Journal of Clinical and Preventive Cardiology最新文献

{"title":"The prevalence, causes, and management strategies for stress among health-care professionals of Delhi-National Capital Region","authors":"R. Mehrotra, Mayanka Gupta, Mohit M. Bhagwati, D. Jain","doi":"10.4103/jcpc.jcpc_4_21","DOIUrl":"https://doi.org/10.4103/jcpc.jcpc_4_21","url":null,"abstract":"Background: Stress at workplace has an adverse impact not only on the employees in terms of health, well being, and job dissatisfaction, but also affects the organization in terms of quality of output, absenteeism, and attrition which ultimately has detrimental financial implications. Health care professionals comprise of an important group that are majorly affected by workplace stress because of the nature of their work environment. Methods: The current study was undertaken to ascertain the presence of self perceived stress among healthcare workers in multispecialty hospitals of the National Capital Region of Delhi and to find the expected remedial measures that could be implemented to mitigate stress. In a questionnaire based study, a self administered questionnaire was used to assess stress and related factors using convenience-sampling technique. The response data were extracted and analyzed using Microsoft Excel, which was used for data analysis, tabulation, and graphical presentation. Results: Total 110 responses were received. Three quarter of the respondents identified significant stress in their life, with the highest stress reported by nursing staff at 98%, doctors at 67%, and administrative staff at 56%. The study shows a significant association of self reported stress with age of the respondents (P < 0.001). Respondents among age group of 15–25 years reported the highest prevalence of stress (P < 0.001). Women reported a higher level of stress than men, (P < 0.001), and nurses reported the highest level of stress followed by doctors and then administrative staff. Different methods to relieve stress were also discussed and it was found that two thirds (67%) of our study respondents would like to meditate at work. Conclusion: Stress is common among all categories of healthcare workers.Meditation can be a safe, effective, and feasible modality which can be offered at the workplace to safeguard the mental health of the health care workers and reduce their levels of stress.","PeriodicalId":31371,"journal":{"name":"Journal of Clinical and Preventive Cardiology","volume":"10 1","pages":"85 - 94"},"PeriodicalIF":0.0,"publicationDate":"2021-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46432498","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clopidogrel resistance in cardiovascular disease patients and its association with gene polymorphisms: A pilot study","authors":"S. Parameshwara, B. Manjula, Geetha Bhaktha, G. Kallaganad, G. Ranjith Kumar","doi":"10.4103/jcpc.jcpc_71_20","DOIUrl":"https://doi.org/10.4103/jcpc.jcpc_71_20","url":null,"abstract":"Aims: To determine the genotypic and allelic frequencies of multidrug resistance protein 1 (MDR1), CYP2C19, and P2Y12 gene and their polymorphisms in the Shimoga population who admitted for treatment in McGann teaching district hospital-Shimoga Institute of Medical Sciences (SIMS), Shimoga. Materials and Methods: It is a cross-sectional study that was conducted in McGann teaching district hospital, SIMS, Shimoga. Patients who were admitted to the Intensive coronary care unit due to cardiovascular disease (CVD) were recruited for the study. Sociodemographic data with venous blood samples (5 ml) were collected along with informed consent. Genotyping of the MDR1, CYP2C19, and P2Y12 polymorphisms were done using the polymerase chain reaction (PCR) restriction fragment length polymorphism method. Descriptive and inferential statistics were done using the Statistical Package for the Social Sciences software. The genotypic and allelic frequency was calculated using the Hardy-Weinberg equilibrium. Results: Out of 40 CVD cases, 60% were male and 40% were female and the mean age was found to be 57.13 ± 11.57 years. The percentage of the obese group was more compared to other groups of body mass index. Risk factors such as diabetes, hypertension, food custom, smoking, and tobacco consumption were not significant while alcohol consumption was seen to be significant among the study population at a 5% level of significance. The genotypic frequencies for a heterozygous and mutant type of MDR1 (C3435T) and CYP2C19*2 (G681A) were found to be 35%, 2.5%, 57.5%, and 5%, respectively. Whereas the gene polymorphism of CYP2C19*3 