Clinical Oncology and Cancer Research最新文献

{"title":"Effect of neo-adjuvant chemotherapy on postoperative cognitive dysfunction in elderly patients after one-lung ventilation surgery","authors":"Kaiyuan Wang, Ling Liu, Jingcheng Li, P. Tang, Hui-xia Li, X. Duan","doi":"10.3969/J.ISSN.1000-8179.20140081","DOIUrl":"https://doi.org/10.3969/J.ISSN.1000-8179.20140081","url":null,"abstract":"Objective: We aimed to investigate the effect of neo-adjuvant chemotherapy on postoperative cognitive dysfunction (POCD) in elderly patients who underwent one-lung ventilation (OLV) surgery. Methods: A total of 90 esophageal carcinoma patients aged 60 years old or older were included. These patients were scheduled for esophagectomy, including two or three-field lymphadenectomy, and were randomly divided into two groups based on the American Society of Anesthesiologists status (I or II) and the Tumor-Node-Metastasis (TNM) classification stage (II orIII), as follows: the neo-adjuvant chemotherapy group (Group N: n=45) that received preoperative neo-adjuvant chemotherapy; and the control group (Group C: n=45) that did not receive chemotherapy. The neuropsychological test was performed 1 d before and 7 d after surgery to evaluate the changes in cognitive function. The incidence of POCD was also determined via the Z-value method in the two groups. Results: A total of 44 patients in Group N and 41 patients in Group C completed the neuropsychological tests. No statistical differences were observed in the demographics, TNM stage, and the intraand post-operative clinical data between the groups. POCD was observed in 21 of the patients in Group N (47.7%) and 11 of the patients in Group C (26.8%), and the differences were significant (χ=3.949, P=0.047). Conclusion: Neo-adjuvant chemotherapy can aggravate the impairment of cognitive function in the elderly patients undergoing OLV surgery and can significantly increase the incidence of POCD.","PeriodicalId":314105,"journal":{"name":"Clinical Oncology and Cancer Research","volume":"41 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2014-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130035998","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Frequency and suppressor function of CD4+ CD25+ T cells in ascites and blood of patients with ovarian cancer","authors":"Hairong Yao, Jing Tian, Yingchun Li, Wenqi Zhang, Q. Hao","doi":"10.3969/J.ISSN.1000-8179.20131281","DOIUrl":"https://doi.org/10.3969/J.ISSN.1000-8179.20131281","url":null,"abstract":"","PeriodicalId":314105,"journal":{"name":"Clinical Oncology and Cancer Research","volume":"38 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2014-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"122300112","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Transformation of follicular lymphoma to \"double-hit\" or \"triple-hit\" lymphoma with c-MYC gene rearrangement: A report of three cases","authors":"Le Zhang, Xiao-xiao Xu, Shanqi Guo, Yafei Wang, Yizhuo Zhang, Bao-cun Sun, Ling Zhang","doi":"10.3969/J.ISSN.1000-8179.20131468","DOIUrl":"https://doi.org/10.3969/J.ISSN.1000-8179.20131468","url":null,"abstract":"","PeriodicalId":314105,"journal":{"name":"Clinical Oncology and Cancer Research","volume":"19 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2014-06-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"116909219","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of trichosanthin on apoptosis and cytoskeleton microtubule structure reconfiguration in lung cancer A549 cells","authors":"J. Zhuang, Changgang Sun, Congcong Wang, F. Feng, Qingliang Lv, Huaqing Wang, Mian-hua Wu","doi":"10.3969/J.ISSN.1000-8179.20140473","DOIUrl":"https://doi.org/10.3969/J.ISSN.1000-8179.20140473","url":null,"abstract":"","PeriodicalId":314105,"journal":{"name":"Clinical Oncology and Cancer Research","volume":"80 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2014-06-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"123614710","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The effects of preoperative level of serum CA19-9 on the prognosis of gastric cancer patients after radical resection","authors":"Shupeng Zhang, H. Liang, J. Deng","doi":"10.3969/J.ISSN.1000-8179.20140009","DOIUrl":"https://doi.org/10.3969/J.ISSN.1000-8179.20140009","url":null,"abstract":"摘要 目的:探讨胃癌患者术前检测血清CA19-9的必要性及其对患者预后评估的意义。