Clinical Oncology and Cancer Research最新文献_第7页

The correlation of peripheral blood lymphocyte subsets with prognosis in lung cancer patients 肺癌患者外周血淋巴细胞亚群与预后的关系

Clinical Oncology and Cancer Research Pub Date : 2014-03-30 DOI: 10.3969/J.ISSN.1000-8179.20131278

Xi-yin Wei, Cui-cui Zhang, F. Zang, Kai Li

{"title":"The correlation of peripheral blood lymphocyte subsets with prognosis in lung cancer patients","authors":"Xi-yin Wei, Cui-cui Zhang, F. Zang, Kai Li","doi":"10.3969/J.ISSN.1000-8179.20131278","DOIUrl":"https://doi.org/10.3969/J.ISSN.1000-8179.20131278","url":null,"abstract":"Objective: To study the relationship of lymphocyte subsets with prognosis and clinico-pathologic features in lung can- cer patients. Methods: Flow cytometry was used to analyze the distribution of T-lymphocyte subsets and natural killer cells in the pe- ripheral blood of lung cancer patients, patients with benign pulmonary diseases, and healthy controls. The peripheral-blood lymphocyte levels of the subjects were compared. Clinical data obtained from 102 lung cancer cases were reviewed retrospectively, and the relation- ship of lymphocyte subsets with prognosis and clinico-pathologic features was analyzed. Results: The level of CD4+ T cells was lower in the peripheral blood of lung cancer patients than that of the healthy controls (P 0.05). However, the abnormal distribution of lympho- cyte subsets was related to lymphatic metastasis, TNM stage, and tumorigenesis P<0.05). Conclusion: The distribution of T-lympho- cyte subsets and natural killer cells was abnormal in the peripheral blood of lung cancer patients, and the dynamic changes in distribu- tion can help assess the immune functions of lung cancer patients. Cellular immune function can act as a prognostic indicator in lung cancer patients.","PeriodicalId":314105,"journal":{"name":"Clinical Oncology and Cancer Research","volume":"2 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2014-03-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"124172036","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Progress in the research on venous thromboembolism in malignant lymphoma 恶性淋巴瘤静脉血栓栓塞的研究进展

Clinical Oncology and Cancer Research Pub Date : 2014-03-30 DOI: 10.3969/J.ISSN.1000-8179.20130696

Pengfei Liu, Yaning Li, Hua-qing Wang

{"title":"Progress in the research on venous thromboembolism in malignant lymphoma","authors":"Pengfei Liu, Yaning Li, Hua-qing Wang","doi":"10.3969/J.ISSN.1000-8179.20130696","DOIUrl":"https://doi.org/10.3969/J.ISSN.1000-8179.20130696","url":null,"abstract":"Venous thromboembolism (VTE) is the second leading cause of death and is a major cause of morbidity in patients with cancer. The prevention and the treatment of VTE are important. The risk of thrombosis among cancer patients is increaseds by sev- en times, but this risk may be 28 times higher in patients with hematological tumors. This increased risk seriously affects the quality of life and the prognosis of malignant lymphoma patients. However, the pathogenesis and risk factors for VTE in the lymphoma patients are not well well-defined. This study reveals that tissue factors, micro-particles, and single nucleotide polymorphisms of gene are associ- ated with VTE. Therefore, the identification of patients with the highest risk of VTE is important to improve the diagnostic rate of VTE. These patients would benefit from thrombo-prophylaxis. We therefore need a simple and effectual risk assessment model for predicting the incidence rates of VTE. Moreover, peripheral blood biomarkers might improve the accuracy of the diagnosis. Patients with lympho- ma have a high risk for hemorrhage, and receiving anticoagulant therapy is challenging for them. This review summarizes the current knowledge of the epidemiology, pathogenesis, prophylaxis, and treatment of VTE in patients with lymphoma.","PeriodicalId":314105,"journal":{"name":"Clinical Oncology and Cancer Research","volume":"54 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2014-03-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"133117274","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Low carbon lifestyle of tumor cells 肿瘤细胞的低碳生活方式

Clinical Oncology and Cancer Research Pub Date : 2014-03-30 DOI: 10.3969/J.ISSN.1000-8179.20140147

Yongsheng Jia, Z. Tong

引用次数: 0

Neoadjuvant chemoradiotherapy combined with mini-invasive esophagectomy in advanced esophageal cancer: A case report 新辅助放化疗联合微创食管切除术治疗晚期食管癌1例

Clinical Oncology and Cancer Research Pub Date : 2014-03-30 DOI: 10.3969/J.ISSN.1000-8179.20140280