and P2Y12 was not observed in the present study population. Conclusions: This is the first gene polymorphism study with respect to clopidogrel resistance in the Shimoga population. We have demonstrated the presence of polymorphism in the MDR1 and CYP2C19 genes in this study population. A further elaborate study should be conducted for a better understanding of genetic with nongenetic factors involved in poor response toward clopidogrel drug using a large population.","PeriodicalId":31371,"journal":{"name":"Journal of Clinical and Preventive Cardiology","volume":"10 1","pages":"80 - 84"},"PeriodicalIF":0.0,"publicationDate":"2021-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45831080","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Left-sided anomalous origin of the coronary artery from the opposite sinus: Single anomalous left anterior descending artery originating from the right coronary artery – A rare case","authors":"A. Sarojadevi, S. Thenmozhi, Badrinath Kuppuswamy, Suresh Somasundharam","doi":"10.4103/jcpc.jcpc_8_21","DOIUrl":"https://doi.org/10.4103/jcpc.jcpc_8_21","url":null,"abstract":"Anomalous origin of the coronary artery from the opposite sinus (ACAOS) is a significant subclass of coronary artery anomalies. Ischemic symptoms can develop at any age and judicious use of imaging modalities is needed to guide treatment. We present a short review of this rare coronary anomaly left-sided ACAOS diagnosed in a 42-year-old gentleman.","PeriodicalId":31371,"journal":{"name":"Journal of Clinical and Preventive Cardiology","volume":"10 1","pages":"117 - 119"},"PeriodicalIF":0.0,"publicationDate":"2021-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48644111","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The association between nonalcoholic fatty liver disease and cardiovascular disease: A window of opportunity","authors":"N. Choudhary, N. Saraf, Mohammad Shafi Kuchay, R. Kasliwal","doi":"10.4103/jcpc.jcpc_31_21","DOIUrl":"https://doi.org/10.4103/jcpc.jcpc_31_21","url":null,"abstract":"Cardiovascular diseases (CVDs) are the leading cause of mortality in India. Nonalcoholic fatty liver disease (NAFLD) is the most common liver disease in India. People with NAFLD generally share common metabolic risk factors with CVD; yet, NAFLD is independently associated with CVD. As NAFLD is easily diagnosed due to the availability of ultrasound, the awareness regarding association of NAFLD to CVD may prevent both cardiovascular and liver-related morbidity/mortality. We discuss association of NAFLD and CVD and preventive potential in the Indian population.","PeriodicalId":31371,"journal":{"name":"Journal of Clinical and Preventive Cardiology","volume":"10 1","pages":"112 - 116"},"PeriodicalIF":0.0,"publicationDate":"2021-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48805510","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison of global registry of acute coronary events and thrombolysis in myocardial infarction risk scores in non-ST-elevation acute coronary syndrome","authors":"S. Routray, C. Satpathy, N. Mohanty, Bijaykumar Dash, R. Satapathy","doi":"10.4103/jcpc.jcpc_25_21","DOIUrl":"https://doi.org/10.4103/jcpc.jcpc_25_21","url":null,"abstract":"Context: The Global Registry of Acute Coronary Events (GRACE) and Thrombolysis in Myocardial Infarction (TIMI) scores in predicting coronary disease severity in patients with non-ST-elevation acute coronary syndromes (NSTE-ACS) have not been proved. Aims: We aimed to compare the GRACE score with TIMI risk score for prediction of the angiographic severity of coronary artery disease (CAD) in patients with NSTE-ACS. Settings and Design: This was an observational cross-sectional study. Subjects and Methods: Total 202 NSTE-ACS (NSTE myocardial infarction and unstable angina) patients were included. The GRACE and TIMI scores were estimated. Coronary angiogram was done and the Gensini score and vessel score were used to assess the severity of CAD. Statistical Analysis Used: SPSS software version 27.0 was used for statistical analysis. For comparison of two means, independent sample t-test/Mann–Whitney U-test was used, while for more than two means, one-way ANOVA/Kruskal–Wallis test was used. The receiver operating characteristic (ROC) curve was applied for the predictability of GRACE and TIMI scores for severity of disease. Results: A positive association between the Gensini score and vessel score was observed with both the GRACE (P = 0.001) and TIMI (P = 0.001) scores. The area under the ROC curve for the GRACE score was 0.765 (95% confidence interval [CI] = 