Advances in Pharmacology & Clinical Trials最新文献

{"title":"Medicinal Herbal Plants and Allopathic Drugs to Treat Diabetes Mellitus: A glance","authors":"Saurabh Nimesh","doi":"10.23880/apct-16000151","DOIUrl":"https://doi.org/10.23880/apct-16000151","url":null,"abstract":"The present study was based on Diabetes Mellitus, its cure using herbal drugs over allopathic drugs. According to the official World Health Organisation (WHO) data, India tops the list of countries with the highest number of diabetics; China, America, Indonesia, Japan, Pakistan, Russia, Brazil, Italy and Bangladesh follow. In the year 2000, the total number of diabetics in India stood at 31.7 million and is expected to rise by more than 100% in the year 2030 to account to a whopping 79.4 million. Despite the use of advanced Allopathic drugs for the treatment, use of herbal remedies is gaining higher importance because of Allopathic drugs have drawbacks and limitations. Natural herbs have been highly esteemed source of medicine throughout the human history. They are widely used today indicating that herbs are a growing part of modern high-tech medicine. The herbal drugs with anti-diabetic activity are extensively formulated commercially because of easy availability, affordability and less side effects as compared to the synthetic anti-diabetic drugs. The WHO has listed 21,000 plants, which are used for medicinal purposes around the world. A list of medicinal herbal plants with proven anti-diabetic and related beneficial effects and of herbal drugs used in treatment of diabetes is compiled. Thus, this review article undertakes the attempt for providing updated information on the type of diabetes and herbal formulations which will enhance the existing knowledge of the researchers.","PeriodicalId":313915,"journal":{"name":"Advances in Pharmacology & Clinical Trials","volume":"232 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"122623820","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Antibiotic Resistance Correlated to Patient Profile Factors in the Central Region of Romania","authors":"C. Dobrea","doi":"10.23880/apct-16000171","DOIUrl":"https://doi.org/10.23880/apct-16000171","url":null,"abstract":"","PeriodicalId":313915,"journal":{"name":"Advances in Pharmacology & Clinical Trials","volume":"72 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"125491979","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of Sodium Valproate and Levetiracetam on Thyroid Hormones in Pediatric Patients with Epilepsy","authors":"D. S","doi":"10.23880/apct-16000182","DOIUrl":"https://doi.org/10.23880/apct-16000182","url":null,"abstract":"","PeriodicalId":313915,"journal":{"name":"Advances in Pharmacology & Clinical Trials","volume":"79 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"128930184","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of Psychotropic Drugs and Falls among Discharged Elderly Patients in Sana’a City, Yemen","authors":"Ali Alyahawi","doi":"10.23880/apct-16000208","DOIUrl":"https://doi.org/10.23880/apct-16000208","url":null,"abstract":"Background: In the elderly, falls are a common and important problem. One of the most feared consequences of falling is a hip fracture. Psychotropic drugs are used extensively among older people and there is a risk of falling that these drugs are used long-term and off-label. In addition to treatment of mental health problems such as depression, anxiety, and insomnia, with psychotropic drugs, these drugs are also prescribed to older patients for behavioral and psychological symptoms of dementia (BPSD). Aims of the study: To investigate whether psychotropic drugs are associated with an increased risk of fall injuries in older adults. Materials and Methods: A retrospective cross-sectional study was conducted on 170 discharge prescriptions of neurosurgery department from Mar 2022 to May 20202. In the present study, the elderly patients of 65 years and above were included in this study. The relevant data were collected from computerized records of a teaching hospital in Sana’a, Yemen. The prescriptions were evaluated and reviewed for investigate whether psychotropic drugs are associated with an increased risk of fall injuries. The obtained data was analyzed using descriptive statistics SPSS version 26. Categorical variables were presented as frequencies and percentages. Also, data were analyzed by chi-square test to know the relationship between the poly-pharmacy and major drug-drug interactions. A value of P-value > 0.05 was considered statistically significant. Results: A total of 170 discharge prescriptions were enrolled. 99 (58.3%) were male patients and 71 (41.8%) were female. It was showed that the major morbidity pattern was depression 79 (46.5). It had been found that (14 drugs) were drugs that generally should be avoided in older adults. The benzodiazepines were the most. The drugs that should be used with caution when prescribe to older adults were 6 drugs and the antidepressant SSRI was the most. Drugs to be avoided or dosage reduced with varying levels of kidney function were 3 drugs on discharge based on AGS 2019. According to the study results, 16.5% of patients had poly-pharmacy on discharge and 83.5% with no poly-pharmacy. The study results revealed that 62 (25.3%) of patients had at least one major drug-drug interactions on discharge. The most common drug-drug interaction was between antidepressant drugs (amitriptyline) with benzodiazepines (lorazepam) which result increase of falls and injuries. The relationship between poly-pharmacy at discharge and major drug-drug interaction was statistically significant in this study. Conclusion: This study showed a high prevalence of PIMs which are mostly psychotropic drugs that should be avoided or used with caution among older patients. Also, this study identifies the major drug-drug interactions that make falls and