The American journal of clinical nutrition最新文献

{"title":"Chronic and postprandial effect of blueberries on cognitive function, alertness, and mood in participants with metabolic syndrome – results from a six-month, double-blind, randomized controlled trial","authors":"Peter J Curtis, Vera van der Velpen, Lindsey M. Berends, Amy Jennings, Laura Haag, A. Minihane, Preeti Chandra, Colin D Kay, E. B. Rimm, Aedín Cassidy","doi":"10.1016/j.ajcnut.2023.12.006","DOIUrl":"https://doi.org/10.1016/j.ajcnut.2023.12.006","url":null,"abstract":"","PeriodicalId":315016,"journal":{"name":"The American journal of clinical nutrition","volume":"29 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139881758","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cognition after a 4-week high phenylalanine intake in adults with phenylketonuria – a randomized controlled trial","authors":"Roman Trepp, Raphaela Muri, Stephanie Maissen-Abgottspon, Alan G Haynes, Michel Hochuli, R. Everts","doi":"10.1016/j.ajcnut.2023.11.007","DOIUrl":"https://doi.org/10.1016/j.ajcnut.2023.11.007","url":null,"abstract":"","PeriodicalId":315016,"journal":{"name":"The American journal of clinical nutrition","volume":"12 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139887592","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Predictive validity of the Academy of Nutrition and Dietetics/American Society for Parenteral and Enteral Nutrition indicators to diagnose malnutrition tool in hospitalized adults: a cohort study","authors":"E. Jimenez, E. Lamers-Johnson, Julie M Long, George P McCabe, Xingya Ma, L. Woodcock, Courtney Bliss, Jenica K Abram, A. Steiber","doi":"10.1016/j.ajcnut.2023.12.012","DOIUrl":"https://doi.org/10.1016/j.ajcnut.2023.12.012","url":null,"abstract":"","PeriodicalId":315016,"journal":{"name":"The American journal of clinical nutrition","volume":"327 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139831839","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Monitoring Body Composition Change for Intervention Studies with Advancing 3D Optical Imaging Technology in Comparison to Dual-Energy X-Ray Absorptiometry","authors":"M. Wong, J. Bennett, L. Leong, I. Tian, Y. E. Liu, N. Kelly, C. McCarthy, Julia M. W. Wong, C. Ebbeling, D. S. Ludwig, B. Irving, Matthew C. Scott, James E. Stampley, B. Davis, Neil M. Johannsen, Rachel Matthews, Cullen M Vincellette, A. Garber, G. Maskarinec, E. Weiss, J. Rood, Alyssa N. Varanoske, S. Pasiakos, S. Heymsfield, J. Shepherd","doi":"10.1101/2022.11.14.22281814","DOIUrl":"https://doi.org/10.1101/2022.11.14.22281814","url":null,"abstract":"Recent 3D optical (3DO) imaging advancements have provided more accessible, affordable, and self-operating opportunities for assessing body composition. 3DO is accurate and precise with respect to clinical measures made by dual-energy X-ray absorptiometry (DXA). However, the sensitivity for monitoring body composition change over time with 3DO body shape is unknown. Therefore, this study aimed to evaluate 3DO ability to monitor body composition changes across multiple intervention studies. A retrospective analysis was performed using intervention studies on healthy adults that were complimentary to the cross-sectional study, Shape Up! Adults. Each participant received a DXA (Hologic Discovery/A system) and 3DO (Fit3D ProScanner) scan at baseline and follow-up. 3DO meshes were digitally registered and reposed using Meshcapade to standardize the vertices and pose. Each 3DO mesh was transformed into principal components (PCs) using an established statistical shape model. The PCs were used to predict whole-body and regional body composition values using published equations. Body composition changes (follow-up minus baseline) were compared to DXA with linear regression. The analysis included 128 participants (43 females) in six studies. The mean (SD) length of follow-up was 13 (5) weeks, range of 3-23 