Advances in Pharmacology & Clinical Trials最新文献

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The Safety, Toleration, and Pharmacokinetics Comparison of Two Intravenous Voriconazole Formulations in Healthy Chinese Volunteers after Three Ascending Doses 三次上升剂量后两种伏立康唑静脉注射制剂在中国健康志愿者中的安全性、耐受性和药代动力学比较
Advances in Pharmacology & Clinical Trials Pub Date : 1900-01-01 DOI: 10.23880/apct-16000193
Jin Wang
{"title":"The Safety, Toleration, and Pharmacokinetics Comparison of Two Intravenous Voriconazole Formulations in Healthy Chinese Volunteers after Three Ascending Doses","authors":"Jin Wang","doi":"10.23880/apct-16000193","DOIUrl":"https://doi.org/10.23880/apct-16000193","url":null,"abstract":"Voriconazole is a triazole antifungal agent with potent activity against a broad spectrum of clinically significant pathogens to treat infections and invasive aspergillosis and immunocompromised patients as prophylactic drug. The large variability of plasma exposure of voriconazole for injection is related with adverse drug reactions (ADRs), including visual impairment, rash and abnormal liver function test. Because the poorly dissolution of voriconazole in aqueous media, the toxicity of the excipient accumulation of sulfobutyl ether-beta-cyclodextrin sodium salt (SBECD) contained in the intravenous voriconazole may occur in renally impaired patients. The Betadex sulfobutyl ether sodium and SBECD as a solubilizer in the new formulation of intravenous voriconazole injection may improve the related ADRs. The present article evaluate the safety, toleration, and pharmacokinetics (PKs) comparison of two intravenous voriconazole injection formulations after three ascending dose administrations in healthy Chinese subjects by a randomized, double-blind, placebo- and positive-controlled trial.","PeriodicalId":313915,"journal":{"name":"Advances in Pharmacology & Clinical Trials","volume":"24 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"129319260","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Dermatology Prescriptions by Abulcasis Al-Zahrawi (C.936-C.1013) 阿布卡西斯·扎赫拉维(C.936-C.1013)的皮肤病处方
Advances in Pharmacology & Clinical Trials Pub Date : 1900-01-01 DOI: 10.23880/apct-16000175
L. M. Arvide Cambra
{"title":"Dermatology Prescriptions by Abulcasis Al-Zahrawi (C.936-C.1013)","authors":"L. M. Arvide Cambra","doi":"10.23880/apct-16000175","DOIUrl":"https://doi.org/10.23880/apct-16000175","url":null,"abstract":"","PeriodicalId":313915,"journal":{"name":"Advances in Pharmacology & Clinical Trials","volume":"57 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"132021904","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Local Perception of Coronavirus and Disease Care in Southwestern Nigeria 尼日利亚西南部当地对冠状病毒的认知和疾病护理
Advances in Pharmacology & Clinical Trials Pub Date : 1900-01-01 DOI: 10.23880/apct-16000179
Aderemi Sa
{"title":"Local Perception of Coronavirus and Disease Care in Southwestern Nigeria","authors":"Aderemi Sa","doi":"10.23880/apct-16000179","DOIUrl":"https://doi.org/10.23880/apct-16000179","url":null,"abstract":"","PeriodicalId":313915,"journal":{"name":"Advances in Pharmacology & Clinical Trials","volume":"20 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"127591414","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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