. Measurement of C- reactive protein (CRP) adds to the predictive value of total cholesterol (TC) and HDL cholesterol (HDL-C) in determining subsequent risk of first myocardial infarction. Methods: This cross-sectional analytical study was undertaken to observe association between high sensitive CRP and lipid profile level with chronic ischaemic heart disease and was conducted in the Department of Biochemistry, Dhaka Medical College, Dhaka from July 2010 to June 2011. A total 50 cases were selected purposively according to the selection criteria from the patients admitted in the Department of Cardiology, Dhaka Medical College Hospital with chronic ischaemic heart disease (IHD). Diagnosed IHD patients were taken as cases; age- & sex- matched 50 healthy subjects were taken as controls. Serum hsCRP and serum TC, TAG, LDL-C & HDL-C were measured in all study subjects. Results: The mean serum CRP concentration in cases and controls were 11.22+/-7.64 mg/dl and 1.72+/-0.98 mg/dl respectively. Mean serum TC, TAG, HDL-C and LDL-C in cases groups were 314+/-74 mg/dl, 288+/-60 mg/dl, 36+/-4 mg/dl, and 178+/-22 mg/dl respectively and in controls groups were 175+/-19 mg/dl, 118+/-12 mg/dl, 43+/-2 mg/dl & 126+/-11 mg/dl respectively. Serum hsCRP, Total Cholesterol, TAG & LDL-C were significantly higher in cases than control subjects. Serum HDL-C was significantly lower in cases than control subjects. Conclusions: The present study reveals that the patients of chronic ischaemic heart disease have been found to have close association of increased level of hsCRP and lipid profile.","PeriodicalId":315974,"journal":{"name":"Journal of Medical Science &amp; Research","volume":"8 2 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"116782064","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}