weeks; change in percent fat was 2.8% (2.1%), with a range of 2.4 - 8.3%. Agreement between 3DO and DXA (R2) for changes in total fat mass (FM), total fat-free mass (FFM), and appendicular lean mass, respectively, were 0.89, 0.77, and 0.69 with RMSEs of 1.78 kg, 1.42 kg, and 0.37 kg in females, and 0.77, 0.76, and 0.46 with RMSEs of 2.28 kg, 1.67 kg, and 0.51 kg in males. Statistical significance of individual changes agreed for both DXA and 3DO in the majority of the sample for total FM (70%) and FFM (81%). Further adjustment with demographic descriptors improved the 3DO change agreement to changes observed with DXA. Compared to DXA, 3DO was highly sensitive in detecting body shape changes over time. The 3DO method was sensitive enough to detect even small changes in body composition during intervention studies. The safety and accessibility of 3DO allow users to self-monitor frequently throughout interventions.","PeriodicalId":315016,"journal":{"name":"The American journal of clinical nutrition","volume":"26 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-11-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"122135537","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Preventive small-quantity lipid-based nutrient supplements reduce severe wasting and severe stunting among young children: an individual participant data meta-analysis of randomized controlled trials","authors":"K. Dewey, C. Arnold, K. Wessells, Elizabeth L. Prado, S. Abbeddou, S. Adu-Afarwuah, H. Ali, B. Arnold, P. Ashorn, U. Ashorn, Sania Ashraf, Elodie Becquey, K. Brown, P. Christian, J. Colford, S. Dulience, L. Fernald, E. Galasso, L. Hallamaa, S. Hess, J. Humphrey, L. Huybregts, Lora L Iannottie, K. Jannat, A. Lartey, A. L. Port, Jef L Leroy, S. Luby, K. Maleta, Susana L. Matias, M. Mbuya, M. Mridha, Minyanga Nkhoma, C. Null, Rina R Paul, Harriet Okronipa, J. Ouédraogo, A. Pickering, A. Prendergast, M. Ruel, S. Shaikh, A. Weber, Patricia B Wolff, A. Zongrone, C. Stewart","doi":"10.1101/2022.06.16.22276521","DOIUrl":"https://doi.org/10.1101/2022.06.16.22276521","url":null,"abstract":"Background: Meta-analyses show that small-quantity lipid-based nutrient supplements (SQ-LNS) reduce child wasting and stunting. There is little information regarding effects on severe wasting or stunting. Objective: We aimed to identify the effect of SQ-LNS on severe wasting (weight-for-length z-score < -3) and severe stunting (length-for-age z-score < -3). Methods: We conducted a two-stage meta-analysis of individual participant data from 14 randomized controlled trials of SQ-LNS provided to children 6 to 24 mo of age. We generated study-specific and subgroup estimates of SQ-LNS vs. control and pooled the estimates using fixed-effects models. We used random effects meta-regression to examine study-level effect modifiers. In sensitivity analyses, we examined whether results differed depending on study arm inclusion criteria and types of comparisons. Results: SQ-LNS provision led to a relative reduction of 31% in severe wasting (Prevalence Ratio, PR 0.69 (0.55, 0.86), n=34,373) and 17% in severe stunting (PR 0.83 (95% CI: 0.78, 0.90), n=36,795). Results were similar in most of the sensitivity analyses but somewhat attenuated when comparisons using passive control arms were excluded: PR 0.74 (0.57, 0.96), n=26,327 for severe wasting and PR 0.88 (0.81, 0.95), n=28,742 for severe stunting. Study-level characteristics generally did not significantly modify the effects of SQ-LNS, but results suggested greater effects of SQ-LNS in sites with greater burdens of wasting or stunting, or with poorer water quality or sanitation. Conclusions: Including SQ-LNS in preventive interventions to promote healthy child growth and development is likely to reduce rates of severe wasting and stunting. Registered at www.crd.york.ac.uk/PROSPERO as CRD42019146592.","PeriodicalId":315016,"journal":{"name":"The American journal of clinical