injures. Poly-pharmacy and chronic conditions were predictors for increased use of PIMs among older patients. Increase the knowledge about PIMs, psychotropic drugs and their poten","PeriodicalId":313915,"journal":{"name":"Advances in Pharmacology & Clinical Trials","volume":"21 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"126823225","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Development and Validation of Three Different UV Spectrophotometric Methods for Determination of New Antifungal Combination Used in Treatment of External Fungal Infections and Their Comparison Using ANOVA","authors":"Ruchi Kansotia","doi":"10.23880/apct-16000188","DOIUrl":"https://doi.org/10.23880/apct-16000188","url":null,"abstract":"Luliconazole and Terbinafine hydrochloride combination is used for external fungal infections and is newly introduced in market. Hence it is necessary to develop a appropriate method of analysis for rapid and accurate determination of these drugs. Three simple, sensitive, accurate, precise and economical UV-spectrophotometric methods (A,B,C) have been developed for simultaneous estimation of Luliconazole and Terbinafine hydrochloride in their pharmaceutical dosage form and their comparison by ANOVA. Method (A) is well based on first order derivative spectrophotometric method, in which zero crossing points for Luliconazole is 249.50 nm and Terbinafine hydrochloride is 258.50 nm. Linearity was found in range of 3-18 µg/ ml for both the drugs using methanol as a common solvent. Method (B) is constructed on the principle of dual wavelength method using absorbance difference at 281 and 306 nm for Luliconazole & 262 and 296 nm for Terbinafine hydrochloride. Method (C) is based on norm of Q-absorbance ratio method where iso-absorptive point was obtained at 250 nm and the λ max selected was of Terbinafine hydrochloride 282 nm. The developed methods were validated as per ICH guideline. Accuracy and precision of methods were determined and validated. All the developed methods showed good reproducibility and recovery with % RSD <2. These three methods developed were compared using one way ANOVA and the fcal value was found to be less than ftab value indicating that there is no significant difference in the assay results of the three methods. All three methods were found to be rapid, specific, precise and accurate and found no interferences from the cream excipients so it can be used for routine investigation of both drugs in quality control laboratories.","PeriodicalId":313915,"journal":{"name":"Advances in Pharmacology &amp; Clinical Trials","volume":"3 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"132774597","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Assessment of Drug Prescriptions at the University Hospital Center, National Center of Odontostomatology (CHU-CNOS) in Bamako, Mali","authors":"Sanou Coulibaly Kho","doi":"10.23880/apct-16000186","DOIUrl":"https://doi.org/10.23880/apct-16000186","url":null,"abstract":"Introduction: The prescription is an order for delivery and an act by which the practitioner draws up a list of products or hygienic-dietetic measures. Methodology: This is a cross-sectional, descriptive study to assess the quality of prescriptions. It took place at the University Hospital for Odontostomatology over a period of six months, during which 870 medical prescriptions were included. Result: The most important information to figured out orders such as the prescription date, the qualification of the prescriber, the signature and stamp were not mentioned, respectively, in 3; 81; 5 and 7% of cases. Almost no prescription prescribed referred to weights (99% of cases). The duration of treatment is not specified in 99% of cases. The full name of the patient and readability of orders were still noted in all cases. Discussion/Conclusion: For a prescription, certain legal references can incriminate prescribers and lead patients into therapeutic errors","PeriodicalId":313915,"journal":{"name":"Advances in Pharmacology &amp; Clinical Trials","volume":"208 ","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"133586764","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Role of Insulin in Prevention of Hypertrophic Scars","authors":"R. Chittoria","doi":"10.23880/apct-16000173","DOIUrl":"https://doi.org/10.23880/apct-16000173","url":null,"abstract":"","PeriodicalId":313915,"journal":{"name":"Advances in Pharmacology &amp; Clinical Trials","volume":"6 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"117110599","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"DNA Binding Effect and Antibacterial Effect of Bezafibrate, an Antilipemic Agent","authors":"I. Arman","doi":"10.23880/apct-16000176","DOIUrl":"https://doi.org/10.23880/apct-16000176","url":null,"abstract":"","PeriodicalId":313915,"journal":{"name":"Advances in Pharmacology &amp; Clinical Trials","volume":"4 3","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"120852617","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Isolation and Biochemical Identification of Enterococcus Faecalis on Moribund Nile Tilapia (Oreochromis Niloticus L)","authors":"Alvin T Reyes","doi":"10.23880/apct-16000177","DOIUrl":"https://doi.org/10.23880/apct-16000177","url":null,"abstract":"","PeriodicalId":313915,"journal":{"name":"Advances in Pharmacology &amp; Clinical Trials","volume":"4 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"124758864","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Secondary Prevention of Coronary Heart Disease and PCSK9 Inhibitors","authors":"Kuznetsov Andrey","doi":"10.23880/apct-16000187","DOIUrl":"https://doi.org/10.23880/apct-16000187","url":null,"abstract":"","PeriodicalId":313915,"journal":{"name":"Advances in Pharmacology &amp; Clinical Trials","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"131502815","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}