Clinical Oncology and Cancer Research最新文献

{"title":"Relationship between the effect of induction chemotherapy and timing of radiotherapy in limited-disease small-cell lung cancer","authors":"Weishuai Liu, Lujun Zhao, Yong Guan, Wencheng Zhang, Z. Yuan, Ping Wang","doi":"10.3969/J.ISSN.1000-8179.20131273","DOIUrl":"https://doi.org/10.3969/J.ISSN.1000-8179.20131273","url":null,"abstract":"Objective: This study aims to analyze the relationship between the effect of induction chemotherapy and the timing of radiotherapy in limited-disease or limited-stage small-cell lung cancer (LSCLC). Methods: Data from 148 LSCLC patients who re- ceived induction chemotherapy and radiotherapy between January 2009 and December 2012 were retrospectively analyzed. The effect of two to three cycles of induction chemotherapy was evaluated according to the RECIST version 1.1, which includes complete re- sponse (CR), partial response (PR), stable disease, and progressive disease. CR and PR were used to calculate response rate. The pa- tients were divided into early and late groups based on immediate radiotherapy after two to three cycles of induction chemotherapy. The survival rate was analyzed using the Kaplan-Meier method. Log-rank test and Cox regression model were used to evaluate the influenc- ing factors of the survival rate. Results: The median overall survival (OS) and progression-free survival (PFS) were 22.8 and 13.0 months, respectively. The early and late radiotherapy groups exhibited OS of 34.0 and 18.0 months, respectively, and corresponding PFS of 16.8 and 10.9 months. In the subgroup analysis, for the patients who responded to the induction chemotherapy, the early and late radiotherapy groups showed median OS of 18.0 and 19.5 months, respectively, and corresponding PFS of 19.4 and 11.7 months. For the patients who had no response to the induction chemotherapy, the early and late radiotherapy groups exhibited median OS of 18.0 and 9.5 months, respectively, and corresponding PFS of 12.4 and 10.3 months. Conclusion: All LSCLC patients who received two to three cycles of induction chemotherapy should receive radiotherapy as soon as possible after chemotherapy, regardless of their response to the induction chemotherapy.","PeriodicalId":314105,"journal":{"name":"Clinical Oncology and Cancer Research","volume":"16 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2014-01-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"133529976","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Molecular mechanism of synergistic antitumor activity and induced apoptosis of zoledronic acid and paclitaxel","authors":"Xia Liu, Huilai Zhang, Shi-yong Zhou, Z. Qian, Xianhuo Wang, Hua-qing Wang","doi":"10.3969/J.ISSN.1000-8179.20121735","DOIUrl":"https://doi.org/10.3969/J.ISSN.1000-8179.20121735","url":null,"abstract":"Objective: This study aimed to investigate the inhibitory effect of zoledronic acid(ZOL) alone or the combined treatment of ZOL and paclitaxel(PTX) on the cell growth of lung cancer cell line in vitro. Methods: The effects of different concentrations of ZOL alone, 2 nM PTX, and combined treatment of ZOL and PTX on the growth of A-549 cell line were determined using methyl thiazolyl tetrazolium(MTT) method. The mechanism of the curative effect was analyzed by flow cytometry on the basis of apoptotic rate. AKT, phospho-AKT, ERK, phospho-ERK, and Bcl-2 expressions were determined by western blot analysis. AKT and ERK gene expressions were determined by RT-PCR. Results: MTT results showed that ZOL alone could inhibit the growth of lung cancer cell line A-549 in a dose-dependent manner. The combined therapy of ZOL and PTX could inhibit cell growth. This combined treatment is more effective than the single treatment with either ZOL or PTX alone. The synergistic inhibition rate is dependent on drug sequencing. Furthermore, maximum inhibition was induced by sequence order, i.e., initial treatment with PTX and then with ZOL. RT-PCR results demonstrated that the mRNA of ERK and AKT of the group treated with PTX and then ZOL were lower than that in other treatment groups. Western blot analysis results demonstrated that the ERK and AKT levels of the treated groups were parallel in the cell line. However, the lowest phospho-ERK, phospho-AKT, and Bcl-2 levels were observed in the PTX then ZOL group. The cell lines treated with PTX alone and ZOL alone ranked second and third among the lowest results, respectively. The highest level was observed in the control group. Conclusion: The combined ZOL and PTX treatment induced the downregulation of phospho-ERK, phospho-AKT, and Bcl-2 protein expressions in RAF/MEK/ERK and PI3K/AKT signaling pathway. This pathway could be one of the synergistic antitumor mechanisms of the two drugs.","PeriodicalId":314105,"journal":{"name":"Clinical Oncology and Cancer Research","volume":"32 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2014-01-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"125797736","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Therapeutic strategy to prevent the recurrence of esophageal carcinoma after radical resection","authors":"Bo-ai Li, Wencheng