nutrition","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-06-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"129744979","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Overall Diet Quality and Proinflammatory Diet in Relation to Risk of Obstructive Sleep Apnea in Three Prospective US Cohorts.","authors":"Yue Liu, F. Tabung, M. Stampfer, S. Redline, Tianyi Huang","doi":"10.1164/ajrccm-conference.2022.205.1_meetingabstracts.a3736","DOIUrl":"https://doi.org/10.1164/ajrccm-conference.2022.205.1_meetingabstracts.a3736","url":null,"abstract":"BACKGROUND\u0000Inflammation-related mechanisms may be important in the development of obstructive sleep apnea (OSA), and diet plays a crucial role in modulating inflammation. Current epidemiologic evidence for the associations between dietary patterns and OSA risk is limited to cross-sectional studies.\u0000\u0000\u0000OBJECTIVES\u0000We investigated prospectively the associations of overall diet quality and proinflammatory diet with OSA risk.\u0000\u0000\u0000DESIGN\u0000We followed 145,801 participants in the Nurses' Health Study (2002-2012), Nurses' Health Study II (1995-2013), and Health Professionals Follow-up Study (1996-2012). The Alternative Healthy Eating Index (AHEI) and Empirical Dietary Inflammatory Pattern (EDIP) scores were calculated based on validated food frequency questionnaires administered every 4 years. Cox models were used to estimate hazard ratios (HR) and 95% confidence intervals (95% CI).\u0000\u0000\u0000RESULTS\u0000We documented 8,856 incident OSA cases during follow-up. In pooled analyses adjusted for potential confounders, higher diet quality (higher AHEI scores) was associated with lower OSA risk (HR comparing the highest versus lowest quintiles of AHEI: 0.76; 95% CI: 0.71, 0.82; P-trend < 0.001), and higher dietary inflammatory potential (higher EDIP scores) was associated with significantly increased risk (HR comparing participants with highest versus lowest quintiles of EDIP: 1.94; 95% CI: 1.81, 2.08; P-trend < 0.001). Additional adjustment for metabolic factors attenuated both associations. The association with AHEI was no longer statistically significant (comparable HR: 0.98; 95% CI: 0.91, 1.05; P-trend = 0.54), whereas the association with EDIP remained statistically significant (comparable HR: 1.31; 95% CI: 1.22, 1.41; P-trend < 0.001).\u0000\u0000\u0000CONCLUSIONS\u0000A healthier diet, particularly the one with anti-inflammatory potential, was associated with lower OSA risk.","PeriodicalId":315016,"journal":{"name":"The American journal of clinical nutrition","volume":"20 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"125988478","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Low linoleic acid foods with added DHA given to Malawian children with severe acute malnutrition improve cognition: a randomized, triple-blinded, controlled clinical trial","authors":"","doi":"10.1101/2021.09.07.21263231","DOIUrl":"https://doi.org/10.1101/2021.09.07.21263231","url":null,"abstract":"Background: There is concern that the PUFA composition of ready-to-use therapeutic food (RUTF) for treatment of severe acute malnutrition (SAM) is suboptimal for neurocognitive recovery. Objective: We tested the hypothesis that RUTF made with reduced amounts of linoleic acid, achieved using high oleic (HO) peanuts, with or without added DHA, improves cognition when compared to standard RUTF (S-RUTF). Methods: A triple-blind, randomized, controlled clinical feeding trial was conducted among children with uncomplicated SAM in Malawi with 3 types of RUTF; DHA-HO- RUTF, HO-RUTF and S-RUTF. The primary outcomes, measured in a subset of subjects, were the Malawi Developmental Assessment Tool (MDAT) global and 4 domain (gross motor, fine motor, language and social) z-scores and a modified Willatts problem solving assessment (PSA) intention score for 3 standardized problems, measured 6 months and