0.676–0.854), significantly superior to the area under the ROC curve of the TIMI score (0.715; 95% CI = 0.618–0.812). Risk factors such as higher age, hypertension, smoking history, dyslipidemia, ECG changes such as ST deviation and T inversion, and Killip classification showed a statistically significant association with severity of disease. Conclusions: Both the GRACE and TIMI risk scores were a good predictor of angiographic severity of CAD in patients with NSTE-ACS, and the GRACE score was found to be superior to the TIMI risk score.","PeriodicalId":31371,"journal":{"name":"Journal of Clinical and Preventive Cardiology","volume":"10 1","pages":"106 - 111"},"PeriodicalIF":0.0,"publicationDate":"2021-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44475360","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Editor's Page July 2021","authors":"R. Kasliwal","doi":"10.4103/2250-3528.326477","DOIUrl":"https://doi.org/10.4103/2250-3528.326477","url":null,"abstract":"","PeriodicalId":31371,"journal":{"name":"Journal of Clinical and Preventive Cardiology","volume":"10 1","pages":"79 - 79"},"PeriodicalIF":0.0,"publicationDate":"2021-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43299868","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A study of spectrum of rheumatic heart disease in children at a tertiary care hospital in Western India","authors":"P. Vyas, Joshi Hasit, Radhakisan Dake, I. Patel, K. Patel","doi":"10.4103/jcpc.jcpc_49_20","DOIUrl":"https://doi.org/10.4103/jcpc.jcpc_49_20","url":null,"abstract":"Context: Rheumatic heart disease (RHD) predominantly affects adults. However, in developing countries like India, it is the most common acquired heart disease in children. The prevalence of RHD also varies from the region to region in the same country due to the differences in educational, economic, and social status as well as health-care facilities of the region. Aim: The aim of the study is to establish and discuss the spectrum of RHD in children from Western India and to explore the relationship between severity of valvular lesion by the age and sex of the children with RHD. Methods: Echocardiographic findings of children (N = 820) ≤18 years with RHD seen at our institute from January 2018 to December 2018 were retrospectively analyzed. RHD was screened by echocardiography. All the echocardiogram were analyzed for the pattern and severity of various valve lesions and associated abnormalities. Results: Eight hundred and twenty children had a diagnosis of RHD. Maximum patients [476 (57.1%)] were from the age group of 13–18 years without any gender difference (418 male and 402 female). Mitral regurgitation (MR) was the most common lesion found in 81.46% children. Aortic regurgitation (AR) was seen in 29.76%, mitral stenosis (MS) was found in 20.48%, tricuspid regurgitation was seen in 66.83%, and aortic stenosis (AS) was found in 0.73% children. AR was found more common in males as compared to females (P = 0.0004). Majority of patients (69.5%) had single mitral valve involvement. Four hundred and eight patients (49.8%) had severe MR, 122 patients (14.9%) had severe MS, 62 patients (7.6%) had severe aortic regurgitation, and 2 (0.2%) patients had severe AS at the time of first presentation. Pulmonary hypertension was found in 69% of children. Children with MS and AS were older than those without MS and AS (P = 0.0001). Conclusion: Majority of children had severe valvular lesion and pulmonary hypertension at the time of first presentation. RHD is the leading cause of heart failure in children with requirement of surgical/catheter intervention and long-term medical management.","PeriodicalId":31371,"journal":{"name":"Journal of Clinical and Preventive Cardiology","volume":"10 1","pages":"48 - 53"},"PeriodicalIF":0.0,"publicationDate":"2021-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44175737","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Eptifibatide-induced acute profound thrombocytopenia in a patient with left main artery plaque rupture complicated by cardiogenic shock and gastrointestinal bleeding","authors":"S. Nandal, W. van Gaal, F. Ponnuthurai","doi":"10.4103/jcpc.jcpc_67_20","DOIUrl":"https://doi.org/10.4103/jcpc.jcpc_67_20","url":null,"abstract":"Eptifibatide inhibits platelet aggregation by reversibly binding to the platelet receptor glycoprotein (GP) IIb/IIIa of human platelets, thus preventing the binding of fibrinogen and adhesion proteins such as fibronectin, vitronectin, and von Willebrand factor to form cross bridges with adjacent platelets. There are two other GP IIb/IIIa