Spatula DD - Peer Reviewed Journal on Complementary Medicine and Drug Discovery最新文献_第2页

Carbohydrate-Mediated Drug Targeting-A Review 碳水化合物介导的药物靶向研究综述

Spatula DD - Peer Reviewed Journal on Complementary Medicine and Drug Discovery Pub Date : 1900-01-01 DOI: 10.5455/SPATULA.20150330105811

K. Seyrek, D. Aksit, H. Aksit, O. Yildiz

{"title":"Carbohydrate-Mediated Drug Targeting-A Review","authors":"K. Seyrek, D. Aksit, H. Aksit, O. Yildiz","doi":"10.5455/SPATULA.20150330105811","DOIUrl":"https://doi.org/10.5455/SPATULA.20150330105811","url":null,"abstract":"ABSTRACT Conventional drugs used in cancer therapy have extended the survival time of patients, however mortality has not significantly decreased. It is evident that there is a need to develop a new, more effective and less toxic compounds in cancer treatment. A promising new approach is based on the deciphering of biological information encoded in β-galactose-containing glycoconjugates and to find out the biological role(s) of carbohydrate binding proteins/galectins, which able to convert encoded information into biological and pathological reactions. Galectins can alter cellular interactions and have important roles in cell cycle, apoptosis and metastases. This review aimed to provide an overview on the potential advantages concerning understanding the mechanism of action of galectin-3 (gal-3) as a therapeutic agent for cancer. Galectin-3 has been found to be upregulated in many types of cancer including colon, gastric, renal and non-small cell lung cancer. Results of several studies indicating that gal-3 plays a dynamic role in the tumorogenesis and metastatic process, and showing that blockers/inhibitors of gal-3 could have important therapeutic potential in cancer.","PeriodicalId":309051,"journal":{"name":"Spatula DD - Peer Reviewed Journal on Complementary Medicine and Drug Discovery","volume":"11 10 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"116024080","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effect of potassium iodide on growth of Sporothrix schenckii in yeast form 碘化钾对酵母形态申氏孢子丝菌生长的影响

Spatula DD - Peer Reviewed Journal on Complementary Medicine and Drug Discovery Pub Date : 1900-01-01 DOI: 10.5455/SPATULA.20160414060306

Rajesh Bareja, P. Grover, S. Mehra

引用次数: 0

The Medical Usage of Caffeic Acid Phenethyl Ester (CAPE), an Active Compound of Propolis, in Neurological Disorders and Emergencies 蜂胶活性化合物咖啡酸苯乙酯(CAPE)在神经系统疾病和紧急情况中的医学应用

Spatula DD - Peer Reviewed Journal on Complementary Medicine and Drug Discovery Pub Date : 1900-01-01 DOI: 10.5455/SPATULA.20110208013739

S. Akyol, F. Armutcu, M. R. Yiğitoğlu

{"title":"The Medical Usage of Caffeic Acid Phenethyl Ester (CAPE), an Active Compound of Propolis, in Neurological Disorders and Emergencies","authors":"S. Akyol, F. Armutcu, M. R. Yiğitoğlu","doi":"10.5455/SPATULA.20110208013739","DOIUrl":"https://doi.org/10.5455/SPATULA.20110208013739","url":null,"abstract":"Propolis is a compound produced by honey bee with a heavy beautiful odor after a serial process in his saliva. Normally, this product has been used by honey bee to protect the hives from some enfected single cells such as bacteria and fungi, to embalm the foreign materials, and to repair all the cracks within the hives. Grunberger and his friends from Columbia University located in New York extracted and identified caffeic acid phenethyl ester (CAPE) from propolis. It is an active compound which has several functions like antioxidant. After that time, a lot of scientists started to study this great compound and published their hundreds of findings in medical journals. In early 1990s, CAPE was produced by Sigma-Aldrich company as a commercial product and the scientists have been easily get it from the company branches and use it their medical researches. \u0000In this review article, it is going to be tried to answer some questions on what was CAPE’s usage and how in neurological disorders and neurological emergencies. In the experimental studies, it has been found to be a unique agent in preventing reperfusion injuries after ischemia reperfusion processes and also it is going to find a new usage area in geriatric disorders itself under the light of the findings from experimental animal models.","PeriodicalId":309051,"journal":{"name":"Spatula DD - Peer Reviewed Journal on Complementary Medicine and Drug Discovery","volume":"55 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"117314728","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 6

Effects of smoking on periodontal health and oral hygiene habits 吸烟对牙周健康及口腔卫生习惯的影响

Spatula DD - Peer Reviewed Journal on Complementary Medicine and Drug Discovery Pub Date : 1900-01-01 DOI: 10.5455/spatula.20150708051821

Ahmet Aydoðdu, Müge Lütfioðlu, E.Eser Sakallýoðlu

引用次数: 0

Mutagenic and antimicrobial evaluation of methanol extract from Allium kharputense Freyn Et. Sint 大蒜甲醇提取物的致突变性和抗菌性评价

Spatula DD - Peer Reviewed Journal on Complementary Medicine and Drug Discovery Pub Date : 1900-01-01 DOI: 10.5455/SPATULA.20151124063207

E. Erdogan, Erdal Yabalak, A. Everest, A. Gizir

引用次数: 3

Antioxidant Activity of Aloeswood Tea in vitro 沉香茶体外抗氧化活性的研究

Spatula DD - Peer Reviewed Journal on Complementary Medicine and Drug Discovery Pub Date : 1900-01-01 DOI: 10.5455/SPATULA.20120331054309