方法:收集2003年1月至2008年 10月间天津医科大学肿瘤医院收治的513例术前检测血清CA19-9的胃癌患者的临床病理资料,分析CA19-9水平与临床病理因 素的关系及其与预后的关系。结果:513例患者中CA19-9升高者86例(16.8%),CA19-9升高与高龄、大体分型(BorrmannIII、IV 型)、组织学类型(低分化、未分化)及浸润深度相关。CA19-9正常(<39 U/mL)和升高(≥39 U/mL)患者5年生存率分别为45.7% 和25.6%,差异有统计学意义(P<0.001)。分层分析显示,CA19-9水平仅与TNMIII期患者预后相关(P=0.001)。多因素预后分析 证实,CA19-9升高是影响胃癌患者根治术后生存的独立危险因素(HR=1.47,P=0.008)。结论:术前检测血清CA19-9可为胃癌患 者预后评估提供信息,CA19-9升高可能是胃癌根治术后影响患者预后的独立危险因素。 关键词 胃肿瘤 CA19-9 预后 doi:10.3969/j.issn.1000-8179.20140009","PeriodicalId":314105,"journal":{"name":"Clinical Oncology and Cancer Research","volume":"65 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2014-06-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130439736","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Research of colon cancer stem cell-like cells induced to differentiate into vascular endothelial cells","authors":"Yixian Li, Baocun Sun, Zhi-yong Liu, Xiulan Zhao, Yanhui Zhang, Runfen Cheng, L. Qi","doi":"10.3969/J.ISSN.1000-8179.20132206","DOIUrl":"https://doi.org/10.3969/J.ISSN.1000-8179.20132206","url":null,"abstract":"","PeriodicalId":314105,"journal":{"name":"Clinical Oncology and Cancer Research","volume":"232 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2014-05-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"133462842","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Current situation and development of HER-2 testing in breast cancer","authors":"Q. Geng, X. Qian, L. Fu","doi":"10.3969/J.ISSN.1000-8179.20140377","DOIUrl":"https://doi.org/10.3969/J.ISSN.1000-8179.20140377","url":null,"abstract":"","PeriodicalId":314105,"journal":{"name":"Clinical Oncology and Cancer Research","volume":"211 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2014-05-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"132495918","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Preoperative blood neutrophil to lymphocyte ratio as an independent prognostic predictor for epithelial ovarian cancer","authors":"Zhang Zhang, Q. Hao","doi":"10.3969/J.ISSN.1000-8179.20130874","DOIUrl":"https://doi.org/10.3969/J.ISSN.1000-8179.20130874","url":null,"abstract":"Objective: This study aims to evaluate the effect of an elevated preoperative neutrophil to lymphocyte ratio (NLR) on outcome after comprehensive staging laparotomy or optimal tumor debulking surgery for epithelial ovarian cancer (EOC) and determine the value of the NLR as an independent prognostic prediction marker. Methods: A total of 80 women with primary EOC and with complete clinical and pathological information documented at the time of surgery were selected for this study. The optimum cut-off value of the preoperative NLR was identified through receiver operator characteristic (ROC) curve, and the patients were then classified into two groups: low and high NLR group. Univariate and multivariate analyses were performed to assess the prognostic effect of the preoperative NLR patients who underwent comprehensive staging laparotomy or optimal tumor debulking surgery. The levels of expression of CD68 were measured through immunohistochemistry. Results: The optimal cut-off value of the NLR was 3.8. The preoperative NLR differed significantly in the FIGO stage between the low NLR group (NLR ≤3.8) and the high NLR group (NLR >3.8), but no discrimination was observed in other parameters. The mean follow-up time was 45 months, and the post-operative 1- and 3-year survival rates were 93.7% and 60.0%, respectively. The preoperative NLR > 3.8 and stage Ⅲ/Ⅳ were all risk factors for poor overall and disease-free survival. Multivariate analysis revealed the patients with high NLR (P<0.05) and stage Ⅲ/Ⅳ (P<0.05) had prognostic