Zhang, Lujun Zhao, Ningbo Liu, Q. Pang, Z. Yuan, Weishuai Liu, Ping Wang","doi":"10.3969/J.ISSN.1000-8179.20131379","DOIUrl":"https://doi.org/10.3969/J.ISSN.1000-8179.20131379","url":null,"abstract":"Objective: To evaluate the radiotherapeutic strategy for the treatment of recurrent esophageal cancer after radical re- section and determine relevant prognostic factors. Methods: A total of 66 patients with esophageal carcinoma and exhibited recurrence after radical surgery were retrospectively reviewed from Jan 2007 to Jun 2010. The median interval of recurrence from the initial sur- gery was 10.6 months. Among the 66 patients, 50 suffered from loco-regional recurrences alone, and 16 developed distant metastases in addition to loco-regional recurrences. Among the 66 patients, 10 were treated with radiotherapy after recurrence, 23 were treated with chemotherapy alone, and 33 were treated with radiotherapy combined with chemotherapy. Among the 33 patients, 22 were initially treat- ed with chemotherapy and 11 were initially treated with radiotherapy. The median total dose of the external radiotherapy was 60 Gy with 6 MV X-ray of a linear accelerator. Results: The median survival period after recurrence was 14.3 months (95% CI = 12.4~16.2 months). The 1-, 2-, and 3-year survival rates were 61.9%, 25.9%, and 16.5%, respectively. The median survival period after recurrence in the patients who were treated with chemotherapy alone, radiotherapy alone, and radiotherapy combined with chemotherapy were 11.4, 25.5, and 14.3 months, respectively. The patients who developed distant metastases treated with chemotherapy initially showed better survival outcome than those treated with radiotherapy (P = 0.032). Univariate analysis results showed the following prognostic factors: tumor location before surgery; operation mode; whether or not recurrence was detected with distant metastases; and therapy af- ter recurrence. Multivariate analysis results showed that tumor location before surgery was an independent prognostic factor. Conclu- sion: Tumor location may indicate prognosis after recurrence. Patients with recurrent esophageal carcinoma and developed distant me- tastases treated with chemotherapy may initially benefit from a longer survival rate.","PeriodicalId":314105,"journal":{"name":"Clinical Oncology and Cancer Research","volume":"46 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2013-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"129626549","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinicopathological features and prognostic factors of breast cancer in women aged under 25 years: A report of 77 cases","authors":"Yanqi Zhang, Lina Zhang, L. Gu","doi":"10.3969/J.ISSN.1000-8179.20130959","DOIUrl":"https://doi.org/10.3969/J.ISSN.1000-8179.20130959","url":null,"abstract":"tion between age, lactation, tumor size, axillary node status, surgical approach, pathological stage, indicators of immunohistochemistry treatment modality, and prognosis was analyzed using statistical software. Results: All patients were female, and their average age was 22.94 ± 1.94 years. The diagnosis depended on pathological examination. In the follow-up visits, recurrence or metastasis was found in 27 patients, of which 18 died . The median overall survival was 39 months, and the median progression-free survival was 36 months. The 3 year overall survival rates of stages Ⅰ, Ⅱ, Ⅲ, and Ⅳ were 100%, 92.44%, 59.97%, and 0, respectively. The 5 year overall survival rates of the four stages were 100%, 86.84%, 59.97%, and 0, respectively. Univariate factor analysis showed that tumor size, axillary lymph node status, surgical approach, pathological stage, and estrogen receptor were impact factors, whereas lactation, progesterone receptor, human epidermal growth factor receptor-2, p53, molecular subtyping, chemotherapy, and radiotherapy were not. Cox multivariate analysis showed that axillary lymph node status was an independent prognostic factor for breast cancer in women aged 25 years or less. Conclusion: Breast cancer in young women is rare and has unique characteristics in biological behaviors, diagnosis, prognosis, and other factors. Axillary lymph node status was an independent prognostic factor. The crucial factors in the treatment were diagnosis and on time and early-stage treatment.","PeriodicalId":314105,"journal":{"name":"Clinical Oncology and Cancer Research","volume":"66 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2013-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"125410912","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Research progress on the dual regulation of c-FLIP in apoptosis and proliferation and the relationship between c-FLIP and tumor prognosis, chemotherapy, and TRAIL treatment in cancers","authors":"F. Zang, Baocun Sun","doi":"10.3969/J.ISSN.1000-8179.20131080","DOIUrl":"https://doi.org/10.3969/J.ISSN.1000-8179.20131080","url":null,"abstract":"","PeriodicalId":314105,"journal":{"name":"Clinical Oncology and Cancer Research","volume":"21 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2013-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"127926221","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Research