immediately after completing RUTF therapy, respectively. Plasma fatty acid content, anthropometry and eye tracking were secondary outcomes. Comparisons were made between the novel PUFA RUTFs and S-RUTF. Results: Among the 2565 SAM children enrolled, global MDAT z-score was -0.69 {+/-} 1.19 and -0.88 {+/-} 1.27 for children receiving DHA-HO-RUTF and S-RUTF, respectively (difference 0.19, 95% CI 0.01 to 0.38). The gross motor and social domains had higher z-scores among children receiving either DHA-HO-RUTF than S-RUTF. The PSA problem 3 scores did not differ by dietary group (Odds ratio 0.92, 95% CI 0.67 to 1.26 for DHA-HO-RUTF). After 4 weeks of treatment, plasma phospholipid EPA and a- linolenic acid were greater in children consuming DHA-HO-RUTF or HO-RUTF when compared to S-RUTF (for all 4 comparisons P values < 0.001), but only plasma DHA was greater in DHA-HO-RUTF than S-RUTF ( P <0.001). Conclusions: Treatment of uncomplicated SAM with DHA-HO-RUTF resulted in an improved MDAT score, conferring a cognitive benefit six months after completing diet therapy. This treatment should be explored in operational settings.","PeriodicalId":315016,"journal":{"name":"The American journal of clinical nutrition","volume":"4 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-09-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"122680271","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Important food sources of fructose-containing sugars and adiposity: A systematic review and meta-analysis of controlled feeding trials.","authors":"L. Chiavaroli, A. Cheung, Sabrina Ayoub-Charette, Amna Ahmed, Danielle Lee, F. Au‐Yeung, Néma D McGlynn, V. Ha, T. Khan, S. B. Mejia, V. Choo, R. Souza, Tom Wolever, Lawrence A Leiter, C. Kendall, D. Jenkins, J. Sievenpiper","doi":"10.1093/CDN/NZAB053_010","DOIUrl":"https://doi.org/10.1093/CDN/NZAB053_010","url":null,"abstract":"BACKGROUND\u0000Sugar-sweetened beverages (SSBs) providing excess energy increase adiposity. The effect of other food sources of sugars at different energy control levels is unclear.\u0000\u0000\u0000OBJECTIVES\u0000To determine the effect of food sources of fructose-containing sugars by energy control on adiposity.\u0000\u0000\u0000METHODS\u0000In this systematic review and meta-analysis, MEDLINE, Embase, and Cochrane Library were searched through April 2022 for controlled trials ≥2 wk. We prespecified 4 trial designs by energy control: substitution (energy-matched replacement of sugars), addition (energy from sugars added), subtraction (energy from sugars subtracted), and ad libitum (energy from sugars freely replaced). Independent authors extracted data. The primary outcome was body weight. Secondary outcomes included other adiposity measures. Grading of Recommendations Assessment, Development, and Evaluation (GRADE) was used to assess the certainty of evidence.\u0000\u0000\u0000RESULTS\u0000We included 169 trials (255 trial comparisons, n = 10,357) assessing 14 food sources at 4 energy control levels over a median 12 wk. Total fructose-containing sugars increased body weight (MD: 0.28 kg; 95% CI: 0.06, 0.50 kg; PMD = 0.011) in addition trials and decreased body weight (MD: -0.96 kg; 95% CI: -1.78, -0.14 kg; PMD = 0.022) in subtraction trials with no effect in substitution or ad libitum trials. There was interaction/influence by food sources on body weight: substitution trials [fruits decreased; added nutritive sweeteners and mixed sources (with SSBs) increased]; addition trials [dried fruits, honey, fruits (≤10%E), and 100% fruit juice (≤10%E) decreased; SSBs, fruit drink, and mixed sources (with SSBs) increased]; subtraction trials [removal of mixed sources (with SSBs) decreased]; and ad libitum trials [mixed sources (with/without SSBs) increased]. GRADE scores were generally moderate. Results were similar across secondary outcomes.