significance for poor overall survival. The number of CD68-positive tumor-associated macrophages was significantly higher in the high NLR group than in the low NLR group (54.65±8.78 and 41.78±9.10, respectively; P<0.001). Conclusion: An elevated blood preoperative NLR indicates poor prognosis in patients with EOC. Preoperative NLR may function as an important independent prognostic factor for patients with EOC.","PeriodicalId":314105,"journal":{"name":"Clinical Oncology and Cancer Research","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2014-05-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"117032444","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Gemcitabine, Navelbine, and Therarubicin (GNT) as treatment for patients with refractory or relapsed T-cell lymphoma","authors":"Shaohua Wu, Hua-qing Wang, Z. Qian, Huilai Zhang, Shi-yong Zhou, L. Qiu, Z. Song, Xianhuo Wang","doi":"10.3969/J.ISSN.1000-8179.20140559","DOIUrl":"https://doi.org/10.3969/J.ISSN.1000-8179.20140559","url":null,"abstract":"","PeriodicalId":314105,"journal":{"name":"Clinical Oncology and Cancer Research","volume":"230 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2014-05-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"131503610","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Posterior laminectomy and vertebroplasty combined with radiofrequency ablation in spinal metastases from malignant tumors","authors":"Chao Zhang, Guo-wen Wang, Xiuxin Han, Sheng Teng, Yu-lin Ma, Jian Duo, Jilong Yang","doi":"10.3969/J.ISSN.1000-8179.20130911","DOIUrl":"https://doi.org/10.3969/J.ISSN.1000-8179.20130911","url":null,"abstract":"Objective: To investigate the safety and efficacy of laminectomy combined with vertebroplasty in spinal metastases from rapid-growth tumors. Methods: Clinical data of 23 patients with spinal metastases of lung cancer, who were admitted to the Cancer Hospital from July 2008 to May 2012, were retrospectively analyzed. Thirteen male and ten female patients, with an age range from 40 years to 65 years and a mean age of 51.5, were examined. All patients received posterior laminectomy to relieve spinal cord compression. Afterward, vertebroplasty combined with radiofrequency ablation was conducted, followed by the internal fixation of vertebrae (instrumental fixation). Operation time, blood loss, and bone cement leakage rate were analyzed. One month before and after the operation, pain measurement was conducted using visual analog scale (VAS) and neurologic deficit (spinal cord injury) by Frankel Grade. Functional impairment was classified by Karnofsky performance status (KPS) score. Quality of life was assessed by the European Organization for Research and Treatment questionnaire (EORTC QLQ-C30). Results: The mean operation time was 163±87.36 min. Blood boss was 430±130.35 mL. Bone cement leakage rate was 21.7%. One month before and after surgery, the VAS showed statistical significance (t=25.6, P<0.01). After surgery, 78.3% of all patients exhibited functionally satisfactory Frankel Grade D or E, compared with 43.5% of patients before the operation. KPS score (80 to 100) percentage was 69.6% after surgery compared with 34.8% before surgery. One month after the operation, remission of various degrees was seen in 10 of 18 patients who had sphincteric dysfunction before surgery (55.6%). The EORTC QLQ-C30 score was 85.39±8.99 before and 52.78±15.17 after operation. The quality of life improved significantly (t=11.6, P<0.01). Conclusion: Posterior laminectomy and vertebroplasty combined with radiofrequency ablation for spinal metastases from lung cancer is safe and effective. The treatment can improve pain, function, and life quality of patients with lung cancer spinal metastases.","PeriodicalId":314105,"journal":{"name":"Clinical Oncology and Cancer Research","volume":"21 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2014-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"123501225","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}