The correlation of peripheral blood lymphocyte subsets with prognosis in lung cancer patients

Clinical Oncology and Cancer Research Pub Date : 2014-03-30 DOI:10.3969/J.ISSN.1000-8179.20131278

Xi-yin Wei, Cui-cui Zhang, F. Zang, Kai Li

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引用次数: 2

Abstract

Objective: To study the relationship of lymphocyte subsets with prognosis and clinico-pathologic features in lung can- cer patients. Methods: Flow cytometry was used to analyze the distribution of T-lymphocyte subsets and natural killer cells in the pe- ripheral blood of lung cancer patients, patients with benign pulmonary diseases, and healthy controls. The peripheral-blood lymphocyte levels of the subjects were compared. Clinical data obtained from 102 lung cancer cases were reviewed retrospectively, and the relation- ship of lymphocyte subsets with prognosis and clinico-pathologic features was analyzed. Results: The level of CD4+ T cells was lower in the peripheral blood of lung cancer patients than that of the healthy controls (P 0.05). However, the abnormal distribution of lympho- cyte subsets was related to lymphatic metastasis, TNM stage, and tumorigenesis P<0.05). Conclusion: The distribution of T-lympho- cyte subsets and natural killer cells was abnormal in the peripheral blood of lung cancer patients, and the dynamic changes in distribu- tion can help assess the immune functions of lung cancer patients. Cellular immune function can act as a prognostic indicator in lung cancer patients.

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肺癌患者外周血淋巴细胞亚群与预后的关系

目的:探讨肺癌患者淋巴细胞亚群与预后及临床病理特征的关系。方法:采用流式细胞术分析肺癌患者、肺部良性疾病患者和健康对照者外周血t淋巴细胞亚群和自然杀伤细胞的分布。比较两组患者外周血淋巴细胞水平。回顾性分析102例肺癌患者的临床资料，分析淋巴细胞亚群与预后及临床病理特征的关系。结果:肺癌患者外周血CD4+ T细胞水平明显低于正常对照组(P < 0.05)。而淋巴细胞亚群的异常分布与淋巴结转移、TNM分期及肿瘤发生有关(P<0.05)。结论:肺癌患者外周血t淋巴细胞亚群和自然杀伤细胞分布异常，其分布的动态变化有助于评价肺癌患者的免疫功能。细胞免疫功能可作为肺癌患者的预后指标。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Clinical Oncology and Cancer Research

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