W. Han, Xican Li

{"title":"Antioxidant Activity of Aloeswood Tea in vitro","authors":"W. Han, Xican Li","doi":"10.5455/SPATULA.20120331054309","DOIUrl":"https://doi.org/10.5455/SPATULA.20120331054309","url":null,"abstract":"AIM: As a typical healthcare tea, aloeswood tea becomes more popular in China now. The present study tried to systematically evaluate the antioxidant ability in vitro of aloeswood tea for the first time. \u0000METHODS: Methanolic extract of aloeswood tea (MEAT) was prepared and measured by DPPH•, ABTS+•, •O2, •OH, reducing power (Fe3+ & Cu2+), lipid peroxidation, metal-chelating assays (Fe2+ & Cu2+). Then, the total phenol content was measured by spectrophotometre method. \u0000RESULTS: The IC50 values of MEAT were calculated as 11.63±0.16, 2.05±0.060, 7.73±0.35, 31.20±0.57, 18.56±1.60, 16.25±0.10, 0.49±0.05, 94.24±3.19, 134.01±7.04 μg/mL, respectively, for DPPH•, ABTS+•, •O2-, •OH, reducing power (Fe3+ & Cu2+), lipid peroxidation, metal-chelating assays (Fe2+ & Cu2+). The total phenol content in MEAT was found to be 157.41±6.51 mg GAE/g. \u0000CONCLUSION: Aloeswood tea shows excellent in vitro antioxidant activity which may contribute to its healthcare functions and pharmacological benefits. Its antioxidant ability could be attributed to phenolic compounds, especially flavonoids which may exert antioxidant action in vitro by both chelating metal ions, and scavenging free radicals via donating hydrogen atom (H•) or electron (e).","PeriodicalId":309051,"journal":{"name":"Spatula DD - Peer Reviewed Journal on Complementary Medicine and Drug Discovery","volume":"90 2 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"127734368","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 12

A Comparative Clinical Study on the Effects of Mehjama Nariya and Hijamat Bila Shart in Irqunnasa (Sciatica) Mehjama Nariya与Hijamat Bila Shart治疗坐骨神经痛的临床比较研究

Spatula DD - Peer Reviewed Journal on Complementary Medicine and Drug Discovery Pub Date : 1900-01-01 DOI: 10.5455/SPATULA.20131127023056

Mohammed Sheeraz, Mohd. Aleemuddin Quamari, Zaheer Ahmed

{"title":"A Comparative Clinical Study on the Effects of Mehjama Nariya and Hijamat Bila Shart in Irqunnasa (Sciatica)","authors":"Mohammed Sheeraz, Mohd. Aleemuddin Quamari, Zaheer Ahmed","doi":"10.5455/SPATULA.20131127023056","DOIUrl":"https://doi.org/10.5455/SPATULA.20131127023056","url":null,"abstract":"Aim: Irqunnasa (Sciatica) is one of the commonest neuralgic pains in lower limbs. The overall incidence of this condition is approximately between 13% and 40 % with the malady has the potential to become chronic and intractable with major socioeconomic implications. Several Unani medical regimens are claimed to be effective in its treatment, but are not corroborated. In order to validate scientifically, two different regimens viz; Mehjama Nariya (Fire cupping) and Hijamat Bila Shurt (Dry cupping) were selected to evaluate their effects comparatively in Irqunnasa by an open label, prospective, simple randomized, observational study. \u0000Methods: Diagnosed cases of Irqunnasa aged between 18 to 65 years of either gender fulfilling the inclusion criteria were selected and randomly allocated after obtaining voluntary informed consent into two groups of 20 patients each viz; Group A Mehjama Nariya and Group B Hijamat Bila Shurt. Treatment protocol was followed for 15 days in both groups. \u0000Results: Mean visual analogue scale (VAS) scores before treatment in Group A was 10 and Group B was 9.4, while after treatment it declined to 6 in Group A and 6.6 in Group B. This reduction was found statistically significant in both groups (p< 0.01). The Oswestry disability index (ODI) scores in both groups revealed significant difference (p","PeriodicalId":309051,"journal":{"name":"Spatula DD - Peer Reviewed Journal on Complementary Medicine and Drug Discovery","volume":"46 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"128090978","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 4

Use of herbal drugs as alternative medicine: Experience of Iraqi patients - 使用草药作为替代药物:伊拉克病人的经验

Spatula DD - Peer Reviewed Journal on Complementary Medicine and Drug Discovery Pub Date : 1900-01-01 DOI: 10.5455/SPATULA.20160313010203

K. A. Kadhim, A. N. Abbas, S. Hussain

引用次数: 2

Comparative assessment of annual wormwood and local accessions of bitter leaf for antioxidant composition and activity 一年生苦艾与本地苦叶的抗氧化成分及活性比较

Spatula DD - Peer Reviewed Journal on Complementary Medicine and Drug Discovery Pub Date : 1900-01-01 DOI: 10.5455/spatula.20160419022147

P. N. Chukwurah, E. A. Brisibe, Lenin Imoh Ekwere, E. Ekerette, Kilsi Borgbara

引用次数: 0

Argan Yağının Biyolojik Aktiviteleri ve Tedavide Kullanılışı

Spatula DD - Peer Reviewed Journal on Complementary Medicine and Drug Discovery Pub Date : 1900-01-01 DOI: 10.5455/SPATULA.20150616061703

Mukadder Çetin, Didem Deliorman Orhan

引用次数: 0