{"title":"新辅助化疗对老年患者单肺通气术后认知功能障碍的影响","authors":"Kaiyuan Wang, Ling Liu, Jingcheng Li, P. Tang, Hui-xia Li, X. Duan","doi":"10.3969/J.ISSN.1000-8179.20140081","DOIUrl":null,"url":null,"abstract":"Objective: We aimed to investigate the effect of neo-adjuvant chemotherapy on postoperative cognitive dysfunction (POCD) in elderly patients who underwent one-lung ventilation (OLV) surgery. Methods: A total of 90 esophageal carcinoma patients aged 60 years old or older were included. These patients were scheduled for esophagectomy, including two or three-field lymphadenectomy, and were randomly divided into two groups based on the American Society of Anesthesiologists status (I or II) and the Tumor-Node-Metastasis (TNM) classification stage (II orIII), as follows: the neo-adjuvant chemotherapy group (Group N: n=45) that received preoperative neo-adjuvant chemotherapy; and the control group (Group C: n=45) that did not receive chemotherapy. The neuropsychological test was performed 1 d before and 7 d after surgery to evaluate the changes in cognitive function. The incidence of POCD was also determined via the Z-value method in the two groups. Results: A total of 44 patients in Group N and 41 patients in Group C completed the neuropsychological tests. No statistical differences were observed in the demographics, TNM stage, and the intraand post-operative clinical data between the groups. POCD was observed in 21 of the patients in Group N (47.7%) and 11 of the patients in Group C (26.8%), and the differences were significant (χ=3.949, P=0.047). Conclusion: Neo-adjuvant chemotherapy can aggravate the impairment of cognitive function in the elderly patients undergoing OLV surgery and can significantly increase the incidence of POCD.","PeriodicalId":314105,"journal":{"name":"Clinical Oncology and Cancer Research","volume":"41 1","pages":"0"},"PeriodicalIF":0.0000,"publicationDate":"2014-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"1","resultStr":"{\"title\":\"Effect of neo-adjuvant chemotherapy on postoperative cognitive dysfunction in elderly patients after one-lung ventilation surgery\",\"authors\":\"Kaiyuan Wang, Ling Liu, Jingcheng Li, P. Tang, Hui-xia Li, X. Duan\",\"doi\":\"10.3969/J.ISSN.1000-8179.20140081\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Objective: We aimed to investigate the effect of neo-adjuvant chemotherapy on postoperative cognitive dysfunction (POCD) in elderly patients who underwent one-lung ventilation (OLV) surgery. Methods: A total of 90 esophageal carcinoma patients aged 60 years old or older were included. These patients were scheduled for esophagectomy, including two or three-field lymphadenectomy, and were randomly divided into two groups based on the American Society of Anesthesiologists status (I or II) and the Tumor-Node-Metastasis (TNM) classification stage (II orIII), as follows: the neo-adjuvant chemotherapy group (Group N: n=45) that received preoperative neo-adjuvant chemotherapy; and the control group (Group C: n=45) that did not receive chemotherapy. The neuropsychological test was performed 1 d before and 7 d after surgery to evaluate the changes in cognitive function. The incidence of POCD was also determined via the Z-value method in the two groups. Results: A total of 44 patients in Group N and 41 patients in Group C completed the neuropsychological tests. No statistical differences were observed in the demographics, TNM stage, and the intraand post-operative clinical data between the groups. POCD was observed in 21 of the patients in Group N (47.7%) and 11 of the patients in Group C (26.8%), and the differences were significant (χ=3.949, P=0.047). Conclusion: Neo-adjuvant chemotherapy can aggravate the impairment of cognitive function in the elderly patients undergoing OLV surgery and can significantly increase the incidence of POCD.\",\"PeriodicalId\":314105,\"journal\":{\"name\":\"Clinical Oncology and Cancer Research\",\"volume\":\"41 1\",\"pages\":\"0\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2014-06-30\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"1\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Clinical Oncology and Cancer Research\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.3969/J.ISSN.1000-8179.20140081\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Clinical Oncology and Cancer Research","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.3969/J.ISSN.1000-8179.20140081","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Effect of neo-adjuvant chemotherapy on postoperative cognitive dysfunction in elderly patients after one-lung ventilation surgery
Objective: We aimed to investigate the effect of neo-adjuvant chemotherapy on postoperative cognitive dysfunction (POCD) in elderly patients who underwent one-lung ventilation (OLV) surgery. Methods: A total of 90 esophageal carcinoma patients aged 60 years old or older were included. These patients were scheduled for esophagectomy, including two or three-field lymphadenectomy, and were randomly divided into two groups based on the American Society of Anesthesiologists status (I or II) and the Tumor-Node-Metastasis (TNM) classification stage (II orIII), as follows: the neo-adjuvant chemotherapy group (Group N: n=45) that received preoperative neo-adjuvant chemotherapy; and the control group (Group C: n=45) that did not receive chemotherapy. The neuropsychological test was performed 1 d before and 7 d after surgery to evaluate the changes in cognitive function. The incidence of POCD was also determined via the Z-value method in the two groups. Results: A total of 44 patients in Group N and 41 patients in Group C completed the neuropsychological tests. No statistical differences were observed in the demographics, TNM stage, and the intraand post-operative clinical data between the groups. POCD was observed in 21 of the patients in Group N (47.7%) and 11 of the patients in Group C (26.8%), and the differences were significant (χ=3.949, P=0.047). Conclusion: Neo-adjuvant chemotherapy can aggravate the impairment of cognitive function in the elderly patients undergoing OLV surgery and can significantly increase the incidence of POCD.