P. Tang, X. Duan, Hongjing Jiang, Zhentao Yu, Jianyu Xiao, Z. Zhan, Q. Pang, Hong-li Li

引用次数: 0

Status and prospect of argon-helium cryosurgery system for the treatment of gliomas 氩氦冷冻系统治疗胶质瘤的现状与展望

Clinical Oncology and Cancer Research Pub Date : 2014-03-15 DOI: 10.3969/J.ISSN.1000-8179.20121335

Peng Li, Wenliang Li, Zeng-feng Sun, Zhi-gang Guo

引用次数: 1

Correlation of neuropilin-1 and VEGF expression with tumor angiogenesis in human gastric carcinoma neuropilin-1和VEGF表达与胃癌血管生成的关系

Clinical Oncology and Cancer Research Pub Date : 2014-03-15 DOI: 10.3969/J.ISSN.1000-8179.20131989

Ming Li, Qiang Li

{"title":"Correlation of neuropilin-1 and VEGF expression with tumor angiogenesis in human gastric carcinoma","authors":"Ming Li, Qiang Li","doi":"10.3969/J.ISSN.1000-8179.20131989","DOIUrl":"https://doi.org/10.3969/J.ISSN.1000-8179.20131989","url":null,"abstract":"Objective: To investigate the expression of Neuropilin-1 (NRP-1) and vascular endothelial growth factor (VEGF) in gastric carcinoma tissue and to examine their relationship with tumor angiogenesis and the biological behavior of gastric carcinoma. Methods: The expressions of NRP-1mRNA and VEGFmRNA were detected by the reverse transcription polymerase chain reaction (RT-PCR) method. Microvascular density (MVD) marked by CD105-positive vascular with SP immunohistochemical staining was also assessed in surgical specimens of gastric carcinoma (GC) and normal gastric tissues (NG). The correlation of NRP-1mRNA, VEGFmRNA with clinical patholo¬gical factors and the relationship among NRP-1mRNA, VEGFmRNA, and MVD were analyzed. Results: The expressions of NRP-1mRNA, VEGFmRNA, and CD105 in GC were significantly higher than those in NG (P<0.01). The expressions of NRP-1mRNA and VEGFmRNA were closely correlated with the depth of invasion and lymph node metastasis in GC (P<0.05). A positive correlation was observed between the expressions of NRP-1mRNA and VEGFmRNA (r=0.58, P<0.01). MVD correlated with NRP-1 (r=0.52, P<0.01) and with VEGF (r= 0.74, P<0.01). Conclusion: Results indicated that the NRP-1 and VEGF expressions could be involved in the angiogenesis and tumor progression of human gastric carcinoma. The combined detection of NRP-1 and VEGF could also determine the invasion and progression of gastric carcinoma, which plays a particular role in guiding the anti-angiogenic ther-","PeriodicalId":314105,"journal":{"name":"Clinical Oncology and Cancer Research","volume":"43 3","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2014-03-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"114107842","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A study on the expression of miR-106b ∼ 25 cluster in human glioma miR-106b ~ 25簇在人胶质瘤中的表达研究

Clinical Oncology and Cancer Research Pub Date : 2014-03-15 DOI: 10.3969/J.ISSN.1000-8179.20131716

M. Ye, An-ling Zhang, Kun Wang, Miao-jing Wu, Qiang Huang, Xin-gen Zhu

引用次数: 1

Research progress on AQP1 in gliomas 胶质瘤中AQP1基因的研究进展

Clinical Oncology and Cancer Research Pub Date : 2014-03-15 DOI: 10.3969/J.ISSN.1000-8179.20140210

Jia He, Wenliang Li, Feng Gu, Yongjie Ma

引用次数: 0

Adenoid cystic carcinoma of the tracheobronchial tree: MSCT features 气管支气管树腺样囊性癌:MSCT特征

Clinical Oncology and Cancer Research Pub Date : 2014-03-15 DOI: 10.3969/J.ISSN.1000-8179.20131520

Xiaoyan Meng, Zhaoxiang Ye, Xubin Li, Juxiang Ma, Hongren Wang, Xiaonan Cui

引用次数: 0

Low expression profiling of microRNA in non-small cell lung cancer tissues microRNA在非小细胞肺癌组织中的低表达谱分析

Clinical Oncology and Cancer Research Pub Date : 2014-03-15 DOI: 10.3969/J.ISSN.1000-8179.20131531

Xiaozhou Yu, F. Wei, Fan Yan, Wenwen Yu, Hui Li, X. Ren

引用次数: 1