inhibitors, namely abciximab and tirofiban, available for clinical use. Profound thrombocytopenia is an uncommon but clinically important complication of GP IIb/IIIa inhibitors. This case discusses a 64-year-old male patient who developed profound thrombocytopenia within 4 h of first administration of eptifibatide. This report adds a case of eptifibatide-induced thrombocytopenia complicated by gastrointestinal bleeding to the medical literature. It highlights the need for complex decision-making regarding cessation of antiplatelet therapy in patients with recent percutaneous coronary intervention and the lack of robust evidence for the benefit of GP IIb/IIIa inhibitors in the ticagrelor era when compared to clopidogrel and aspirin.","PeriodicalId":31371,"journal":{"name":"Journal of Clinical and Preventive Cardiology","volume":"13 3","pages":"74 - 77"},"PeriodicalIF":0.0,"publicationDate":"2021-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41246543","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Role of N-terminal pro-B-type natriuretic peptide in predicting mortality in heart failure","authors":"K. Jena, N. Vishwanathan, G. Manohar, Prashant Singh, Nayan Chakraborty","doi":"10.4103/jcpc.jcpc_65_20","DOIUrl":"https://doi.org/10.4103/jcpc.jcpc_65_20","url":null,"abstract":"Background: N-terminal pro-B-type natriuretic peptide (NT-proBNP) improves emergency room diagnosis and is a prognostic marker of acutely decompensated heart failure (HF) after hospitalization. We tried to assess the prognosis in heart failure with preserved ejection fraction (HFpEF) and heart failure with reduced ejection fraction (HFrEF) using the biomarker. Methods: Patients were categorized into HFpEF (left ventricular ejection fraction [LVEF] ≥50%) (n = 102), HF with midrange EF (LVEF of 40%–49%) (n = 106), and HFrEF (LVEF ≤40%) (n = 112) as per the ESC classification of HF subtypes. Prognosis by absolute and percentage change in NT-proBNP at admission and at the 10th day of treatment was found in 3-month follow-up. Mortality after discharge was also assessed. Results: Among all HF groups, a reduction of NT-proBNP <20% at 10 days predicted mortality, hazard ratio (HR) – 14.9 (95% confidence interval [CI]: 3.8–57.9), P = 0.0001. The risk of mortality in HF patients with NT-proBNP reduction of <20% in 10 days was 14.9 times higher in 3-month follow-up. NT-proBNP more than 12,000 pg/mL at admission had a mortality risk of 23.3% in the HFrEF group, HR – 23.45 (95% CI: 2.9–189.4), P = 0.003. NT-proBNP on the 10th day, more than 9000 pg/mL, had a mortality risk of 21.4% in the HFrEF group, HR – 23.3 (95% CI: 4.9–110.5), P = 0.001. Conclusion: NT-proBNP proved to be a superior modality in finding out prognosis in HF. Patients with the HFrEF group had a higher mortality in our study. Comorbidities play an important role in affecting the prognosis in patients with HFpEF with lower NT-proBNP.","PeriodicalId":31371,"journal":{"name":"Journal of Clinical and Preventive Cardiology","volume":"10 1","pages":"63 - 67"},"PeriodicalIF":0.0,"publicationDate":"2021-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42753087","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Peripartum cardiomyopathy in Indian population: A pooled analysis","authors":"R. Agarwal, R. Baid, D. Sinha","doi":"10.4103/jcpc.jcpc_61_20","DOIUrl":"https://doi.org/10.4103/jcpc.jcpc_61_20","url":null,"abstract":"Introduction: Peripartum cardiomyopathy (PPCM) refers to heart failure of unknown etiology in later gestation or early postpartum period. Data regarding its incidence, clinical features, risk factors, and outcomes in the Indian population are scarce. Materials and Methods: We performed a pooled analysis of seven Indian studies on PPCM, including 221 patients to study PPCM. Results: The incidence of PPCM in the Indian population was 1 in 1340 live births. Indian women developed PPCM at a mean age of 27 years and most commonly in the postpartum period (60% cases). Hypertensive disorders and anemia were associated with PPCM in nearly half the number of patients. Maternal mortality was 11.7% and fetal mortality 14.2%. Conclusion: Our study provides data on PPCM in the Indian population. Larger studies with higher number of patients are needed to study PPCM in detail in the Indian subset.","PeriodicalId":31371,"journal":{"name":"Journal of Clinical and Preventive Cardiology","volume":"10 1","pages":"54 - 57"},"PeriodicalIF":0.0,"publicationDate":"2021-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42564646","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}