advancement on BNIP3 in gastrointestinal cancer","authors":"Hongdian Zhang, Chuan-gui Chen, Zhentao Yu","doi":"10.3969/J.ISSN.1000-8179.20121527","DOIUrl":"https://doi.org/10.3969/J.ISSN.1000-8179.20121527","url":null,"abstract":"","PeriodicalId":314105,"journal":{"name":"Clinical Oncology and Cancer Research","volume":"7 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2013-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"133293590","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Advances in the research of neurolytic celiac plexus block","authors":"Kun Wang, Y. Shao","doi":"10.3969/J.ISSN.1000-8179.20131974","DOIUrl":"https://doi.org/10.3969/J.ISSN.1000-8179.20131974","url":null,"abstract":"","PeriodicalId":314105,"journal":{"name":"Clinical Oncology and Cancer Research","volume":"27 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2013-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"132171003","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of herbs on preventing diarrhea caused by irinotecan and its correlation with gene polymorphism of UGT1A1*28","authors":"Z. Pan, Zhansheng Jiang, Y. Ba, Jianzhong Liu, Yumei Feng, G. Xie","doi":"10.3969/J.ISSN.1000-8179.20131327","DOIUrl":"https://doi.org/10.3969/J.ISSN.1000-8179.20131327","url":null,"abstract":"Objective: This study aimed to determine the function of herbs in preventing diarrhea after irinotecan chemotherapy and analyze the efficacy of the herbs based on UGT1A1*28 gene polymorphism. Methods: A total of 200 patients admitted to the Department of Synergistic Chinese and Western Medicine, Tianjin Medical University Cancer Institute and Hospital between October 2011 and May 2013 were randomly divided into the control (chemotherapy alone) and herb (chemotherapy combined with herbs) groups. All patients consented to UGT1A1*28 gene polymorphism detection prior to chemotherapy. Herbs were administered from 2 d prior to chemotherapy to 5 d post chemotherapy, with or without the regimen of fluorouracil, folinic acid, and irinotecan. Adverse reactions were recorded, and short-term effect was evaluated regularly. Results: A total of 144 patients had TA6/6 wild genotype, and another 56 patients had non-wild genotype (12 of the 56 cases were TA7/7 homozygous, and the other 44 cases were TA6/7 hybrid). A total of 58 patients experienced grades 2 to 4 diarrhea. A 14% decrease in the incidence of diarrhea was observed in the herb group compared with that of the control group (22% vs. 36%, P=0.029). In addition to diarrhea, grades 2 to 4 vomiting was significantly lower in the herb group than in the control group (15% vs. 27%, P=0.037). The overall response rate was 37.5%. No significant difference was found between the two groups (40% vs. 35%, P=0.465). The incidences of grades 2 to 4 diarrhea (22.9% vs. 44.6%, P=0.002) and grades 2 to 4 vomiting (23.2% vs. 16.7%, P=0.016) were lower in patients with the UGT1A1*28 wild genotype than in those with the non-wild genotype. However, in the herb group, the incidences of grades 2 to 4 diarrhea (22.2% vs. 21.9%, P=0.974) and vomiting (18.5% vs. 13.7%, P=0.777) were not significant between the non-wildand wild-type groups. Conclusion: Herbs can effectively pre作者单位:1天津医科大学肿瘤医院中西医结合科,国家肿瘤临床医学研究中心,天津市肿瘤防治重点实验室(天津市300060);2消化肿瘤内科; 3结直肠肿瘤科;4生化及分子生物学研究室 􀆽本文课题受天津市中医药管理局中医中西医结合科研项目(编号:11107)资助 通信作者:谢广茹 xieguangru@126.com 1441 中国肿瘤临床 2013年第40卷第23期 Chin J Clin Oncol 2013, Vol. 40, No. 23 www.cjco.cn vent the late diarrhea caused by irinotecan, which is also applicable in UGT1A1*28 non-wild genotype patients. Incidence of diarrhea was obviously higher in the cases with UGT1A1*28 non-wild type than in those with wild genotype. Hence, the UGT1A1*28 gene type should be detected prior to chemotherapy with irinotecan.","PeriodicalId":314105,"journal":{"name":"Clinical Oncology and Cancer Research","volume":"18 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2013-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"122213003","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical treatment of primary cutaneous anaplastic large cell lymphoma","authors":"Bo-ai Li, Xi-Mei Zhang, Li-Ming Xu, Ningbo Liu, Lujun Zhao, Z. Yuan, Ping Wang","doi":"10.3969/J.ISSN.1000-8179.20131605","DOIUrl":"https://doi.org/10.3969/J.ISSN.1000-8179.20131605","url":null,"abstract":"","PeriodicalId":314105,"journal":{"name":"Clinical Oncology and Cancer Research","volume":"89 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2013-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"122446457","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prevention of surgery-related complications of radical lymphadenectomy for gastric cancer","authors":"H. Liang","doi":"10.3969/J.ISSN.1000-8179.20131562","DOIUrl":"https://doi.org/10.3969/J.ISSN.1000-8179.20131562","url":null,"abstract":"","PeriodicalId":314105,"journal":{"name":"Clinical Oncology and Cancer Research","volume":"15 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2013-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"133479837","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}