\u0000\u0000\u0000CONCLUSIONS\u0000Energy control and food sources mediate the effect of fructose-containing sugars on adiposity. The evidence provides a good indication that excess energy from sugars (particularly SSBs at high doses ≥20%E or 100 g/d) increase adiposity, whereas their removal decrease adiposity. Most other food sources had no effect, with some showing decreases (particularly fruits at lower doses ≤10%E or 50 g/d). This trial was registered at clinicaltrials.gov as NCT02558920 (https://clinicaltrials.gov/ct2/show/NCT02558920).","PeriodicalId":315016,"journal":{"name":"The American journal of clinical nutrition","volume":"14 7","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"113944581","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Maternal caffeine intake and DNA methylation in newborn cord blood.","authors":"K. Polinski, A. Purdue-Smithe, S. Robinson, S. Zhao, K. Schliep, R. Silver, W. Guan, E. Schisterman, S. Mumford, E. Yeung","doi":"10.1093/CDN/NZAB046_099","DOIUrl":"https://doi.org/10.1093/CDN/NZAB046_099","url":null,"abstract":"BACKGROUND\u0000Epigenetic mechanisms may underlie associations between maternal caffeine consumption and adverse childhood metabolic outcomes. However, limited studies have examined neonate DNA methylation (DNAm) patterns in the context of preconception or prenatal exposure to caffeine metabolites.\u0000\u0000\u0000OBJECTIVE\u0000We examined preconception and pregnancy caffeine exposure with DNAm alterations in neonate cord blood (n = 378).\u0000\u0000\u0000DESIGN\u0000In a secondary analysis of the Effects of Aspirin in Gestation and Reproduction Trial (EAGeR), we measured maternal caffeine, paraxanthine, and theobromine concentrations from stored serum collected preconception (on average 2 months before pregnancy) and at 8 weeks of gestation. In parallel, self-reported caffeinated beverage intake was captured via administration of questionnaires and daily diaries. We profiled DNAm from the cord blood buffy coat of singletons using the MethylationEPIC BeadChip. We assessed associations of maternal caffeine exposure and methylation β-values using multivariable robust linear regression. A false discovery rate (FDR) correction was applied using the Benjamini-Hochberg method.\u0000\u0000\u0000RESULTS\u0000In preconception the majority of women reported consuming one or fewer servings/day on average and caffeine and paraxanthine metabolite levels were 88 and 36 µmol/L, respectively. Preconception serum caffeine metabolites were not associated with individual CpG sites (FDR > 5%), though pregnancy theobromine was associated with DNAm at cg09460369 near RAB2A (β = 0.028; SE = 0.005; FDR P = 0.012). Preconception self-reported caffeinated beverage intake compared to no intake was associated with DNAm at cg09002832 near GLIS3 (β = -0.013; SE = 0.002; FDR P = 0.036). No associations with self-reported intake during pregnancy were found.\u0000\u0000\u0000CONCLUSIONS\u0000Few effects of maternal caffeine exposure on neonate methylation differences in leukocytes were identified in this relatively low caffeine consumption population.Clinical Trial Registry: #NCT00467363.","PeriodicalId":315016,"journal":{"name":"The American journal of clinical nutrition","volume":"46 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"116389277","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Editorial Matter","authors":"E. Matter, Andrew I. E. Ewoh, Andrew I. E. Ewoh, Hashim Gibrill, E. Kalipeni, Leo U. Ukpong, D. Setsetse, Nicholas O. Alozie, M. L. McNulty, Kelechi A. Kalu, David Ngene, J. S. Guseh, Ikechukwu S. Ndolo","doi":"10.4135/9781452229669.n1140","DOIUrl":"https://doi.org/10.4135/9781452229669.n1140","url":null,"abstract":"","PeriodicalId":315016,"journal":{"name":"The American journal of clinical nutrition","volume":"3 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2020-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"115349010","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}